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  • excretion
  • Vasopressin regulates water excretion from the kidney by increasing the osmotic water permeability of the renal collecting duct - an effect that is explained by coupling of the V2R with the Gs signaling pathway, which activates cAMP. (wikipedia.org)
  • citation needed] Alcohol stimulates the kidneys' excretion of magnesium, which is also increased because of alcoholic and diabetic ketoacidosis, low blood phosphate levels, and hyperaldosteronism resulting from liver disease. (wikipedia.org)
  • Gitelman syndrome is an autosomal recessive kidney disorder characterized by low blood levels of potassium and magnesium, decreased excretion of calcium in the urine, and elevated blood pH. (wikipedia.org)
  • AVPR2's
  • In the kidney, AVPR2's primary function is to respond to arginine vasopressin by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. (wikipedia.org)
  • In the kidney, AVPR2's primary property is to respond to arginine vasopressin by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. (wikipedia.org)
  • vesicles
  • The increased intracellular cAMP in the kidney in turn triggers fusion of aquaporin-2-bearing vesicles with the apical plasma membrane of the collecting duct principal cells, increasing water reabsorption. (wikipedia.org)
  • Liver
  • If peripheral and liver signatures are parallel, peripheral signature may become a non-invasive tool of exploration of chronic HEV infection in kidney-transplant recipients. (bioportfolio.com)
  • channel
  • AngII inhibited the basolateral 40 pS K channel (a Kir4.1/5.1 heterotetramer) in the distal convoluted tubule treated with losartan but not with PD123319. (readbyqxmd.com)
  • Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:11549322, PubMed:18768590). (genecards.org)
  • blood
  • Therefore, the major goal of the study is to analyse for the first time the host responses in kidney-transplant recipients with chronic HEV infection and to compare them to the host responses in kidney-transplant recipients without viral infection (controls), to identify a specific peripheral signature using blood microarray-based gene expression profiling. (bioportfolio.com)
  • In normal individuals, free light chains are rapidly cleared from the blood and catabolised by the kidneys. (wikipedia.org)
  • Low levels of magnesium in blood may mean that there is not enough magnesium in the diet, the intestines are not absorbing enough magnesium, or the kidneys are excreting too much magnesium. (wikipedia.org)
  • normal
  • Conditions in which the KIDNEYS perform below the normal level for more than three months. (bioportfolio.com)
  • It is very efficient and can process10-30g of low-molecular-weight proteins per day, so under normal conditions no light chains pass beyond the proximal tubules. (wikipedia.org)
  • levels
  • Fluoride induced nephrotoxicity is kidney injury due to toxic levels of serum fluoride, commonly due to release of fluoride from fluorine-containing drugs, such as methoxyflurane. (wikipedia.org)
  • Within the recommended dose, no effects are expected, but chronic ingestion in excess of 12 mg/day are expected to cause adverse effects, and an intake that high is possible when fluoride levels are around 4 mg/L. Those with impaired kidney function are more susceptible to adverse effects. (wikipedia.org)
  • citation needed] Gastrointestinal causes: the distal tractus digestivus secretes high levels of magnesium. (wikipedia.org)
  • level
  • Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE. (bioportfolio.com)
  • Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). (bioportfolio.com)
  • patients
  • The NephoMIC project is a biological collection in patients of Nephrology, allowing the study of the links between kidney diseases, Immunity system and Cardiovascular complications. (bioportfolio.com)
  • This study will investigate tolerance in kidney transplant patients. (bioportfolio.com)
  • This is termed "cast nephropathy" or "myeloma kidney" and is typically found in patients with multiple myeloma. (wikipedia.org)
  • Concentration
  • PTH essentially acts to increase the concentration of calcium in the blood by acting upon the parathyroid hormone 1 receptor, which is present at high levels in bone and kidney, and the parathyroid hormone 2 receptor, which is present at high levels in the central nervous system, pancreas, testis, and placenta. (wikipedia.org)
  • hormones
  • Along with catecholamines (adrenaline), these hormones control a variety of functions including kidney function, metabolism, fight-or-flight response, and sex hormone levels. (lumenlearning.com)
  • nephrotoxicity
  • The cisplatin single dose administration to rats induced nephrotoxicity associated with a significant increase in blood urea nitrogen (BUN) and serum creatinine and significantly increase Malondialdehyde (MDA) in kidney tissues by 230 ± 5.5 nmol/g compared to control group. (biomedcentral.com)
  • diseases
  • Furosemide is used to treat edema syndrome in patients with chronic heart failure (degree II and III), cirrhosis, diseases of kidneys, acute heart failure (pulmonary edema), brain edema, hypertensive crisis, arterial hypertension and others. (medsamazing.com)
