• scaffold
  • In a scaffold complex protein to form large molecular assemblies that store Fe(III) and 4Fe-4S seen as secondary to defects inactivated to accomplish its functions as physiologically relevant form(s) Fe/S proteins Iron regulatory protein 1 (IRP1) is regulated through prevents deficiencies and increased mutation rates that characterized a plant P loop NTPase with sequence similarity to Nbp35 homologue's of NUBP1. (wikipedia.org)
  • atoms
  • In the newer R/S system of designating chirality, based on the atomic numbers of atoms near the asymmetric carbon, cysteine (and selenocysteine) have R chirality, because of the presence of sulfur (resp. (wikipedia.org)
  • sequence
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • hydrogenases
  • We first develop appropriate parameters to describe models of the redox site of rubredoxins, followed by some preliminary calculations of multinuclear iron systems of relevance to hydrogenases. (biochemsoctrans.org)
  • Examples include zinc in zinc fingers and alcohol dehydrogenase, copper in the blue copper proteins, iron in cytochrome P450 and nickel in the [NiFe]-hydrogenases. (wikipedia.org)
  • enzymes
  • Both of them have the same function, which is to facilitate the reaction of enzymes and protein. (wikipedia.org)
  • The term coenzyme refers specifically to enzymes and, as such, to the functional properties of a protein. (wikipedia.org)
  • Calcium is another special case, in that it is required as a component of the human diet, and it is needed for the full activity of many enzymes, such as nitric oxide synthase, protein phosphatases, and adenylate kinase, but calcium activates these enzymes in allosteric regulation, often binding to these enzymes in a complex with calmodulin. (wikipedia.org)
  • structural
  • The PDBFlex database explores the intrinsic flexibility of protein structures by analyzing structural variations of the same protein across the archive. (rcsb.org)
  • This allows for the easy identification of regions and types of structural flexibility present in a protein of interest. (rcsb.org)
  • The thiol is susceptible to oxidization to give the disulfide derivative cystine, which serves an important structural role in many proteins. (wikipedia.org)
  • centre
  • This iron-sulphur protein is an electron carrier, and it is easy to distinguish its metallic centre changes: the oxidized state is reddish (due to a ligand metal charge transfer), while the reduced state is colourless (because the electron transition has an energy of the infrared level, which is imperceptible for the human eye). (wikipedia.org)
  • amino
  • PsaA and PsaB are both integral membrane proteins of 730 to 750 amino acids that seem to contain 11 transmembrane segments. (wikipedia.org)
  • reaction
  • The preliminary data from site-directed mutagenesis of LytB (including H42A, H42F, H124A, H124F, E126A and E126Q) identified several mutations that have different effects on iron-sulfur cluster or reaction intermediate. (auburn.edu)
  • Another theory is that, in diabetic hearts, accelerated phosphorylation of heart aconitase by protein kinase C causes aconitase to speed up the final step of its reverse reaction relative to its forward reaction. (wikipedia.org)
  • recombinant
  • If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production , custom recombinant protein production or custom antibody production . (mybiosource.com)
  • Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications. (mybiosource.com)
  • aconitase
  • Expression of IRE-BP in cultured cells has revealed that the protein functions either as an active aconitase, when cells are iron-replete, or as an active RNA-binding protein, when cells are iron-depleted. (wikipedia.org)
  • Humans express the following two aconitase isozymes: Click on genes, proteins and metabolites below to link to respective articles. (wikipedia.org)
  • Another disease associated with aconitase is Friedreich's ataxia (FRDA), which is caused when the Fe-S proteins in aconitase and succinate dehydrogenase have decreased activity. (wikipedia.org)
  • A proposed mechanism for this connection is that decreased Fe-S activity in aconitase and succinate dehydrogenase is correlated with excess iron concentration in the mitochondria and insufficient iron in the cytoplasm, disrupting iron homeostasis. (wikipedia.org)
  • bind
  • The diphosphate group does not directly bind to iron-sulfur cluster based on the distance calculated from the 31P superhyperfine coupling. (auburn.edu)
  • The thiol group also has a high affinity for heavy metals, so that proteins containing cysteine, such as metallothionein, will bind metals such as mercury, lead and cadmium tightly. (wikipedia.org)
  • regulate
  • Iron regulatory elements (IREs) constitute a family of 28-nucleotide, non-coding, stem-loop structures that regulate iron storage, heme synthesis and iron uptake. (wikipedia.org)
  • Annotation
  • p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. (uniprot.org)
  • species
  • The HesB family are found in species as divergent as Homo sapiens (Human) and Haemophilus influenzae suggesting that these proteins are involved in basic cellular functions. (wikipedia.org)
  • High
  • Photosystem I (PSI) is an integral membrane protein complex that uses light energy to produce the high energy carriers ATP and NADPH. (wikipedia.org)
  • role
  • The prevalence of these proteins on the metabolic pathways of most organisms leads some scientists to theorize that iron-sulfur compounds had a significant role in the origin of life in the iron-sulfur world theory. (wikipedia.org)