• In addition, the ability of the cerebellum to respond to trophic stimulation by a beta-adrenergic agonist, isoproterenol, was attenuated markedly. (duke.edu)
  • In the current study, the β-adrenergic receptor agonist isoproterenol, alone or in combination with the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (IBMX), was used to increase cAMP in neutrophils. (arizona.edu)
  • In human mononuclear leukocytes, beta-AR agonist isoproterenol and platelet-activating factor were able to induce translocation of beta ARK from cytosol to membrane. (unich.it)
  • Participants rated their affective and sensory experiences following bolus infusions of either isoproterenol, a rapidly acting peripheral β-adrenergic agonist akin to adrenaline, or saline. (jneurosci.org)
  • SIGNIFICANCE STATEMENT We found that monozygotic twins with focal bilateral amygdala lesions report panic anxiety in response to intravenous infusions of isoproterenol, a β-adrenergic agonist similar to adrenaline. (jneurosci.org)
  • Myocardial injury was induced in tamoxifen-treated Cre-positive p38α KO mice or control littermates via chronic infusion of the β-adrenergic receptor agonist isoproterenol. (whiterose.ac.uk)
  • These junctional tachycardias are most often observed in the setting of digitalis toxicity, recent cardiac surgery, acute myocardial infarction, or isoproterenol infusion. (medscape.com)
  • This occasionally is observed in digitalis toxicity, following cardiac surgery (typically valve replacement), during acute myocardial infarction, or during isoproterenol infusion. (medscape.com)
  • In vivo magnetic resonance imaging (MRI) showed that left ventricular mass increased by 37% and end-diastolic and systolic volumes increased by 33% and 73%, respectively, following isoproterenol infusion. (ox.ac.uk)
  • Myocardial palmitate oxidation rates were 25% lower, and citrate synthase and medium chain acyl-coenzyme A dehydrogenase activities were reduced by 25% and 29%, respectively, following isoproterenol infusion. (ox.ac.uk)
  • Basal glycolysis and glycogen concentration were not changed, yet insulin stimulated glycolysis was decreased by 32%, accompanied by 33% lower insulin stimulated glucose transporter, GLUT4, protein levels in rat hearts following isoproterenol infusion, compared with controls. (ox.ac.uk)
  • In conclusion, isoproterenol infusion impaired in vivo cardiac function, induced hypertrophy, and decreased both fatty acid and glucose metabolism, changes similar in direction and magnitude to those found in the rat heart following moderate severity myocardial infarction. (ox.ac.uk)
  • Isoproterenol infusion in control mice promoted overt cardiac hypertrophy and dysfunction (reduced ejection fraction, increased end systolic volume, increased cardiac weight index, increased cardiomyocyte area, increased fibrosis, and up-regulation of myocyte fetal genes and hypertrophy-associated microRNAs). (whiterose.ac.uk)
  • Isoproterenol infusion can be used to shorten AV conduction time. (medscape.com)
  • Study of the therapeutic and cardioprotective effects of herbal extracts on isoproterenol-induced myocardial necrosis in rats. (fapesp.br)
  • We will study the myocardium of rats,using a classical model of catecholamine induced-injury, isoproterenol (a synthetic catecholamine). (fapesp.br)
  • Isoproterenol (5 mg.kg(-1).day(-1)) was infused for 7 days in male Wistar rats (n = 22). (ox.ac.uk)
  • This study was designed to evaluate the cardio protective effect of the semi-purified flavonoids from banana blossoms on the basis of histopathological parameters and biochemical analysis in isoproterenol induced myocardial infarction in rats. (ajphs.com)
  • After pretreatment, two doses of isoproterenol (85mg/kg body weight per dose, subcutaneously) were injected to rats at an interval of 24 hr for two days (20th and 21st day) to induce myocardial infarction. (ajphs.com)
  • Twenty-four hours after the last dose of isoproterenol, all rats were sacrificed via cervical dislocation. (ajphs.com)
