• Therapeutic potential of silymarin as a natural iron-chelating agent in β-thalassemia intermedia. (greenmedinfo.com)
  • Therapeutic approaches based on the use of ferrochelating agents such as lactoferrin combined with antimicrobial drugs may help to counteract the reduced efficacy of current antibiotics. (nih.gov)
  • Rarely, iron in therapeutic doses produces gastrointestinal reactions, such as diarrhea or constipation. (rxlist.com)
  • Picinni and Ricciotti suggested in 1982, that "the therapeutic effectiveness of Polysaccharide Iron Complex when compared with iron fumarate in the treatment of iron deficiency anemia, appears to be as active as the iron fumarate and as well tolerated, however, it exerted a greater influence on the level of hemoglobin and on the number of red cells. (nih.gov)
  • Exploration of the chemical constituents of mangrove plants is necessary to find new therapeutic agents and this information is very important to the local community. (intechopen.com)
  • When end-stage liver disease progresses despite iron-reduction therapy, orthotopic liver transplantation is the only therapeutic option. (medscape.com)
  • NTA has been proposed as a therapeutic chelating agent for manganese poisoning Footnote 2 and for the treatment of iron overloading, as it has a synergistic effect on the mobilization of iron by desferrioxamine. (canada.ca)
  • EDTA is a chelating agent used in various industries including water treatment, food, cleaning and other industrial applications. (brenntag.com)
  • By 1948, the US Navy successfully used EDTA as a chelating agent for lead poisoning. (preventionandhealing.com)
  • In addition to EDTA, many chelating agents have been developed for a variety of heavy metal toxicities. (preventionandhealing.com)
  • EDTA as a chelating agent has been the most well known for lead toxicity. (preventionandhealing.com)
  • EDTA, NTA, 1,3-PDTA are the major types of chelating agents consumed in cleaning compounds, pulp & paper industry and water treatment industry. (techsciresearch.com)
  • However, due to environmental & ecological effects of EDTA, NTA & other classical chelating agents, consumers are shifting their focus towards biodegradable chelating agents such as gluconic acid & glucoheptonic acids. (techsciresearch.com)
  • During selective precipitation, ethylenediaminetetraacetic acid (EDTA) is used as a stabilizing agent to prevent iron and phosphorus co-precipitation. (rsc.org)
  • In pulp bleaching liquors, iron and manganese ions are desired to be trapped by a chelating agent, thereby inhibiting these metal ions from catalyzing the decomposition of the bleaching agents, hydrogen peroxide or peroxy acids. (justia.com)
  • An optimized reagent ratio of TCE: Chelating Agent: Iron : Hydrogen Peroxide has been developed based on the local geochemical conditions of the PGDP through extensive experimentation using site groundwater and groundrock. (confex.com)
  • Diminishing the risk of hydrogen peroxide bleaching in the presence of iron ions in paper. (abk-stuttgart.de)
  • Bleaching with hydrogen peroxide can cause massive degradation of cellulose in the presence of iron ions in the paper and can lead to brightness reversion. (abk-stuttgart.de)
  • This book includes discussions of management and treatment strategies for hemoglobin disorders, such as transfusions, iron-chelating agents, gene therapy, and stem cell transplantation. (cshlpress.com)
  • As a result of multiple transfusions over the years, various organs become severely overloaded with iron, and, in order to avoid death in adolescence, regular subcutaneous infusion of an iron-chelating agent is essential. (who.int)
  • Oral iron chelation agent that is demonstrated to reduce the liver iron concentration in adults and children who receive repeated RBC transfusions. (medscape.com)
  • Thus, regular blood transfusions can lead to a buildup of iron in the blood. (pediatriconcall.com)
  • This white, water-soluble solid is widely used to bind to iron and calcium ions. (brenntag.com)
  • It binds these ions as a hexadentate ('six-toothed') chelating agent. (brenntag.com)
  • Because there is naturally a high concentration of calcium ions in the bleaching liquors, a chelating agent effectively chelating calcium would be consumed by calcium ions. (justia.com)
