• Quinolizidine and isoquinoline are a widely distributed, heterogeneous group of alkaloids with members of each group having known toxicity to humans and domestic animals. (medscape.com)
  • Assays for isoquinoline or quinolizidine alkaloids are not routinely available. (medscape.com)
  • β-Phenylethylamines and the isoquinoline alkaloids. (novapublishers.com)
  • These effects of Rhizoma coptidis are attributed to its alkaloid components, especially isoquinoline alkaloids [ 10 ]. (springer.com)
  • We chose five isoquinoline alkaloids (berberine, coptisine, palmatine, jateorrhizine, epiberberine) and one aporphine alkaloid (magnoflorine) of Rhizoma coptidis as research goals (Fig. 1 ). (springer.com)
  • b Substituents of the five isoquinoline alkaloids. (springer.com)
  • Eletefine (1998), an isoquinoline alkaloid Naphthalene, an analog without the nitrogen atom Nomenclature of Organic Chemistry : IUPAC Recommendations and Preferred Names 2013 (Blue Book). (wikipedia.org)
  • A practical method for the synthesis of an isoquinoline alkaloid 6,7-dimethoxy-2-methylisoquinoline-1,3,4(2H)-trione and its analogues has been demonstrated. (tcu.edu)
  • In enzymology, the (S)-norcoclaurine synthase (EC 4.2.1.78) is an enzyme that catalyzes a biological Pictect-Spengler synthesis: Intramolecular aza Wittig reactions also afford isoquinolines. (wikipedia.org)
  • Synthesis and reactivity of naphthalene, quinolines and isoquinolines. (bath.ac.uk)
  • Isoquinoline and quinoline are benzopyridines, which are composed of a benzene ring fused to a pyridine ring. (wikipedia.org)
  • Weissgerber developed a more rapid route in 1914 by selective extraction of coal tar, exploiting the fact that isoquinoline is more basic than quinoline. (wikipedia.org)
  • These precursors and dienophiles are based on and drived from isoquinolines and isocarbostyrils. (tcu.edu)
  • the only difference being that an additional hydroxy group in the reactant provides a site for dehydration under the same reaction conditions as the cyclization to give the isoquinoline rather than requiring a separate reaction to convert a dihydroisoquinoline intermediate. (wikipedia.org)
  • 1H-Benz[de]isoquinoline-1,3(2H)-dione, 6-bromo-2-methyl- can be analyzed by this reverse phase (RP) HPLC method with simple conditions. (sielc.com)
  • abstract = "In 4-fluoro-isoquinoline-5-sulfonyl chloride, C9H 5ClFNO2S, (I), one of the two sulfonyl O atoms lies approximately on the isoquinoline plane as a result of minimizing the steric repulsion between the chloro-sulfonyl group and the neighbouring F atom. (elsevierpure.com)
  • Two kinds of [3 + 2] cycloaddition intermediates generated from the three-component reactions of 2-bromobenzaldehydes and maleimides with amino esters or amino acids were used for a one-pot N -allylation and intramolecular Heck reactions to form pyrrolidinedione-fused hexahydropyrrolo[2,1- a ]isoquinolines. (beilstein-journals.org)
  • In a broader sense, the term isoquinoline is used to make reference to isoquinoline derivatives. (wikipedia.org)
  • Although isoquinoline derivatives can be synthesized by several methods, relatively few direct methods deliver the unsubstituted isoquinoline. (wikipedia.org)
  • Several other methods are useful for the preparation of various isoquinoline derivatives. (wikipedia.org)
  • The Pomeranz-Fritsch reaction provides an efficient method for the preparation of isoquinoline. (wikipedia.org)
  • The melting point determination of 2-octadecyl-1H-thioxantheno[2,1,9-def]isoquinoline- 1,3(2H)-dione (CAS No. 27870-92-4) was done following OECD Guideline 102 and according to the metal block capillary method. (europa.eu)
  • The isoquinoline ring in these natural compound derives from the aromatic amino acid tyrosine. (wikipedia.org)
  • The isoquinoline ring in these natural compound derives from the aromatic amino acid tyrosine. (wikipedia.org)
  • Amino group-substituted compounds, especially 5-piperazinyl indeno[1,2-c]isoquinoline 7f, displayed potent topoisomerase I inhibitory activity as well as cytotoxicities against five different tumor cell lines. (ewha.ac.kr)
  • Wego Chemical Group is a long-experienced distributor of Isoquinoline. (wegochem.com)
  • Isoquinoline is a heterocyclic aromatic organic compound. (wikipedia.org)
  • Eletefine (1998), an isoquinoline alkaloid Naphthalene, an analog without the nitrogen atom Nomenclature of Organic Chemistry : IUPAC Recommendations and Preferred Names 2013 (Blue Book). (wikipedia.org)
  • To evaluate these interactions during chronic administration, we treated mice with lorazepam for 1 to 14 days alone or in combination with the peripheral-type site ligand PK11195 [N-methyl-N-(methyl-1-propyl)chloro-2-phenyl-1-isoquinoline-3-carboxamid e]. (nih.gov)
  • The structure-aided and cell-based structure-activity relationship studies on a series of tetrahydro-isoquinolines lead to efficient discovery of a qualified lead compound (16) with the high potency and selectivity, well-characterized binding mechanism, high cell permeability, good safety and pharmacokinetic profile, and impressive in vivo efficacy on antipsoriasis, in particular with a topical application. (rcsb.org)
  • The Pomeranz-Fritsch reaction provides an efficient method for the preparation of isoquinoline. (wikipedia.org)