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  • Oral
  • Ketoconazole is used to treat serious fungal or yeast infections, such as candidiasis (thrush, oral thrush), blastomycosis (Gilchrist's disease), coccidioidomycosis (Valley fever, San Joaquin Valley fever), histoplasmosis (Darling's disease), chromoblastomycosis (chromomycosis), or paracoccidioidomycosis (South American blastomycosis, Lutz-Splendore-Almeida disease). (mayoclinic.org)
  • In 2013 the European Medicines Agency's Committee on Medicinal Products for Human Use (CHMP) recommended that a ban be imposed on the use of oral ketoconazole for systemic use in humans throughout the European Union, after concluding that the risk of serious liver injury from systemic ketoconazole outweighs its benefits. (wikipedia.org)
  • The oral formulation of ketoconazole was discontinued in Australia in 2013 and in China in 2015. (wikipedia.org)
  • synthesis
  • Ketoconazole inhibits the hormone synthesis in animals and treated animals have decreased levels of cortisol (cortisone), testosterone and other sex hormones. (petplace.com)
  • Interpretations of in vivo studies suggest that ketoconazole impairs the synthesis of ergosterol, which is a vital component of fungal cell membranes. (drugs.com)
  • While ketoconazole blocks the synthesis of the sterol ergosterol in fungi, in humans, at high dosages (>800 mg/day), it potently inhibits the activity of several enzymes necessary for the conversion of cholesterol to steroid hormones suchas testosterone and cortisol. (wikipedia.org)
  • Based on these antiandrogen and antiglucocorticoid effects, ketoconazole has been used with some success as a second-line treatment for certain forms of advanced prostate cancer and for the suppression of glucocorticoid synthesis in the treatment of Cushing's syndrome. (wikipedia.org)
  • Dosage
  • Ketoconazole is also sometimes prescribed by veterinarians for use on pets, often as unflavored tablets that may need to be cut to smaller size for correct dosage. (wikipedia.org)
  • patients
  • Ketoconazole 2% was not detected in plasma in 39 patients who shampooed 4-10 times per week for 6 months, or in 33 patients who shampooed 2-3 times per week for 3-26 months (mean: 16 months). (drugs.com)
  • No information is available on the relationship of age to the effects of ketoconazole in geriatric patients. (mayoclinic.org)
  • further, patients may initiate bisphosphonate therapy at the time of ketoconazole initiation. (knowcancer.com)
  • To evaluate the proportion of patients who have achieved a response to ketoconazole with hydrocortisone and then, following progression achieved a second >30% decline in PSA upon receiving dexamethasone along with ketoconazole. (knowcancer.com)
  • At least one study has been performed showing that ketoconazole may be useful in temporarily reducing erectile function in postoperative penile surgery patients. (wikipedia.org)
  • fungi
  • Ketoconazole has activity against many kinds of fungi that may cause human disease, such as Candida, Histoplasma, Coccidioides, and Blastomyces (although it is not active against Aspergillus). (wikipedia.org)
  • Cats
  • Ketoconazole has caused changes in the hair coat of animals, causing a lightening of the hair color in dogs and a drying of the hair coat in cats. (petplace.com)
  • drug
  • Cyclosporine is an expensive drug and Ketoconazole is sometimes used to allow for a reduction in dose of the drug cyclosporine. (petplace.com)