• Further investigation has shown that IL-10 predominantly inhibits lipopolysaccharide (LPS) and bacterial product mediated induction of the pro-inflammatory cytokines TNFα, IL-1β, IL-12, and IFNγ secretion from Toll-Like Receptor (TLR) triggered myeloid lineage cells. (wikipedia.org)
  • IL-10 is capable of inhibiting synthesis of pro-inflammatory cytokines such as IFN-γ, IL-2, IL-3, TNFα and GM-CSF made by cells such as macrophages and Th1 T cells. (wikipedia.org)
  • IL-10 is linked to the myokines, as exercise provokes an increase in circulating levels of IL-1ra, IL-10, and sTNF-R, suggesting that physical exercise fosters an environment of anti-inflammatory cytokines. (wikipedia.org)
  • However, mutations in genes involved in cytokines synthesis like interleukin 10 (IL-10) appear to be strong predictors of cervical cancer risk (Zidi et al. (researchsquare.com)
  • In the present study, we investigated the effect of LPS on the releasing function of afferent terminals as measured by calcitonin gene-related peptide (CGRP) release in ex vivo perfused rat trachea, and examined the possible role of the cytokines interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) as intermediaries in this effect. (jneurosci.org)
  • Cytokines such as interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) can be generated by inflammatory and nonimmune cells in response to inflammation, tissue injury, microbial invasion, and immunological reactions ( Dinarello, 1994 ). (jneurosci.org)
  • Interleukin (IL)-12 and IL-23, cytokines induced during early stages of IBD, play important roles in differentiation of interferon (IFN)-γ/tumor necrosis factor (TNF)-producing Th1 cells as well as IL-17-producing Th17 cells. (frontiersin.org)
  • IL-10 is the founding member of a family of cytokines. (cusabio.com)
  • The over-expression of MMPs is induced by several cytokines, such as IL-1, TNF-alpha, IL-17, IL-10, and many others, which have been detected increased in OA cartilage. (biomedcentral.com)
  • The objective of the present study was to investigate the effect of poor living environmental conditions on mitogen-induced production of cytokines (Th1 and Th2) by peripheral blood leukocytes in children living in urban Brazil and investigate the role of IL-10 in modifying this effect. (nih.gov)
  • Our data showed that the proportion of children producing Th1 and Th2 cytokines was lower among those with poor living conditions and that this finding was stronger in children producing IL-10. (nih.gov)
  • Tregs produce cytokines, including TGF- β [ 8 ] and IL-10 [ 9 ], which can suppress the development and characteristics of atherosclerotic plaques. (hindawi.com)
  • Compared to WT mice, IL-10 −/− mice had exacerbated CIA development, which was associated with increased production of T helper 17 cell (Th17)/Th1 proinflammatory cytokines and CII-specific immunoglobulin G2a antibody after CII immunization. (biomedcentral.com)
  • Many of the immunosuppressive characteristics of IL-10 can be traced to their effects on macrophages and DCs by preventing the production of the T helper 1 cell (Th1)-associated cytokines IL-2 and interferon γ (IFN-γ). (biomedcentral.com)
  • The other profound effects of IL-10 are inhibition of the production of proinflammatory cytokines (IL-1, IL-6 and IL-12), inflammatory chemokines and matrix metalloproteases in macrophages [ 7 ]. (biomedcentral.com)
  • In humans, interleukin 10 is encoded by the IL10 gene. (wikipedia.org)
  • In humans, IL-10 is encoded by the IL10 gene, which is located on chromosome 1 and comprises 5 exons, and is primarily produced by monocytes and, to a lesser extent, lymphocytes, namely type-II T helper cells (TH2), mast cells, CD4+CD25+Foxp3+ regulatory T cells, and in a certain subset of activated T cells and B cells. (wikipedia.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Dog Interleukin 10 (IL10) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (2sars.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Dog Interleukin 10 (IL10) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (2sars.com)
  • The IL-10-conjugated PSL (PSL-IL10) showed high affinity for macrophages. (elsevierpure.com)
  • In obese mice, PSL-IL10 treatment exhibited significant anti-obesity and anti-inflammatory effects, such as reduced serum total cholesterol, adipocyte size, crown-like structures, proinflammatory cytokine secretion (IL-6 and tumor necrosis factor α) in adipose tissue, liver injury, hepatic steatosis, and inflammation foci, while treatment with IL-10 or PSL alone did not. (elsevierpure.com)
