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  • degenerative
  • The paracrine soluble factors produced by stem cells, known as the stem cell secretome, has been found to be the predominant mechanism by which stem cell-based therapies mediate their effects in degenerative, auto-immune and inflammatory diseases. (wikipedia.org)
  • When he was nine years old, he was diagnosed with a degenerative hip disease, called Legg-Calve-Perthes, that confined him to a full leg brace and crutches for two years, and made it impossible for him to play sports. (wikipedia.org)
  • limp
  • The area becomes intensely inflamed and irritated and your child may begin to show signs of the disease, such as a limp or different way of walking. (aaos.org)
  • adult
  • Adult stem cell therapy for treating heart disease was commercially available in at least five continents as of 2007. (wikipedia.org)
  • usually
  • Most of the time the clinical signs of this disease occur in 4 to 11 month old dogs and usually consist of lameness of one leg only. (vetinfo.com)
  • Girls have an outcome worse than that of boys, and girls usually have a more severe form of the disease , in part due to hormonal changes as they age. (yourcareeverywhere.com)
  • orthopedic
  • The Orthopedic Foundation for Animals (OFA) is a not-for-profit organization based in Columbia, Missouri that aims to research and prevent orthopedic and hereditary diseases in companion animals. (wikipedia.org)
  • OFA supported research is not limited to orthopedic disease, and has included cancers, heart disease, and thyroid disease as examples. (wikipedia.org)
  • Conditions
  • They can suffer from hip dysplasia and elbow dysplasia as well as hypothyroidism, von Willebrand's disease, and thrombopathia, and should be assessed for all of these conditions. (wikipedia.org)
  • Research is underway to develop various sources for stem cells, and to apply stem-cell treatments for neurodegenerative diseases and conditions such as diabetes, heart disease, and other conditions. (wikipedia.org)
  • include
  • The disease is theorized to include the artery of the ligmentum teres femoris being constricted or even blocked too early, not allowing for time when the medial circumflex femoral artery takes over. (wikipedia.org)
  • often
  • The reossification stage is often the longest stage of the disease and can last a few years. (aaos.org)
  • onset
  • How close the shape is to round will depend on several factors, including the extent of damage that took place during the fragmentation phase, as well as the child's age at the onset of disease, which affects the potential for bone regrowth. (aaos.org)
  • early
  • Perthes is generally diagnosed between 5 and 12 years of age, although it has been diagnosed as early as 18 months. (wikipedia.org)
  • The disease is theorized to include the artery of the ligmentum teres femoris being constricted or even blocked too early, not allowing for time when the medial circumflex femoral artery takes over. (wikipedia.org)
  • means
  • Bilateral Perthes, which means both hips are affected, should always be investigated thoroughly to rule out multiple epiphyseal dysplasia. (wikipedia.org)
  • Foundation
  • As a private not-for-profit foundation, the OFA has funded nearly $3 million in research aimed at reducing the incidence and prevalence of inherited companion animal disease. (wikipedia.org)
  • heart
  • A bounding pulse and heart murmur are signs of this disease. (tripod.com)
  • OFA supported research is not limited to orthopedic disease, and has included cancers, heart disease, and thyroid disease as examples. (wikipedia.org)
  • Research is underway to develop various sources for stem cells, and to apply stem-cell treatments for neurodegenerative diseases and conditions such as diabetes, heart disease, and other conditions. (wikipedia.org)
  • Stems cells are being studied in those with severe heart disease. (wikipedia.org)
  • serious
  • There are no set standards for the diagnosis of suspected transient synovitis, so the amount of investigations will depend on the need to exclude other, more serious diseases. (wikipedia.org)
  • this process can go too far, however, leading to graft vs host disease, the most serious side effect of this treatment. (wikipedia.org)
  • research
  • Research has been conducted on the effects of stem cells on animal models of brain degeneration, such as in Parkinson's, Amyotrophic lateral sclerosis, and Alzheimer's disease. (wikipedia.org)