  • Therefore, chelating agents to selectively complex iron and manganese ions are desired. (justia.com)
  • In order to simultaneously complex different metal ions in aqueous solutions, it is essential in many applications to have a mixture of chelating agents having different ligand structure. (justia.com)
  • Metal indicators and chelating agents are used to determine the concentration of specific metal ions in solution by chelate titration. (dojindo.com)
  • Colorimetric chelating reagents form colored complexes with metal ions in pH-controlled solutions. (dojindo.com)
  • Thus, iron can be determined without interference from other metal ions. (dojindo.com)
  • Water-soluble colorimetric chelating agents enable the determination of metal ions in aqueous solution without solvent extraction. (dojindo.com)
  • Chelating agents are chemical compounds added to these products/processes to reduce the deleterious effects of metal ions. (techsciresearch.com)
  • A treatment has to be found to reduce these risks by removing or complexing the iron ions prior to bleaching. (abk-stuttgart.de)
  • Iron also catalyzes free radical formation, acts as an oxidizer, and, when plasma protein binding is saturated, combines with water to form iron hydroxide and free H+ ions, compounding the metabolic acidosis. (msdmanuals.com)
  • 1,2 dimethyl-3-hydroxypyridine-4-one is a member of a family of hydroxypyridine-4-one (HPO) chelators that requires 3 molecules to fully bind iron (III), each molecule providing 2 coordination sites (bidentate chelation). (medscape.com)
  • Metal indicators, colorimetric metal chelators, and fluorometric metal chelators are chromogenic chelating agents. (dojindo.com)
  • Currently, there are limited FDA-approved therapies for MDS, which include hypomethylating agents such as azacitidine and decitabine, iron chelators such as deferasirox, and lenalidomide. (medscape.com)
  • The manganese and iron hydroxides represent the basic phase, where the heavy metals found in small quantities are adsorbed, co-precipitated and integrated in the soil. (omicsonline.org)
  • Is iron necessary to promote the production of lipid peroxides, or can other substances take the place of iron in ferroptosis? (nature.com)
  • Berberine protects the liver and kidneys against ferrous sulfate-induced toxicity by reduction in lipid peroxidation and ability to chelate iron. (greenmedinfo.com)
  • Mechanisms of iron loading and toxicity. (medscape.com)
  • Prior studies in rats demonstrated that Polysaccharide Iron Complex (PIC), administered as a single oral dose to Sprague Dawley rats did not produce evidence of toxicity at a dosage level of 5000 mg Iron/kg: (An Acute Oral Toxicity Study in Rats with Polysaccharide-Iron Complex. (nih.gov)
  • Aetna considers laboratory testing medically necessary for heavy metal poisoning (e.g., arsenic, cadmium, copper, gold, iron, mercury) for members with specific signs and symptoms of heavy metal toxicity and/or a history of likely exposure to heavy metals. (aetna.com)
  • However, these chemotherapeutic agents can cause a range of dose-limiting toxicity (DLT) symptoms, such as weight loss and heart, liver, and kidney toxicity [ 4 ]. (hindawi.com)
  • There are many standard pharmaceutical chelating agents available for heavy metal toxicity in both oral and intravenous form through the care of a physician. (preventionandhealing.com)
  • DMPS as a chelating agent has been used for mercury toxicity in Europe for over 50 years. (preventionandhealing.com)
  • Children's chewable multivitamins with iron usually have such small amounts that toxicity rarely occurs. (msdmanuals.com)
  • Toxicity depends on the amount of elemental iron that has been ingested. (msdmanuals.com)
  • Binds iron with high affinity in a 2:1 ratio (tridentate complex). (medscape.com)
  • It is treated by removing excess iron from the blood, either by removing blood from the body (phlebotomy) or by taking a medicine (chelating agent) that binds to and removes iron from the body. (stlukesonline.org)
  • Does not affect iron in the cytochromes or hemoglobin. (medscape.com)
  • The hemoglobin in red blood cells is an iron-rich protein. (pediatriconcall.com)
  • Hemoglobin is an iron-containing protein in red blood cells that transports oxygen to tissues throughout the body. (cshlpress.com)
