• species
  • Among these proteins 27 had not been described before and 15 were identified in the newly sequenced species. (nih.gov)
  • Within a species, the vast majority of nucleotides are identical between individuals, but sequencing multiple individuals is necessary to understand the genetic diversity. (wikipedia.org)
  • RNAs
  • For example, the RNA interference (RNAi) mechanism of small interfering RNAs derived from L1 sequences can cause suppression of L1 retrotransposition. (wikipedia.org)
  • insertion
  • Insertion of an interspersed DNA element breaks this linkage, allowing independent evolution of a new gene. (wikipedia.org)
  • Because insertion of an interspersed repeat is a saltatory event the evolution of the new gene will also be saltatory. (wikipedia.org)
  • Initial studies into lncRNA conservation noted that as a class, they were enriched for conserved sequence elements, depleted in substitution and insertion/deletion rates and depleted in rare frequency variants, indicative of purifying selection maintaining lncRNA function. (wikipedia.org)
  • Comparisons of LINE DNA sequences can be used to date transposon insertion in the genome. (wikipedia.org)
  • Genetic
  • Severe hypomethylation of Sat2 sequences is associated with copy number alterations of the adjacent euchromatin, suggesting that hypomethylation may be one factor predisposing to specific genetic alterations commonly occurring in GBMs. (aacrjournals.org)
  • similarity
  • There have been several attempts to delineate the different categories of selection signatures seen amongst lncRNAs including: lncRNAs with strong sequence conservation across the entire length of the gene, lncRNAs in which only a portion of the transcript (e.g. 5' end, splice sites) is conserved, and lncRNAs that are transcribed from syntenic regions of the genome but have no recognizable sequence similarity. (wikipedia.org)
  • typically
  • A microsatellite is a tract of repetitive DNA in which certain DNA motifs (ranging in length from 1-6 or more base pairs) are repeated, typically 5-50 times. (wikipedia.org)
  • Multigene families typically consist of members with similar sequences and functions, though a high degree of divergence (at the sequence and/or functional level) does not lead to the removal of a gene from a gene family. (wikipedia.org)
  • Melody notes are interspersed among arpeggios, and musical phrases typically contain long series of staccato notes, often played at very rapid tempos. (wikipedia.org)
  • Transcription
  • However, further investigations into vertebrate lncRNAs revealed that while lncRNAs are conserved in sequence, they are not conserved in transcription. (wikipedia.org)
  • While the turnover of lncRNA transcription is much higher than initially expected, it is important to note that still, hundreds of lncRNAs are conserved at the sequence level. (wikipedia.org)
  • cDNA
  • Though its DNA sequence is similar to the cDNA product of the actual HK2 mRNA transcript, it lacks an open reading frame for gene expression. (wikipedia.org)
  • coli
  • Here, Brosius began to develop plasmid vectors for the selection of promoters and terminators, as well as widely used vectors for the high-level expression of recombinant proteins in E. coli, often employing regulatory sequences or modules from the rRNA operon. (wikipedia.org)
  • Among the thousands of completed genome sequencing projects include those for rice, a mouse, the plant Arabidopsis thaliana, the puffer fish, and the bacteria E. coli. (wikipedia.org)
  • Human DNA
  • By using special Alu sequence as target locus, specific human DNA can be obtained from clone of TAC, BAC, PAC or human-mouse cell hybrid. (wikipedia.org)
  • longer
  • The shorter Alu or SINE repetitive DNA are specialized for uncoupling intrachromosomal gene conversion while the longer LINE repetitive DNA are specialized for uncoupling interchromosomal gene conversion. (wikipedia.org)
  • Since fragment of DNA can be inserted into sequences, if an exon is inserted into intron, the transcript will be longer than usual and this transcript can be trapped by analysis. (wikipedia.org)
  • Due to the accumulation of random mutations, the sequence of many LINES has degenerated to the extent that they are no longer transcribed or translated. (wikipedia.org)
  • among
  • The fingerprint map is a high-resolution integrative data resource that provides genome-ordered associations among BAC, YAC, and PAC clones and the assembled sequence of the rat genome. (wustl.edu)
  • types
  • The GSS division contains (but is not limited to) the following types of data: Random "single pass read" genome survey sequences is GSSs that generated along single pass read by random selection. (wikipedia.org)
  • example
  • For example, the sequence TATATATATA is a dinucleotide microsatellite, and GTCGTCGTCGTCGTC is a trinucleotide microsatellite (with A being Adenine, G Guanine, C Cytosine, and T Thymine). (wikipedia.org)