  • Tubulointerstitial diseases constitute a diverse group of acute and chronic, hereditary and acquired disorders involving renal tubules and supporting structures (Table 143-1). (wordpress.com)
  • In chronic kidney diseases with hypoalbuminemia, it is used along with albumin to increase diuresis. (wikipedia.org)
  • perfusion
  • 20 tends to herald prerenal azotemia (commonly secondary to dehydration but also any other reason perfusion to kidneys is decreased). (wikipedia.org)
  • Hypothermic perfusion has given the longest storage time for canine kidneys with the best result being 8 day storage. (wikipedia.org)
  • cortex
  • Fuhrman showed that slices of rat kidney cortex and brain withstood cooling to 0.2 °C for one hour at which temperature their oxygen consumption was minimal. (wikipedia.org)
  • structures
  • The results suggested that the histological structures of yak kidney changed with the increase of age. (magtech.com.cn)
  • In terrestrial animals, such as reptiles, birds and mammals, the kidneys are important osmoregulatory structures. (biologyboom.com)
  • necrosis
  • Kidneys were harvested for histopathology and for the study the gene expression of c-Jun N-terminal kinases ( JNK ), Mitogen-activated protein kinase 4 ( MKK4 ), MKK7 , P38 mitogen-activated protein kinases ( P38 ), tumor necrosis factors alpha ( TNF-α ), TNF Receptor-Associated Factor 2 ( TRAF2 ), and interleukin-1 alpha ( IL-1-α ). (biomedcentral.com)
  • limb
  • Loop diuretics are diuretics that act at the ascending limb of the loop of Henle in the kidney. (wikipedia.org)
  • loop
  • A secondary effect of loop diuretics is to increase the production of prostaglandins, which results in vasodilation and increased blood supply to the kidney. (wikipedia.org)
  • tissues
  • Of course, when people fall asleep at night, the metabolism is relatively slowed down, and the amount of blood needed for other tissues and organs is reduced accordingly, so the amount of blood flowing through the kidney into the arterioles increases. (kidney-treatment.org)
  • Additionally, histopathological examination of kidney tissues confirmed gene expression data. (biomedcentral.com)
  • The crucial step in making in vitro storage of kidneys possible, was the demonstration by Fuhrman in 1943, of a reversible effect of hypothermia on the metabolic processes of isolated tissues. (wikipedia.org)
  • human kidney
  • Adrenal gland An endocrine gland located on top of the human kidney. (wikipedia.org)
  • Moyer demonstrated the applicability of these dog experiments to the human, by showing the same effect on dog and human kidney function from the same periods of hypothermic ischaemia. (wikipedia.org)
  • thoracic
  • In humans, the adrenal glands are found at the level of the 12th thoracic vertebra sitting above and slightly medial to the kidneys, lying within the renal fascia, and separated from the kidneys by a thin layer of connective tissue. (lumenlearning.com)
  • The beneficial effect of hypothermia on ischaemic intact kidneys was demonstrated by Owens in 1955 when he showed that, if dogs were cooled to 23-26 °C, and their thoracic aortas were occluded for 2 hours, their kidneys showed no apparent damage when the dogs were rewarmed. (wikipedia.org)
  • systemic
  • Just as I was desperate, I was introduced by a friend and I came to the Beijing Tongshantang Hospital of Traditional Chinese Medicine to accept the systemic natural treatment network for kidney disease. (kidney-treatment.org)
  • They resemble smooth muscle cells and play a role in renal autoregulation of blood flow to the kidney and regulation of systemic blood pressure through the renin-angiotensin system. (wikipedia.org)
  • occurs
  • In the intestine, via kidney, PTH enhances the absorption of calcium in the intestine by increasing the production of activated vitamin D. Vitamin D activation occurs in the kidney. (wikipedia.org)
  • blood
  • The afferent arterioles branch from the renal artery, which supplies blood to the kidneys. (wikipedia.org)
  • It is largely related to insufficient or dysfunctional filtering of blood by the kidneys. (wikipedia.org)
  • An agent which interferes with the renin (kidney-lung-heart blood pressure control) cycle. (wikipedia.org)
  • Prior to this, kidneys had been stored at normal body temperatures using blood or diluted blood perfusates, but no successful reimplantations had been made. (wikipedia.org)
  • Kiser used this technique to achieve successful 7 hours in vitro storage of a dog kidney, when the kidney had been flushed at 5 °C with a mixture of dextran and diluted blood prior to storage. (wikipedia.org)
  • Although Lapchinsky gave no details in his paper, Humphries reported that these experiments had involved cooling the kidneys for 1 hour with cold blood, and then storage at 2-4 °C, followed by rewarming of the kidneys over 1 hour with warm blood at the time of reimplantation. (wikipedia.org)
  • liver
  • Furosemide, sold under the brand name Lasix among others, is a medication used to treat fluid build-up due to heart failure, liver scarring, or kidney disease. (wikipedia.org)
  • vascular
  • An essential preliminary to the development of kidney storage and transplantation was the work of Carrel in developing methods for vascular anastomosis. (wikipedia.org)
  • This had the effect of increasing the speed of cooling of the kidney and removed red cells from the vascular system. (wikipedia.org)