• selective
  • In the presence of TKI the binding of ATP is blocked, phosphorylation is prevented and Bcr-Abl expressing cells either have a selective growth disadvantage or undergo apoptotic cell death. (wikipedia.org)
  • K562
  • K562 cells were the first human immortalised myelogenous leukemia line to be established. (wikipedia.org)
  • K562 cells are of the erythroleukemia type, and the line is derived from a 53-year-old female chronic myelogenous leukemia patient in blast crisis. (wikipedia.org)
  • There are many different cellular components involved in the cycle of apoptosis such as, BCR/ABL, Bcl-2, Bax protein, and cytochrome C. The tumor suppressor gene p53 is also important in the cell cycle regulation of K562 cells. (wikipedia.org)
  • Vánky, F. (1976), "Properties of the K562 cell line, derived from a patient with chronic myeloid leukemia", International Journal of Cancer, 18 (4): 421-31, doi:10.1002/ijc.2910180405, PMID 789258 Andersson, L.C. (wikipedia.org)
  • kinase domain
  • Since then crystallographic studies have revealed that imatinib binds to the kinase domain of Abl only when the domain adopts the inactive or "closed" conformation. (wikipedia.org)
  • This is due to the replacement of the myristoylated cap region, which when present induces a conformational change rendering the kinase domain inactive, with a truncated portion of the BCR protein. (wikipedia.org)
  • Hematopoietic
  • Within the hematopoietic system, MSI2 is highly expressed in the most primitive progenitors, in stem cell compartments, and its overexpression has been found in myeloid leukemia cell lines. (wikipedia.org)
  • As Musashi2 is involved in the generation of hematopoietic cells, it is also linked with cancer pathologies: It has been found that MSI2 plays an important role in myeloid leukemia. (wikipedia.org)
  • Proteins
  • Since ABL activates a number of cell cycle-controlling proteins and enzymes, the result of the BCR-Abl fusion is to speed up cell division. (wikipedia.org)
  • blast crisis
  • Blast crisis is diagnosed if any of the following are present in a patient with CML: >20% myeloblasts or lymphoblasts in the blood or bone marrow Large clusters of blasts in the bone marrow on biopsy Development of a chloroma (solid focus of leukemia outside the bone marrow) The only curative treatment for CML is a bone marrow transplant or an allogeneic stem cell transplant. (wikipedia.org)
  • KBM-7 cells were derived from a 39-year-old man with chronic myeloid leukemia in blast crisis. (wikipedia.org)
  • Cancer
  • Cyclophosphamide is a prescription medicine used alone, or in combination with other medications to treat several types of cancer including lymphoma, leukemia, ovarian, and breast cancer. (rxwiki.com)
  • Skin cancer and leukemia , which can be fatal, have been reported in patients receiving long-term hydroxyurea for conditions other than sickle cell anemia. (rxwiki.com)
  • Chronic myelogenous leukemia (CML) is a cancer of the white blood cells. (wikipedia.org)
  • Even though the first Bcr-Abl TK inhibitor was named "the magic bullet" to cure cancer by TIME magazine, a second generation of Bcr-Abl TKI was subsequently developed to combat the initial resistance that emerged. (wikipedia.org)
  • adherence
  • However, another study suggests that bcr:abl over-expression may actually increase cell adherence to cell culture plastic. (wikipedia.org)