• varicose veins
  • Klinefelter syndrome can lead to weak bones (osteoporosis), varicose veins, and autoimmune diseases (when the immune system acts against the body), such as lupus or rheumatoid arthritis. (hormone.org)
  • Klinefelter syndrome is associated with an increased risk for breast cancer, a rare tumor called extragonadal germ cell tumor, lung disease, varicose veins and osteoporosis. (genome.gov)
  • patients
  • The physical findings in patients with Klinefelter syndrome vary. (medscape.com)
  • These will be related to clinically relevant metabolic and inflammatory patterns as well as fertility to identify individual risks as well as treatment strategies for Klinefelter patients. (clinicaltrials.gov)
  • this quote needs a citation] Klinefelter comments on gynecomastia: A few years after the syndrome was described, Heller and Nelson reported that the gynecomastia was not a necessary part of the syndrome, though it occurred in about 75% of the patients. (wikipedia.org)
  • hormone
  • Klinefelter HF Jr, Reifenstein EC Jr, Albright F. Syndrome characterized by gynecomastia aspermatogenesis without a-Leydigism and increased excretion of follicle-stimulating hormone. (medscape.com)
  • under the supervision of Fuller Albright he described a group of nine men with "gynecomastia, aspermatogenesis without aleydigism, and increased excretion of follicle-stimulating hormone", the first description of what would be called the Klinefelter syndrome. (wikipedia.org)
  • The title, "A Syndrome Characterized by Gynecomastia, Aspermatogenesis without Aleydigism, and Increased Excretion of Follicle-Stimulating Hormone," was so long that the syndrome came to be known by my name, though it was really just another of Dr. Albright's diseases. (wikipedia.org)
  • osteoporosis
  • For example, guys with Klinefelter syndrome may be more likely to get some types of cancer and other diseases, like type 2 diabetes and osteoporosis, a condition where the bones become weaker later in life. (kidshealth.org)
  • findings
  • Klinefelter described his findings as follows: I first worked under Dr. Howard Means, measuring oxygen consumption of adrenal gland slices in the Warburg apparatus, but I was so unsuccessful at it, breaking most of the apparatus, that in September, I asked Dr. Means if I might work with Dr. Fuller Albright, since I primarily wanted to learn some clinical endocrinology. (wikipedia.org)
  • Small
  • Older moms have a slightly higher chance of having a boy with Klinefelter, but the increase in probability is very small. (webmd.com)
  • A small proportion of male gynecomastia cases may be seen with rare inherited disorders such as spinal and bulbar muscular atrophy and the very rare aromatase excess syndrome. (wikipedia.org)
  • often
  • Since high-school life often revolves around schoolwork and sports, guys with Klinefelter may feel like they don't fit in or lack self-confidence. (kidshealth.org)
  • Often, men don't even know they have Klinefelter until they run into problems trying to have a child. (webmd.com)
  • Males with XYY syndrome are fertile and are not often aware that they have an abnormality. (wikipedia.org)
  • gynecomastia
  • The onset of adolescence in Klinefelter s Syndrome is marked by the lack of testosterone, poor growth of secondary sexual characters, gynecomastia and sterility. (medindia.net)
  • Medications such as aromatase inhibitors have been found to be effective in rare cases of gynecomastia from disorders such as aromatase excess syndrome or Peutz-Jeghers syndrome, but surgical removal of the excess tissue is usually required. (wikipedia.org)