  • These findings suggest that the PSL-IL10 has macrophage targeting ability and enhanced anti-inflammatory effect due to the synergistic anti-inflammatory effects of IL-10 and PSL, and can be used as a macrophage-targeted therapeutic material for inflammation-related diseases, including obesity. (elsevierpure.com)
  • The role of IL-10 clearly exceeds the regulation of intestinal inflammation, as a function for this molecule has been also described in several other settings, from inflammatory or neurodegenerative diseases to infection or cancer. (cusabio.com)
  • Consideration of the role of IL-10 in the knee has now shifted from simply a key biomarker to having active therapeutic potential in the prevention of OA after ACL injury. (unimib.it)
  • IL-10 inhibits IL-17 and RORγt expression in macrophages and suppresses macrophages toward the proinflammatory M1 phenotype, which is important for the role of IL-10 in mediating the pathogenesis of CIA. (biomedcentral.com)
  • We show that the disparate effects of IL-10 on tumor immunity are indeed due to the different modes of IL-10 production in the various studies. (jefferson.edu)
  • Conclusion: Acculturated Hispanics who lack the protective effects of IL-10 experience a markedly higher risk of preterm birth than nonacculturated Hispanics. (elsevierpure.com)
  • To reveal the effects of IL-10 on involution, expression profiles of apoptosis-related genes were examined in mice transgenic for IL-10 as well as in IL-10(-/-) mice. (ewha.ac.kr)
  • Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. (wikipedia.org)
  • IL-10 was discovered 30 yr ago as a secreted cytokine synthesis inhibitory factor, produced by T helper (Th) 2 cell clones shown to inhibit cytokine production by Th1 cells. (cusabio.com)
  • IL-10 is a cytokine with multiple, pleiotropic, effects in immunoregulation and inflammation. (wikipedia.org)
  • We have studied the relationship between clinical and biochemical parameters and C-peptide and anti-inflammatory IL-10, as well as selected markers of inflammation and endothelial dysfunction such as: CCL2, CRP, sICAM-1, sVCAM-1 and E-selectin in obese women with various degree of glucose metabolism disturbance. (medsci.org)
  • IL-10 deficiency might promote macrophage polarization toward the proinflammatory M1 phenotype, which contributes to the rheumatoid arthritis inflammation response. (biomedcentral.com)
  • Th1 cells that produce IL-2, IFN- γ , TNF- α, and TNF- β evoke cell-mediated immunity and phagocyte-dependent inflammation while Th2 cells that produce IL-5, IL-4, IL-6, IL-10, and IL-13 induce a strong antibody response that comprises the IgE class and eosinophil accumulation, but it inhibits several functions of phagocytic cells [ 7 ]. (hindawi.com)
  • Although interleukin-10 (IL-10) is known to contribute to inflammation and pathogenesis in mammalian organs, little is known about its precise role in the mammary gland. (ewha.ac.kr)
  • ABSTRACT Single nucleotide polymorphisms (SNPs) in the Interleukin (IL)-28B gene, namely rs12979860, could predict response to pegylated interferon--ribavirin (PR) therapy in hepatitis C virus genotype 1 (HCV-1)-infected patients. (who.int)
  • Interleukin-10 combines with itself to form a homodimeric molecule that is the biologically active form of the protein. (curehunter.com)
  • Elevated expression of TRAIL and of death receptor 4 (DR4) protein was identified at the involution stage of normal mammary glands as well as at the lactation stage of the IL-10 transgenic mice. (ewha.ac.kr)
  • Expression of IL-10 from transfected tumor cell lines in IL-10 transgenic mice or dosing with IL-10 leads to control of primary tumor growth and decreased metastatic burden. (wikipedia.org)
  • A study in mice has shown that IL-10 is also produced by mast cells, counteracting the inflammatory effect that these cells have at the site of an allergic reaction. (wikipedia.org)
  • Lack of IL-10 has been shown to cause COX activation and resultant Thromboxane receptor activation to cause vascular endothelial and cardiac dysfunctions in mice. (wikipedia.org)
  • Interleukin 10 knockout frail mice develop cardiac and vascular dysfunction with increased age. (wikipedia.org)
  • Consequently, growth of MB49 in IL-10 knockout (KO) mice, whose infiltrating cells are unable to produce IL-10, allows for the removal of the IL-10 normally associated with this tumor. (jefferson.edu)
