CytokinesReceptorsAntibodiesRecombinantPleiotropicAtherosclerosisInhibitory FactorCytokine producedInflammationEncodesSubunitReceptor alphaAntigenMiceInhibitorsLymphocyteSerumHeterodimerExpressionHumansPatientsProteinsDeficiencyInvolvementHumanProliferationEfficacyAsthmaCombinesMoleculeBetaTissueLevelsDevelopmentFamilyFound
Cytokines9
- Interleukins (ILs) are a group of cytokines (secreted proteins and signal molecules) that are expressed and secreted by white blood cells (leukocytes) as well as some other body cells. (wikipedia.org)
- Some interleukins are classified as lymphokines, lymphocyte-produced cytokines that mediate immune responses. (wikipedia.org)
- Interleukin 1 alpha and interleukin 1 beta (IL1 alpha and IL1 beta) are cytokines that participate in the regulation of immune responses, inflammatory reactions, and hematopoiesis. (wikipedia.org)
- Interleukins are a group of cytokines (secreted signaling molecules) that were first seen to be expressed by white blood cells ( leukocytes , hence the -leukin ) as a means of communication ( inter- ). (wikidoc.org)
- Other cytokines that signal through receptors containing gp130 are Interleukin-11 (IL-11), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine (CLC), leukemia inhibitory factor (LIF), oncostatin M (OSM), Kaposi's sarcoma associated herpes virus interleukin 6 like protein (KSHV-IL6). (dadamo.com)
- Thus, the expression of proinflammatory interleukins and their receptors has been demonstrated in atheromatous tissue, and the serum levels of several of these cytokines have been found to be positively correlated with (coronary) arterial disease and its sequelae. (aspetjournals.org)
- The interleukin-1 (IL-1) family is a growing group of cytokines, consisting of at least 11 members, and the balance between pro- and anti-inflammatory cytokines is crucial in the pathogenesis of many human diseases ( 3 ). (frontiersin.org)
- 1: In the haematopoietic microenvironment, bone marrow stromal cells play an important role in regulating haematopoiesis by expressing various cytokines, including leukaemia inhibitory factor (LIF) and interleukin-6 (IL-6). (unboundmedicine.com)
- Using three distinct assay systems, we evaluated the secretion of three different cytokines, including interferon gamma (IFN-gamma), tumor necrosis factor alpha (TNF-alpha), and interleukin 8 (IL-8). (cdc.gov)
Receptors2
- Interleukin receptors on astrocytes in the hippocampus are also known to be involved in the development of spatial memories in mice. (wikipedia.org)
- However, when mice with this genetic deletion have wild-type neural precursor cells injected into their hippocampus and these cells are allowed to mature into astrocytes containing the interleukin-1 receptors, the mice exhibit normal hippocampal-dependent memory function, and partial restoration of long-term potentiation. (wikipedia.org)
Antibodies1
- Several approaches have produced promising results in this respect, including the transfer of anti-inflammatory interleukins and the administration of decoys and antibodies directed against proinflammatory interleukins. (aspetjournals.org)
Recombinant4
- Recombinant expression enables cells to process precursor Interleukin 1 Beta to the mature form of the enzyme. (wikipedia.org)
- WB.Recombinant Interleukin 7 (IL7) is Available at Gentaur Genprice with the fastest. (proteomecommons.org)
- WB.Recombinant Interleukin 1 Beta (IL1b) is Available at Gentaur Genprice with. (proteomecommons.org)
- WB.Recombinant Interleukin 1 Alpha (IL1a) is Available at Gentaur Genprice with. (proteomecommons.org)
Pleiotropic4
- Interleukin-13 is a pleiotropic TH2 cytokine that has been shown to be central to the pathogenesis of asthma. (nih.gov)
- The chronic nature of the disease and the generally pleiotropic effects of interleukins, however, will demand high specificity of action and/or effective targeting to prevent the emergence of adverse side effects with such treatments. (aspetjournals.org)
- Recent evidence indicated that interleukin (IL)-27 showed pleiotropic properties in immune diseases. (hindawi.com)
- Interleukin-6 (IL-6) is a multifunctional cytokine that regulates pleiotropic roles in immune regulation, inflammation, hematopoiesis, and oncogenesis. (sbhsciences.com)