  • The pathophysiological consequences of hemoglobin disorders (e.g., ineffective erythropoiesis and aberrant iron homeostasis), their clinical manifestations, and epidemiological trends are also described. (cshlpress.com)
  • The drug is siderophore (iron-binder) derived from the bacterium Streptomyces pilosus . (medscape.com)
  • Albomycins are broad-host range antibiotics that consist of a hydroxamate-type iron-chelating siderophore, and an antibiotically active, thioribosyl pyrimidine moiety. (rcsb.org)
  • The structural information derived from this study provides novel insights into the diverse array of antibiotic moieties that can be linked to the distal portion of iron-chelating siderophores and offers a structural platform for the rational design of hydroxamate-type siderophore-antibiotic conjugates. (rcsb.org)
  • Helps prevent damage to the liver and bone marrow from iron deposition. (medscape.com)
  • Liver iron concentrations and urinary hepcidin in beta-thalassemia. (medscape.com)
  • Iron accumulation in alcoholic liver diseases. (medscape.com)
  • B12 [ vitamin b12 (liver-stomach concentrate with intrinsic factor)] is an anti- anemia preparation used to treat anemias that respond to oral hematinics, including pernicious anemia and other megaloblastic anemia and also iron-deficiency anemia. (rxlist.com)
  • Ferritin is an iron-storage protein found in most cells of the body, particularly the liver, and which provides a readily available reserve. (sas-centre.org)
  • Demonstration of iron histologically or total iron measurement in a liver biopsy are more reliable if the diagnosis of genetic haemochromatosis is uncertain. (sas-centre.org)
  • As iron accumulates in the liver with age, re-calculation of the concentration to give the 'hepatic iron index' (liver Fe in µmol g-1/ age in years) is a useful approach. (sas-centre.org)
  • Small amounts of iron are normally stored in the liver and heart, but excess iron will eventually damage these organs. (stlukesonline.org)
  • An increase in tolerability is observed with the (patented formulation) and is believed to occur as the result of distributing the total iron content in the composition among compounds that provide iron to the patient's blood stream via two different mechanisms. (nih.gov)
  • These compounds represent a specific means by which potent antimicrobial agents, covalently linked to iron-chelating siderophores, can be actively transported across the outer membrane of gram-negative bacteria. (rcsb.org)
  • Simple coumarins and analogues are a large class of compounds that have attracted their interest for a long time due to their biological activities: they have shown to be useful as antitumoural, anti-HIV agents and as CNS-active compounds. (benthamscience.com)
  • The new grant will specifically use a chelating agent that removes excess iron from the body and is currently used to treat certain blood disorders. (newswise.com)
  • Successful development of a more widely accessible and acceptable, oral iron-chelating agent could solve the problem of compliance in countries with limited resources, where morbidity and mortality are mainly caused by limited access to appropriate medical care. (who.int)
  • The treatment for genetic haemochromatosis consists of repeated venesection until iron stores as reflected by the serum ferritin are not excessive. (sas-centre.org)
  • A low serum ferritin is probably the best biochemical indicator of iron deficiency. (sas-centre.org)
  • Serum iron and transferrin concentrations alter in many physiological conditions and are difficult to interpret. (sas-centre.org)
  • In acute iron poisoning, a serum iron concentration above 90 µmol/L (5 mg/L), 2-6 hours post ingestion, indicates severe poisoning. (sas-centre.org)
  • Diagnosis is by measuring serum iron, detecting radiopaque iron tablets in the gastrointestinal tract, or detecting unexplained metabolic acidosis in patients with other findings suggesting iron poisoning. (msdmanuals.com)
  • It is a product of ferric iron complexed to a low molecular weight polysaccharide. (nih.gov)
  • Our mixed metal ferric iron complex is inherently soluble in alkaline solutions. (rockwellautomation.com)
  • As observed with other hydroxamate-type siderophores, the three-dimensional structure of albomycin reveals an identical coordination geometry surrounding the ferric iron atom. (rcsb.org)
