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  • casein kinase 1
  • From drug screening to target deconvolution: a target-based drug discovery pipeline using Leishmania casein kinase 1 isoform 2 to identify compounds with antileishmanial activity," Antimicrobial Agents and Chemotherapy , vol. 60, no. 5, pp. 2822-2833, 2016. (hindawi.com)
  • Leishmania casein kinase 1 isoform 2 (CK1.2) has been identified as an exokinase capable of phosphorylating host proteins, thus exerting a potential immune-suppressive action on infected host cells. (asm.org)
  • Salmonella
  • Acetalated dextran's unique properties has also resulted in its application in polymeric micro/nanoparticles for use in formulating the anti-infective OSU-03012 for use against Leishmania donovani,Salmonella enterica, and Francisella tularensis. (wikipedia.org)
  • amastigotes
  • Its prophylactic activity was further confirmed in hamsters by giving 2 split doses of 3 mg/kg of the compound spaced at 2 weeks, i.e. on day −7 and +7 of challenge with L. donovani amastigotes. (springer.com)
  • strains
  • When PCR fingerprinting and restriction analysis of ITS region were applied, highly similar fragment patterns were observed for all strains of L. donovani studied. (hu-berlin.de)
  • Strains of L. donovani derived from other geographical areas were found to have different ITS2 patterns. (hu-berlin.de)
  • We sequenced the whole genomes and transcriptomes of Leishmania donovani strains throughout their adaptation to in vivo conditions mimicking natural vertebrate and invertebrate host environments. (asm.org)
  • C57BL
  • The therapeutic efficacy of CP-46,665-1, a synthetic lipoidal amine with proven immunomodulatory and anti-tumor properties, in combination with chemotherapy was evaluated in L. donovani -infected C57Bl/6 mice. (ajtmh.org)
  • pathogens
  • M. Fiebig, S. Kelly, E. Gluenz, and P. J. Myler, "Comparative life cycle transcriptomics revises Leishmania mexicana genome annotation and links a chromosome duplication with parasitism of vertebrates," PLoS Pathogens , vol. 11, no. 10, Article ID e1005186, 2015. (hindawi.com)
  • Molecular
  • Probing druggability and biological function of essential proteins in Leishmania combining facilitated null mutant and plasmid shuffle analyses," Molecular Microbiology , vol. 93, no. 1, pp. 146-166, 2014. (hindawi.com)
  • genome
  • With this system, it was possible to generate loss-of-function insertion and deletion mutations and introduce drug selection markers and the GFP sequence precisely into the L. donovani genome. (asm.org)
  • The whole genome sequence of L. donovani obtained from southeastern Nepal was published in 2011. (wikipedia.org)
  • gene
  • Transcriptomic profiling of gene expression and RNA processing during Leishmania major differentiation," Nucleic Acids Research , vol. 43, no. 14, pp. 6799-6813, 2015. (hindawi.com)
  • The goal of the current study was to clone the β-tubulin gene from Leishmania donovani and evaluate its role as a reference control for RT-qPCR gene expression studies. (jyi.org)
  • We cloned the β-tubulin gene from Leishmania donovani using primers designed based on the known sequences of the β-tubulin gene from the L. major database. (jyi.org)
  • expression
  • We introduced the Cas9 nuclease into L. donovani and generated guide RNA (gRNA) expression vectors by using the L. donovani rRNA promoter and the hepatitis delta virus (HDV) ribozyme. (asm.org)
  • pathway
  • This study further revealed that double-stranded DNA breaks created by CRISPR-Cas9 were repaired by the homology-directed repair (HDR) pathway and microhomology-mediated end joining (MMEJ) in Leishmania . (asm.org)
  • disease
  • Only a small fraction of all L. donovani infections are known to lead to clinically overt disease, with most infections remaining asymptomatic. (frontiersin.org)
  • assay
  • Development of a reverse transcriptase loop-mediated isothermal amplification (LAMP) assay for the sensitive detection of Leishmania parasites in clinical samples. (springer.com)
  • Trop
  • PLoS Negl Trop Dis 6(5):e1622 Debrabant A, Joshi MB, Pimenta PF, Dwyer DM (2004) Period of Leishmania donovani axenic amastigotes: their broadening and biological characteristics. (polnep.ac.id)