Centrifugum marginatumSubungualLesionGrzybowskiEruptive keratoacanthomasCarcinomasCutaneousWitten and ZakSolitaryLesionsTumorExcisionVemurafenibSpontaneouslyRegressGiantInhibitorHistologicalCarcinomaVariantBenignInvasiveEpidermalActinicEtiologyVariantsSpontaneous regressionRapidlyScarSyndromesUnclearScalyCancersAcitretinVismodegibCommonlyNoduleUsually occursInherited diseaseSharplyTypicallyClinical featuresTraumaSkin
Centrifugum marginatum5
- 763 Keratoacanthoma centrifugum marginatum is a cutaneous condition, a variant of keratoacanthomas, which is characterized by multiple tumors growing in a localized area. (wikipedia.org)
- While solitary typical keratoacanthomas are the most common presentation, there are also giant (2-15 cm in diameter), subungual, mucosal, and keratoacanthoma centrifugum marginatum (prominent horizontal growth pattern) variants. (logicalimages.com)
- According to the histological picture and the clinical course we diagnosed a keratoacanthoma centrifugum marginatum. (cdlib.org)
- Clinically, three types of the persisting, destructive variant of keratoacanthoma can be distinguished: mutilating keratoacanthoma, aggregated keratoacanthoma, the keratoacanthoma centrifugum marginatum (KCM). (cdlib.org)
- Keratoacanthoma centrifugum marginatum: an unusual clinical and histopathological diagnostic pitfall. (eyewiki.org)
Subungual1
- 763 : 644 A solitary keratoacanthoma (also known as "Subungual keratoacanthoma") is a benign, but rapidly growing, locally aggressive tumor which sometimes occur in the nail apparatus. (wikipedia.org)
Lesion6
- Keratoacanthomas presents as a fleshy, elevated and nodular lesion with an irregular crater shape and a characteristic central hyperkeratotic core. (wikipedia.org)
- If the entire lesion is removed, the pathologist will probably be able to differentiate between keratoacanthoma and squamous cell carcinoma. (wikipedia.org)
- Each lesion clinically resembles a solitary keratoacanthoma, and lesions scar with resolution. (logicalimages.com)
- Keratoacanthomas are usually excised through formal excision, which ensures the lesion is removed completely. (southeastskinclinic.com.au)
- Aknemycin treatment did not improve the situation, the lesion continued growing, no pus was formed and the lesion measured around 4mm in diameter by day 7 ( fig.2 top left ), suggesting a second keratoacanthoma. (classimed.de)
- Keratoacanthoma SYMPTOMS Usually asymptomatic, possible irritation SIGNS Dome-shaped lesion, rolled edges, central plug WORK-UP Thorough history. (odclinicals.com)
Grzybowski8
- 667, 764 : 644 Generalized eruptive keratoacanthoma (also known as "Generalized eruptive keratoacanthoma of Grzybowski") is a cutaneous condition, a variant of keratoacanthomas, characterized by hundreds to thousands of tiny follicular keratotic papules over the entire body. (wikipedia.org)
- There is a rare generalized eruptive keratoacanthoma of Grzybowski. (medscape.com)
- In eruptive keratoacanthomas of Grzybowski, hundreds of lesions occur in a generalized distribution and may involve mucous membranes. (logicalimages.com)
- Occasionally, multiple keratoacanthomas develop sporadically, such as the eruptive keratoacanthomas of the Grzybowski type or in the context of familial syndromes like the Ferguson-Smith syndrome or the Muir-Torre syndrome. (cdlib.org)
- however, we report a case of multiple eruptive keratoacanthomas in the form of Grzybowski syndrome after initiation of sorafenib. (biomedcentral.com)
- Histopathology showed eruptive invasive keratoacanthomas (Grzybowski syndrome). (biomedcentral.com)
- however, generalized eruptive keratoacanthomas (Grzybowski syndrome) related to sorafenib has not been previously identified. (biomedcentral.com)
- We report a patient who developed multiple keratoacanthomas consistent with Grzybowski syndrome after initiation of sorafenib therapy. (biomedcentral.com)
Eruptive keratoacanthomas4
