• Myenteric interstitial cells of Cajal (ICC-MY) serve as pacemaker cells that generate the bioelectrical events known as slow waves. (wikipedia.org)
  • To investigate the interstitial cells of Cajal (the gut pacemaker cells), together with myenteric and submucosal ganglion and glial cells, in patients with diverticulosis. (bmj.com)
  • ICLCs are pacemaker cells for gastrointestinal movement and are involved in the transmission of nerve impulses . (bvsalud.org)
  • These are sometimes called the "pacemaker cells of the digestive tract" because they regulate the movement of food through the digestive system. (yalemedicine.org)
  • Due to the presence of tyrosine kinase receptors within the tumour tissue, GIST is thought to originate from gastrointestinal pacemaker cells, the interstitial cells of Cajal (ICC). (biomedcentral.com)
  • longitudinally oriented smooth muscle cells (SMCs) modulated by different control systems, including pacemaker cells (i.e. intersti- tial cells of Cajal or ICCs) and the enteric nervous system (ENS) [3]. (fxr-agonists.com)
  • Interstitial cells of Cajal (ICC) are generally known as the pacemaker cells of gastrointestinal tract, and it has been reported that acute gastroenteritis induces intestinal dysmotility by means of antibody to vinculin, a cytoskeletal protein in intestine, leading to small intestinal. (forsker.net)
  • medical citation needed] ICCs are thought to be the cells from which gastrointestinal stromal tumours (GISTs) arise. (wikipedia.org)
  • This type of tumor is thought to grow from specialized cells found in the gastrointestinal tract called interstitial cells of Cajal (ICCs) or precursors to these cells. (medlineplus.gov)
  • IHC of CD117 Before the recognition of CD117 manifestation in GISTs, CD34 was regarded as the best marker for GIST, but it was neither sensitive (only for two-thirds of GISTs) nor specific (immunoreactive in fibroblastic and endothelial cell tumors) Rabbit Polyclonal to Claudin 4 [20]. (mycareerpeer.com)
  • Morphologically, GISTs vary from cellular spindle cell tumors (70% - 80%) to epithelioid (20% - 30%) or mixed. (scirp.org)
  • As a result, the proteins and the signaling pathways are constantly turned on (constitutively activated), which increases the proliferation and survival of cells and leads to the formation of tumors. (medlineplus.gov)
  • These tumors start from special hormone-making cells in the intestine. (uchealth.org)
  • These tumors start from special cells in the wall of the colon called the interstitial cells of Cajal. (uchealth.org)
  • Another group of tumors once thought to arise from cells around blood vessels, hemangiopericytoma, is now termed solitary fibrous tumor/hemangiopericytoma, since the tumors all appear to be very similar in terms of their biology. (sarctrials.org)
  • Most experts believe the tumors originate within cells known as the interstitial cells of Cajal (ICC). (yalemedicine.org)
  • Over time, this uncontrolled cell growth leads to the formation of tumors. (yalemedicine.org)
  • Gastrointestinal stromal tumors (GISTs) are mesenchymal neoplasms of the gastrointestinal (GI) tract and are thought to develop from the interstitial cells of Cajal, innervated cells associated with the Auerbach plexus. (medscape.com)
  • Histologically, GISTs can be categorized as cellular spindle cell tumors (70%), epithelioid tumors (20%), or pleomorphic/mixed morphology tumors, but such histologic distinction does not carry clear prognostic significance. (medscape.com)
  • Transitional dendritic cells are distinct from conventional DC2 precursors and mediate proinflammatory antiviral responses. (stanford.edu)
  • This uncommon group of sarcomas appear to arise from the lining of blood vessels (endothelial cells) or their precursors. (sarctrials.org)
  • It cannot be denied that there are still disturbances in the pattern of defecation after definitive surgery, even though the pull-through segment has enough ganglion cells. (balimedicaljournal.org)
  • Chen X, Zhang H, Li N, Feng J. Pathological changes of interstitial cells of Cajal and ganglion cells in the segment of resected bowel in Hirschsprung's disease. (balimedicaljournal.org)
  • In all cases, reactive, dystrophic, severe degenerative-necrotic changes of ganglion cells, as well as the details of their death, were described in detail. (eco-vector.com)
  • Along with pathological changes in nerve cells in the myenteric nerve plexus and gliosis, features of neuron-glial relationships were described, and the death of ganglion cells in the human colon with the active participation of specialized astrocyte-like glial cells was also established for the first time. (eco-vector.com)
