• Ligands
  • The L-selectin ligands on HEV are a set of mucin-like glycoproteins, for which glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1) is a candidate. (nih.gov)
  • Imparting these modifications to GlyCAM-1, together with appropriate fucosylation, yields enhanced rolling ligands for both peripheral blood lymphocytes and Jurkat cells in flow chamber assays as compared with those generated with exogenous fucosyltransferase. (nih.gov)
  • receptor
  • J.RT3-T3.5 cells have a mutation in the T cell receptor beta chain locus precluding expression of this chain. (wikipedia.org)
  • They do not express surface CD3 or produce the T cell receptor alpha/beta heterodimer. (wikipedia.org)
  • The D1.1 cell line does not express CD4 molecule, an important co-receptor in the activation pathway of helper T cells. (wikipedia.org)
  • The J.gamma1 subline contains no detectable phospholipase C-gamma1 (PLC-γ1) protein and therefore has profound defects in T cell receptor (TCR) calcium mobilization, and nuclear factor of activated T-cells (NFAT) activation (an important transcription factor in T cells). (wikipedia.org)
  • To investigate the requirement for CD2 expression in activation of T lymphocytes via the CD3-Ti antigen/MHC receptor complex, we produced and characterized a series of CD2- Jurkat variants. (rupress.org)
  • Assuming that the Jurkat cell line is representative of normal cycling human T lymphocytes, we conclude that the presence of the CD2 molecule on the plasma membrane is not in itself a requirement for an operational CD3-Ti-alpha/beta receptor. (rupress.org)
  • CD27 is a member of the tumor necrosis factor (TNF) receptor superfamily, which includes the T cell co-stimulatory receptors OX40, 4-1BB and herpesvirus entry mediator (HVEM). (bpsbioscience.com)
  • It has also been called T-cell surface antigen T11/Leu-5, LFA-2, LFA-3 receptor, erythrocyte receptor and rosette receptor. (wikipedia.org)
  • It associates with the cytoplasmic tails of the CD4 and CD8 co-receptors on T helper cells and cytotoxic T cells, respectively, to assist signaling from the T cell receptor (TCR) complex. (wikipedia.org)
  • human
  • Recently, three related sulfotransferases (keratan sulfate galactose-6-sulfotransferase [KSGal6ST], high endothelial cell N-acetylglucosamine-6-sulfotransferase [GlcNAc6ST], and human GlcNAc6ST) were cloned, which can generate Gal-6-sulfate and GlcNAc-6-sulfate in GlyCAM-1. (nih.gov)
  • In this study, using the human T-lymphoma cell line, Jurkat cells, we investigated the apoptotic signal transduction mediated by FTY720, in particular comparing its role on the cleavage of caspases, with that mediated by etoposide or anti-Fas antibody. (aspetjournals.org)
  • membrane
  • Though it has not been observed to localize to the cell membrane, it can be found in the outer cell surface. (wikipedia.org)
  • The N-terminal tail of Lck is myristoylated and palmitoylated, which tethers the protein to the plasma membrane of the cell. (wikipedia.org)
  • apoptotic cells
  • Pretreatment with a broad caspase inhibitor [benzyloxycarbonyl-Val-Ala-Asp-(Ome) fluoromethyl ketone] markedly decreased the incidence of apoptotic cells induced by FTY720, etoposide, and anti-Fas antibody, through the abrogation of cleavage of Bid, poly(ADP-ribose) polymerase, and caspases 3, 8, and 9. (aspetjournals.org)
  • Alternatively, apoptotic cells may secrete antigens, including eEF1A and other elongation factors, to induce an autoimmune response during cancer. (wikipedia.org)
  • induces
  • 2-Amino-2-[2-(4-octylphenyl)ethyl] propane-1,3-diol hydrochloride (FTY720), a synthetic product derived from a metabolite of Isaria sinclairii , has been demonstrated to have a potent immunosuppressive activity that induces apoptotic cell death in T cells and several other cell lines. (aspetjournals.org)
