Interleukin 7 receptor alpha subunit. Medical search. Frequent questions

Interleukin-7 receptor (IL7R) ,is a hematopoietin receptor superfamily member. (prospecbio.com)

A low affinity interleukin-5 receptor subunit that combines with the CYTOKINE RECEPTOR COMMON BETA SUBUNIT to form a high affinity receptor for INTERLEUKIN-5. (harvard.edu)
At the C-terminal region of the cell membrane, a conserved sequence called SEFIR defines the IL-17R family as a novel cytokine receptor family. (betalifesci.com)
Interleukin 22 binding protein (IL-22BP), also known as CRF2-10, CRF2-X, and IL-22 RA2, is a 35-45 kDa secreted glycoprotein in the type II cytokine receptor family (CRF). (rndsystems.com)
Mature mouse LIF R alpha consists of a 785 amino acid (aa) extracellular domain (ECD) with two cytokine receptor homology domains, one WSxWS motif, and three fibronectin type III repeats, followed by a 25 aa transmembrane segment and a 239 aa cytoplasmic domain (2, 3). (rndsystems.com)

integrin subunit alpha 2b [Source:H. (gsea-msigdb.org)
integrin subunit alpha 4 [Sou. (gsea-msigdb.org)
integrin subunit alpha M [Sou. (gsea-msigdb.org)

ataxin 7 like 3B [Source:HGNC Symbo. (gsea-msigdb.org)
choline kinase alpha [Source:HGNC S. (gsea-msigdb.org)
EPH receptor B6 [Source:HGNC Symbol. (gsea-msigdb.org)
interleukin 7 receptor [Source:HGNC. (gsea-msigdb.org)
alkB homolog 7 [Source:HGNC S. (gsea-msigdb.org)

IL20RA, along with the IL-20 receptor, beta subunit, form the heterodimeric interleukin-20 receptor, which binds the cytokines IL-19, IL-20 and IL-24. (wikipedia.org)
Unlike many other cytokines that act on lymphocytes, IL-7 production by stromal cells is not substantially affected by extrinsic stimuli. (medchemexpress.com)
IL-7RA (also known as CD127) is a type 1 membrane glycoprotein folded to bind and mediate the action of IL7 and other alpha helical cytokines. (medchemexpress.com)
IL-17 cytokines, receptors and signaling. (betalifesci.com)
Meanwhile, cytokines like tumor necrosis factor alpha (TNF-α), interleukin 1-beta (IL-1b), and interleukin 6 (IL-6) show increased concentration in the serum and cerebrospinal fluid of PD patients [ 7 ]. (biomedcentral.com)
Its biological activities are shared by IL-6-family of cytokines such as leukemia inhibitory factor and oncostatin M. IL-6 exerts its biological activities through interaction with specific receptors expressed on the surface of target cells. (sbhsciences.com)

This type of activation, called "trans-signalling", renders virtually all cells capable of responding to IL-6/sIL-6R alpha complexes, making for a large new spectrum of IL-6 activities, ranging from the control of the immune response to involvement in pathological states. (sbhsciences.com)
Complement and complement receptors play a critical role in immune defense by initiating the rapid destruction of invading microorganisms, amplifying the innate and adaptive immune responses, and mediating solubilization and clearance of immune complexes. (medscape.com)
The CR1 receptor preferentially binds C3b that is covalently attached to immune complexes, and it has a weaker affinity for bound C4b and iC3b. (medscape.com)
IL-10 R beta is also a component of the receptor complexes for IL-10, IL-26, IL-28, and IL-29 (1, 2). (rndsystems.com)
gp130 associates with different ligand-specific receptors to form signaling receptor complexes for the other IL-6 family ligands (1). (rndsystems.com)

The IL20RA receptor is involved in both pro-inflammatory and anti-inflammatory responses, signaling through the JAK-STAT pathway. (wikipedia.org)
Receptors made up of IL20RA signal through a JAK-STAT signaling pathway. (wikipedia.org)
Furthermore, IL-17 family members exhibit binding affinity towards specific receptors, triggering downstream signaling pathways that regulate immune cell functions and immune responses. (betalifesci.com)
In our previous studies in vivo , we have found that the Fc receptors appear to have a key role in α-SYN-induced inflammation: deficiency of FcγRs blocks α-SYN-induced NF-κB-driven pro-inflammatory signaling, and attenuates microglial activation and DA neurodegeneration [ 15 ]. (biomedcentral.com)
Subunits (alpha, beta and gamma) of the interleukin-2 receptor complex (IL-2R) are involved in both proliferative and activation-induced cell death (AICD) signaling of T cells. (unideb.hu)
However, the molecular mechanisms responsible for recruiting/sorting the alpha chains to the signaling chains at the cell surface are not clear. (unideb.hu)
Peptides #7 and #2 were identified as having the strongest inhibitory activity on the IL-23 signaling pathway. (rowan.edu)
Included under this heading are signaling receptors, non-signaling receptors and accessory proteins required for receptor signaling. (edu.au)