  • 1.It has been shown that enteric ganglion cells arise from the vagal (somites 1-7) levels of the neural crest by the use of quail-chick chimaeras. (nii.ac.jp)
  • Histologically, not absolutely all GISTs are comprised of spindle cells, which makes up about just 70% of GISTs, and various other subtypes such as for example epithelioid cells and blended spindle and epithelioid cells take into account 20% and 10% of GISTs. (mycareerpeer.com)
  • GISTs begin when genetic mutations occur in certain genes, leading to uncontrolled cell growth. (yalemedicine.org)
  • GISTs are typically defined by the expression of c- KIT (CD117) in the tumor cells, as these activating KIT mutations are seen in 85-95% of GISTs. (medscape.com)
  • Patients with pediatric-type GISTs present with a purely epithelioid or mixed epithelioid/spindle cell cellularity. (medscape.com)
  • Physiology and pathophysiology of the interstitial cell of Cajal: from bench to bedside. (medscape.com)
  • In 1906, Cajal and Camillo Golgi (the Italian physician-scientist who developed the tissue staining technique that Cajal used) shared the Nobel Prize in Physiology or Medicine "in recognition of their work on the structure of the nervous system. (nih.gov)
  • submucosal and myenteric plexus neurones and glial cells were assessed by means of anti-PGP 9.5 and anti-S-100 monoclonal antibodies, respectively. (bmj.com)
  • All subtypes of interstitial cells of Cajal were significantly (p = 0.0003) reduced compared with controls, as were glial cells (p = 0.0041). (bmj.com)
  • Interstitial cells of Cajal and glial cells are decreased in colonic diverticular disease, whereas enteric neurones appear to be normally represented. (bmj.com)
  • Glial cells were observed in the Auerbach and Meissner plexuses at 14 day of incubation. (nii.ac.jp)
  • fBB 4 -R expression in cells widely used for other Bn receptor subtypes was unsuccessful as was expression in two frog cell lines. (acs.org)
  • At least two populations of c-kit positive interstitial cells of Cajal (ICC) lie in the gastric wall, one located at the myenteric plexus level has a pace-making function and the other located intramuscularly is intermediary in the neurotransmission and regenerates the slow waves. (unipa.it)
  • Noniatrogenic neonatal gastric perforation: the role of interstitial cells of Cajal. (utsouthwestern.edu)
  • http://www.nobelprize.org/nobel_prizes/medicine/laureates/1906/cajal-article.html Accessed May 9, 2016. (medscape.com)
  • Before considering these cells further, it is of utmost physiological importance to consider that these cells arise, during embryonic development, from local gut mesenchyme -- NOT neural crest cells. (wikipedia.org)
  • They arise from interstitial cells of Cajal. (longdom.org)
  • Many studies have shown that interstitial Cajal-like cell (ICLC) abnormalities are closely related to a variety of dynamic gastrointestinal disorders . (bvsalud.org)
  • A gastrointestinal stromal tumor (sometimes called a "GIST") is an uncommon type of cancer that forms in cells of the digestive tract wall. (yalemedicine.org)
  • ICC and another type of interstitial cell, known as platelet-derived growth factor receptor alpha (PDGFRα) cells, are electrically coupled to smooth muscle cells via gap junctions, that work together as an SIP functional syncytium. (wikipedia.org)
  • Slow waves conduct to smooth muscle cells and cause phasic contractions. (wikipedia.org)
  • This cell type can be characterized morphologically as having a small cell body often triangular or stellate-shaped with several long processes branching out into secondary and tertiary extensions - these processes often contact smooth muscle cells. (wikipedia.org)
  • Electrical slow waves spread from ICC to smooth muscle cells and the resulting depolarization initiates calcium ion entry and contraction. (wikipedia.org)
  • Interstitial cells of Cajal (ICC) are the pacemaker in smooth muscle contraction in the intestine. (balimedicaljournal.org)
  • The bladder detrusor smooth muscle cells (SMCs) and fibroblasts were observed under transmission electron microscopy (TEM). (hindawi.com)
  • Three types of cells, Namely smooth muscle-like cells, interdigitated fibroblast-like cells with smooth muscle cells, fibroblast-like cells, connected with smooth muscle cells and nerve fibers. (nii.ac.jp)
  • Since it was recognized that interstitial cells of Cajal express the gene product of c-kit, we performed immunohistochemistry for c-kit protein in ciliary muscle specimens of monkeys' eyes. (scielo.br)
