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  • leukaemia
  • This gene is frequently mutated in cancer, being one of 127 frequently mutated genes identified in the Cancer Genome Atlas project DNMT3A mutations were most commonly seen in acute myeloid leukaemia (AML) where they occurred in just over 25% of cases sequenced. (wikipedia.org)
  • remission
  • Children with AML who have a white blood cell count (WBC) greater than 100,000 per cubic milliliter, secondary AML, and leukemic cells with a monosomy 7 karyotype have low remission induction rates, whereas children with leukemia cell chromosomal abnormalities t(8;21) and inv 16 have a high likelihood of achieving remission. (meds.com)
  • While appendectomy is the treatment of choice for these patients, diagnosis and management of leukemia have a greater impact on remission and survival. (hindawi.com)
  • Long-lasting remissions have been documented in sporadic cases, usually occurring in young patients who have been treated with acute leukemia-type induction therapy, followed by allogenic HSCT in first complete remission. (wikipedia.org)

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  • leukemic
  • Acute appendicitis with leukemic infiltration as the initial manifestation of AML has only been described in two other cases in the literature with an average associated morbidity of 32.6 days. (hindawi.com)
  • Other chemotherapy agents, specifically epipodophyllotoxins and anthracyclines, have also been associated with treatment-related leukemias, which are often associated with specific chromosomal abnormalities in the leukemic cells. (wikipedia.org)
  • Leukemic transformation can occur in any of these two cells, but transformation of myeloid dendritic cell is less common and it leads to a form of leukemia known as acute myeloid dendritic cell leukemia. (wikipedia.org)
  • childhood
  • Children with Down syndrome have an increased risk of leukemia with a ratio of ALL to AML typical for childhood acute leukemia, except during the first 3 years of life when AML (especially M7) predominates. (meds.com)
  • However, the condition is rare and represents approximately 3% of all leukemias during childhood and has an incidence of 1.1 - 1.7 per million per year. (wikipedia.org)
  • symptoms
  • Occasionally, a person may show no symptoms, and the leukemia may be discovered incidentally during a routine blood test. (wikipedia.org)
  • genomic
  • Occasional cases require in situ hybridization to identify the myeloperoxidase gene315 or genomic profiling for early myeloid-associated genes. (wikipedia.org)
  • syndrome
  • 10 ] Interestingly, the majority of children with Down syndrome and AML can be cured of their leukemia. (meds.com)