• strain
  • Another study, lead by Zhang B, created a L.lactis strain that maintains a plasmid containing a tumor metastasis-inhibiting peptide known as KISS1. (wikipedia.org)
  • In order to evaluate the impact of antigen location on vaccine prototype efficacy, a L. lactis strain producing cytoplasm-located rCjaAD was also generated. (frontiersin.org)
  • In this study, a recombinant strain of L. lactis containing complimentary DNA (cDNA) for the human interleukin-10 (IL-10) gene was used to treat CD with IL-10, an anti-inflammatory cytokine. (wikipedia.org)
  • phage
  • Molecular and Cellular Biology portal As of this edit, this article uses content from "1.E.18 The Lactococcus lactis Phage r1t Holin (r1t Holin) Family", which is licensed in a way that permits reuse under the Creative Commons Attribution-ShareAlike 3.0 Unported License, but not under the GFDL. (wikipedia.org)
  • Holin
  • The Putative Lactococcus lactis Holin (LLHol) Family", which is licensed in a way that permits reuse under the Creative Commons Attribution-ShareAlike 3.0 Unported License, but not under the GFDL. (wikipedia.org)
  • secretion
  • The success of this strain's construction helped to inhibit migration and expansion of cancer cells, showing that the secretion properties of L.lactis of this particular peptide illustrates a hopeful future in Cancer therapy. (wikipedia.org)
  • Secretion of IL-10 from L. lactis in the gut is considered to be a topical administration of the drug to the epithelium, permitting healing in local tissues damaged by inflammation. (wikipedia.org)
  • enzyme
  • It catalyses the following chemical reaction Hydrolyses Xaa-Pro bonds to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-p-nitroanilide and (sequentially) Tyr-Pro--Phe-Pro--Gly-Pro--Ile The intracellular enzyme from Lactococcus lactis (190-kDa) is the type example of peptidase family S15. (wikipedia.org)
  • Best known for its action on caseins, although it has been shown to hydrolyse hemoglobin and oxidized insulin B chain This enzyme is associated with the cell envelope of Lactococcus lactis and attached via a C-terminal membrane anchor sequence. (wikipedia.org)
  • proteinase
  • To investigate the antimicrobial peptide of L. lactis , the spent culture medium (SCM) of L. lactis was treated with or without proteinase K after collection by centrifugation, and the antibacterial activity of SCM against periodontopathogens was assessed. (go.jp)
  • The SCM of L. lactis exhibited antimicrobial activity against the periodontopathogens, whereas the proteinase K-treated SCM showed little antimicrobial activity. (go.jp)
  • genes
  • Consistent with the results from comparative genomics (see references above) this resulted in L. lactis losing or down-regulating genes which are dispensable in milk and the up-regulation of peptide transport. (wikipedia.org)
  • The genes expressing these proteins were transcribed under control of the L. lactis Usp45 promoter and their products contain the Usp45 signal sequences. (frontiersin.org)
  • mice
  • Intragastric administration of IL-10-secreting Lactococcus lactis caused a 50% reduction in colitis in mice treated with dextran sulfate sodium and prevented the onset of colitis in IL-10 −/− mice. (sciencemag.org)
  • milk
  • Bacteriophages specific to L. lactis cause significant economic losses each year by preventing the bacteria from fully metabolizing the milk substrate. (wikipedia.org)
  • study
  • Here is another study that that shows how L.lactis can be used to combat diseases. (wikipedia.org)
  • The purpose of this study was to investigate the inhibitory effects of L. lactis on the bioactivity of periodontopathogens. (go.jp)
  • production
  • In addition, the L. lactis suspension had a neutralizing effect on the VSCs produced by periodontopathogens, and UV-killed L. lactis inhibited the production of IL-6 and TNF-α induced by the LPS. (go.jp)
  • cell
  • LPS from the periodontopathogens was extracted by an LPS extraction kit with little modification, and THP-1 cells as a monocytic cell line were treated with the extracted LPS in the presence or absence of UV-killed L. lactis . (go.jp)