In 1995, the receptor (IL-17R) for IL-17 proteins was discovered, and the receptor family consists of five members designated as IL-17RA to IL-17RE. (betalifesci.com)
We also have observed that Fcγ receptors (FcγR), proteins present on the surface of microglia that bind immunoglobulin G (IgG) and other ligands, are key modulators of α-SYN-induced neurodegeneration. (biomedcentral.com)
Fc gamma receptors (FcγR) are proteins expressed on the surface of microglia as well as other cell types, including natural killer cells, neutrophils, and mast cells. (biomedcentral.com)
Effector proteins interacting with the Fc portion of immunoglobulin M (IgM) include complement and complement receptors. (medscape.com)
Partial or complete deficiencies of the components of the complement system, including its receptors and regulatory proteins, are now described in humans and may be of a genetic or familial origin or acquired. (medscape.com)
Defects in the expression of complement or complement receptors may result in loss of tolerance to self-proteins and the development of immune complex-mediated autoimmune diseases such as systemic lupus erythematosus (SLE). (medscape.com)
G-proteins are key elements of these pathways in the regulation of cellular responses by transmission of signals from receptors to effector proteins. (neurotransmitter.net)

A CD8-positive, alpha-beta T cell that has not experienced activation via antigen contact and has the phenotype CD45RA-positive, CCR7-positive and CD127-positive. (ontobee.org)
Finally, some are engineering chimeric antigen receptor (CAR) T-cell systems that attack solid tumors and overcome the harsh barriers of the tumor microenvironment (TME). (genengnews.com)

The type I receptor for IL-4, which is expressed on hematopoietic cells, is a heterodimer of the ligand binding IL-4 R alpha and the common gamma chain (a shared subunit of the receptors for IL-2, -7, -9, -15, and -21). (bio-techne.com)

C-C motif chemokine receptor 7 [Sou. (gsea-msigdb.org)
C-X-C motif chemokine receptor 4 [S. (gsea-msigdb.org)

IL20RA also forms a complex with the IL-10 receptor, beta subunit, which binds the cytokine IL-26. (wikipedia.org)
In this pathway, after a cytokine binds IL20RA and the beta subunit, JAKs linked to intracellular domains of IL20R activate and phosphorylate tyrosine residues found in the longer alpha chains of IL20RA. (wikipedia.org)
LIF R alpha binds the pleiotropic cytokine LIF with low affinity, and the soluble isoform retains LIF-binding activity (5). (rndsystems.com)
The p40 is also part of IL-12 and binds to the IL-12 receptor beta 1 (IL-12Rβ1) subunit. (rowan.edu)

IL4R is the common ligand binding subunit shared by the IL-4 receptors type I (receptor for IL-4) and type II (receptor for IL-4 and IL-13). (guidetomalariapharmacology.org)
IL-17R is a transmembrane protein with two fibronectin III-like domains (FN domains) located outside the cell membrane, responsible for mediating ligand-receptor binding. (betalifesci.com)
Binding affinity is increased by the ligand-induced association of LIF R alpha with the signal transducing subunit gp130 (6, 7). (rndsystems.com)

The receptors are widely expressed in humans. (medscape.com)

Thus, it follows that the IL-23 receptor is comprised of the IL-12Rβ1 and IL-23 receptor alpha (IL23Rα) subunits. (rowan.edu)

We studied the expression of the IL-5 receptor alpha-subunit (IL-5R alpha) on bone marrow-derived cluster of differentiation molecule 34 positive (CD34+) progenitor cells in asthmatics to prove the ability of progenitor cells to respond to IL-5 more readily. (tmu.edu.tw)

PM 2.5 increased the mRNA and protein expression of M1 markers including interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α) and inducible nitric oxide synthase (iNOS) in RAW264.7 cells. (medsci.org)

Complement receptors have only been identified in the last 2 decades. (medscape.com)
Four distinct complement receptors, CR1, CR2, CR3, and CR4, have been described for the surface-bound complement fraction C3 and its cleavage fragments. (medscape.com)

IL-23 is a heterodimeric protein, composed of a p19 alpha chain and a p40 beta chain. (rowan.edu)

In direct ELISAs, no cross-reactivity with recombinant human LIF R alpha is observed. (rndsystems.com)

Interleukin-7 (IL-7) is produced by stromal cells in lymphoid tissues and is required for the development of T cells and for their persistence in the periphery. (medchemexpress.com)

