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  • Collagenase
  • In 1967, Lacy's group described a novel collagenase-based method (later modified by Dr. Camillo Ricordi, then working with Dr. Lacy) to isolate islets, paving the way for future in vitro and in vivo islet experiments. (wikipedia.org)
  • glucose
  • Yet despite continued procedural improvements, only about 10% of islet recipients in the late 1990s achieved euglycemia (normal blood glucose). (wikipedia.org)
  • donor
  • Group B will receive, in addition to Daclizumab, Sirolimus, and Tacrolimus, a dose of infliximab and islets from a single donor, as per the Edmonton protocol. (clinicaltrials.gov)
  • In 2000, Dr. James Shapiro and colleagues published a report describing seven consecutive patients who achieved euglycemia following islet transplantation using a steroid-free protocol and large numbers of donor islets, since referred to as the Edmonton protocol. (wikipedia.org)
  • In an opposite twist, Ganogen Research Institute CEO Eugene Gu is studying how to transplant human fetal hearts and kidneys into animals for future transplantation into human patients to address the shortage of donor organs. (wikipedia.org)
  • Tacrolimus
  • Group C, in addition to Daclizumab, Sirolimus, and Tacrolimus, will receive Etanercept in the peri-transplant period and islets from one or more donors. (clinicaltrials.gov)
  • therapeutic
  • Insulitis scoring and immunofluorescence staining revealed that both anti-IL-17 and IL-25 significantly reduced peri-islet T-cell infiltrates.Both treatments also decreased GAD65 autoantibody levels.Further development of Th17-targeted therapeutic agents may be of benefit in this disease. (nih.gov)
  • cell
  • Participants in this study have received up to three islet cell infusions as a previous participant in the ITN005CT (NIS01) protocol. (clinicaltrials.gov)
  • Insulitis scoring and immunofluorescence staining revealed that both anti-IL-17 and IL-25 significantly reduced peri-islet T-cell infiltrates. (nih.gov)
  • In 1989, that work eventuated in the first successful islet-cell transplant in a human being. (wikipedia.org)
  • blockade
  • The efficacy of CD40 ligand blockade in discordant pig-to-rat islet xenotransplantation is correlated with an immunosuppressive effect of immunoglobulin. (diva-portal.org)
  • These data suggest that Idd loci can facilitate or impair induction of transplantation tolerance by costimulation blockade, and that Idd3 (IL-2) is critical component in this process. (umassmed.edu)
  • normal
  • Yet despite continued procedural improvements, only about 10% of islet recipients in the late 1990s achieved euglycemia (normal blood glucose). (wikipedia.org)