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  • Novel
  • Their topics include genetic and cellular multiple drug resistance in a diagnostic and therapeutic strategy in acute leukemia in children and adults, herb-drug interactions and implication in drug monitoring, bacteriophage therapies and enzybiotics as novel solutions to antibiotic resistance, nutrition and tuberculosis, reversing multidrug resistance by the isoquinoline alkaloid glaucine, and finding the genetic solution for cancer in the mechanism of taxol cytotoxicity. (thefreedictionary.com)
  • Structure-based drug design of novel isoquinoline-5-sulfonamide inhibitors of PKB as potential antitumour agents was investigated. (rcsb.org)
  • reaction
  • In enzymology, an isoquinoline 1-oxidoreductase (EC 1.3.99.16) is an enzyme that catalyzes the chemical reaction isoquinoline + acceptor + H2O ⇌ {\displaystyle \rightleftharpoons } isoquinolin-1(2H)-one + reduced acceptor The 3 substrates of this enzyme are isoquinoline, acceptor, and H2O, whereas its two products are isoquinolin-1(2H)-one and reduced acceptor. (wikipedia.org)
  • The reaction is most notably used in the synthesis of dihydroisoquinolines, which can be subsequently oxidized to isoquinolines. (wikipedia.org)
  • Isoquinoline itself is efficiently prepared using the Pomeranz-Fritsch reaction, but can also be prepared from benzylamine and glyoxal acetal by an analogous approach known as the Schlittler-Müller modification to the Pomeranz-Fritsch reaction. (wikipedia.org)
  • shown
  • It exists in its keto form [C2-C3-C8 = 117.6 (5)°], as shown in Fig. 1, and the isoquinoline moiety is essentially planar (r.m.s. deviation = 0.0424 Å). (iucr.org)
  • This derivative, shown below, is prepared by N-alkylation of isoquinoline with the appropriate dihalide. (wikipedia.org)
  • present
  • Herein, we present our preliminary results on the asymmetric hydrogenation of quinolines and isoquinolines by this strategy (Scheme 1). (docme.ru)