• The nephrotoxic beta-lactam antibiotics cause acute proximal tubular necrosis. (nih.gov)
  • Beta-lactams are antibiotics that have a beta-lactam ring nucleus. (merckmanuals.com)
  • In the latest study, an international group of researchers further developed and optimised compounds discovered by Schofield group at the University of Oxford that imitate in their binding function penicillins, cephalosporins, carbapenems and other antibiotics in the β-lactam group. (helsinki.fi)
  • Metallo-β-lactamase (MBL) enzymes in bacterial strains resistant to β-lactam antibiotics are capable of breaking down the β-lactam structure of, for example, carbapenem. (helsinki.fi)
  • The application describes a method for quantification of four β-lactam antibiotics in water samples such as wastewater effluent in the low ng/L concentration range. (chromatographyonline.com)
  • Beta-lactam antibiotics, including penicillins and the non-penicillin classes, share a basic chemical structure that includes a three-carbon, one-nitrogen cyclic amine structure known as the beta-lactam ring. (niir.org)
  • With few exceptions, the major classes of antibiotics used to manage infections with the E cloacae complex include the beta-lactams, carbapenems, the fluoroquinolones, the aminoglycosides, and TMP-SMZ. (medscape.com)
  • These mutants are highly resistant to most beta-lactam antibiotics and are considered stably derepressed. (medscape.com)
  • As a class, beta-lactam antibiotics are a mainstay of therapy and are recommended for nearly all infection types in clinical practice guidelines 1 , 2 , 3 , 4 , 5 , and 6 , often as first-line agents. (mhmedical.com)
  • These antibiotics called cephalosporins contain, in common with the penicillins, a β-lactam ring. (brainkart.com)
  • In addition to the numerous penicillins and cephalosporins in use, three other classes of β-lactam antibiotics are available for clinical use. (brainkart.com)
  • All β-lactam antibiotics have the same bactericidal mechanism of action. (brainkart.com)
  • This study aimed to assay the prevalence of common β-lactam resistance genes including bla TEM , bla SHV , bla CTX-M and bla CMY and phenotypic resistance to commonly used β-lactam and fluoroquinolone antibiotics in UTIs. (biomedcentral.com)
  • Several antibiotics are considered for treatment of cystitis and pyelonephritis, including oral β-lactams (amoxicillin-clavulanic acid or third-generation cephalosporin), fluoroquinolones (ciprofloxacin or levofloxacin), nitrofurantoin, fosfomycin or trimethoprim-sulfamethoxazole [ 5 ]. (biomedcentral.com)
  • Marabotti, A. Bifunctional Beta-Lactam Antibiotics. (encyclopedia.pub)
  • Bifunctional Beta-Lactam Antibiotics" Encyclopedia , https://encyclopedia.pub/entry/7047 (accessed December 02, 2023). (encyclopedia.pub)
  • The molecular structure of β-lactam antibiotics can be modified either to introduce another β-lactam ring (the pharmacophore conferring bactericidal activities to these molecules), or to add other pharmacophores that modify their pharmacological properties and spectrum of action. (encyclopedia.pub)
  • The serendipitous discovery of the first representative of the β-lactam antibiotics, penicillin G, is generally attributed to Alexander Fleming in 1929 [ 1 ] , although there are pieces of evidence that, about fifteen years before, an Italian physician, Vincenzo Tiberio, had already identified in molds a "principle with bactericidal action" [ 2 ] . (encyclopedia.pub)
  • The other classes of β-lactam antibiotics, namely carbapenems and monobactams, were discovered more recently [ 7 ] [ 8 ] , in an effort to identify new members of this broad group of molecules. (encyclopedia.pub)
  • This resistance is caused by the development of many different "escape strategies", such as the alteration of the target, the development of pumps to export the antibiotics outside the microbial cell, and in particular for β-lactam antibiotics, the widespread diffusion of β-lactamases, enzymes able to inactivate their pharmacophoric core by hydrolysis of the β-lactam ring [ 11 ] . (encyclopedia.pub)
  • Bażikament l-antibijotiċi kollha li jinkludu β-lactam core fl-istruttura molekulari tagħhom jappartjenu għal β-lactams Antibiotics. (ballyabio.com)
  • Penicillin and other ß-lactam antibiotics have a crucial role in treating STIs. (cdc.gov)
  • Llinás, A & Page, MI 2004, ' Intramolecular general acid catalysis in the aminolysis of β-lactam antibiotics ', Organic and Biomolecular Chemistry , vol. 2, no. 5, pp. 651-654. (hud.ac.uk)