  • IL-10-knockout (IL-10 −/− ) mice and wild-type (WT) mice were immunized with chicken type II collagen (CII) to induce arthritis. (biomedcentral.com)
  • The expression levels of IL-17 and retinoid-related orphan receptor γt (RORγt) in macrophages and joint tissues of IL-10 −/− and WT mice were analyzed by enzyme-linked immunosorbent assay, quantitative RT-PCR (qRT-PCR) and Western blotting. (biomedcentral.com)
  • Macrophages in IL-10 −/− mice had increased amounts of IL-17 and RORγt compared with the amounts in WT mice with CIA. (biomedcentral.com)
  • Immunofluorescence microscopy showed that the number of IL-17-producing macrophages in synovial tissues was significantly higher in IL-10 −/− mice than in WT mice. (biomedcentral.com)
  • Furthermore, TRAIL was down-regulated 4-fold in the IL-10(-/-) mice at the involution stage. (ewha.ac.kr)
  • on days +10 through +12 the mice received test article on the dorsal aspect of each ear. (cdc.gov)
  • We describe two features of a murine model of transitional cell carcinoma, MB49, that render it an attractive in vivo model with which to study the effect of IL-10 on tumor immunity. (jefferson.edu)
  • Interestingly, during the course of these studies conflicting reports emerged in the literature regarding the effect of IL-10 in tumor systems. (jefferson.edu)
  • 2009 ). The IL-10 gene, which contains five exons, has been found on the long arm of chromosome 1q31-32 in humans (Eskdale et al. (researchsquare.com)
  • The involvement of IL-10 in many disease states has been demonstrated, both in animal models and in humans with mutations in the IL-10/IL-10R axis. (cusabio.com)
  • To investigate the relationship between single-nucleotide polymorphisms (SNPs) of interleukin-10 (IL-10) and syndrome types of traditional Chinese medicine (TCM) in posthepatitis B cirrhosis. (jcimjournal.com)
  • Interleukin 12B rs3212227 and rs6887695 single nucleotide polymorphisms are associated with the susceptibility to preeclampsia: Genetic, haplotype and bioinformatics analysis. (nih.gov)
  • IL-10 gene polymorphisms are possibly associated with liver disease susceptibility or severity. (wjgnet.com)
  • This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. (nih.gov)
  • Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. (nih.gov)
  • Interleukin-23 ( IL-23 ) is a heterodimeric cytokine composed of an IL12B ( IL-12p40 ) subunit (that is shared with IL12 ) and the IL23A ( IL-23p19 ) subunit. (wikidoc.org)
  • Using MB49, we demonstrate that tumor-induced IL-10 inhibits the generation of a type I immune response against a tumor antigen as measured by Interferon (IFN)-γ production, cytotoxic T lymphocyte (CTL) generation, and delayed type hypersensitivity (DTH) reaction. (jefferson.edu)
  • Quantitative real-time polymerase chain reaction revealed ∼100 times higher IL-10, but not interferon-γ or transforming growth factor-β in DN than in single-positive T cells. (elsevierpure.com)
  • Description: A sandwich ELISA kit for detection of Interleukin 10 from Dog in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (2sars.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Interleukin 10 Receptor Alpha (IL10Ra) in samples from tissue homogenates, cell lysates or other biological fluids. (tuberculosisdrugresearch.org)
  • Description: A sandwich ELISA kit for detection of Interleukin 18 from Guinea pig in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (ibiomagazine.org)
  • Sera concentration of circulating sCD40L and IL-10 were assayed using ELISA in 30 HCV-positive patients with HCC, 30 HCV-positive patients with liver cirrhosis and 30 age-matched healthy volunteers with negative anti-HCV-Ab as a control group. (who.int)
  • More specifically, PEGylated recombinant human IL-10 (PEG-rHuIL-10) has been shown to enhance CD8+ T cell secretion of the cytotoxic molecules Granzyme B and Perforin and potentiate T cell receptor dependent IFNγ secretion. (wikipedia.org)
  • Recombinant human IL-10 has been produced and is currently tested in clinical trials. (wjgnet.com)
  • The serum IL-10 level was measured by immunoassay method, and compared by using Independent Student's t-test. (ui.ac.id)
  • Serum IL-10 measurement is a quite superior method to distinguish acute and stable condition, eventhough it is not as good as hsCRP for the same purpose. (ui.ac.id)
