Treatments for depression have evolved from seizure and convulsion treatments, to amphetamines, to the modern era of psychotropics, beginning with imipramine, iproniazid, and isocarboxazid. (psychiatrist.com)
Inhibitors1
Iproniazid is able to displace non-hydrazine inhibitors, but not other hydrazine inhibitors from the active site of the enzyme. (wikipedia.org)
Marsilid1
Iproniazid (Marsilid) had been marketed since 1958 but was quickly overtaken by tranylcypromine (Parnate) from 1960, popular both alone and combined with a small dose of Stelazine as Parstelin. (inhn.org)
Isoniazid2
Iproniazid was originally developed for the treatment of tuberculosis, but in 1952, its antidepressant properties were discovered when researchers noted that patients became inappropriately happy when given isoniazid, a structural analog of iproniazid. (wikipedia.org)
The structure of iproniazid is chemically, in both structure and reactivity, similar to isoniazid. (wikipedia.org)
Antidepressant effects1
The history of antidepressants dates back to the 1950s, when iproniazid was first discovered to have antidepressant effects. (telemind.com)
Tuberculosis3
Fatal toxic encephalitis occurring during iproniazid therapy in pulmonary tuberculosis. (webmd.com)
The fifth , iproniazid , was synthesized in 1951 by Herbert Fox at Roche Laboratories in Nutley, New Jersey, for the chemotherapy of tuberculosis (Fox and Gibbs 1952). (inhn.org)
Dr. David Bosworth was the principal invited Guest speaker, who discussed the status of Iproniazid therapy for tuberculosis. (neos-bone.org)
Reserpine5
LSD in combination with either 2 mg. reserpine or 100 mg. iproniazid. (erowid.org)
Psychic effects of LSD plus reserpine (10 trials) or LSD plus iproniazid (17 trials) or LSD plus reserpine plus iproniazid [number of trials? (erowid.org)
The physical findings after LSD administration (among which mydriasis was the most constant) are different from those after reserpine plus iproniazid. (erowid.org)
The main objective of this study was to find out whether subjects discriminate between LSD and other drugs, whether addition of reserpine or iproniazid to LSD alters the psychic effect of LSD, and whether reserpine plus iproniazid induce LSD-like symptoms as Shore and Brodie, LSD No. 316, found the latter combination to have an LSD-like effect in the rabbit. (erowid.org)
The 3 reports of an LSD-like effect after reserpine plus iproniazid possibly refer to subjective bodily symptoms. (erowid.org)
Monoamine3
Iproniazid is a substituted hydrazine of which the isopropyl hydrazine moiety is essential for the inhibition of monoamine oxidase activity. (wikipedia.org)
Iproniazid is a known monoamine oxidase inhibitor, it inhibits the activity of monoamine oxidases (MAOs) by itself and through an active metabolite, isopropylhydrazine. (wikipedia.org)
Inhibition of MAOs by iproniazid is competitive and sensitive to changes in pH and temperature, similar to oxidation of the monoamine substrate. (wikipedia.org)
Metabolism2
Nevertheless, iproniazid has historic value as it helped establish the relationship between psychiatric disorders and the metabolism of neurotransmitters. (wikipedia.org)
The presence of the isopropyl radical was indicated by another observed product of the metabolism of iproniazid: the gas propane. (wikipedia.org)
Treatment2
Dangerous potentiation of pethidine by iproniazid, and its treatment. (webmd.com)
Ablating DHHC9 in tubular cells aggravated, while inducing DHHC9 overexpression with adeno-DHHC9 transfection or iproniazid treatment protected against kidney fibrosis in male mouse models. (bvsalud.org)
Effects1
2.Papp C, Benaim S. Toxic effects of iproniazid in a patient with angina. (webmd.com)
Drug1
Iproniazid was the first psychotropic drug introduced with a proposed rational for its possible mode of action. (inhn.org)
Anti-tuberculosis drug2
Thorazine was actually a major tranquilizer, Miltown was a muscle relaxant, and Iproniazid was an anti-tuberculosis drug. (mindfreedom.org)
Antidepressants first began to appear in 1958 when an anti-tuberculosis drug, iproniazid (Marsilid), started to be used off-label for depression. (sunshinentc.com)
A connection of galactose utilization and polyamine metabolism may exist (as in yeasts) since iproniazid, an amine oxidase inhibitor, repairs to some extent growth of these suppressors on galactose. (gla.ac.uk)
19581
These drugs were marketed to the public as the antipsychotic Thorazine (1954), the anti-anxiety drug Miltown (1955), and the antidepressant Iproniazid (1958). (mindfreedom.org)
Antidepressant1
Their discovery occurred serendipitously when iproniazid, a drug initially used to treat tuberculosis, was found to have antidepressant properties. (sagepub.com)
Inhibitor1
Iproniazid is a known monoamine oxidase inhibitor, it inhibits the activity of monoamine oxidases (MAOs) by itself and through an active metabolite, isopropylhydrazine. (wikipedia.org)
Inhibition3
Iproniazid is a substituted hydrazine of which the isopropyl hydrazine moiety is essential for the inhibition of monoamine oxidase activity. (wikipedia.org)
Inhibition of MAOs by iproniazid is competitive and sensitive to changes in pH and temperature, similar to oxidation of the monoamine substrate. (wikipedia.org)
MAO inhibition can be decreased by addition of glutathione, suggesting non enzymatic conjugation of either iproniazid or isopropylhydrazine with glutathione. (wikipedia.org)
Present1
The formation of isopropylhydrazine from iproniazid has been observed without MAOs present. (wikipedia.org)