  • The β-lactam antibiotics inhibit transpeptidases by acting as alternative substrates. (pharmacy180.com)
  • The β-lactam bond (common to all members of the β-lactam antibiotics) is broken but the remaining portion of the antibiotic is not released immediately. (pharmacy180.com)
  • Led by Director CHANG Sukbok, scientists from the Center for Catalytic Hydrocarbon Functionalizations within the Institute for Basic Science (IBS) have made a significant advancement in the synthesis of β-lactam scaffolds, which are structural components frequently found in essential antibiotics such as penicillins and carbapenems. (ibs.re.kr)
  • The core chemical structure that makes up penicillins is a four-membered cyclic amide scaffold called chiral β-lactam,which is also frequently found in other types of major antibiotics like carbapenems and cephalosporins. (ibs.re.kr)
  • Director Chang commented, "Through this study, we were able to easily synthesize chiral β-lactam, the backbone of major antibiotics such as penicillin and carbapenem from cheap nickel catalysts and feedstock chemicals. (ibs.re.kr)
  • Classification of antibiotics and beta-lactam compound. (pharmacygyan.com)
  • Objective: The indiscriminate use of antibiotics has led to the creation of resistant microorganisms, with the aim of this study was to compare in vitro the degree of effectiveness of beta-lactam antibiotics and glycopeptide in the inhibition of Staphylococcus aureus by comparing its effectiveness in surgical wound infection. (bvsalud.org)
  • Oxacillin, a β-lactam antibiotic, can reduce the virulence of MRSA and open it up to attack from the host immune system and other antibiotics, new research has shown. (scienceblog.com)
  • MRSA is able to show resistance to methicillin and other β-lactam antibiotics by replacing the protein normally targeted by the drugs with one which isn't quite as susceptible. (scienceblog.com)
  • What this means is that, instead of simply forgetting about β-lactams in the treatment of MRSA because the bacteria developed a resistance to their action, we can still use them as an adjunct treatment alongside other antibiotics to boost their efficacy. (scienceblog.com)
  • At a time when increasing resistance rates are forcing us to take another look at how we use antibiotics, this research has shown that β-lactam antibiotics could make a comeback in the fight against MRSA, by weakening the bacteria and making it easier for our immune system and other anti-staphylococcal antibiotics to deal the killing blow. (scienceblog.com)
  • The MICs were low for β-lactam antibiotics, whereas high MICs were recorded for ciprofloxacin and trimethoprim. (lu.se)
  • However, there is a risk of additive effect with other beta-lactam antibiotics. (janusinfo.se)
  • Beta-lactamases are a diverse class of enzymes produced by bacteria that break open the beta-lactam ring, inactivating the beta-lactam antibiotic. (merckmanuals.com)
  • However, development of antibiotic resistance, driven by misuse of beta-lactam and beta-lactamase inhibitors and the time taken for the regulatory approval is projected to impede the market growth. (pharmiweb.com)
  • The effect of the new β-lactam antibiotic FL 1060 on urinary tract pathogens, of which 71 were sensitive to and 100 resistant to ampicillin, is presented here. (bmj.com)
  • The Beta-lactams Rapid Test Kit is a lateral flow assay that determines a qualitative level for the presence of beta-lactams antibiotic residues in raw cow's milk. (mzfoodtest.com)
  • This study's results confirmed an explosion of antibiotic resistance amongst E. coli isolates from UTI against β-lactams and fluoroquinolones. (biomedcentral.com)
  • Cefalonium is the first-generation β-lactam cephalosporin antibiotic that is widely used to research bovine mastitis caused by Gram-positive bacteria including staphylococci. (medchemexpress.com)
  • One large study in an STI clinic revealed that 8.3% of patients reported penicillin or another ß-lactam antibiotic allergy ( 659 ). (cdc.gov)
  • Multiple studies have described that persons with reported penicillin or another ß-lactam antibiotic allergy have higher rates of surgical-site infections, methicillin-resistant Staphylococcus aureus infections, and higher medical care usage ( 653 , 662 - 664 ). (cdc.gov)
  • In a Baltimore, Maryland, STI clinic study, only 7.1% of the patients who reported allergy to penicillin or to another ß-lactam antibiotic had an objective positive test for penicillin allergy ( 659 ). (cdc.gov)