  • Assessment of serum IL-10 levels in HCV patients may provide a possible predictive marker for disease progression. (who.int)
  • During chronic infection, plasma IL-10 and transcriptomic signatures of IL-10 signaling were correlated with the cell-associated SIV-DNA content within LN CD4+ memory subsets, including Tfh cells, and predicted the frequency of CD4+ Tfh cells and their cell-associated SIV-DNA content during ART, respectively. (nih.gov)
  • Aim To compare plasma IL-10 concentrations in patients with Acute Coronary Syndrome (ACS) with those in Coronary Artery Disease (CAD). (ui.ac.id)
  • Second, MB49 does not produce IL-10 itself but rather induces infiltrating cells to produce IL-10. (jefferson.edu)
  • Those studying tumors engineered to produce IL-10 by way of gene-transfection uniformly reported that IL-10 enhances the anti-tumor immune response. (jefferson.edu)
  • IL-10 binding induces STAT3 signalling via the phosphorylation of the cytoplasmic tails of IL-10 receptor 1 + IL-10 receptor 2 by JAK1 and Tyk2 respectively. (wikipedia.org)
  • IL-10 also induces its own expression by human monocyte-derived macrophages. (biomedcentral.com)
  • These results indicate that the elevated expression of IL-10 at the involution stage recruits lymphocytes and induces the expression of TRAIL and DR4. (ewha.ac.kr)
  • Interleukin (IL)-10 is an important immunoregulatory cytokine produced by many cell populations. (wjgnet.com)
  • Interleukin 10 (IL-10) is an important immunoregulatory cytokine produced by many cell populations, including macrophages, dendritic cells (DCs), T-cell subsets (Th2, Tc2 and Tr1) and B cells [ 3 ]. (biomedcentral.com)
  • In contrast, those studying IL-10 in tumor systems by other means consistently reported that IL-10 inhibits anti-tumor immunity. (jefferson.edu)
  • In summary, our studies clearly demonstrate that IL-10 inhibits anti-tumor immunity. (jefferson.edu)
  • IL-10 may autoregulate its expression via a negative feed-back loop involving autocrine stimulation of the IL-10 receptor and inhibition of the p38 signaling pathway. (wikipedia.org)
  • Genetic or pharmacological inhibition of IL-10 signaling or δOR triggered relapse to pain in both sexes. (iasp-pain.org)
  • 2015 ). The significance of the IL-10 gene in the control of immune-mediated illness responses has resulted in the discovery of numerous polymorphisms in different portions of the gene, including the promoter region (Eskdale et al. (researchsquare.com)
  • Interleukin-10 is fully biologically active when compared to standard. (genaxxon.com)
  • Interleukin-10 (IL-10) is an immunosuppressive cytokine that signals through STAT3 to regulate T follicular helper (Tfh) cell differentiation and germinal center formation. (nih.gov)
  • Interleukin (IL)-10 is a potent immunosuppressive cytokine that is found in elevated quantities both at the tumor site and systemically in a variety of cancers. (jefferson.edu)
  • In patients with obesity and type 2 diabetes, altered serum concentrations of Il-10 seems to be dependent on the degree of insulin resistance and proinflammatory status. (medsci.org)
  • in addition, three studies described IL-10 concentrations after ACL reconstruction. (unimib.it)
  • Les concentrations sériques de sCD40L circulant et d'interleukine 10 circulante ont été analysées à l'aide de la méthode immuno-enzymatique chez 30 patients positifs pour le VHC avec un CHC, chez 30 patients patients positifs pour le VHC avec une cirrhose du foie, et chez 30 volontaires d'âge correspondant en bonne santé avec des anticorps anti-VHC négatifs servant de groupe témoin. (who.int)
  • Une corrélation positive significative a été détectée entre les concentrations sériques de sCD40L et d'IL-10 (r = 0,85 p (who.int)
  • Janowska J, Chudek J, Olszanecka-Glinianowicz M, Semik-Grabarczyk E, Zahorska-Markiewicz B. Interdependencies among Selected Pro-Inflammatory Markers of Endothelial Dysfunction, C-Peptide, Anti-Inflammatory Interleukin-10 and Glucose Metabolism Disturbance in Obese Women. (medsci.org)
  • Efficient delivery of therapeutic anti-inflammatory molecules, such as interleukin (IL)-10, to macrophages can dramatically improve therapeutic efficacy of obesity treatments. (elsevierpure.com)
  • PSL), which have macrophage targeting ability and anti-inflammatory functions, as a biomaterial carrier for the delivery of IL-10 to macrophages. (elsevierpure.com)
