• macrophages
  • An exosome-based secretion pathway is responsible for protein export from Leishmania and communication with macrophages," Journal of Cell Science , vol. 123, no. 6, pp. 842-852, 2010. (hindawi.com)
  • He is reported to have identified the survival mechanisms of salmonella against host macrophages and his work has assisted in widening the understanding of hemoglobin endocytosis in Leishmania, thus assisting in exploring new drug targets for diseases such as typhoid fever and kala azar. (wikipedia.org)
  • chemotherapy
  • The therapeutic efficacy of CP-46,665-1, a synthetic lipoidal amine with proven immunomodulatory and anti-tumor properties, in combination with chemotherapy was evaluated in L. donovani -infected C57Bl/6 mice. (ajtmh.org)
  • Molecular
  • Probing druggability and biological function of essential proteins in Leishmania combining facilitated null mutant and plasmid shuffle analyses," Molecular Microbiology , vol. 93, no. 1, pp. 146-166, 2014. (hindawi.com)
  • strains
  • When PCR fingerprinting and restriction analysis of ITS region were applied, highly similar fragment patterns were observed for all strains of L. donovani studied. (hu-berlin.de)
  • Strains of L. donovani derived from other geographical areas were found to have different ITS2 patterns. (hu-berlin.de)
  • Biology
  • In this work, amalgamating the tools and techniques of computational systems biology with rigorous manual curation, a constraint-based metabolic model for Leishmania donovani BPK282A1 has been developed. (rsc.org)
  • The results from this study provide evidence to support the involvement of a mitochondrial HSP70 (HSPA9B) in experimental HePC resistance, a mechanism that is not yet fully understood, and reveal potential fundamental roles of HSPA9B in the biology of Leishmania . (biomedcentral.com)
  • life cycle
  • M. Fiebig, S. Kelly, E. Gluenz, and P. J. Myler, "Comparative life cycle transcriptomics revises Leishmania mexicana genome annotation and links a chromosome duplication with parasitism of vertebrates," PLoS Pathogens , vol. 11, no. 10, Article ID e1005186, 2015. (hindawi.com)
  • major
  • Transcriptomic profiling of gene expression and RNA processing during Leishmania major differentiation," Nucleic Acids Research , vol. 43, no. 14, pp. 6799-6813, 2015. (hindawi.com)
  • We cloned the β-tubulin gene from Leishmania donovani using primers designed based on the known sequences of the β-tubulin gene from the L. major database. (jyi.org)
  • disease
  • Only a small fraction of all L. donovani infections are known to lead to clinically overt disease, with most infections remaining asymptomatic. (frontiersin.org)