  • Antibiotic containing the beta-lactam (alpha-4 membraned cyclic amide) ring structure constitute the dominant class of agents currently employed for the chemotherapy of bacterial infections. (pharmacygyan.com)
  • beta-lactam antibiotic are a broad class of antibiotic, the structure having a lactam group with a heteroatom structure consisting of the cyclic amide with 3 carbon atoms and one nitrogen atom. (pharmacygyan.com)
  • A 2022 study in Clinical Infectious Diseases looked at whether administration of a broad-spectrum β-lactam (e.g., cefepime, piperacillin-tazobactam, etc.) before the infusion of vancomycin, as the first dose of antibiotic therapy, is protective against mortality in the first 7 days for hospitalized patients with BSIs. (brownmedpedsresidency.org)
  • Of 3376 eligible patients across 5 hospitals, 2685 (79.5%) received a β-lactam and 691 (20.5%) received vancomycin as their initial antibiotic. (brownmedpedsresidency.org)
  • The research, conducted by teams of scientists from the National University of Ireland Galway and the University of Liverpool and published in the Journal of Infectious Diseases on the 15th November, shows that oxacillin, a β-lactam antibiotic of the penicillin class, can seriously impact on MRSA's ability to produce harmful toxins while simultaneously leaving it vulnerable for attack on another front. (scienceblog.com)
  • In the study, 60 MRSA-infected patients were treated with either vancomycin, or a combination of both vancomycin and flucloxacillin (a β-lactam antibiotic). (scienceblog.com)
  • This backs up the theory that when the β-lactam antibiotic causes repression of Agr, it leaves the bacteria open to our own defence mechanisms, allowing our immune cells to kill them. (scienceblog.com)
  • Beta-lactams exhibit bactericidal activity by binding to penicillin-binding proteins and, ultimately, inhibiting cell wall synthesis. (mhmedical.com)
  • Resistance against β-lactam agents can occur via (i) mutation or expression of alternative penicillin-binding proteins (PBPs) as the drug target, (ii) downregulation of porins to reduce the bacterial permeability against β-lactams, (iii) over-expression of efflux systems which are membrane transport proteins to export drug substrates and (iv) production of β-lactamases that hydrolyze the β-lactam amide [ 6 ]. (biomedcentral.com)
  • Patients often are incorrectly labeled as allergic to penicillin and are therefore denied the benefit of a ß-lactam therapy. (cdc.gov)
  • However, when patients with high-risk penicillin allergy histories are excluded, 99% of patients could receive ß-lactams. (cdc.gov)
  • Penicillin and cephalosporins both contain a ß-lactam ring. (cdc.gov)
  • The Penicillin (Beta-lactams) Strip Test Kit from REAGEN INC is a Beta-lactams Strip Test Kit, also known as Penicillin Strip Test Kit. (elisatest-kits.com)
  • Penicillin, as one of the most commonly used Beta-lactams, is extremely important to detect in the milk, as it can be harmful to humans. (elisatest-kits.com)
  • The REAGEN Penicillin (Beta-lactams) Strip Test Kit (Model Number RNS92020) is a small, accurate test kit manufactured by REAGEN INC in the USA. (elisatest-kits.com)
  • It is used to test for the presence of Penicillin (Beta-lactams) in samples, providing accurate results. (elisatest-kits.com)
  • General synthetic methods are used for the organic synthesis of lactams. (wikipedia.org)
  • A convenient Kinugasa reaction protocol enables a one-pot synthesis of 4-substituted β-lactams from inexpensive calcium carbide and nitrone derivatives. (organic-chemistry.org)
  • Catalytic generation of a ketene species directly from a terminal alkyne in the presence of a Rh(I) catalyst and 4-picoline N -oxide provides a novel and efficient entry to the Staudinger synthesis of β-lactams with high trans diastereoselectivity under mild conditions. (organic-chemistry.org)
  • A catalytic, highly diastereoselective synthesis of trans -β-lactams is based on a phosphonium fluoride precatalyst that both activates the nucleophile and directs the reaction process for high yield and diastereoselectivity. (organic-chemistry.org)
  • The Staudinger synthesis, an overall [2 + 2] cycloaddition of a ketene with an imine, provides a nicely convergent route to biologically and synthetically interesting β-lactams. (organic-chemistry.org)
  • A practical methodology for the catalytic, asymmetric synthesis of β-lactams results from the development of a catalyzed reaction of ketenes (or their derived zwitterionic enolates) and imines using benzoylquinine as chiral catalyst and proton sponge as the stoichiometric base. (organic-chemistry.org)