  • It has been reported that IL-27 performs an anti-inflammatory function by acting on conventional CD4 + T cells to induce IL-10-producing cells that are implicated in controlling inflammatory responses [ 3 ]. (hindawi.com)
  • Thus, the anti-inflammatory response mediated by IL-10 provides pivotal regulation of suppression of autoimmune disease development. (biomedcentral.com)
  • There's an anti-inflammatory response with cytokine interleukin-10. (medscape.com)
  • Consequently, the functional receptor consists of four IL-10 receptor molecules. (wikipedia.org)
  • More recently, PEGylated recombinant murine IL-10 (PEG-rMuIL-10) has been shown to induce IFNγ and CD8+ T cell dependent anti-tumor immunity. (wikipedia.org)
  • Additionally, IL-10 inhibited the killing of intracellular pathogens. (cusabio.com)
  • After that, chondrocytes were cultured in 24-well plate in DMEM supplemented with 10% FCS for 48 hours and then beta 1 integrin surface expression and intracellular IL-10 and TNF-alpha levels were evaluated by flow-cytometry. (biomedcentral.com)
  • Following ESW application, while beta1 integrin expression remain unchanged, a significant decrease of IL-10 and TNF-alpha intracellular levels was observed both in osteoarthritic and healthy chondrocytes. (biomedcentral.com)
  • Nonetheless, ESW treatment application down-regulate the intracellular levels of TNF-alpha and IL-10 by chondrocytes, suggesting that ESW might restore TNF-alpha and IL-10 production by osteoarthritic chondrocytes at normal levels. (biomedcentral.com)
  • Intracellular flow-cytometric analysis indicated the IL-10-expressing CD3 + CD4 - CD8 - cells in patients with lymphoproliferation. (elsevierpure.com)
  • Here, we show that chronic activation of both human and murine CD4+ T cells in the presence of interleukin (IL)-10 gives rise to CD4+ T-cell clones with low proliferative capacity, producing high levels of IL-10, low levels of IL-2 and no IL-4. (ox.ac.uk)
  • IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. (wikipedia.org)
  • Our objective in the present study was to determine the signaling pathway of interleukin 10 (IL-10) for modulating IL-17 expression in macrophages and the importance of this mediation in collagen-induced arthritis (CIA). (biomedcentral.com)
  • metaphysically to its interleukin 10 1995 in spiritual 1991, sensitive clients on place in the Soviet Union lived rather Christian. (whmoodie.com)
  • children of interleukin 10 1995, mixing handicrafts, people and indications, evaluated represented into Christo-Platonic institutions for American panelist. (whmoodie.com)
  • For the interleukin 10 1995 of western plans, community were migrant. (whmoodie.com)
  • MATERIALS AND METHODS: We conducted a systematic review of the literature in order to consolidate evidence of IL-10 profiles in synovial fluid (SF) of patients with ACL tears. (unimib.it)
  • In human RA, IL-10 suppresses the expression of tumor necrosis factor α (TNF-α), IL-1β and major histocompatibility complex (MHC) class II in macrophages in the synovial fluid of RA patients [ 12 ]. (biomedcentral.com)
  • Discovered in 1991, IL-10 was initially reported to suppress cytokine secretion, antigen presentation and CD4+ T cell activation. (wikipedia.org)
  • The authors used logistic regression to understand whether the presence or the absence of IL-10 levels was related to acculturation and the risk of preterm birth. (elsevierpure.com)
  • Results: The authors observed interactions between undetectable IL-10 levels and years in the United States and undetectable IL-10 levels and being born in the United States in models predicting preterm birth. (elsevierpure.com)
  • Thus IL-10 drives the generation of a CD4+ T-cell subset, designated T regulatory cells 1 (Tr1), which suppresses antigen-specific immune responses and actively downregulates a pathological immune response in vivo. (ox.ac.uk)
  • Treg deletion accelerates the development of atherosclerosis, and adoptive transfer Treg suppresses atherosclerosis [ 10 ]. (hindawi.com)
  • Thus, these data support a role for IL-10 in maintaining a pool of target cells in lymphoid tissue that serve as a niche for viral persistence. (nih.gov)
  • IL-10 can be produced by monocytes upon PD-1 triggering in these cells. (wikipedia.org)
  • In ART-treated rhesus macaques, cells harboring SIV-DNA by DNAscope were preferentially found in the LN B cell follicle in proximity to IL-10. (nih.gov)
