Intramolecular lyases, oxidoreductases and transferases catalyze the interconversion of structural isomers. (wikipedia.org)
Although racemases and epimerases (EC 5.1) and cis-trans isomerases (EC 5.2) are sensibly grouped according to changes of stereochemistry, the overall chemistry of intramolecular oxidoreductases (EC 5.3), intramolecular transferases (EC 5.4) and intramolecular lyases (EC 5.5) is challenging. (researchgate.net)
Intramolecular Lyases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
This graph shows the total number of publications written about "Intramolecular Lyases" by people in this website by year, and whether "Intramolecular Lyases" was a major or minor topic of these publications. (ucdenver.edu)
Below are the most recent publications written about "Intramolecular Lyases" by people in Profiles. (ucdenver.edu)
Isomerases2
Isomerases facilitate intramolecular rearrangements in which bonds are broken and formed. (wikipedia.org)
In addition, the separation of groups of isomerases sharing similar chemistry such as oxidosqualene cyclases and pseudouridine synthases from chemically complex sub-subclasses like intramolecular transferases acting on \other groups' (EC 5.4.99) might also improve the classification. (researchgate.net)
Synthase1
Biosynthesis of Vitroprocines by α-Oxoamine Synthase and Oxidoreductase Identified from Vibrio sp. (tmu.edu.tw)
Disulphide2
A mechanism involving reaction of DTNB with Cys 149, followed by formation of an intramolecular disulphide bridge between Cys 149 and a second thiol, is shown to be unlikely. (edu.au)
TheThis oxidation is significant in the be developed via intramolecular disulphide bonds, as items the cysteine of formation of inter- andindirect reactions of lipoperoxidation well as in withformationand histidine residues [166]. (hivinhibitor.com)
Activity1
This glutathionylation regulates the redox-driven signal transduction cascades and metabolic pathways [163] and may be reversed by way of thioldisulphide oxidoreductase (thioltransferase) activity [164]. (hivinhibitor.com)
Protein1
Productive folding of the protein moiety is facilitated during this period by the calnexin/calreticulin cycle in mammalian cells, which relies on G1M9-specific lectin-type chaperones (calnexin and calreticulin) associated with the oxidoreductase ERp57, and UDP-glucose:glycoprotein glucosyltransferases 1 and 2, which are capable of re-adding glucose to M9 if the protein moiety is not yet folded. (elifesciences.org)
Groups1
The reaction of 5,5' dithiobis(2 nitrobenzoic acid) (DTNB) with rabbit muscle glyceraldehyde 3 phosphate dehydrogenase [d glyceraldehyde 3 phosphate: NAD + oxidoreductase (phosphorylating), EC 1.2.1.12] consists of an initial burst of reaction over several minutes, corresponding to 2 thiols/subunit, followed by a further slow reaction of the 2 remaining groups. (edu.au)
Enzymes1
Modern oxidoreductase enzymes employ differential binding between reduced and oxidized forms of redox cofactors to alter cofactor reduction potential and enhance the enzyme's catalytic capabilities. (nature.com)
Disulfide5
Thioredoxin functions in nearly all organisms as the major thiol-disulfide oxidoreductase within the cytosol. (diamond.ac.uk)
Its prime purpose is to maintain cysteine-containing proteins in the reduced state by converting intramolecular disulfide bonds into dithiols in a disulfide exchange reaction. (diamond.ac.uk)
2004). This suggested that the catalytic cysteine residues are involved in the interaction of TRX1 with ASK1 and that the formation of an intramolecular disulfide bond between these cysteines upon oxidation causes TRX1 dissociation from ASK1, regardless of the thiol-reductase activity of TRX1. (bms-833923.com)
2016). The ASK1-TBD sequence has seven conserved Cys residues, thereby suggesting that oxidative stress may induce intramolecular disulfide bond formation, which may affect the structure of ASK1-TBD and its interaction with TRX1. (bms-833923.com)
Indeed, the oxidation of ASK1-TBD was shown to induce the formation of several intramolecular disulfide bonds, predominantly Cys185-Cys200 and Cys200-Cys206 and, to a lesser extent, Cys225/Cys226-Cys250 concurrently to conformational changes in ASK1-TBD (Kylarova et al. (bms-833923.com)
Residues1
Data altogether support a mechanism whereby the Cripto-1 CFC domain refolds by virtue of long-range intramolecular interactions that involve residues close to cysteines of the second and third bridge. (cnr.it)
Transferases1
Intramolecular lyases, oxidoreductases and transferases catalyze the interconversion of structural isomers. (wikipedia.org)
Human1
Jorns, M. S. Synthesis and evaluation of potent novel inhibitors of human sulfide:quinone oxidoreductase. (fctdi.com)