• A kinin is any of various structurally related polypeptides, such as bradykinin and kallidin. (wikipedia.org)
  • Kinin peptides (kallidin and bradykinin) are located in human blood and urine. (wikipedia.org)
  • Kinins (bradykinin and lys-bradykinin) are endogenous vasodilators and natriuretic peptides known best for their ability to antagonize angiotensin-induced vasoconstriction and sodium retention. (nature.com)
  • Hypotensive effects of Lys-des-Arg9-bradykinin and metabolically protected agonists of B1 receptors for kinins. (aspetjournals.org)
  • B1 receptors for kinins are selectively stimulated by bradykinin (BK) or Lys-BK (kallidin) fragments without the C terminal arginine residue. (aspetjournals.org)
  • Nevertheless, emerging evidence suggests that bradykinin and other kinins are stored in the central nervous system and may act as neuromediators in the control of nociceptive response. (unifesp.br)
  • Incubation of plasma from the red-eared turtle with glass beads in the presence of the kininase inhibitor 1, 10- phenanthroline resulted in activation of the kallikrein-kinin system and generation of bradykinin-like immunoreactivity. (uaeu.ac.ae)
  • The amino acid sequence of the turtle kinin Arg-Pro-Pro- Gly-Phe-Thr-Pro-Phe-Arg contains the substitution Thr for Ser at position 6 compared with mammalian bradykinin. (uaeu.ac.ae)
  • These therapies act on different targets within the contact/kinin system (CKS) to reduce bradykinin production or its effects, decrease angioedema, and improve outcomes in patients with HAE. (ajmc.com)
  • Kinins transmit their effects through G protein- coupled receptors. (wikipedia.org)
  • There are two types of kinin receptors, B1 and B2. (wikipedia.org)
  • Here we determined whether leukocyte-derived microvesicles bear B1-kinin receptors during vasculitis, and if microvesicles transfer functional B1-receptors to recipient cells, thus promoting inflammation. (lu.se)
  • Thus, we found a novel mechanism by which microvesicles transfer functional receptors and promote kinin-associated inflammation. (lu.se)
  • Plevin, R & Owen, PJ 1988, ' Multiple B 2 kinin receptors m mammalian tissues ', Trends in Pharmacological Sciences , vol. 9, no. 11, pp. 387-389. (hud.ac.uk)
  • In summary, our data show that disruption of kinin B1 and B2 receptors has a profound impact on metabolic homeostasis in mice, by improving glucose tolerance and preventing HFD-induced obesity. (pubchase.com)
  • During vasculitis, activation of the kinin system induces inflammation, whereby the kinin B1-receptor is expressed and activated after ligand binding. (lu.se)
  • to propose that the excess of fluid in the lungs seen in COVID-19 patients may be because kinins are not being neutralized due to the shortage of the ACE2 receptor. (ru.nl)
  • If this hypothesis is correct, it would mean that directly inhibiting the receptor for the kinins (or the proteins that they come from) may be the only way to stop fluid leaking into the lungs of COVID-19 patients in the early stage of disease. (ru.nl)
  • We analyzed the chemotactic effect of kinin B 1 receptor agonists on neutrophils isolated from peripheral blood of human healthy subjects. (uai.cl)
  • A generation of kinin B 1 receptor agonists during the early phase of acute inflammation may favor the recruitment of neutrophils to the inflammatory site. (uai.cl)
  • Here we show that the kinin-B2 receptor (B2BKR) is differentially expressed during in vitro neuronal differentiation of P19 cells. (unifesp.br)
  • This study tested the beneficial effects of the non-peptide and orally active kinin B 1 receptor antagonist SSR240612 against tactile and cold allodynia in a rat model of insulin resistance. (johnshopkins.edu)
  • Kinin B1 and B2 receptor deficiency protects against obesity induced by a high-fat diet and improves glucose tolerance in mice. (pubchase.com)
  • However, it is also known that in the absence of B1 receptor, the B2 receptor is overexpressed and can take over the function of its B1 counterpart, rendering uncertain the role of each kinin receptor in these metabolic effects. (pubchase.com)
  • Therefore, we investigated the impact of ablation of each kinin receptor on energy metabolism using double kinin receptor knockout (B1B2KO) mice. (pubchase.com)
  • Kinins are peptides that are cleaved from kininogens by the process of kallikreins. (wikipedia.org)
  • Kinin are short lived peptides that cause pain sensation, arteriolar dilation, increase vascular permeability and cause contractions in smooth muscle. (wikipedia.org)
  • In animals, kinins are peptides released by enzyme action which contraction of smooth muscle and elevate blood pressure , thus playing an important role in inflammation and shock . (daviddarling.info)