  • All beta-lactams bind to and inactivate enzymes required for bacterial cell wall synthesis. (merckmanuals.com)
  • Although lactam analogues of TAN-2483B were not obtained in this study, progress was made toward their synthesis. (figshare.com)
  • This breakthrough overcomes challenges in β-lactam synthesis to promise streamlined pathways for drug development. (ibs.re.kr)
  • They managed to achieve high enantioselectivity by utilizing chiral iridium catalysts, however, the same approach could not be applied to the synthesis of the four-membered variant, β-lactam. (ibs.re.kr)
  • Overcoming this critical regioselectivity issue, while achieving high enantioselectivity at the same time, remains highly challenging for the synthesis of β-lactams. (ibs.re.kr)
  • Enantioselective formation of chiral β-lactams has also become possible through combination with chiral ligands, which can be applied to the synthesis of biorelevant compounds. (ibs.re.kr)
  • The researchers at IBS further demonstrated the value of their findings by simpliefied synthesis of a number of β-lactam compounds that previously required more complicated processes. (ibs.re.kr)
  • Intramolecular Hydroamidation of Alkenes Enabling Asymmetric Synthesis of β-Lactams via Transposed NiH Catalysis. (ibs.re.kr)
  • A concise protocol for the synthesis of α-methylene-β-hydroxy- γ-carboxy-γ-lactams has been described via alkylation of amino acid derived iminoesters with α-bromomethylmethacrylate, followed by allylic hydroxylation. (researchwithrowan.com)
  • In penicillins, cephalosporins, and carbapenems, this ring is fused to another 5- or 6-member ring, whereas in monobactams, the β-lactam ring is monocyclic ( Figure 1 ). (encyclopedia.pub)
  • Penicillins, cephalosporins, carbapenems and monobactams all inhibit peptidoglycan cross-linking through interaction of the common β-lactam ring with the transpeptidase enzymes. (pharmacy180.com)
  • The kit is designed to help dairy farmers and producers to quickly and effortlessly detect the presence of Beta-lactams in their milk supply. (elisatest-kits.com)
  • The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria. (lookformedical.com)
  • Back in 2019, the IBS group unveiled a catalytic reaction that allowed access to chiral γ-lactams, five-membered amide structures that differ in the ring size from β-lactams. (ibs.re.kr)
  • Greek prefixes in alphabetical order indicate ring size: This ring-size nomenclature stems from the fact that hydrolysis of an α-lactam gives an α-amino acid and that of a β-Lactam gives a β-amino acid, and so on. (wikipedia.org)
  • The goal is to advance to clinical trials in the near future the novel indole-2-carboxylate derivative developed in the study, which imitates the binding of β-lactams with MBL enzymes. (helsinki.fi)
  • The production of extended spectrum β-lactamases (ESBLs) is a primary β-lactam resistance mechanism in Gram-negative bacteria. (biomedcentral.com)
  • ß- lactam -resistant Enterobacteriaceae , including extended-spectrum ß-lactamases (ESBLs)-producing, AmpC ß-lactamases, and carbapenemases, have been isolated from a wide variety of vegetables . (bvsalud.org)
  • D-Lysine lactam is the cyclic amine formed by the dehydration of the amino acid, D-lysine. (bioaustralis.com)
  • They first tackled the challenge in suppressing the formation of five-membered γ-lactams by harnessing the catalytic properties of nickel-hydride (NiH) species and the alkene dioxazolone substrate. (ibs.re.kr)
  • Beta-lactam and Beta-lactamase Inhibitors Market Like to. (pharmiweb.com)
  • Pune, Maharashtra, India, February 22 2021 (Wiredrelease) Allied Analytics -:Beta-lactam and beta-lactamase inhibitors are chemical compounds of natural or semi-synthetic or synthetic origin. (pharmiweb.com)
  • The beta-lactam and beta-lactamase inhibitors market is expected to exhibit significant growth during the forecast period due to increased consumption in low and middle-income countries (LMICs) and rise in prevalence of infectious diseases. (pharmiweb.com)
  • In addition, development of novel approaches for new beta-lactam and beta-lactamase inhibitors for treating bacterial infections and a large number of clinical trials, further supplement the market growth. (pharmiweb.com)
  • The cephalosporin segment accounted more than two-fifths of the total beta-lactam and beta-lactamase inhibitors market share in 2018. (pharmiweb.com)
  • Asia-Pacific was the leading revenue contributor to the global beta-lactam and beta-lactamase inhibitors market in 2018, and is expected to remain dominant throughout the forecast period. (pharmiweb.com)