  • At 50mg/kg, the semi-purified flavonoids extract exhibited cardio protection comparable to that of Aspirin hence indicating that the semi-purified flavonoids from banana blossom has a cardioprotectiveeffect against isoproterenol-induced myocardial infarction in rats. (ajphs.com)
  • A cardiac fibrosis model was established in Sprague-Dawley rats through a subcutaneous injection of isoproterenol (ISO, 5 mg/kg/d). (dovepress.com)
  • Study protocol for the data shown in the table: overnight fasted ob/ob mice, Sprague Dawley rats, high fat fed hamsters, and isoproterenol stimulated hamsters were treated orally with either vehicle or NNC0076-0079. (novonordisk.com)
  • The effects of prenatal exposure to ethylene - glycol -monomethyl-ether (109864) (EGME) on heart function in neonatal rats were examined by measuring basal heart ornithine-decarboxylase (ODC) activity and ODC activity after isoproterenol challenge. (cdc.gov)
  • Chronic isoproterenol administration produces a rapid, highly reproducible rodent model of cardiac hypertrophy. (ox.ac.uk)
  • Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A. (ox.ac.uk)
  • The high levels of beta ARK expression in human peripheral blood leukocytes together with the ability of isoproterenol and platelet-activating factor to induce beta ARK translocation, suggest a role for beta ARK in modulating some receptor-mediated immune functions. (unich.it)
  • Scholars@Duke publication: Effects of neonatal treatment with 6-aminonicotinamide on basal and isoproterenol-stimulated ornithine decarboxylase activity in cerebellum of the development rat. (duke.edu)
  • Exposure on days 7-13 of gestation caused significant decreases in ODC activity for both the basal and the isoproterenol challenged groups. (cdc.gov)
  • Isoproterenol induces in vivo functional and metabolic abnormalities: similar to those found in the infarcted rat heart. (ox.ac.uk)
  • Based upon previous mechanistic interpretations of force transients, and on an analysis developed here to relate crossbridge events to the frequency-dependence of stiffness, we argue that our observations provide evidence that isoproterenol induces an acceleration of crossbridge cycling rate. (njit.edu)
  • Aumento del efecto arritmogénico de isoproterenol. (prvademecum.com)
  • Efecto del isoproterenol sobre la liberación de histamina en mastocitos de pulmón de rata. (bvsalud.org)
  • Age-dependence of isoproterenol-induced dna synthesis in submandibular glands of balb/c mice. (jax.org)
  • Isoproterenol (ISO) (150 mg/kg/day, i.p for 2 consecutive days) was administered to mice to cause myocardial necrosis. (biomedcentral.com)
  • Phlorizin (400 mg/kg/day i.p twice daily for 2 days) and Ritonavir (10 mg/kg/day i.p twice daily for 2 days) were administered in two different groups of mice before isoproterenol administration. (biomedcentral.com)
  • Fibroblast-specific p38α KO mice exhibited marked protection against myocardial injury, with isoproterenol-induced alterations in cardiac function, histology, and molecular markers all being attenuated. (whiterose.ac.uk)
  • We determined the effects of ablation of the Pak-1 gene on the response of the myocardium to chronic stress of isoproterenol (ISO) administration. (ox.ac.uk)
  • Cardiovascular effects such as arrhythmias, angina pectoris, or increased BP occur more commonly with isoproterenol compared to other bronchodilators because isoproterenol stimulates beta-1 receptors of the heart as well as beta-2 receptors on the lungs. (mhmedical.com)
  • Yet, despite widespread use of this model, the effects of isoproterenol on in vivo cardiac function and substrate metabolism are unknown. (ox.ac.uk)
  • In these hearts, we will evaluate two different mechanisms of action of isoproterenol: action on beta1 and beta2 adrenergic receptors and receptor kinase GRK-2 and oxidative stress production. (fapesp.br)
  • In the present study, we evaluated the role of Ritonavir in isoproterenol-induced myocardial necrosis in vivo and compared the effect with Phlorizin, a nonslective SGLTs inhibitor. (biomedcentral.com)
  • The incorporation of [ 3 H]acetate into PAF and the synthesis of leukotrienes in response to ionophore A23187 were significantly inhibited by 10 μM isoproterenol. (arizona.edu)