- Keratoacanthomas, including multiple eruptive keratoacanthomas, have been described in patients taking BRAF inhibitors such as vemurafenib and dabrafenib. (logicalimages.com)
- We report a 63-year-old Caucasian male who developed multiple cutaneous eruptive keratoacanthomas after starting sorafenib 400 mg twice daily. (biomedcentral.com)
- A 63-year-old Caucasian male with known hepatocellular carcinoma presented with multiple cutaneous eruptive keratoacanthomas approximately three and half months after starting sorafenib 400 mg twice daily. (biomedcentral.com)
- Eruptive keratoacanthomas in tattoos. (nih.gov)
Carcinomas5
- In contrast to squamous cell carcinomas, keratoacanthomas appear and grow rapidly over the course of a few weeks to a month. (logicalimages.com)
- Squamous cell carcinomas develop rather slowly without pain, while Keratoacanthomas grow fast and show pressure pain. (classimed.de)
- Whole genome amplified DNA (not amplified by any specific PCR primers) from 91 skin lesions [41 squamous cell skin carcinomas (SCCs), 8 keratoacanthomas, 22 actinic keratoses, 3 basal cell carcinomas and 17 SCCs in situ] were sequenced. (nih.gov)
- Immunohistochemical evaluation of serial stored paraffin sections from 42 keratoacanthomas and 11 squamous cell carcinomas demonstrated that skin tumors from UVB-exposed mice showed an inverse relationship (>95%) between p53 protein expression and phospho-Chk1 (Ser317) however not phospho-Chk1 (Ser345) protein expression. (technologybooksindustrialprojectreports.com)
- Inhalation of 1-BP produced alveolar/bronchiolar adenomas and carcinomas in female mice, adenomas of the large intestine in female rats, and keratoacanthoma/squamous cell carcinoma of the skin in male rats. (cdc.gov)
Cutaneous1
- 763 : 645 Multiple keratoacanthomas (also known as "Ferguson-Smith syndrome," "Ferguson-Smith type of multiple self-healing keratoacanthomas,") is a cutaneous condition, a variant of keratoacanthomas, which is characterized by the appearance of multiple, sometimes hundreds of keratoacanthomas. (wikipedia.org)
Witten and Zak2
- In familial keratoacanthomas of Witten and Zak, multiple larger and smaller keratoacanthomas are found. (logicalimages.com)
- Multiple familial keratoacanthoma of Witten and Zak. (dermnetnz.org)
Solitary2
- Keratoacanthomas typically present as a solitary, rapidly growing nodule on sun- exposed skin of the face and upper limbs. (dermnetnz.org)
- Approximately 98 percent of keratoacanthomas fall into the classic, solitary type that mainly occurs in elderly persons on exposed areas. (cdlib.org)
Lesions1
- Epidemiologic data of keratoacanthoma is notably similar to SCC and Bowen disease (SCC in situ) concerning age, sex, and the anatomic site of lesions. (medscape.com)
Tumor4
- Keratoacanthoma (KA) is a relatively common low-grade tumor that originates in the pilosebaceous glands and closely resembles squamous cell carcinoma (SCC). (medscape.com)
- Keratoacanthoma is a rapidly-growing tumor, which histologically resembles squamous cell carcinoma. (korea.ac.kr)
- The tumor was successfully removed without relapse and identified again as squamous cell carcinoma with differential diagnosis keratoacanthoma although its clinical development ressembled more to a keratoacanthoma. (classimed.de)
- I am also interested in mechanisms of carcinogenesis, particularly as they relate to squamous cell carcinoma of the skin and a spontaneously regressing tumor called keratoacanthoma. (yale.edu)
Excision2
- Although it may regress spontaneously, keratoacanthoma is routinely treated by excision. (korea.ac.kr)
- The tissue was identified as squamous cell carcinoma with Keratoacanthoma as differential diagnosis and surgical excision was recommended. (classimed.de)
Vemurafenib2
- Many new treatments for melanoma are also known to increase the rate of keratoacanthoma, such as the BRAF inhibitor medications vemurafenib and dabrafenib. (wikipedia.org)
