• Alkaloid Isolated
  • Zhang, Wei-Dong 2018-07-12 00:00:00 Delavatine A, an unusual isoquinoline alkaloid isolated from I. delavayi, was first studied for anti-inflammatory effect using lipopolysaccharide (LPS)-induced BV-2 microglia. (deepdyve.com)
  • Delavatine A, an unusual isoquinoline alkaloid isolated from I. delavayi, was first studied for anti-inflammatory effect using lipopolysaccharide (LPS)-induced BV-2 microglia. (deepdyve.com)
  • Inhibition
  • Table 2 CYP inhibition screening results organized according to the isoquinoline alkaloid subgroups. (thefreedictionary.com)
  • At 10 mM, isoquinoline and isoquinolinium ion were associated with complete inhibition of complex I, whereas the effects of TIQ (20%), N-methyl-TIQ (65%), (R/S) salsolinol (55%), and N-methyl-(R/S) salsolinol (60%) were less dramatic. (alpfmedical.info)
  • The IC50 values for N-methyl-TIQ (4.3 mM) and N-methyl-isoquinolinium ion (1.3 mM) reported by McNaught et al.6 were similar to those provided earlier by Suzuki and co-workers.52 For comparison, the complex I IC50 for MPP+ is about 4.1 mM.6 Only isoquinoline, 6,7-dimethox-yisoquinoline and N-methyl-(R/S)salsolinol produced notable inhibition of complex II-III. (alpfmedical.info)
  • reaction
  • In enzymology, an isoquinoline 1-oxidoreductase (EC 1.3.99.16) is an enzyme that catalyzes the chemical reaction isoquinoline + acceptor + H2O ⇌ {\displaystyle \rightleftharpoons } isoquinolin-1(2H)-one + reduced acceptor The 3 substrates of this enzyme are isoquinoline, acceptor, and H2O, whereas its two products are isoquinolin-1(2H)-one and reduced acceptor. (wikipedia.org)
  • Isoquinoline itself is efficiently prepared using the Pomeranz-Fritsch reaction, but can also be prepared from benzylamine and glyoxal acetal by an analogous approach known as the Schlittler-Müller modification to the Pomeranz-Fritsch reaction. (wikipedia.org)
  • Novel
  • Their topics include genetic and cellular multiple drug resistance in a diagnostic and therapeutic strategy in acute leukemia in children and adults, herb-drug interactions and implication in drug monitoring, bacteriophage therapies and enzybiotics as novel solutions to antibiotic resistance, nutrition and tuberculosis, reversing multidrug resistance by the isoquinoline alkaloid glaucine, and finding the genetic solution for cancer in the mechanism of taxol cytotoxicity. (thefreedictionary.com)
  • potential
  • 2-(1,1'-Biphenyl-4-yl)- 1,2,4-triazole[5,1-a] isoquinoline (L 14105), a potential orally active contragestational agent for the bitch: studies in the rat, hamster and dog. (biomedsearch.com)
  • shown
  • It exists in its keto form [C2-C3-C8 = 117.6 (5)°], as shown in Fig. 1, and the isoquinoline moiety is essentially planar (r.m.s. deviation = 0.0424 Å). (iucr.org)
  • This derivative, shown below, is prepared by N-alkylation of isoquinoline with the appropriate dihalide. (wikipedia.org)