Chemicals and DrugsPhenomena and Processes
Leucine TransaminaseAlanine Transaminase4-Aminobutyrate TransaminaseTransaminasesLeucine ZippersAspartate AminotransferasesD-Alanine Transaminase
IsoleucineAminotransferasePhenylalanineLysineEnzyme that catalyzesAspartateBiosynthetic pathwayAMINO ACIDThreonineGlutamateTyrBCofactorZIPPERTransferasesSupplementationRegulation of blood sugarBCAACommonlyBranched-chainSpecificDomainValineGlutamic pyruvic transaminaseAminopeptidasePyruvateEnzymeSerum1.42Amino acidsCatabolismUreaLiverRich repeatPathwayReactionIndividual
Isoleucine5
  • This enzyme participates in 3 metabolic pathways: valine, leucine and isoleucine degradation, valine, leucine and isoleucine biosynthesis, and pantothenate and coa biosynthesis. (wikipedia.org)
  • Also acts on L-leucine and, more slowly, on L-isoleucine, L-2- aminopentanoate and L-aspartate. (expasy.org)
  • DL39 (DE3) Chemically Competent E. coli cells are deficient in the aromatic (TyrB), branched-chain (JIvE), and aspartate (AspC) transaminases and are auxotrophic for aspartic acid, isoleucine, leucine, phenylananine, tyrosine, and valine residues. (goldbio.com)
  • As proven, branched-chain proteins (leucine, isoleucine, and valine) are reversibly transaminated by branched-chain amino acidity transaminase 1/2 to create BCKA. (angiogenesis-blog.com)
  • The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. (mcw.edu)
Aminotransferase3
  • The systematic name of this enzyme class is L-leucine:2-oxoglutarate aminotransferase. (wikipedia.org)
  • Other names in common use include L-leucine aminotransferase, leucine 2-oxoglutarate transaminase, leucine aminotransferase, and leucine-alpha-ketoglutarate transaminase. (wikipedia.org)
  • This means that Dianabol users may have elevated liver enzymes, particularly aspartate transaminase and alanine aminotransferase, hur mycket proteinpulver per dag. (zuspelle.com)
Phenylalanine1
  • GoldBio's DL39 (DE3) Chemically Competent E. coli cells are engineered with a T7 expression system to transform and express proteins in order to label residues such as phenylalanine or leucine. (goldbio.com)
Lysine4
  • A zinc containing enzyme of the hydrolase class that catalyzes the removal of the N-terminal amino acid from most L-peptides, particularly those with N-terminal leucine residues but not those with N-terminal lysine or arginine residues. (lookformedical.com)
  • L-Lysine 6-Transaminase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
  • This graph shows the total number of publications written about "L-Lysine 6-Transaminase" by people in this website by year, and whether "L-Lysine 6-Transaminase" was a major or minor topic of these publications. (ouhsc.edu)
  • Below are the most recent publications written about "L-Lysine 6-Transaminase" by people in Profiles. (ouhsc.edu)
Enzyme that catalyzes3
  • In enzymology, a leucine transaminase (EC 2.6.1.6) is an enzyme that catalyzes the chemical reaction L-leucine + 2-oxoglutarate ⇌ {\displaystyle \rightleftharpoons } 4-methyl-2-oxopentanoate + L-glutamate Thus, the two substrates of this enzyme are L-leucine and 2-oxoglutarate, whereas its two products are 4-methyl-2-oxopentanoate and L-glutamate. (wikipedia.org)
  • An enzyme that catalyzes the first step in the biosynthetic pathway to LEUCINE , forming isopropyl malate from acetyl-CoA and alpha-ketoisovaleric acid. (lookformedical.com)
  • According to the prediction of bioinformatics software of Miranda, we showed that 5′-UTR regions of hsa-miR-124-3p, a mature sequence of human miR-124 precursor, could bind to 3′-UTR region of branched chain amino acid transaminase 1(BCAT1) gene, the enzyme that catalyzes branched-chain alpha-keto acids to branched-chain L-amino acids essential for cell growth [ 15 , 16 ]. (biomedcentral.com)
Aspartate1
Biosynthetic pathway1
  • It thus appears that, in yeast, the first specific enzyme in the leucine biosynthetic pathway (α-isopropylmalate synthase) is particulate, whereas the next two enzymes in the pathway (isopropylmalate isomerase and β-isopropylmalate dehydrogenase) are "soluble," with glutamate-α-ketoisocaproate transaminase activity being located in both the cytosol and particulate cell fractions. (ku.edu)
AMINO ACID5
  • A large superfamily of transcription factors that contain a region rich in BASIC AMINO ACID residues followed by a LEUCINE ZIPPER domain. (lookformedical.com)