  • Finally, we demonstrated that the in vivo neutralization of soluble IL-10 in ART-treated, SIV-infected macaques reduced B cell follicle maintenance and, by extension, LN memory CD4+ T cells, including Tfh cells and those expressing PD-1 and CTLA-4. (nih.gov)
  • Interleukin (IL)-12, which is secreted by antigen-presenting cells, acts via signal transducer and activator of transcription (STAT)4 to promote the differentiation of naïve T cells into Th1 cells ( 9 - 11 ). (frontiersin.org)
  • Interleukin 10 is a growth factor for a population of regulatory T cells. (ox.ac.uk)
  • IL-10 was exclusively expressed in DN αβ but not γδT cells. (elsevierpure.com)
  • Circulating DN αβT cells may constitutively express IL-10 and contribute to the ALPS phenotype. (elsevierpure.com)
  • Additionally, IL-10 expression is extensively regulated at the post-transcriptional level, which may involve control of mRNA stability via AU-rich elements and by microRNAs such as let-7 or miR-106. (wikipedia.org)
  • Additionally, the cyclooxygenase inhibitor ketorolac (10 μ m ) significantly attenuated the facilitatory effects of LPS and IL-1β, indicating involvement of prostanoids. (jneurosci.org)
  • In SIV-infected macaques, levels of IL-10 in plasma and lymph nodes (LNs) were induced by infection and not normalized with antiretroviral therapy (ART). (nih.gov)
  • At baseline, osteoarthritic chondrocytes expressed significantly lower levels of beta1 integrin and higher levels and IL-10 and TNF-alpha levels. (biomedcentral.com)
  • IL-10 levels decreased at any impulses and energy levels, while a significant reduction of TNF-alpha was mainly found at middle energies. (biomedcentral.com)
  • Our study confirmed that osteoarthritic chondrocytes express low beta 1 integrin and high TNF-alpha and IL-10 levels. (biomedcentral.com)
  • To investigate whether IL-10 serum level could predict ACS, the sensitivity and specificity of this parameter towards SKA in various IL-10 serum levels were calculated as well. (ui.ac.id)
  • RESULTS: IL-10 levels in SF were higher after ACL injury and ACL reconstruction compared to control knees. (unimib.it)
  • IL-10 levels were most elevated shortly after injury, but, decreased to more normal levels in chronic lesions. (unimib.it)
  • In the peripheral blood plasma, TGF- β and IL-10 expression were increased, while the levels of IFN- γ and IL-17 were reduced. (hindawi.com)
  • Two patients with DN αβT-cell expansion showed higher serum interleukin 10 (IL-10) levels than one patient without it. (elsevierpure.com)
  • We found that IL-10 levels fluctuated during the mouse mammary cycle, showing little expression at the lactation stage and the highest expression at the involution stage. (ewha.ac.kr)
  • [10] Ustekinumab , a monoclonal antibody directed against this cytokine, is used clinically to treat certain autoimmune conditions. (wikidoc.org)
  • Extensive IL-10 locus remodeling is observed in monocytes upon stimulation of TLR or Fc receptor pathways. (wikipedia.org)
  • In patients with posthepatitis B cirrhosis, allele C in IL-10-819 locus may be related to spleen deficiency with overabundance of dampness syndrome, and TT genotype in IL-10-819 locus may be related to liver stagnation syndrome. (jcimjournal.com)
  • CONCLUSIONS: IL-10 is a modulatory cytokine with an active role in antagonizing TNF-α in the knee joint environment. (unimib.it)
  • The expression of IL-10 is minimal in unstimulated tissues and seems to require triggering by commensal or pathogenic flora. (wikipedia.org)
  • IL-10 expression is tightly regulated at the transcriptional and post-transcriptional level. (wikipedia.org)
  • IL-10 upregulated expression and analgesic activity of δ-opioid receptor (δOR) in the dorsal root ganglion. (iasp-pain.org)
  • The purpose of this study was to investigate the effects of extra corporeal shock waves (ESW) therapy on the metabolism of healthy and osteoarthritic human chondrocytes, and particularly on the expression of IL-10, TNF-alpha and beta1 integrin. (biomedcentral.com)
  • As for lesions, the mRNA expression of Foxp3, TGF- β , and IL-10 was increased, while that of IFN- γ and IL-17 was reduced. (hindawi.com)
  • On day +13 animals were euthanized, draining lymph nodes were excised, and mRNA was isolated immediately or following 24 or 48 h of culture in the presence or absence of concanavalin (Con) A. Differential expression of cytokine mRNA was most notable following 24 h incubation with Con A. Modulation of IL-4, -10, and IFN-gamma following chemical exposure was consistent with previous studies. (cdc.gov)