  • Treatment of neutrophils with isoproterenol and IBMX significantly reduced the production of lyso PAF and PAF from 1-alkyl- 2-arachidonoyl sn-glycero-3-phosphocholine. (arizona.edu)
  • The response to isoproterenol was not significantly altered by exposure to EGME. (cdc.gov)
  • The present study aimed to investigate the biomolecular mechanisms underlying cardioprotective effects of diallyl trisulfide (DATS) as well as captopril (CAP) in isoproterenol (ISO) induced AMI focusing on autophagy & PI3K/Akt signaling. (springeropen.com)
  • If symptoms do not occur, a drug (eg, isoproterenol ) may be given to induce them. (msdmanuals.com)
  • Isoproterenol has been reported to cause insulin resistance leading to diabetic ketoacidosis. (wikipedia.org)
  • Fatty acid transporter protein levels were 11-52% lower and triglyceride concentrations were 55% lower in isoproterenol-infused rat hearts. (ox.ac.uk)
  • In standard animal or human pharmacological tests, beta-adrenoreceptor blocking activity of atenolol tablets have been demonstrated by: (1) reduction in resting and exercise heart rate and cardiac output, (2) reduction of systolic and diastolic blood pressure at rest and on exercise, (3) inhibition of isoproterenol induced tachycardia, and (4) reduction in reflex orthostatic tachycardia. (nih.gov)
  • To better understand the mechanism involved in the inhibition of PAF formation, the major biosynthetic steps were examined in the presence and absence of a maximally effective concentration of isoproterenol and IBMX. (arizona.edu)
  • Isoproterenol alone or in the presence of IBMX had no measurable effect on the ionomycin-induced increase in cytosolic calcium concentration, as assessed by fura-2 fluorescence. (arizona.edu)
  • To determine whether catecholamines produce alterations in myocardialmyosin-actin cycling kinetics, we investigated the effects of isoproterenol upon mechanical characteristics of constantly activated heart muscle thought to reflect crossbridge behavior. (njit.edu)
  • Isoproterenol has chronotropic as well as inotropic effects, which result in an increase in cardiac output. (medscape.com)
  • Additional functional disturbances were not noted, even under isoproterenol challenge. (cdc.gov)
  • In vitro study with heart homogenate confirmed no antioxidant effect of ritonavir and phlorizin in the absence and presence of isoproterenol. (biomedcentral.com)
  • Effect of isoproterenol on the liberation of histamine from rat lung mast cells]. (bvsalud.org)
  • Treating intact neutrophils with a combination of isoproterenol and IBMX did not inhibit acetyl-transferase activity when assayed in a subsequent broken cell preparation. (arizona.edu)
  • ODC activity was stimulated in all isoproterenol groups at all times. (cdc.gov)
  • Isoproterenol has beta1- and beta2-adrenergic receptor activity. (medscape.com)
  • In the present study, we inhibited SGLTs and GLUTs transporters in heart by using pharmacological inhibitors, phlorizin (nonselective SGLT blocker) and ritonavir (nonselective GLUTs blocker) respectively, and evaluated the relative importance of these transporters during myocardial necrosis induced by isoproterenol. (biomedcentral.com)
  • Emergency Central , emergency.unboundmedicine.com/emergency/view/Davis-Drug-Guide/51419/all/isoproterenol. (unboundmedicine.com)
  • Isoproterenol infusions induced anxiety in both patients, and full-blown panic in one (patient B.G.). Although both patients demonstrated signs of diminished awareness for cardiac sensation, patient A.M., who did not panic, reported a complete lack of awareness for dyspnea, suggestive of impaired respiratory interoception. (jneurosci.org)
  • However, in patients with severe bradycardia or those with the possibility of progression to higher-degree AV block, medications (eg, atropine, isoproterenol) can be used in anticipation of insertion of a cardiac pacemaker. (medscape.com)
  • Isoproterenol should not be used in patients with hypertrophic cardiomyopathy or severe coronary artery disease. (msdmanuals.com)