IL-6 Receptor (IL-6R, gp80) is 80 kDa alpha subunit, transmembrane glycoprotein that is 449 aa long. (sbhsciences.com)
Leukemia Inhibitory Factor Receptor alpha (LIF R alpha ), also known as LIFR beta (due to its participation in signal transduction) and CD118, is a 190 kDa type I transmembrane protein in the Interleukin-6 receptor family. (rndsystems.com)

Upon binding of IL-6 to the receptor (alpha subunit), gp130 is homodimerized and is subsequently involved in down-stream signal processes binding tyrosine kinases and activating STAT1 and STAT3 transcriptional factors. (sbhsciences.com)
Interestingly, the association of IL-6 with the soluble form of IL-6R alpha is capable of eliciting a biological response in cells that express only the membrane gp130. (sbhsciences.com)
The LIF R alpha /gp130 receptor complex also transduces Oncostatin M signals, although LIF R alpha alone does not interact with Oncostatin M (6). (rndsystems.com)
The CNTF receptor is a ternary complex that contains CNTF R alpha and gp130 as well as LIF R alpha (8, 9). (rndsystems.com)

The type II receptor on nonhematopoietic cells consists of IL-4 R alpha and IL-13 R alpha 1. (bio-techne.com)

The aim of the present study was to test a possible effect of the G-protein beta3-subunit (Gbeta3) C825T gene variant on the antidepressant activity of selective serotonin reuptake inhibitors (SSRIs) in a sample of major and bipolar depressives, with or without psychotic features. (neurotransmitter.net)

Regulation of myelopoiesis through syntenin-mediated modulation of IL-5 receptor output. (harvard.edu)
Interleukin-6 (IL-6) is a multifunctional cytokine that regulates pleiotropic roles in immune regulation, inflammation, hematopoiesis, and oncogenesis. (sbhsciences.com)
The complement system, interacting with its regulatory molecules and cellular receptors, plays a central role in the induction and regulation of immunity. (medscape.com)
The purinergic P2X 7 receptor: regulation of uterine function in labour and preterm labour. (nottingham.ac.uk)
Glucagon is secreted by PANCREATIC ALPHA CELLS and plays an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes. (edu.au)

PE-Cy5 tandem fluorochromes have been reported to bind some classes of human macrophages and granulocytes via Fc receptors, and PE has been reported to bind to mouse B lymphocytes via Fc receptors. (bdbiosciences.com)
Receptors present on activated T-LYMPHOCYTES and B-LYMPHOCYTES that are specific for INTERLEUKIN-2 and play an important role in LYMPHOCYTE ACTIVATION. (edu.au)

CR1 and CR2 have been shown to influence the immune environment in a B-cell receptor-independent manner. (medscape.com)

Initial clinical studies indicate the levels of sIL-6R, the alpha subunit, in the serum of patients with various diseases as summarized in table1. (sbhsciences.com)

The type II receptor also transduces IL-13 mediated signals. (bio-techne.com)

This subunit is the molecular target of the investigational monoclonal antibody dupilumab, that is in clinical trial as a therapy for atopic allergic conditions and nasal polyposis. (guidetomalariapharmacology.org)
METHODS: Non-adherent non-T cells (NANT) were separated from heparinized bone marrow blood from 6 asthmatics and 3 normal subjects, loaded with CD34+ and IL-5R alpha monoclonal antibodies conjugated with immunofluorescence and then analyzed by flow cytometry. (tmu.edu.tw)

IL-22 signals through a receptor complex consisting of IL-22 R and IL-10 R beta. (rndsystems.com)

LIF R alpha is widely expressed, and LIF induces the proliferation, differentiation, and activation of cells in many tissues (10, 11). (rndsystems.com)

Alternative splicing generates a 90 kDa soluble form of the mouse LIF R alpha ECD (4). (rndsystems.com)

A recently identified polymorphism of a G-protein beta3 subunit (C825T) has been shown to be associated with increased signal transduction and ion transport activity. (neurotransmitter.net)
Association between a G-protein beta3 subunit gene polymorphism and the symptomatology and treatment responses of major depressive disorders. (neurotransmitter.net)

