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  • leukemic
  • Rarely, the first sign of leukemia may be the development of a solid leukemic mass or tumor outside of the bone marrow, called a chloroma. (wikipedia.org)
  • chromosome
  • MLL5, a homolog of Drosophila trithorax located within a segment of chromosome band 7q22 implicated in myeloid leukemia," Oncogene , vol. 21, no. 31, pp. 4849-4854, 2002. (hindawi.com)
  • patients
  • Mucormycosis is a rare and acute fungal infection which is frequently lethal, usually observed in non-controlled diabetic patients. (pubfacts.com)
  • Because fludarabine is highly active in lymphoid malignancies, these regimens can further be used when patients have biphenotypic AML, in which cells display properties of both myeloid and lymphoid cells. (wikipedia.org)
  • bone
  • Note the small number of B-cell precursors in normal bone marrow relative to the large abnormal B-cell population lacking CD45 expression (bottom left) in the patient with leukemia. (asmscience.org)
  • Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cells. (wikipedia.org)
  • The underlying mechanism involves replacement of normal bone marrow with leukemia cells, which results in a drop in red blood cells, platelets, and normal white blood cells. (wikipedia.org)
  • Leukemias and lymphomas both belong to a broader group of tumors that affect the blood, bone marrow, and lymphoid system, known as tumors of the hematopoietic and lymphoid tissues. (wikipedia.org)
  • cells
  • Persistent fever, infection prolonged healing: Most of the white blood cells are leukemia cells, no normal function, leading to decreased immunity, susceptible to infection. (wikipedia.org)
  • Immediate treatment is required in acute leukemia because of the rapid progression and accumulation of the malignant cells, which then spill over into the bloodstream and spread to other organs of the body. (wikipedia.org)
  • Symptoms
  • Occasionally, a person may show no symptoms, and the leukemia may be discovered incidentally during a routine blood test. (wikipedia.org)
  • Lymphomas
  • As those elements are all intimately connected through both the circulatory system and the immune system , a disease affecting one will often affect the others as well, making myeloproliferation and lymphoproliferation (and thus the leukemias and the lymphomas ) closely related and often overlapping problems. (omicsgroup.org)
  • Historically, hematological malignancies have been most commonly divided by whether the malignancy is mainly located in the blood ( leukemia ) or in lymph nodes ( lymphomas ). (omicsgroup.org)
  • Leukemias and lymphomas both belong to a broader group of tumors that affect the blood, bone marrow, and lymphoid system, known as tumors of the hematopoietic and lymphoid tissues. (wikipedia.org)
  • Flow Cytometry
  • Histopathology and flow cytometry of relapsed leukemia specimen. (nih.gov)
  • A bone marrow aspirate showing a densely packed marrow (A) as well as large, atypical, vacuolated blasts (B). Flow cytometry (C) of relapsed leukemia was positive for B cell markers including CD19, CD24, CD22, and cCD79a, as well as positive for myeloid markers MPO and CD15. (nih.gov)
  • Multiple Myeloma
  • Patients with multiple myeloma (MM) or monoclonal gammopathy of undetermined significance (MGUS) have a significantly high risk of developing MDS, CMML, or acute myeloid leukemia (AML) compared with healthy controls. (hindawi.com)
  • Etoposide
  • This phase I/II trial studies the side effects and best dose of decitabine followed by mitoxantrone hydrochloride, etoposide, and cytarabine and to see how well they work in treating patients with acute myeloid leukemia or high-risk myelodysplastic syndrome that has returned after a period of improvement or does not respond to treatment. (clinicaltrials.gov)
  • Bone
  • Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cells. (wikipedia.org)
  • The underlying mechanism involves replacement of normal bone marrow with leukemia cells, which results in a drop in red blood cells, platelets, and normal white blood cells. (wikipedia.org)