  • Leucine is an amino acid commonly found as a component of total parenteral nutrition. (drugbank.com)
  • This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. (thermofisher.com)
  • D-amino acid transaminase. (unipr.it)
  • Dougherty, T.J. (1995) Staphylococcus haemolyticus contains two D-glutamic acid biosynthetic activities, a glutamate racemase and a D-amino acid transaminase J Bacteriol 177 336-42. (unipr.it)
Threonine2
  • In wild-type transduction of auxotrophic strain E. coli B/r/thr-1/leu-1/ara-12 colonies auxotrophic for leucine or threonine do not all arise at the same time after plating. (degruyter.com)
  • after plating from about 20% of minute colonies grown from single abortively transduced cells there can be isolated cells capable to form genetically stable colonies prototrophic for leucine or threonine. (degruyter.com)
Glutamate1
  • Of the total glutamate-α-ketoisocaproate transaminase activity, approximately 20% was in the initial soluble fraction, whereas solubilization of the remainder again required homogenization of the spheroplast lysate. (ku.edu)
TyrB2
  • In spite of the presence of an active tyrB gene, this mutant was unable to grow on 2-KIC, the immediate leucine precursor. (uconn.edu)
  • Accumulation of 2-KIV in these strains interferes with transamination of 2-KIC to form leucine by the tyrB encoded transaminase, transaminase D.^ The Tn5 insertion in this strain was cloned in vivo using a mini-Mu vector, Mu d114042. (uconn.edu)
Cofactor1
  • Leucine dehydrogenase catalyzes the reversible oxidative deamination of L-LEUCINE, to 4-methyl-2-oxopentanoate (2-ketoisocaproate) and AMMONIA, with the corresponding reduction of the cofactor NAD+. (lookformedical.com)
ZIPPER1
  • Leucines occurring in heptad repeats end up on the same sides of the helixes and are adjacent to each other in the stem of the Y (the "zipper" region). (lookformedical.com)
Transferases1
  • This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. (wikipedia.org)
Supplementation1
  • One recent study has shown that supplementation with leucine (approximately 3.6 grams/day for an 80kg individual) increased plasma BCAA concentrations and improved upper body power output and exercise time to exhaustion in a group of rowers (outrigger canoeists). (ast-ss.com)
Regulation of blood sugar1
  • Claim) Leucine helps with the regulation of blood-sugar levels, the growth and repair of muscle tissue (such as bones, skin and muscles), growth hormone production, wound healing as well as energy regulation. (drugbank.com)
BCAA1
  • Vid en kombinerad behandling bor man ta hansyn till halveringstiden for den viktigaste steroiden, bcaa rea. (zuspelle.com)
Commonly1
  • The activity of this enzyme is commonly assayed using a leucine arylamide chromogenic substrate such as leucyl beta-naphthylamide. (lookformedical.com)
Branched-chain1
Specific1
  • A transfer RNA which is specific for carrying leucine to sites on the ribosomes in preparation for protein synthesis. (lookformedical.com)
Domain2
  • Inflammatory factors, including IL‑1β and transforming growth factor (TGF)‑β/1, α‑smooth muscle actin (SMA) and protein levels of nucleotide‑binding oligomerization domain, leucine rich repeat containing family, pyrin domain containing 3 (NLRP3), caspase‑1 and pro‑IL‑1β were measured. (spandidos-publications.com)
  • its role is correlated with activation of the nucleotide-binding oligomerization domain, leucine rich repeat containing family, pyrin domain containing 3 (NLRP3) inflammasome ( 5 ). (spandidos-publications.com)
Valine6
  • This enzyme participates in 3 metabolic pathways: valine, leucine and isoleucine degradation, valine, leucine and isoleucine biosynthesis, and pantothenate and coa biosynthesis. (wikipedia.org)
  • It acts not only on 3-methyl-2-oxobutanaoate, but also on 4-methyl-2-oxopentanoate and ( S )-3-methyl-2-oxopentanoate, so that it acts on the 2-oxo acids that derive from the action of transaminases on valine, leucine and isoleucine. (enzyme-database.org)
  • Enzymes I and III of human tissues showed the same substrate specificities for valine, leucine, and isoleucine, and these amino acids competed for the active site of the enzyme. (eurekamag.com)
  • DL39 (DE3) Chemically Competent E. coli cells are deficient in the aromatic (TyrB), branched-chain (JIvE), and aspartate (AspC) transaminases and are auxotrophic for aspartic acid, isoleucine, leucine, phenylananine, tyrosine, and valine residues. (goldbio.com)