  • Histopathology and immunohistochemistry revealed a mass with submucosal and serosal components together measuring 8-cm in greatest dimension, and a final diagnosis of GIST (spindle cell type) with c-kit/CD 117, CD 34 and cytokeratin positivity. (sages.org)
  • Expression and functional study of cholecystokinin-A receptors on the interstitial Cajal-like cells of the guinea pig common bile duct. (bvsalud.org)
  • Henna N. Expression of Interstitial Cells of Cajal in Colorectum of Patients with Hirschsprung's Disease. (balimedicaljournal.org)
  • EP receptor expression varies depending on the tissue and the cell type [1]. (fxr-agonists.com)
  • These cancers start in cells that make mucus to lubricate the inside of the colon and rectum. (uchealth.org)
  • These are cancers of immune system cells that mostly start in lymph nodes, but they can also start in the colon, rectum, or other organs. (uchealth.org)
  • The interstitial cells of Cajal are named after Santiago Ramón y Cajal, a Spanish pathologist and Nobel laureate. (wikipedia.org)
  • Retraction Note: Overexpression of long non-coding RNA TUG1 alleviates TNF-α-induced inflammatory injury in interstitial cells of Cajal. (nih.gov)
  • EA reduced the infiltration of inflammatory cells in the bladder mucosa layer of diabetic rats. (hindawi.com)
  • More recently, there is evidence that low-grade mucosal inflammation and immune activation (particularly with mast cell involvement) in association with impaired epithelial barrier function and aberrant neuronal sensitivity may play a role in functional GI disorders. (medscape.com)
  • The picture to the right shows an isolated Interstitial cell of Cajal from the Myenteric plexus of the mouse small intestine grown in a primary cell culture. (wikipedia.org)
  • 4.Interstitial cells associated with the deep muscular plexus and the myenteric plexus of the chick small intestine were studies by staining with ZIO and electron microscopy. (nii.ac.jp)
  • Significant changes were observed in the following areas: neurotransmitters, prostaglandins, nerve growth factor, Rho-kinase, interstitial cells of Cajal, and ion and transient receptor potential channels. (deepdyve.com)
  • High-dimensional approaches have revealed heterogeneity amongst dendritic cells (DCs), including a population of transitional DCs (tDCs) in mice and humans. (stanford.edu)
  • PGE2 increases the frequency of peristaltic contractions and evokes the appearance of ectopic sites of waves, an effect that is not observed in interstitial cells of Cajal (ICC) deficient mice [18], sug- gesting a possible effect of PGE2 on ICC. (fxr-agonists.com)
  • Staining for DOG1, also known as anoctamin-1/ANO1, a voltage-gated calcium-activated anion channel highly expressed in the interstitial cells of Cajal, may be useful for cases that cannot be categorized as GIST based on CD117 immunostaining. (arupconsult.com)
  • Using KIT-mutant GIST cell lines, these investigators showed that a small molecule IGF-1R kinase inhibitor (NVPAEW541) reduced cellular proliferation and induced apoptosis. (liferaftgroup.org)
  • Once in the blood vessels or lymph nodes, cancer cells may move to other parts of the body. (uchealth.org)
  • The vessels of the lymphatic system are lined with cells very similar to those found in blood vessels and give rise to what is termed lymphangiosarcoma. (sarctrials.org)
  • Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. (thermofisher.com)
  • A Systematic Review of Mesenchymal Epithelial Transition Factor (MET) and Its Impact in the Development and Treatment of Non-Small-Cell Lung Cancer. (lu.se)
  • BACKGROUND: Resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib, is a limited factor in the treatment of non-small-cell lung cancer (NSCLC) patients. (koreamed.org)
  • Because overexpression of IGF-1R has been identified in several tumor types and because of its role in cellular metabolism, which potentially has relevance to the survival of malignant cells, IGF-1R has become a target for anticancer therapy. (liferaftgroup.org)
  • Another form of tumor with kinship to fibroblasts, the boring cells that hold many parts of our body together. (sarctrials.org)
  • Gfroerer S, Rolle U. Interstitial cells of Cajal in the normal human gut and in Hirschsprung disease. (balimedicaljournal.org)
  • Mouse and human intestinal cell data are available from the Broad Institute Single Cell portal with the accession number SCP1038 . (nature.com)
  • Association between interstitial cells of Cajal and anti-vinculin antibody in human stomach. (forsker.net)
  • 3.The segmental graft of the neural tube show that the neural crest cells at the level of somites 3-5 in the vagal region were the main source to form the ENS of the entire gut. (nii.ac.jp)
