• ocular
  • In addition, administration of ophthalmic corticosteroids in severe ocular disease, especially acute herpes simplex keratitis, may lead to excessive corneal and scleral thinning, increasing the risk for perforation. (drugs.com)
  • He contributed to the discovery of HSV-1 entry receptors and establishing a link between the receptors and HSV-1 induced ocular diseases such as keratitis and retinitis. (wikipedia.org)
  • Clinical
  • A specific clinical diagnosis of HSV as the cause of dendritic keratitis can usually be made by ophthalmologists and optometrists based on the presence of characteristic clinical features. (wikipedia.org)
  • Diagnostic testing is seldom needed because of its classic clinical features and is not useful in stromal keratitis as there is usually no live virus. (wikipedia.org)
  • severe
  • The global incidence (rate of new disease) of herpes keratitis is roughly 1.5 million, including 40,000 new cases of severe monocular visual impairment or blindness each year. (wikipedia.org)
  • immune
  • Plasmacytoid dendritic cells (pDCs) represent a highly functional subset of bone marrow (BM)-derived cells and play a key role in linking the innate and adaptive immune responses. (arvojournals.org)
  • This is known as immune-mediated stromal keratitis. (wikipedia.org)
  • usually
  • Necrotizing keratitis Keratouveitis : is usually granulomatous uveitis with large keratic precipitates on the corneal endothelium. (wikipedia.org)
  • therapy
  • Infectious keratitis can progress rapidly, and generally requires urgent antibacterial, antifungal, or antiviral therapy to eliminate the pathogen. (wikipedia.org)