  • The report provides a comprehensive analysis of the key players operating in the global beta-lactam and beta-lactamase inhibitors market industry, namely, Abbott Laboratories, Allergan Plc. (pharmiweb.com)
  • U.S. generated the highest revenue in the global beta-lactam and beta-lactamase inhibitors in 2018, accounting more than one-fifth of the global market in 2018. (pharmiweb.com)
  • The bacteria designated by the acronym SERMOR-PROVENF (SER = Serratia, MOR = Morganella, PROV = Providencia, EN = Enterobacter, F = freundii for Citrobacter freundii ) have similar, although not identical, chromosomal beta-lactamase genes that are inducible. (medscape.com)
  • This review provides an overview on β-lactam and β-lactone probes and recent advances in their applications in chemical biology. (rsc.org)
  • It was proposed that substituting the lactone for a lactam would increase the stability of the compound in nucleophilic media. (figshare.com)
  • The aim of this thesis was to investigate the viability of a synthetic route toward lactam analogues of TAN-2483B. (figshare.com)
  • The promising bioactivity of the (Z)-ethyl ester analogue was anticipated to be retained in the target lactam analogues. (figshare.com)
  • An alternative route toward lactam analogues of TAN-2483B, via intermediate amines accessed by the substitution of an activated alcohol, was briefly investigated with encouraging results. (figshare.com)
  • The alternative route toward amines that was briefly explored here appears promising, and work is ongoing in the Harvey group to access lactam (and other) analogues of TAN-2483B, in addition to the natural product itself. (figshare.com)
  • The varying sensitivity of the PBPs towards different β-lactams helps to explain the range of morphological effects observed in treated bacteria. (pharmacy180.com)
  • But when methicillin and other β-lactams are introduced, they're able to bind to PBP and stop it from functioning, leading to weakening of the cell wall and death of the bacteria. (scienceblog.com)
  • Essentially, what this gene does is allow the bacteria to produce PBP2a, a protein similar to PBP which carries out the same function but, annoyingly for us, offers much less attraction, or affinity, for β-lactams - which means they won't be able to kill the bacteria any more. (scienceblog.com)
  • ß- lactams have high efficacy against Gram-negative bacteria and low toxicity for eukaryotic cells . (bvsalud.org)
  • Haemophilus influenzae strains in north Lebanon in both invasive and non-invasive disease and to determine the susceptibility pattern and the mechanism of resistance to -lactams [-lactamase-producing strains and -lactamase-negative ampicillin resistant (BLNAR) strains]. (who.int)
  • the resistance pattern to -lactams of these strains was determined by using the disc diffusion and E-test methods followed by molecular methods such as PCR of bla et bla genes. (who.int)
  • 15.3% were not fully susceptible to -lactams or considered low BLNAR strains. (who.int)
  • The aim of this study was to compare the outcomes of patients given benzylpenicillin with patients given wide-spectrum beta-lactams (WSBL) as empirical treatment of lower respiratory tract H. influenzae infections requiring hospital care. (lu.se)
  • Real-time PCR was applied to detect β-lactam resistance genes and conventional PCR was used to determine the phylotypes. (biomedcentral.com)
  • The resulting rhodium enolate reacted as a Reformatsky-type reagent with various imines to give syn -β-lactams in good to excellent yields with high diastereoselectivity. (organic-chemistry.org)
  • Condensation of 2-formylbenzoic acid with α-amino alcohol substrates proceeds with extremely high diastereoselectivity to produce tricyclic γ-lactam products. (hud.ac.uk)
  • Lactams can be formed from cyclisation of amino acids via the coupling between an amine and a carboxylic acid within the same molecule. (wikipedia.org)
  • For example, Fmoc-Dab(Mtt)-OH, although its side-chain amine is sterically protected by extremely bulky 4-Methyltrityl (Mtt) group, the amine can still intramolecularly couple with the carboxylic acid to form a γ-lactam. (wikipedia.org)
  • Reductive amination of a ketone intermediate was envisaged to install the amine prior to a palladium-catalysed carbonylation/lactam formation step. (figshare.com)
  • The prevalence of bacterial pathogens causing BSIs susceptible to broad spectrum β-lactams is higher than the prevalence of pathogens not susceptible to broad-spectrum β-lactams. (brownmedpedsresidency.org)