- Twenty percent of patients who had metastatic melanoma and were treated with vemurafenib, a novel BRAF V600E inhibitor, may develop eruptive keratoacanthoma or squamous cell carcinoma. (medscape.com)
Spontaneously1
- If left untreated, most keratoacanthomas spontaneously involute and resolve within 6 months, leaving an atrophic scar. (logicalimages.com)
Regress1
- On the trunk, arms, and legs, electrodesiccation and curettage often suffice to control keratoacanthomas until they regress. (wikipedia.org)
Giant2
- 763-764 : 643-646 Giant keratoacanthomas are a variant of keratoacanthoma, which may reach dimensions of several centimeters. (wikipedia.org)
- We suggest that intralesional injection of methotrexate is an effective and non-operative modality for the treatment of giant keratoacanthoma. (korea.ac.kr)
Inhibitor1
- The introduction of BRAF inhibitor therapy for melanoma and hedgehog pathway inhibitor therapy for advanced basal cell carcinoma have elicited a surge in keratoacanthoma (KA) incidence. (medscape.com)
Histological1
- There is no single histological finding that can characterize keratoacanthoma. (eyewiki.org)
Carcinoma12
- Keratoacanthoma (KA) is a common low-grade (unlikely to metastasize or invade) rapidly-growing skin tumour that is believed to originate from the hair follicle (pilosebaceous unit) and can resemble squamous cell carcinoma. (wikipedia.org)
- Under the microscope, keratoacanthoma very closely resembles squamous cell carcinoma. (wikipedia.org)
- some pathologists may label KA as "well-differentiated squamous cell carcinoma, keratoacanthoma variant", and prompt definitive surgery may be recommended. (wikipedia.org)
- Frequently reported and reclassified over the last century, keratoacanthoma can be divided into various subtypes and despite being considered benign, their unpredictable behaviour has warranted the same attention as with squamous cell carcinoma. (wikipedia.org)
- Keratoacanthoma may progress rarely to invasive or metastatic carcinoma. (medscape.com)
- Keratoacanthomas may occur within Muir-Torre syndrome along with sebaceous neoplasms and adenomatous colon carcinoma or other low-grade internal malignancies. (logicalimages.com)
- Keratoacanthoma has many similarities with SCC (Squamous Cell Carcinoma) and is often very difficult to tell apart, both clinically and pathologically. (southeastskinclinic.com.au)
- A keratoacanthoma & Squamous Cell carcinoma may look similar - at first glance - to the pathologist. (southeastskinclinic.com.au)
- The distinction beteen squamous cell carcinoma and keratoacanthoma by morphological criteria is difficult ( 1 ) in contrast to the comparatively clear discrimination by molecular biological analysis ( 2 ). (classimed.de)
- I am studying skin cancer, particularly squamous cell carcinoma and keratoacanthoma. (yale.edu)
- Some keratoacanthomas may be a form of squamous cell carcinoma. (merckmanuals.com)
- and 3.73 (1.44) ppm for keratoacanthoma +squamous cell carcinoma of the skin. (cdc.gov)
Variant2
- In fact, strong arguments support classifying keratoacanthoma as a variant of invasive SCC. (medscape.com)
- We present this case because of the strong granulomatous foreign body reaction which might complicate the diagnosis and has not been described for this keratoacanthoma variant so far. (cdlib.org)
Benign2
- Keratoacanthomas are common benign epidermal tumors characterized by the rapid development of a firm, symmetrical dome-shaped nodule with a horn-filled crater in its center and a tendency for spontaneous regression. (cdlib.org)
- Keratoacanthoma (or simply 'KA') is a benign tumour of the sebaceous gland that develops as a red or skin-coloured spot and grows rapidly over a few weeks. (southeastskinclinic.com.au)
Invasive1
- Rarely, keratoacanthoma itself may develop into an invasive SCC. (southeastskinclinic.com.au)
Epidermal1
