• chromosome
  • The IL-5 gene is located on chromosome 11 in the mouse, and chromosome 5 in humans, in close proximity to the genes encoding IL-3, IL-4, and granulocyte-macrophage colony-stimulating factor (GM-CSF), which are often co-expressed in TH2 cells. (wikipedia.org)
  • Genetic linkage gene mapping family studies localize the gene responsible for this disease to chromosome 5 at position q31-q33, between markers D5S642 and D5S816. (wikipedia.org)
  • In humans, IL-10 is encoded by the IL10 gene, which is located on chromosome 1 and comprises 5 exons, and is primarily produced by monocytes and, to a lesser extent, lymphocytes, namely type 2 T helper cells (TH2), mast cells, CD4+CD25+Foxp3+ regulatory T cells, and in a certain subset of activated T cells and B cells. (wikipedia.org)
  • cytokines
  • It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. (wikipedia.org)
  • These type 2 receptors have the ability to bind both IL-4 and IL-13, two cytokines with closely related biological functions. (wikipedia.org)
  • Further investigation has shown that IL-10 predominantly inhibits lipopolysaccharide (LPS) and bacterial product mediated induction of the pro-inflammatory cytokines TNFα, IL-1β, IL-12, and IFNγ secretion from Toll-Like Receptor (TLR) triggered myeloid lineage cells. (wikipedia.org)
  • binds
  • The alpha chain binds to IL5. (abcam.com)
  • Following IL-5 -induced hetero-dimerization, IL-5 receptor binds to multiple signal-transducing proteins, which include Janus kinase 1 ( JAK1 ) and 2 ( JAK2 ), v-yes-1 Yamaguchi sarcoma viral related oncogene homolog ( Lyn ), spleen tyrosine kinase ( Syk ) and SHC transforming protein 1 ( Shc ). (bio-rad.com)
  • It is the Ca2+-sensing subunit of the yeast phosphatidylinositol (PtdIns)-4-OH kinase, PIK1 It binds to many proteins, some in calcium dependent and some in calcium independent ways, and switches many of the targets "on" (some off). (wikipedia.org)
  • recombinant
  • Recombinant protein encompassing a sequence within the center region of human IL5 Receptor alpha. (genetex.com)
  • More specifically, PEGylated recombinant human IL-10 (PEG-rHuIL-10) has been shown to enhance CD8+ T cell secretion of the cytotoxic molecules Granzyme B and Perforin and potentiate T cell receptor dependent IFNγ secretion. (wikipedia.org)
  • ligand
  • The alpha and beta subunits are associated only in the presence of ligand. (bio-rad.com)
  • The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. (wikipedia.org)
  • colony-stimul
  • In fact, IL-5 was originally discovered as an eosinophil colony-stimulating factor, is a major regulator of eosinophil accumulation in tissues, and can modulate eosinophil behavior at every stage from maturation to survival. (wikipedia.org)
  • Interleukin 5 (colony-stimulating factor, eosinophil) ( IL-5 ) is produced by Th2 cells and mast cells after activation by mitogens or antigens [ 1 ]. (bio-rad.com)
  • 1997
  • 1997). "The IL-9 receptor gene, located in the Xq/Yq pseudoautosomal region, has an autosomal origin, escapes X inactivation and is expressed from the Y". Hum. (wikipedia.org)