  • Sensitivity of S. aureus to beta-lactam and glycopeptide. (bvsalud.org)
  • Administration of vancomycin prior to a β-lactam was not associated with improved survival in the subgroup of 524 patients with MRSA BSI (aOR 0.93 [95% CI 0.33-2.63]), supporting the overall study findings of prioritizing β-lactam therapy when there is a heightened suspicion for BSI. (brownmedpedsresidency.org)
  • In sum, for patients likely to be experiencing BSI, prioritizing administration of a β-lactam over vancomycin appears to reduce early mortality, underscoring the significant impact of a relatively simple practice change on improving patient survival. (brownmedpedsresidency.org)
  • The formation of lysine lactams is often encountered as a synthetic by-product of peptide chemistry involving lysine. (bioaustralis.com)
  • Vegetables are vectors of ß- lactam -resistant Enterobacteriaceae , contributing to the dissemination of resistance mechanisms previously observed only in the hospital environment . (bvsalud.org)
  • Through this study, the researchers demonstrated that the synthetic procedure for pharmaceuticals and natural substances, including chiral β -lactam, could be streamlined. (ibs.re.kr)
  • Lactams form from intramolecular attack of linear acyl derivatives from the nucleophilic abstraction reaction. (wikipedia.org)
  • Lactams form by the acid-catalyzed rearrangement of oximes in the Beckmann rearrangement. (wikipedia.org)
  • Lactams form from cyclic ketones and hydrazoic acid in the Schmidt reaction. (wikipedia.org)
  • Thermally promoted reactions of α-acyl-α-diazoacetates with imines deliver α-alkoxycarbonyl-substituted β-lactams with outstanding diastereoselectivity. (organic-chemistry.org)
  • In the presence of imines, the generated ketenes react further to afford β-lactams. (organic-chemistry.org)
  • Phenotypic resistance against β-lactams (ceftazidime, cefotaxime, aztreonam and ceftriaxone) and fluoroquinolones (ciprofloxacin) were identified by the disc diffusion technique. (biomedcentral.com)
  • Various trans -substituted β-lactams derived from amino acids have been prepared. (organic-chemistry.org)
  • Moreover, the lactam nitrogen may provide a site for further functionalisation of the compound for future structure-activity relationship studies. (figshare.com)
  • High regioselectivity is achieved toward the desired formation of β-lactam scaffolds under this new catalytic system, whereby the NiH species react more favorably with the dioxazolone motif than with alkene to induce a β-selective carbon-nitrogen bond formation via nickel-amido intermediates. (ibs.re.kr)
  • In fact, the potential for β-lactams as an adjunct treatment against MRSA has already been demonstrated at the start of this year, in a paper published in the journal Clinical Infectious Diseases . (scienceblog.com)
  • The pharmacodynamic parameter for beta-lactams that best correlates with efficacy is the percentage of the dosing interval that free drug concentration remains above the MIC ( f T>MIC) 9 . (mhmedical.com)
  • Beta-lactam in vivo efficacy is best predicted by the percentage of the dosing interval that free drug concentrations remains above the MIC ( f T>MIC). (mhmedical.com)
  • A catalytic enantioselective Staudinger reaction is described that preferentially furnishes trans β-lactams. (organic-chemistry.org)
  • This review aimed to conduct a literature survey of the last five years (2018-2023) on the occurrence of ß- lactam -resistant Enterobacteriaceae in vegetables . (bvsalud.org)
  • Efficient conversion of Schiff bases and carboxylic acids to β-lactams can be carried out at room temperature in CH 2 Cl 2 , using a cyanuric chloride- N,N -dimethyl formamide complex. (organic-chemistry.org)
  • 2-Azabicyclo[2.2.1]hept-5-en-3-one: Chemical Profile of a Versatile Synthetic Building Block and its Impact on the Development of Therapeutics" Pham, P.-T. (wikipedia.org)
  • Researchers at the Institute for Basic Science (IBS) have developed a novel synthetic method using earth-abundant nickel catalysts to access chiral β -lactams in high enantioselectivity. (ibs.re.kr)
  • He added, "Discovery of new pathways to synthesize high-value materials like chiral β-lactam is a significant achievement that can greatly shorten the drug discovery phase. (ibs.re.kr)
  • Lactams form by copper-catalyzed 1,3-dipolar cycloaddition of alkynes and nitrones in the Kinugasa reaction Diels-Alder reaction between cyclopentadiene and chlorosulfonyl isocyanate (CSI) can be utilized to obtain both β- as well as γ-lactam. (wikipedia.org)