Mice with C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cells. (medscape.com)
Because of their high numbers, red blood cells express an average of 90% of the CR1 receptors despite their having a lower number of antigenic sites per cell. (medscape.com)
Among healthy individuals, the number of CR1 receptors on the red blood cells varies widely, yet the phenotypic expression, regulated by 2 codominant alleles, is stable. (medscape.com)
IL-18 acts in synergy with IL-7 to promote ex vivo expansion of T lymphoid progenitor cells. (ouhsc.edu)
The cytokine interleukin-23 (IL-23) plays an essential role in the expansion of pathogenic Th17 cells. (rowan.edu)
Upregulation of IL-5 receptor expression on bone marrow-derived CD34+ cells from patients with asthma. (tmu.edu.tw)
Colonies grown from progenitor cells cultured in methylcellulose were determined for 14 days in the presence or absence of growth factors, including granulocyte-monocyte colony stimulating factor, stem cell factor, and interleukin-3. (tmu.edu.tw)
CONCLUSION: We demonstrated an increased expression of IL-5R alpha on bone marrow-derived progenitor cells in asthmatics. (tmu.edu.tw)
Dive into the research topics of 'Upregulation of IL-5 receptor expression on bone marrow-derived CD34+ cells from patients with asthma. (tmu.edu.tw)
IL-4 (Interleukin-4) is a cytokine that is primarily expressed by Th2-biased CD4 + T cells, mast cells, basophils, and eosinophils. (bio-techne.com)

IL20RA is an alpha-chain with a long intracellular domain. (wikipedia.org)

Impaired thymopoiesis in interleukin-7 receptor transgenic mice is not corrected by Bcl-2. (ouhsc.edu)

New research in therapeutics for autoimmune disease is attempting to inhibit IL-23 from binding to its receptor. (rowan.edu)

Here we show, in four cell lines of human adult T cell lymphoma/leukemia origin, that the three IL-2R subunits are compartmented together with HLA glycoproteins and CD48 molecules in the plasma membrane, by means of fluorescence resonance energy transfer (FRET), confocal microscopy and immuno-biochemical techniques. (unideb.hu)
Differential IL-7 responses in developing human thymocytes. (ouhsc.edu)
Within the ECD, mouse LIF R alpha shares 73% and 90% aa sequence identity with human and rat LIF R alpha, respectively. (rndsystems.com)
Cellular receptors that bind the human immunodeficiency virus that causes AIDS. (edu.au)

GABA type A receptor associated pro. (gsea-msigdb.org)
GABA type A receptor associat. (gsea-msigdb.org)
The density of CR1 receptors on cell surfaces varies with the cell type and with the activation of the cell for neutrophils and monocytes. (medscape.com)

The mitogen-activated protein kinase homolog, WNK lysine deficient protein kinase 1 (WNK1), is activated downstream of epidermal growth factor receptor during decidualization. (bioone.org)

C9orf72-SMCR8 complex subunit. (gsea-msigdb.org)
The glucocorticoid receptor-glucocorticoid complex acts in the nucleus to induce transcription of DNA. (edu.au)

RESULTS: The proportion of IL-5R alpha expression on the CD34+ cell surface was significantly increased in asthmatics (12.9 +/- 3.3%, n = 6, p = 0.0163) compared to normal subjects (1.8 +/- 0.6%, n = 3). (tmu.edu.tw)
A family of structurally-related cell-surface receptors that signal through an intrinsic PROTEIN-TYROSINE KINASE. (edu.au)
Cell surface receptors that are specific for INTERLEUKIN-1. (edu.au)

Thymocytes between the beta-selection and positive selection checkpoints are nonresponsive to IL-7 as assessed by STAT-5 phosphorylation. (ouhsc.edu)

BACKGROUND: Interleukin-5 (IL-5) is a potent eosinophilopoietic factor implicated in the chronic inflammatory cell accumulation accompanying bronchial asthma. (tmu.edu.tw)
The results of this study suggest that the investigated G-protein beta3 subunit seems to be a susceptibility factor for major depression and maybe even for bipolar disorder, but not for schizophrenia. (neurotransmitter.net)

The mechanisms by which isocyanates cause asthma remain unclear, hampering disease prevention, diagnosis, and treatment.7 It is assumed the reactive nature of N=C=O groups underlies isocyanate asthma, with a hapten-based mechanism as the most obvious pathway to pathogenesis.8 However, the critical "self" reaction targets for isocyanate in vivo remain uncertain. (cdc.gov)

Anatomy18

Organisms14

Diseases4

Chemicals and Drugs146

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Phenomena and Processes51

Disciplines and Occupations1

Information Science3

IL7R1

Cytokine-receptor4

Integrin subunit alpha3

Source:HGNC5

Cytokines6

Complexes5

Signaling8

Proteins7

Antigen2

Gamma1

Chemokine2

Binds4

Ligand3

Humans1

IL23R1

Molecule1

Tumor necro1

Complement receptors2

Heterodimeric1

Reactivity1

Stromal cells1

Transmembrane2

Gp1304

Consists1

Inhibitors1

Regulation5

Lymphocytes2

Immune1

Serum1

Transduces1

Monoclonal2

Signals1

Differentiation1

Soluble1

Polymorphism2

Cells10

Chain1

Mice1

Therapeutics1

Human4

Type3

Downstream1

Complex2

Cell Surface3

Beta1

Factor2

Asthma1