• Collagenase
  • In 1967, Lacy's group described a novel collagenase-based method (later modified by Dr. Camillo Ricordi, then working with Dr. Lacy) to isolate islets, paving the way for future in vitro and in vivo islet experiments. (wikipedia.org)
  • glucose
  • Yet despite continued procedural improvements, only about 10% of islet recipients in the late 1990s achieved euglycemia (normal blood glucose). (wikipedia.org)
  • donor
  • Group B will receive, in addition to Daclizumab, Sirolimus, and Tacrolimus, a dose of infliximab and islets from a single donor, as per the Edmonton protocol. (clinicaltrials.gov)
  • In 2000, Dr. James Shapiro and colleagues published a report describing seven consecutive patients who achieved euglycemia following islet transplantation using a steroid-free protocol and large numbers of donor islets, since referred to as the Edmonton protocol. (wikipedia.org)
  • therapeutic
  • Insulitis scoring and immunofluorescence staining revealed that both anti-IL-17 and IL-25 significantly reduced peri-islet T-cell infiltrates.Both treatments also decreased GAD65 autoantibody levels.Further development of Th17-targeted therapeutic agents may be of benefit in this disease. (nih.gov)
  • cell
  • Participants in this study have received up to three islet cell infusions as a previous participant in the ITN005CT (NIS01) protocol. (clinicaltrials.gov)
  • Insulitis scoring and immunofluorescence staining revealed that both anti-IL-17 and IL-25 significantly reduced peri-islet T-cell infiltrates. (nih.gov)
  • blockade
  • The efficacy of CD40 ligand blockade in discordant pig-to-rat islet xenotransplantation is correlated with an immunosuppressive effect of immunoglobulin. (diva-portal.org)
  • These data suggest that Idd loci can facilitate or impair induction of transplantation tolerance by costimulation blockade, and that Idd3 (IL-2) is critical component in this process. (umassmed.edu)
  • cells
  • After the cells are prepared, the islets are put into the subject's liver. (clinicaltrials.gov)
  • The egg cartons provide oxygen and allow physical separation to prevent damage and death to the cells - known as islet cells - during transport. (medicalxpress.com)
  • Along with the β-cells, other cells within the islet also produce unique and specific hormones. (medicalxpress.com)
  • But because islets are composed of cells with a very high rate of metabolism, they need a lot of nutrients and oxygen. (medicalxpress.com)
  • To assess the effect of infliximab in preventing early islet destruction, and thereby eliminating the need for a second donor's islet cells. (clinicaltrials.gov)
  • As validation, OSMs have been incorporated into alginate beads, commonly used as immunoisolation devices to encapsulate pancreatic islet cells. (spiedigitallibrary.org)
  • However, within an islet of Langerhans the oscillations become synchronized by electrical coupling between closely located beta cells that are connected by gap junctions, and the periodicity is more uniform (3-6 min). (wikipedia.org)
  • The released ATP in turn binds to receptors on neighbouring beta cells leading to a regenerative wave of rapid calcium elevation among the cells within the islet. (wikipedia.org)