- Keratoacanthomas are squamous cell neoplasms known to be abundant in epidermal growth factor receptors (EGFRs). (uky.edu)
Actinic1
- Keratoacanthoma and conventional SCC share very similar epidemiological features, which suggests a possible common pathogenesis, such as actinic damage. (medscape.com)
Etiology2
- These data strongly support a common etiology among keratoacanthoma, SCC, and Bowen disease. (medscape.com)
- Etiology of keratoacanthoma is unknown. (msdmanuals.com)
Variants1
- In addition to the main type, several variants of keratoacanthoma exist and are characterized by lack of spontaneous regression and progressive destructive growth. (cdlib.org)
Spontaneous regression1
- It is thought that the immune system plays a role in spontaneous regression of keratoacanthomas. (logicalimages.com)
Rapidly1
- A keratoacanthoma is a rapidly growing, well-differentiated neoplasm of squamous epithelium. (logicalimages.com)
Scar2
- Keratoacanthomas typically turn into scar tissue over time. (southeastskinclinic.com.au)
- Fig.1 Keratoacanthoma of the right cheek on days 7 ( left ), 28 ( center left ), 62 ( center right ) as well as the several cm long scar 48months after surgical removal on 66.Tag ( right ) (click on images for enlargement). (classimed.de)
Syndromes1
- [ 10 ] Keratoacanthoma is commonly associated with syndromes such as Muir-Torre syndrome, Ferguson-Smith syndrome, xeroderma pigmentosum, and incontinentia pigmenti. (medscape.com)
Unclear1
- It is unclear whether keratoacanthoma risk increases with increasing ultraviolet (UV) exposure. (msdmanuals.com)
Scaly1
- Keratoacanthomas Keratoacanthomas are round, firm, usually pink or flesh-colored growths that have a central crater that is scaly or crusted. (merckmanuals.com)
Cancers1
- Additional skin cancers include sebaceous epitheliomas and keratoacanthomas. (ccalliance.org)
Acitretin2
- Acitretin 25 mg daily was commenced after few weeks, and no further keratoacanthomas developed during his treatment. (biomedcentral.com)
- Temporary interruption and dose reduction of sorafenib and use of acitretin appeared to prevent further development of keratoacanthomas. (biomedcentral.com)
Vismodegib1
- Keratoacanthomas have also been associated with vismodegib and sorafenib use. (logicalimages.com)
Commonly1
- Keratoacanthoma is commonly found on sun-exposed skin, often face, forearms and hands. (wikipedia.org)
Nodule1
- Keratoacanthoma (KA), also known as molluscum sebaceum [1] , is a hyperkeratotic dome-shaped nodule that can grow up to one to three centimeters within a few months. (eyewiki.org)
Usually occurs1
- Keratoacanthomas usually occurs in older individuals. (wikipedia.org)
Inherited disease1
- Ferguson-Smith syndrome is an autosomal dominant inherited disease characterized by multiple self-healing keratoacanthomas. (logicalimages.com)
Sharply1
- Keratoacanthomas are sharply demarcated , firm, erythematous or skin-coloured, with a classic central hyperkeratotic plug and an even shoulder. (dermnetnz.org)
Typically2
- Keratoacanthoma typically affects older people who have fair, sun-exposed skin. (southeastskinclinic.com.au)
- Keratoacanthoma typically has a central core like a Volcano. (southeastskinclinic.com.au)
Clinical features2
- What are the clinical features of a keratoacanthoma? (dermnetnz.org)
- Keratoacanthomas are much less common in patients with skin of colour, but the clinical features are the same. (dermnetnz.org)
Trauma1
- Skin injury may also be a predisposing factor, as there are many reports of keratoacanthomas developing in sites of previous trauma, in surgical scars, after laser resurfacing, and following radiation therapy. (logicalimages.com)
Skin2
- The defining characteristic of a keratoacanthoma is that it is dome-shaped, symmetrical, surrounded by a smooth wall of inflamed skin, and capped with keratin scales and debris. (wikipedia.org)
- Keratoacanthoma may be difficult to distinguish visually from a skin cancer. (wikipedia.org)