  • The developed process achieves around 70% phosphorus recovery as an industrial-grade (19 wt% P) dicalcium phosphate dihydrate product with minimal iron, magnesium, and aluminum contamination, while also producing value-added calcium sulfate dihydrate (gypsum) and iron/magnesium byproducts. (rsc.org)
  • The deacidification with calcium hydroxide and magnesium bicarbonate, calcium and magnesium phytate, the chelating agent diethylenetriaminepentaacetic acid (DTPA) in combination with calcium hydroxide or magnesium bicarbonate, and hydrochloric acid were compared. (abk-stuttgart.de)
  • It attaches to excess iron in the body to form a compound called a 'chelate' that can be removed by the body, mainly in the stool. (europa.eu)
  • In general, metal indicators are utilized for chelate titration, and colorimetric and fluorometric chelating agents are utilized for the determination of the metal concentration by spectrophotometry. (dojindo.com)
  • Some new oral chelating agents are being tried, but appear to chelate other elements e.g. zinc. (sas-centre.org)
  • When treatment combining transfusion and iron-chelating agent is started early and maintained, the patient's quality of life can be very good and the prognosis is optimistic. (who.int)
  • The main challenge with the use of low-grade resources is the difficulty with the efficient and economical separation of phosphorus from the other constituent elements, such as iron, aluminum, and magnesium. (rsc.org)
  • Haemosiderosis, which plays a considerable function in thalassaemia patients before and role in early mortality, can be prevented or after treatment with high-dose deferoxam- postponed by iron-chelating agents which ine. (who.int)
  • [ 91 ] The investigators noted an overall low quality of evidence and a high risk of bias in the trials assessed, and none of the trials evaluated iron-chelating agents or provided mortality data beyond 1 year or long-term follow-up. (medscape.com)
  • Ferroptosis is a novel type of regulated cell death caused by iron-dependent lipid peroxidation [ 26 ]. (hindawi.com)
  • People commonly use iron for preventing and treating different types of anemia caused by low iron levels. (webmd.com)
  • Taking iron by mouth or by IV along with other medications such as epoetin alfa can help build red blood cells and prevent or treat anemia in people with certain chronic diseases. (webmd.com)
  • Low levels of healthy red blood cells (anemia) due to iron deficiency . (webmd.com)
  • Taking iron by mouth or by IV is effective for treating and preventing anemia caused by too little iron in the body. (webmd.com)
  • Taking iron by mouth during pregnancy reduces the risk of anemia caused by too little iron in the body. (webmd.com)
  • Hematinic concentrate with intrinsic factor is a multifactor preparation effective in the treatment of anemias that respond to oral hematinics, including pernicious anemia and other megaloblastic anemias and also iron-deficiency anemia . (rxlist.com)
  • The diagnosis was 'mild iron deficiency anemia,' and iron therapy was prescribed. (cdc.gov)
  • CLINICAL PHARMACOLOGY: Integra FTM is unique in that it utilizes two (2) different forms of iron, i.e. (nih.gov)
  • Consumption of silybin with a meal, compared with water, resulted in a significant reduction in the amount of dietary iron absorbed. (greenmedinfo.com)
  • Aminopolycarboxylic acid, hydroxycarboxylic acid, and organophosphonates, are the three different classes of chelating agents consumed globally, wherein, the consumption of aminopolycarboxylic acid is the highest. (techsciresearch.com)
  • In terms of regional consumption, Asia-Pacific accounts for the largest share of chelating agents across the globe. (techsciresearch.com)
  • Hershko C. Iron loading and its clinical implications. (medscape.com)
  • Other clinical studies had demonstrated that Polysaccharide Iron gives a good hematopoietic response with an almost complete absence of the side effects usually associated with oral iron therapy. (nih.gov)
  • Dr. Galanopoulou and her colleagues will initially evaluate the efficacy of the chelating agent in an animal model in double-blinded, randomized studies at multiple institutions, as is typically done in clinical trials. (newswise.com)
