• arterioles
  • The resistance of the efferent arterioles causes sufficient hydrostatic pressure within the glomerulus to provide the force for ultrafiltration. (wikipedia.org)
  • This provides tighter control over the blood flow through the glomerulus, since arterioles dilate and constrict more readily than venules, owing to their thick circular smooth muscle layer (tunica media). (wikipedia.org)
  • In the kidneys, as a result of benign arterial hypertension, hyaline (pink, amorphous, homogeneous material) accumulates in the walls of small arteries and arterioles, producing the thickening of their walls and the narrowing of the arterial openings, a process known as arteriolosclerosis. (wikipedia.org)
  • Distal Tubule
  • Result: Under the light microscope, the kidney in experimental group show the many anatomical changes as increase in Wight, elongated and increase in width, and showed many histological changes as a glomerular enlargement with decrease of urinary space and dilation in proximal and distal tubule. (journalijar.com)
  • vasculature
  • Eliminating either PDGFRB, or PDGF-B reduces the number of pericytes and vascular smooth muscle cells, and thereby compromises the integrity and/or functionality of the vasculature in multiple organs, including the brain, heart, kidney, skin and eye. (wikipedia.org)
  • Disease
  • Advance Chronic Kidney Disease. (journalijar.com)
  • Lupus nephritis (also known as SLE nephritis) is an inflammation of the kidneys caused by systemic lupus erythematosus (SLE), an autoimmune disease. (wikipedia.org)
  • Class III disease (focal glomerulonephritis) is indicated by sclerotic lesions involving less than 50% of the glomeruli, which can be segmental or global, and active or chronic, with endocapillary or extracapillary proliferative lesions. (wikipedia.org)
  • Thus any immune complex disease that involves the glomerulus may progress to RPGN if severe enough. (wikipedia.org)
  • Type III RPGN may be isolated to the glomerulus (primary, or idiopathic) or associated with a systemic disease (secondary). (wikipedia.org)
  • Hypertensive kidney disease is a medical condition referring to damage to the kidney due to chronic high blood pressure. (wikipedia.org)
  • Hypertensive nephropathy refers to kidney failure that can be attributed to a history of hypertension It is a chronic condition and it is a serious risk factor for the development of end-stage kidney disease (ESKD). (wikipedia.org)
  • However, despite the well-known association between hypertension and chronic kidney disease, the underlying mechanism remains unclear. (wikipedia.org)
  • This leads to a build-up of plaques and they can be deposited in the renal arteries causing stenosis and ischemic kidney disease. (wikipedia.org)
  • She has yielded a number of discoveries in basic biomedical research including: mechanisms of kidney disease, organization of functions that attach cells to one another, and mechanisms of secretions. (wikipedia.org)
  • Transplant glomerulopathy, abbreviated TG, is a disease of the glomeruli in transplanted kidneys. (wikipedia.org)
  • Affected individuals with end-stage kidney disease often require hemodialysis and eventually kidney transplantation to replace the failed kidney function. (wikipedia.org)
  • This condition is called end-stage renal disease (ESRD) and the patients must begin dialysis treatment or receive a kidney transplant. (wikipedia.org)
  • fluid
  • To be sure, the kidney is not the sole organ of extracellular fluid homeostasis ( 80 ). (physiology.org)
  • Nevertheless, the contributions aglomerular kidneys make to extracellular fluid homeostasis leave many intriguing questions unanswered. (physiology.org)
  • Dialysis is used in extreme cases to remove fluid and toxins when your kidneys have severely impaired filtering. (vidanthealth.com)
  • Over 150 liters of fluid enter the glomeruli of an adult every day: 99% of the water in that filtrate is reabsorbed. (wikipedia.org)
  • diseases
  • Farquhar's research focuses on control of intracellular membrane traffic and the molecular pathogenesis of auto immune kidney diseases. (wikipedia.org)
  • glomerulonephritis
  • It is a type of glomerulonephritis in which the glomeruli become inflamed. (wikipedia.org)
  • As the result of SLE, the cause of glomerulonephritis is said to be secondary and has a different pattern and outcome from conditions with a primary cause originating in the kidney. (wikipedia.org)