• Collagenase
  • In 1967, Lacy's group described a novel collagenase-based method (later modified by Dr. Camillo Ricordi, then working with Dr. Lacy) to isolate islets, paving the way for future in vitro and in vivo islet experiments. (wikipedia.org)
  • secretory
  • Additionally, there are complications of maintenance immunosuppressive therapy to control rejection, and there are requirements for retransplantation to offset loss of functional islet mass and insulin secretory reserve that occurs in both early and late follow-up after IPIT ( 1 , 8 9 10 11 ). (diabetesjournals.org)
  • primate
  • This study provides the first evidence that operational tolerance can protect MHC nonhuman primate islets from rejection as well as loss of functional islet mass. (diabetesjournals.org)
  • Lacy
  • Obituary-The New York Times, February 18, 2005, Section A, p. 25 Lacy PE: Electron microscopy of the normal islets of Langerhans: studies in the dog, rabbit, guinea pig, and rat. (wikipedia.org)
  • Lacy PE, Davies J: Preliminary studies on the demonstration of insulin in the islets by the fluorescent antibody technic. (wikipedia.org)
  • therapeutic
  • Insulitis scoring and immunofluorescence staining revealed that both anti-IL-17 and IL-25 significantly reduced peri-islet T-cell infiltrates.Both treatments also decreased GAD65 autoantibody levels.Further development of Th17-targeted therapeutic agents may be of benefit in this disease. (nih.gov)
  • cell
  • Participants in this study have received up to three islet cell infusions as a previous participant in the ITN005CT (NIS01) protocol. (clinicaltrials.gov)
  • Insulitis scoring and immunofluorescence staining revealed that both anti-IL-17 and IL-25 significantly reduced peri-islet T-cell infiltrates. (nih.gov)
  • supply
  • After 10 days, angiogenesis was completed, consisting of a microvascular network similar to those of islets in situ: arterial supply, afferent and efferent capillary loops, and venular drainage. (diabetesjournals.org)