Atherosclerosis3
- Interleukins are considered to be key players in the chronic vascular inflammatory response that is typical of atherosclerosis. (aspetjournals.org)
- As the roles of individual interleukins in atherosclerosis are being uncovered, novel anti-atherogenic therapies, aimed at the modulation of interleukin function, are being explored. (aspetjournals.org)
- Interleukin (IL)-β plays a central role in inflammation and atherosclerosis, but levels of IL-1β, its natural antagonist, IL-1Ra, and their balance in human atherosclerotic lesions, are unknown. (go.jp)
Inhibitory Factor1
- TY - JOUR T1 - Role of mitogen-activated protein kinase family in serum-induced leukaemia inhibitory factor and interleukin-6 secretion by bone marrow stromal cells. (unboundmedicine.com)
Cytokine produced1
- Interleukin (IL)-10 is an important immunoregulatory cytokine produced by many cell populations. (wjgnet.com)
Inflammation1
- Interleukin-6 (IL-6) is a pro-inflammatory cytokine secreted by T cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. (dadamo.com)
Encodes2
- The human genome encodes more than 50 interleukins and related proteins. (wikipedia.org)
- This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. (nih.gov)
Subunit6
- Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. (nih.gov)
- Interleukin-5 Receptor alpha Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
- A low affinity interleukin-5 receptor subunit that combines with the CYTOKINE RECEPTOR COMMON BETA SUBUNIT to form a high affinity receptor for INTERLEUKIN-5. (harvard.edu)
- Several isoforms of the interleukin-5 receptor alpha subunit exist due to multiple ALTERNATIVE SPLICING. (harvard.edu)
- This graph shows the total number of publications written about "Interleukin-5 Receptor alpha Subunit" by people in Harvard Catalyst Profiles by year, and whether "Interleukin-5 Receptor alpha Subunit" was a major or minor topic of these publication. (harvard.edu)
- Below are the most recent publications written about "Interleukin-5 Receptor alpha Subunit" by people in Profiles. (harvard.edu)
Receptor alpha1
- Characterization of a novel nonsense mutation in the interleukin-7 receptor alpha gene in a Korean patient with severe combined immunodeficiency. (lu.se)
Antigen1
- These factors, which include interleukin 2 (IL2), are secreted by lectin- or antigen-stimulated T cells, and have various physiological effects. (wikipedia.org)
Mice1
- Furthermore, studies in mice deficient or transgenic for specific interleukins have demonstrated that, whereas some interleukins are indeed intrinsically pro-atherogenic, others may have anti-atherogenic qualities. (aspetjournals.org)
Inhibitors1
- The aim of this study was to systemically review the efficacy and safety of inhibitors of interleukin 6 (IL-6): clazakizumab, IL-12/23: ustekinumab, and IL-17A: secukinumab, brodalumab, and ixekizumab in psoriatic arthritis (PsA). (medscape.com)
Lymphocyte2
- The name "interleukin" was chosen in 1979, to replace the various different names used by different research groups to designate interleukin 1 (lymphocyte activating factor, mitogenic protein, T-cell replacing factor III, B-cell activating factor, B-cell differentiation factor, and "Heidikine") and interleukin 2 (TSF, etc. (wikipedia.org)
- White blood cell, eosinophil, CD4- and CD8-positive lymphocyte counts, and serum interleukin-5 (IL-5) and IgE levels were determined before, 2 and 4 weeks after switching to vitamin E-bonded dialyzers. (dadamo.com)
Serum1
- Circadian rhythm of serum interleukin-6 in rheumatoid arthritis. (bmj.com)
Heterodimer1
- Interleukin-17AF Heterodimer, 5 ug Orig. (bioconcept.ch)
Expression2
- Hill T, Krougly O, Nikoopour E, Bellemore S, Lee-Chan E, Fouser LA, Hill DJ and Singh B. The involvement of Interleukin-22 in the expression of Pancreatic Beta cell Regenerating REG genes. (bepress.com)
- Also, Interleukin-4 antagonizes the activity of interleukin-1 by inducing the expression and release of this protein. (prospecbio.com)
Humans1
- Interleukin-33 (IL-33) is an important member of the IL-1 family, and in humans is expressed predominantly in skin, lung, adipocytes, and synovial fibroblasts ( 4 ). (frontiersin.org)