  • [ 89 ] Because a normal life span can be expected if iron reduction is initiated before the development of cirrhosis, clinical suspicion and early diagnosis are essential. (medscape.com)
  • Iron is likely safe for most people when used in doses below the tolerable upper intake level (UL) of 45 mg elemental iron daily. (webmd.com)
  • Iron is likely safe to use while pregnant and breast-feeding in doses below the UL of 45 mg of elemental iron by mouth daily. (webmd.com)
  • Iron is likely safe when taken by mouth in doses below the UL of 40 mg of elemental iron daily. (webmd.com)
  • Ferrous Fumarate: Provides about 62.5 mg of elemental iron per dose. (nih.gov)
  • Ferrous Fumarate contrasts very favorably with the availability of the 20% of elemental iron of ferrous sulfate, and the 13% of elemental iron of ferrous gluconate. (nih.gov)
  • Polysaccharide Iron Complex: Provides about 62.5 mg elemental iron, as a cell-contracted akaganèite. (nih.gov)
  • The product families include organic phosphonic series, organic phosphate salt, corrosion inhibitors, chelating agents, dispersants, RO membrane chemicals and etc., covering wide ranges from single to complex agents. (phrmg.org)
  • In this study, we develop an integrated process for the direct recovery and separation of dicalcium phosphate dihydrate for fertilizer and livestock feed additive production from a low-grade (2.0 wt% P) iron-rich (19.7 wt% Fe) phosphate ore. (rsc.org)
  • Once iron stores are depleted, a hypochromic microcytic anaemia is seen on blood films, with other symptoms including intellectual changes such as reduced mental concentration and effects on the immune system. (sas-centre.org)
  • Iron poisoning should be considered in mixed ingestions (because iron is ubiquitous) and in small children with access to iron and unexplained metabolic acidosis or severe or hemorrhagic gastroenteritis. (msdmanuals.com)
  • If you do not have iron deficiency, don't take more than 45 mg daily. (webmd.com)
  • Iron deficiency is one of the most prevalent disorders, even in developed countries. (sas-centre.org)
  • The zinc protoporphyrin concentration in blood is also a sensitive indication of iron deficiency anaemia. (sas-centre.org)
  • As an adjunct to standard measures for the treatment of acute iron intoxication. (nih.gov)
  • Chemotherapeutic agents may cause adverse cardiac effects either directly, by compromising myocardial structure and function, or indirectly, by impairing vascular hemodynamics or other organ systems such as the endocrine glands, which may result in endocrinopathies. (ajmc.com)
  • However, older thalassaemics may have to contend with multiple conditions including early osteoporosis, cardiac disease, pulmonary hypertension and diabetes, some of which result from increased iron deposition in the endocrine glands and myocardial cells. (who.int)
  • The study included 15 thalassaemia allow the formation of more excretable patients aged 15-25 years who had some iron complexes [1,3]. (who.int)
  • Ferrous Fumarate is an anhydrous salt of a combination of ferrous iron and fumaric acid, containing 33% of iron per weight. (nih.gov)
  • Ferrous Fumarate and Polysaccharide Iron Complex (U.S. Patent No: 11/243,043 Pending). (nih.gov)
  • After this time, much iron will be intracellular and measurement is of less value. (sas-centre.org)
  • WO 97/45396 discloses N-bis- and N-tris-[(1,2-dicarboxy-ethoxy)-ethyl]-amine derivatives including N-bis-[(1,2-dicarboxy-ethoxy)-ethyl]-aspartic acid (also called aspartic acid diethoxy succinate or AES), and the use of these derivatives as chelating agents of metals, especially in connection with pulp bleaching. (justia.com)
  • Simply put, chelation is the process of intravenously injecting a chelating agent (in liquid form) that bonds with specific toxic metals. (preventionandhealing.com)
  • By bonding with the chelating agent, the toxic metals are extracted from the tissues and organs of the body. (preventionandhealing.com)
  • Once bound together, the chelating agent and the toxic metals are simply excreted through the kidneys. (preventionandhealing.com)
  • Therefore, there is a need to develop a method for the preparation of mixtures of chelating agents in situ in the same reaction mixture. (justia.com)
  • Regulation of systemic iron homeostasis: how the body responds to changes in iron demand. (medscape.com)