• excretion
  • Vasopressin regulates water excretion from the kidney by increasing the osmotic water permeability of the renal collecting duct - an effect that is explained by coupling of the V2R with the Gs signaling pathway, which activates cAMP. (wikipedia.org)
  • citation needed] Alcohol stimulates the kidneys' excretion of magnesium, which is also increased because of alcoholic and diabetic ketoacidosis, low blood phosphate levels, and hyperaldosteronism resulting from liver disease. (wikipedia.org)
  • AVPR2's
  • In the kidney, AVPR2's primary function is to respond to arginine vasopressin by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. (wikipedia.org)
  • In the kidney, AVPR2's primary property is to respond to arginine vasopressin by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. (wikipedia.org)
  • Liver
  • The asymmetry within the abdominal cavity, caused by the position of the liver, typically results in the right kidney being slightly lower and smaller than the left, and being placed slightly more to the middle than the left kidney. (wikipedia.org)
  • The right kidney sits just below the diaphragm and posterior to the liver. (wikipedia.org)
  • The superior pole of the right kidney is adjacent to the liver. (wikipedia.org)
  • serum
  • Fluoride induced nephrotoxicity is kidney injury due to toxic levels of serum fluoride, commonly due to release of fluoride from fluorine-containing drugs, such as methoxyflurane. (wikipedia.org)
  • medullary
  • V1Rs are found in kidney, where they occur in high density on medullary interstitial cells, vasa recta, and epithelial cells of the collecting duct. (wikipedia.org)
  • high
  • Within the recommended dose, no effects are expected, but chronic ingestion in excess of 12 mg/day are expected to cause adverse effects, and an intake that high is possible when fluoride levels are around 4 mg/L. Those with impaired kidney function are more susceptible to adverse effects. (wikipedia.org)
  • In humans, the kidneys are located high in the abdominal cavity, one on each side of the spine, and lie in a retroperitoneal position at a slightly oblique angle. (wikipedia.org)
  • The risk of high blood potassium is greater in those with kidney problems, diabetes, and those who are older. (wikipedia.org)
  • citation needed] Gastrointestinal causes: the distal tractus digestivus secretes high levels of magnesium. (wikipedia.org)
  • cells
  • AVPR2 is also expressed outside the kidney, and, when stimulated, can cause the release of Von Willebrand Factor from the Weibl-Palade Bodies in the endothelial cells of the vasculature. (wikipedia.org)
  • Specifically, it binds receptors of cells that comprise the distal tubules of the kidneys which then stimulate ion channels to conserve sodium and excrete potassium. (wikipedia.org)
  • blood
  • In normal individuals, free light chains are rapidly cleared from the blood and catabolised by the kidneys. (wikipedia.org)
  • Filtration occurs in the glomerulus: one-fifth of the blood volume that enters the kidneys is filtered. (wikipedia.org)
  • Low levels of magnesium in blood may mean that there is not enough magnesium in the diet, the intestines are not absorbing enough magnesium, or the kidneys are excreting too much magnesium. (wikipedia.org)
  • function
  • These hormones also function in regulating the conservation of water by the kidneys and glucose metabolism, respectively. (wikipedia.org)
  • level
  • The left kidney is approximately at the vertebral level T12 to L3, and the right is slightly lower. (wikipedia.org)
  • disease
  • In this study, we employed a synthetic mitochondrial superoxide dismutase 2 (SOD2) mimic MnTBAP to investigate the role of mitochondrial oxidative stress in modulating the sodium transporters in obstructive kidney disease. (readbyqxmd.com)
  • normal
  • It is very efficient and can process10-30g of low-molecular-weight proteins per day, so under normal conditions no light chains pass beyond the proximal tubules. (wikipedia.org)