Patients4
- 1. Makino T, Noguchi Y, Yoshikawa T, Doi C, Nomura K. Circulating interleukin 6 concentrations and insulin resistance in patients with cancer. (dadamo.com)
- OBJECTIVES: I. Determine the maximum tolerated dose of interleukin-12 (IL-12) in patients with AIDS-associated Kaposi's sarcoma. (knowcancer.com)
- Patients receive interleukin-12 (IL-12) subcutaneously twice a week (at least 3 days apart) for 6 months. (knowcancer.com)
- Placebo effects on all-cause mortality of patients with COVID-19 in randomized controlled trials of interleukin 6 antagonists: A systematic review and network meta-analysis. (bvsalud.org)
Proteins1
- Interleukin-1 receptor accessory protein (IL-1RAcP) is a member of the immunoglobulin superfamily proteins consisting of soluble and membranous isoforms. (lu.se)
Deficiency2
- The function of the immune system primarily depends on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. (wikipedia.org)
- A partial deficiency of interleukin-7R alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency. (lu.se)
Involvement1
- In vitro studies have confirmed the involvement of various interleukins in pro-atherogenic processes, such as the up-regulation of adhesion molecules on endothelial cells, the activation of macrophages, and smooth muscle cell proliferation. (aspetjournals.org)
Human1
- Synthesis and release of interleukin 1 by reoxygenated human mononuclear phagocytes. (jci.org)
Proliferation2
- Numerous reports suggest that interleukin-6 (IL-6) promotes survival and proliferation of tumor cells through the phosphorylation of a cell-signaling protein, signal-transducer-and-activator-of-transcription-3 (STAT3). (greenmedinfo.com)
- Interleukin-1b is produced by activated macrophages, IL-1B stimulates thymocyte proliferation by inducing il-2 release, b-cell maturation and proliferation, and fibroblast growth factor activity. (prospecbio.com)
Efficacy1
- This network meta-analysis (NMA) aimed to identify the source of these inconsistent results by reassessing whether participants treated with standard of care (SoC) plus placebo have different all-cause mortality from those treated with SoC alone and to reevaluate the efficacy of interleukin 6 antagonists in the treatment of COVID-19. (bvsalud.org)
Asthma1
- Title : Interleukin (IL)-33 Immunobiology in Asthma and Airway Inflammatory Diseases Personal Author(s) : Gaurav, Rohit;Poole, Jill A. (cdc.gov)
Combines1
- Interleukin-10 combines with itself to form a homodimeric molecule that is the biologically active form of the protein. (curehunter.com)
Molecule1
- Molecular cloning of the Interleukin 1 Beta converting enzyme is generated by the proteolytic cleavage of an inactive precursor molecule. (wikipedia.org)
Beta1
- In this study production levels of interleukins (IL)-12 and IL-13 were measured by commercial ELISA in culture supernatants of mitogen-stimulated peripheral blood mononuclear cells from 30 non-splenectomized beta-thalassaemia cases with iron overload and 20 age- and sex-matched healthy individuals. (who.int)
Tissue1
- OBJECTIVES--To test the hypothesis of a diurnal variation in circulating levels of interleukin-6 (IL-6) and/or tumour necrosis factor-alpha (TNF-alpha) in rheumatoid arthritis and other inflammatory connective tissue diseases. (bmj.com)
Levels1
- This test is used to identify elevated levels of interleukin 6 (IL-6). (lifeextension.com)
Development1
- This may prove to be the real challenge for the development of interleukin-based anti-atherosclerotic therapies, once the mediators and their targets have been delineated. (aspetjournals.org)
Family2
- Interleukin-33 (IL-33) is a recently identified cytokine, an important member of the interleukin-1 family. (frontiersin.org)
- IL1R2 is a cytokine receptor which is a part of the interleukin-1 receptor family. (prospecbio.com)
Found3
- it has since been found that interleukins are produced by a wide variety of body cells. (wikipedia.org)
- We found that interleukin (IL)-10, a pain resolving cytokine, is persistently produced by resident macrophages in the spinal meninges during remission from pain. (iasp-pain.org)
- She was later found to be homozygous for the interleukin-10 (IL-10)-1082A SNP. (bmj.com)