• chemotherapy
  • 2.Sorafenib priming may augment salvage chemotherapy in relapsed and refractory FLT3-ITD-positive acute myeloid leukemia. (edu.au)
  • Other chemotherapy agents, specifically epipodophyllotoxins and anthracyclines, have also been associated with treatment-related leukemias, which are often associated with specific chromosomal abnormalities in the leukemic cells. (wikipedia.org)
  • Chemotherapy with combination of cytosine arabinoside and either idarubicin, daunomycin, or mitoxantrone as for acute myeloid leukemia has been used. (wikipedia.org)
  • Since NT5C3 can metabolize AraC, a nucleoside analog used in chemotherapy for acute myeloid leukemia patients, genotyping one of its polymorphisms may aid detection of patients who will respond favorably to this therapy. (wikipedia.org)
  • Patients
  • Patients with leukemias that express the progenitor cell antigen CD34 and/or the P-glycoprotein (MDR1 gene product) have an inferior outcome. (healthmedicinet.com)
  • I. Determine effect of treatment with the combination on time to response, time to leukemic transformation and frequency of transformation to leukemia in patients with MDS during the phase II segment of the study. (knowcancer.com)
  • I. To estimate the maximum tolerated dose (MTD) and examine the tolerability of daily oral eltrombopag (eltrombopag olamine) (14 days +/- 2 days after initiation of cytarabine) in patients receiving high dose cytarabine and mitoxantrone for the treatment of acute myeloid leukemia patients with hypoplastic bone marrow 14 days +/- 2 days from initiation of cytarabine. (knowcancer.com)
  • 100 x 10^9/L when eltrombopag is administered following high dose cytarabine and mitoxantrone for the treatment of acute myeloid leukemic patients. (knowcancer.com)
  • Long-lasting remissions have been documented in sporadic cases, usually occurring in young patients who have been treated with acute leukemia-type induction therapy, followed by allogenic HSCT in first complete remission. (wikipedia.org)
  • The typical cutaneous mast cell infiltrates of urticaria pigmentosa are usually not present before, during, or after diagnosis in patients who have mast cell leukemia. (wikipedia.org)
  • Measurement of histidine carboxylase in the marrow cells of patients with mast cell leukemia is a very sensitive marker of mast cells. (wikipedia.org)
  • Although splenectomy has led to brief responses in patients with mast cell leukemia, no firm conclusions as to the efficacy of this treatment are possible. (wikipedia.org)
  • In the first three years of life, megakaryoblastic leukemia is the most common type of leukemia in patients with Down syndrome. (wikipedia.org)
  • Lymphoma
  • Leukemia & Lymphoma. (wikipedia.org)
  • Moreover, co-expression of the interleukin-7 receptor together with LNK was carefully studied, and it was concluded that interleukin-7 receptor expression was significantly more highly expressed than LNK in B-cell acute leukemic lymphoma. (wikipedia.org)
  • This observation distinguished a novel subset of high-risk B-cell acute lymphoblastic lymphoma with a potential therapy targeting the interleukin-7 signaling pathway. (wikipedia.org)
  • Mast
  • In a small proportion of cases, acute mast cell leukemia may evolve from a more progressive form of systemic mastocytosis. (wikipedia.org)
  • The diagnosis of acute mast cell leukemia by the WHO criteria includes the requirement for a prevalence of 20% neoplastic mast cells in marrow and 10% in blood. (wikipedia.org)
  • If the mast cells represent less than 10% of blood cells, the tumor is called "aleukemic" mast cell leukemia. (wikipedia.org)
  • Acute mast cell leukemia is a rapidly progressive disorder with leukemic mast cells in blood and in large numbers in marrow. (wikipedia.org)
  • Total serum tryptase is elevated in mast cell leukemia. (wikipedia.org)
  • Normal total(alpha + beta) serum tryptase is approximately 6 micro g/L (range 0 to 11 micro g/L). Values of several hundred micro g/L are characteristic of mast cell leukemia. (wikipedia.org)
  • Plasma and urinary histamine levels are frequently elevated in mast cell leukemia. (wikipedia.org)
  • Immunotherapy with anti-IgE immunoglobulin raised in sheep resulted in a transient decrease in the numbers of circulating mast cells in one patient with mast cell leukemia. (wikipedia.org)
  • Acute mast cell leukemia is extremely aggressive and has a grave prognosis. (wikipedia.org)
  • inflammation
  • Neutrophils are the most common cell type seen in the early stages of acute inflammation. (wikipedia.org)
  • During the beginning (acute) phase of inflammation, particularly as a result of bacterial infection, environmental exposure, and some cancers, neutrophils are one of the first-responders of inflammatory cells to migrate towards the site of inflammation. (wikipedia.org)
  • basophilia
  • Overt leukemia from MDS associated with marked basophilia," The Japanese Journal of Clinical Hematology , vol. 33, no. 8, pp. 1031-1035, 1992. (hindawi.com)
  • Secondary
  • 10.Acute interstitial nephritis secondary to deferasirox causing acute renal injury needing short-term dialysis. (edu.au)
  • usually occurs
  • Acute erythematous candidiasis usually occurs on the dorsum of the tongue in persons taking long term corticosteroids or antibiotics, but occasionally it can occur after only a few days of using a topical antibiotic. (wikipedia.org)
  • symptoms
  • Occasionally, a person may show no symptoms, and the leukemia may be discovered incidentally during a routine blood test. (wikipedia.org)