  • Publications] Kyoko Tan-Takeuchi: 'Differentiation of neural crest cells in the gut' Journal of Clinical and Experimental Medicine. (nii.ac.jp)
  • The levels of tyrosine kinase receptor (c-kit) and CCK-A receptors in CBD tissues and isolated CBD cells were quantified using the double immunofluorescence labeling technique . (bvsalud.org)
  • Its pharmacology and cell biology are largely unknown, and no known natural cell lines or tissues possess sufficient numbers of fBB 4 -R's to allow either of these to be determined. (acs.org)
  • The IGF/IGF-1R system plays a key role in the biology of normal cells and tissues. (liferaftgroup.org)
  • Ricardo Martínez Murillo, Ph.D., Director of the Instituto Cajal in Madrid, Spain, is pictured in front of NIH's recently dedicated neuroscience research center where the exhibition of Ramón y Cajal original drawings is located. (nih.gov)
  • the dendritic arbor, the cell body, and the axon. (nih.gov)
  • Study of the effects of 50 Hz homogeneous magnetic field on apoptosis and proliferation of SNU cells in vitro [med. (emf-portal.org)
  • The cell apoptosis was determined by flow cytometry analysis. (jcimjournal.com)
  • MPP + can cause severe damage to mitochondrial morphology and the function in SH-SY5Y cells, and echinacoside selectively reverse mitochondrial function and cell apoptosis, yet there is no effect on mitochondrial morphology. (jcimjournal.com)
  • An exhibition featuring revolving sets of seven original illustrations of famed scientist/artist Santiago Ramón y Cajal (on loan from the Instituto Cajal in Madrid, Spain), may be found near the North Entrance, on the first floor, of Building 35 on the NIH Campus. (nih.gov)
  • The KIT and PDGFRA genes provide instructions for making receptor proteins that are found in the cell membrane of certain cell types. (medlineplus.gov)
  • In the 3-day-old chick embryo, quail crest cells can be first found in the proventricule and the gizzard. (nii.ac.jp)
  • An unusual and relatively less aggressive form of sarcoma that shows features of both fibroblasts and cells that retain fat (xanthomas). (sarctrials.org)
  • These signaling pathways control many important cellular processes, such as cell growth and division (proliferation) and survival. (medlineplus.gov)
  • The SDH enzyme is involved in cellular pathways that are critical for converting the energy from food into a form that cells can use. (medlineplus.gov)
  • However, stable fBB 4 -R cell lines were obtained in CHO-K1 cells which were shown to faithfully demonstrate the correct pharmacology of the related Bn receptor, the GRP receptor, when expressed in these cells. (acs.org)
  • Cell cycle kinetics of rat hepatocytes in early putative preneoplastic lesions in hepatocarcinogenesis. (mcmaster.ca)
  • Is the positive c-kit immunostaining associated with the presence of cells analogous to the intersticial cells of Cajal in the ciliary muscle? (scielo.br)
  • RESULTS: We observed some groups of fusiform c-kit expressing cells located amongst muscle bundles of the ciliary muscle. (scielo.br)
  • CONCLUSION: C-kit expressing cells observed in the ciliary muscle of Cebus apella, showed no similarity to melanocytes or mast cells and they could be associated with their gastrointestinal interstitial cells of Cajal counterpart. (scielo.br)
  • Other pigment cells and mast cells were also observed. (scielo.br)
  • Intramuscular Interstitial cells of Cajal (ICC-IM) are involved in mediating responses to neurotransmission. (wikipedia.org)
  • Santiago Ramón y Cajal, a Spanish physician and scientist, was the first to describe the structure of the nervous system with exquisite precision. (nih.gov)
  • A diverse team of cells in the nervous system work in concert to produce all your thoughts, emotions, and abilities. (brainfacts.org)
  • Modern studies have shown, however, that the inferior colliculus actually processes nearly all the input sent to the medial geniculate body and receives signals from the descending auditory pathway, as well as providing the motor integration necessary for auditory reflexes hypothesized by Cajal, making it a true hub for auditory signaling. (nih.gov)
  • Further studies, using quail-chick chimaeras system are in progress to verify the origin and the development of the interstitial cells. (nii.ac.jp)
  • Dysplasia describes an area within a polyp or the lining of the large intestine where the cells look abnormal but don't look like true cancer cells. (uchealth.org)
  • Different from pre-cDCs, tDCs have less turnover, capture antigen, respond to stimuli and activate antigen-specific naive T cells, all characteristics of differentiated DCs. (stanford.edu)