  • leucine, isoleucine, and valine. (ast-ss.com)
  • Alanine can be biosynthesized from pyruvate and branched chain amino acids such as valine, leucine, and isoleucine. (ymdb.ca)
Glutamic pyruvic transaminase3
  • I. Serum lactic dehydrogenase, alkaline phosphatase, leucine aminopeptidase, total acid phosphatase, prostatic acid phosphatase, glutamic pyruvic transaminase, glutamic oxalacetic transaminase activities and LDH isoenzymes: the relations with stage and histological grade]. (nih.gov)
  • I. Changes of serum lactic dehydrogenase, alkaline phosphatase, leucine aminopeptidase, total acid phosphatase, prostatic acid phosphatase, glutamic pyruvic transaminase, glutamic oxalacetic transaminase activity and lactic dehydrogenase isoenzymes in prostatic cancer under anti-androgenic treatment, with special reference to prognosis]. (nih.gov)
  • 16. Serum glutamic oxalacetic transaminase/glutamic pyruvic transaminase ratios in hepatocellular carcinoma. (nih.gov)
Aminopeptidase2
  • Serum lactic dehydrogenase, alkaline phosphatase, leucine aminopeptidase, total acid phosphatase, prostatic acid phosphatase activity and lactic dehydrogenase isoenzymes in prostatic cancer, with special reference to relation with stage and histological malignancy]. (nih.gov)
  • V. Alterations in the serum acid and alkaline phosphatase and leucine aminopeptidase activities following massage of the prostate]. (nih.gov)
Pyruvate1
Enzyme5
  • In enzymology, a leucine transaminase (EC 2.6.1.6) is an enzyme that catalyzes the chemical reaction L-leucine + 2-oxoglutarate ⇌ {\displaystyle \rightleftharpoons } 4-methyl-2-oxopentanoate + L-glutamate Thus, the two substrates of this enzyme are L-leucine and 2-oxoglutarate, whereas its two products are 4-methyl-2-oxopentanoate and L-glutamate. (wikipedia.org)
  • This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. (wikipedia.org)
  • Alanine transaminase ( ALT ) is a transaminase enzyme ( EC 2.6.1.2 ). (wikidoc.org)
  • HN - 2006(1981) MH - 2-Aminoadipate Transaminase UI - D051307 MN - D8.811.913.477.700.120 MS - A PYRIDOXAL PHOSPHATE containing enzyme that catalyzes the transfer of amino group of L-2-aminoadipate onto 2-OXOGLUTARATE to generate 2-oxoadipate and L-GLUTAMATE. (nih.gov)
  • This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. (thermofisher.com)
Serum1
  • Serum ALT level, serum AST ( aspartate transaminase ) level, and their ratio ( AST/ALT ratio ) are commonly measured clinically as biomarkers for liver health. (wikidoc.org)
1.422
  • ID 2.6.1.42 DE branched-chain-amino-acid transaminase. (expasy.org)
  • The isozymes (enzymes I and III) of branched-chain amino acid transaminase (EC 2.6.1.42) from various human tissues were separated by DEAE-cellulose column chromatography. (eurekamag.com)
Amino acids2
  • Transaminases of branched chain amino acids. (wikipedia.org)
  • The stimulatory effect of leucine was stereospecific and not mimicked by other branched chain amino acids but was mimicked by the leucine metabolite alpha-ketoisocaproate (alpha-KIC). (nih.gov)
Catabolism1
  • Leucine catabolism and possible shunts to cholesterol biosynthesis. (nih.gov)
Urea1
  • The BCAAs enter this pathway via the removal of an amino group by a transaminase, which is then fed into the urea cycle. (ast-ss.com)
Liver2
  • The term transaminase is outdated and no longer used in liver disease. (wikidoc.org)
  • Alanine transaminase has an important function in the delivery of skeletal muscle carbon and nitrogen (in the form of alanine) to the liver. (tdmuv.com)
Rich repeat1
  • protein_coding" "EOD05137","No alias","Emiliania huxleyi","BspA type Leucine rich repeat region [Interproscan]. (ntu.edu.sg)
Pathway1
  • Four transaminases, 5 TPP-dependent decarboxylases, 16 alcohol dehydrogenases, 6 aldehyde dehydrogenases and 2 broad-spectrum reductases have roles in the pathway depending mainly upon the amino acid, growth phase of the yeast and other cultivation conditions. (brewingscience.de)
Reaction1
Individual1
  • One recent study has shown that supplementation with leucine (approximately 3.6 grams/day for an 80kg individual) increased plasma BCAA concentrations and improved upper body power output and exercise time to exhaustion in a group of rowers (outrigger canoeists). (ast-ss.com)