  • Thus, these two isoforms demonstrate differences in expression and function: eEF1A1 is expressed in most cells while eEF1A2 is only expressed in adult neuronal and muscle cells, and only eEF1A1 induces HSP70 during heat shock. (wikipedia.org)
  • tumor cells
  • It activates NF-κB and MAPK/JNK signaling upon interaction with its TNF-like ligand, CD70, which is expressed by numerous tumor cells. (bpsbioscience.com)
  • As eEF1A1 is over-expressed in osteoblasts, which proliferate and differentiate in the presence of tumor cells, it may serve as a serum biomarker to track the metastatic progression of prostate cancer. (wikipedia.org)
  • pathways
  • PTPN122 then acts as a switch to convert SHC1 to SgK269-mediated pathways that regulate cell invasion and morphogenesis. (wikipedia.org)
  • fraction
  • Additionally, upon T cell activation, a fraction of kinase active Lck, translocates from outside of lipid rafts (LR) to inside lipid rafts where it interacts with and activates LR-resident Fyn, which is involved in further downstream signaling activation. (wikipedia.org)
  • Adaptor
  • The SHC and its adaptor proteins transmit signaling of the cell surface receptors such as EGFR, erbV-2 and insulin receptors. (wikipedia.org)
  • proteins
  • Lck then phosphorylates and activates ZAP-70, which in turn phosphorylates another molecule in the signaling cascade called LAT (short for Linker of Activated T cells), a transmembrane protein that serves as a docking site for a number of other proteins, the most important of which are Shc-Grb2-SOS, PI3K, and phospholipase C (PLC). (wikipedia.org)
  • SHC proteins are differentially regulated by the Multiple Copies in T-cell malignancy(MCT-1). (wikipedia.org)
  • molecule
  • The T cell surface molecule CD28 can provide costimulatory signals that permit the full activation of T cells. (rupress.org)
  • In addition to its adhesive properties, CD2 also acts as a co-stimulatory molecule on T and NK cells. (wikipedia.org)
  • leukemia
  • Jurkat J6 cells have been found to produce a xenotropic murine leukemia virus (X-MLV) (referred to as XMRV) that could potentially affect experimental outcomes. (wikipedia.org)
  • oxidative
  • When a mutations such as a p66SHC deletion occurs the cardiomyocyte death is reduced and a pool of cardiac stem cells are preserved from oxidative damage - preventing diabetic cardiomyopathy. (wikipedia.org)
  • cardiac
  • mir-143 was found to be the most enriched miRNA in mouse embryonic stem cells that were differentiating into cardiac progenitor cells. (wikipedia.org)
  • It is co-transcribed with miR-145 in cardiac progenitors before becoming vascular smooth muscle cells (VSMCs). (wikipedia.org)
  • line
  • I recently thawed this cell line. (protocol-online.org)
  • This cell line has been screened using the MycoAlert™ Mycoplasma Detection Kit (Lonza, #LT07-118) to confirm the absence of Mycoplasma contamination. (bpsbioscience.com)
  • Purchase of this cell line grants you with a 10-year license to use this cell line in your immediate laboratory, for research use only. (bpsbioscience.com)
  • The license does not permit modification of the cell line in any way. (bpsbioscience.com)
  • Inappropriate use or distribution of this cell line will result in revocation of the license and result in an immediate cease of sales and distribution of BPS products to your laboratory. (bpsbioscience.com)
  • BPS does not warrant the suitability of the cell line for any particular use, and does not accept any liability in connection with the handling or use of the cell line. (bpsbioscience.com)
  • Publications using this cell line should reference BPS Bioscience, Inc., San Diego. (bpsbioscience.com)
  • Abstract
  • http://www.cell.com/cancer-cell/abstract/S1535-6108%2814%2900031-2 Ku DH, Chang CD, Koniecki J, Cannizzaro LA, Boghosian-Sell L, Alder H, Baserga R (Apr 1991). (wikipedia.org)