  • Kinins are biologically active peptides that are powerful mediators of cellular inflammation. (uai.cl)
  • However, the evidence concerning the chemotactic effect of kinin peptides has been contradictory. (uai.cl)
  • This article is a review of exciting, recently generated genetic, biochemical and clinical data from studies that have examined the importance of the tissue kallikrein-kinin system in protection from hypertension, vascular remodeling and renal fibrosis. (nature.com)
  • 4. Our demonstration that two agents with known opposite actions on the kallikrein-kinin system produced predictable and opposite effects on blood pressure may indicate that this system is involved in the homeostatic regulation of blood pressure. (portlandpress.com)
  • Noda, M 2011, Kallikrein-kinin system in the brain . (elsevierpure.com)
  • Dotsenko V.L., Iarovaia G.A., Neshkova E.A. (1989) The use of a tripeptide chromogenic substrate for simultaneous determination of 4 indices of kallikrein-kinin system. (msk.ru)
  • The data suggest that the kallikrein- kinin system may play an important physiological role in the regulation of cardiovascular function in reptiles. (uaeu.ac.ae)
  • The kallikrein-kinin system is well known for its role in pain and inflammation, and has been shown recently by our group to have a role also in the regulation of energy expenditure. (pubchase.com)
  • Presentations for oral FXIIa inhibitors showed that the compounds block the initiation and amplification of the kallikrein kinin system (KKS) in preclinical models. (financialcontent.com)
  • The oral FXIIa inhibitors we are evaluating show great promise by blocking the earliest steps of kallikrein kinin system activation," said Andrew Crockett, Chief Executive Officer of KalVista. (financialcontent.com)
  • Oral FXIIa inhibitor KV998086 suppresses FXII zymogen mediated Kallikrein Kinin System activation. (financialcontent.com)
  • Oral sebetralstat (KVD900) provides rapid inhibition of the kallikrein kinin system in patients with HAE. (financialcontent.com)
  • Kallikrein Kinin System in Disease. (financialcontent.com)
  • From Bench to Clinic: Oral Inhibitors of the Kallikrein-Kinin System for the Treatment of HAE. (financialcontent.com)
  • Kinins function as mediators for inflammatory responses by triggering the immune system. (wikipedia.org)
  • Kinins are proteins in the blood that cause inflammation and affect blood pressure (especially causing blood pressure to go down). (medlineplus.gov)
  • With respect to mediation of arteriolar dilation, histamine is about 10 times more potent compared to kinins. (pharmacology2000.com)
  • Kinin increase vascular permeability by acting on vascular endothelial cells to cause cell contraction. (wikipedia.org)
  • These compounds restrict the accumulation of polymorphonuclear leukocytes and macrophages and reduce the release of vasoactive kinins. (medscape.com)
  • It belongs to a family of molecules known as kinins, and ACE2 is known to inactivate certain kinins. (ru.nl)
  • The beneficial actions of kinins in renal and cardiovascular disease are largely mediated by nitric oxide and prostaglandins, and extend beyond their recognized role in lowering blood pressure to include cardioprotection and nephroprotection. (nature.com)
  • It is a component of the kinin-kallikrein system. (wikipedia.org)
  • Reduced kinin activity can result in high blood pressure, sodium retention and the narrowing of blood vessels. (wikipedia.org)
  • 220 patients admis dans l'unité de soins intensifs en chirurgie, auxquels une sonde nasogastrique avait été posée pendant plus de 24 heures, 68 cas se sont vu administrer du métoclopramide par voie orale (10 mg toutes les 8 heures) et 152 patients témoins n'ont rien reçu. (who.int)
  • Kinins work in conjunction with auxins to promote swelling and division in the plant cells producing lateral buds. (daviddarling.info)
  • Kinins at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Sharma, Jagdish N., ed. (2014). (wikipedia.org)
  • Kinins are mostly produced at inflamed or injured tissue of the body and human body fluids. (wikipedia.org)
  • Kinin was initially discovered by J.E. Abelous and E. Bardier in 1909 when performing experiments utilizing human body fluids. (wikipedia.org)
  • Kinin act on axons to block nervous impulses, which leads to distal muscle relaxation. (wikipedia.org)
  • Here, we hypothesize that a kinin-dependent local lung angioedema via B1R and eventually B2R is an important feature of COVID-19. (ru.nl)
  • Kinin, also called cytokinin or kinetic , is any of a group of plant hormones which affect growth and are used to slow down the aging process in plants, encourage seeds to germinate, and plants to flower, and are involved in plant responses to drought and waterlogging. (daviddarling.info)