CytokineIFNGAssaysIGRAValue of interferon-gammaManufactures the interferon gammaProteinHeterodimeric receptorTYPE I INTERFERONReceptorsCytokinesTuberculin skinInducersProteinsReceptorInducesTumor necrosImmuneTuberculosisAntibodyDetectionGenesAntigensInfectionVitroResponses2020MycobacteriumMacrophageELISAFibroblastsReleaseColiGeneLymphocytesDrugsViralBiochemistryHumanMedicinesDosesConcentrationDiagnosisInjectionFunctional
Cytokine7
- Interferon gamma (IFN-γ) is a dimerized soluble cytokine that is the only member of the type II class of interferons. (wikipedia.org)
- IFN-γ, or type II interferon, is a cytokine that is critical for innate and adaptive immunity against viral, some bacterial and protozoan infections. (wikipedia.org)
- This gene encodes a soluble cytokine that is a member of the type II interferon class. (origene.com)
- Interferon Gamma is a cytokine produced by T helper cells as part of the immune response to various stimuli. (loinc.org)
- Native rabbit interferon gamma is a 167 amino acid cytokine with potent activating, anti-viral and anti-proliferative properties. (bio-rad-antibodies.com)
- Interferon gamma is a major macrophage-activating cytokine during infection with Mycobacterium tuberculosis , the causative pathogen of tuberculosis, and its role has been well established in animal models and in humans. (biomedcentral.com)
- NK cell activity of peripheral blood mononuclear cells was measured using nonradioactive cytotoxicity assay kits and serum cytokine concentrations included interferon (IFN)-γ, tumor necrosis factor (TNF)-α, interleukin (IL)-2, IL-4, IL-10, and IL-12 were measured by Bio-Plex cytokine assay kit. (nih.gov)
IFNG11
- Monoclonal Antibody to Interferon Gamma (IFNg) is Available at Gentaur Genprice with the fastest delivery. (proteomecommons.org)
- This assay has high sensitivity and excellent specificity for detection of Interferon Gamma (IFNg). (uscnk.com)
- No significant cross-reactivity or interference between Interferon Gamma (IFNg) and analogues was observed. (uscnk.com)
- Matrices listed below were spiked with certain level of recombinant Interferon Gamma (IFNg) and the recovery rates were calculated by comparing the measured value to the expected amount of Interferon Gamma (IFNg) in samples. (uscnk.com)
- Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Interferon Gamma (IFNg) were tested 20 times on one plate, respectively. (uscnk.com)
- Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Interferon Gamma (IFNg) were tested on 3 different plates, 8 replicates in each plate. (uscnk.com)
- The linearity of the kit was assayed by testing samples spiked with appropriate concentration of Interferon Gamma (IFNg) and their serial dilutions. (uscnk.com)
- The microtiter plate provided in this kit has been pre-coated with an antibody specific to Interferon Gamma (IFNg). (uscnk.com)
- Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody specific to Interferon Gamma (IFNg). (uscnk.com)
- After TMB substrate solution is added, only those wells that contain Interferon Gamma (IFNg), biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. (uscnk.com)
- The concentration of Interferon Gamma (IFNg) in the samples is then determined by comparing the O.D. of the samples to the standard curve. (uscnk.com)
Assays4
- We performed the largest meta-analysis to date aiming to evaluate the performance of tuberculin skin test (TST) and interferon-gamma release assays (IGRAs) for LTBI diagnosis in various patient populations using Bayesian latent class modelling. (edu.au)
- Higuchi K, Sekiya Y, Igari H, Watanabe A, Harada N. Comparison of specificities between two interferon-gamma release assays in Japan. (who.int)
- Diel R, Loddenkemper R, Nienhaus A. Evidence-based comparison of commercial interferon-gamma release assays for detecting active TB: a metaanalysis. (who.int)
- Interferon-γ release assays for the diagnosis of active tuberculosis: a systematic review and meta-analysis. (who.int)
IGRA9
- Gamma Assay Laboratories manufactures the interferon gamma release assay (igra) reagents distributed by Genprice. (ifn-a.com)
- The Interferon Gamma Release Assay (Igra) reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (ifn-a.com)
- Herein we describe the contacts' closeness to the index TB patient and the positivity of interferon-gamma release assay (IGRA). (who.int)
- Two types of immunological methods are used for detecting Mycobacterium tuberculosis infection: tuberculin skin tests (TSTs) and interferon-gamma release assay (IGRA) blood tests. (cdc.gov)
- Se diagnostica actualmente por detección in vitro de liberación de interferón gamma (IGRA) Quantiferon TB Gold®In tube en sangre, identificándolas en enfermedades reumatológicas, inmunocomprometidos, régimen de trasplante de órgano sólido, contactos familiares, personal de salud con pacientes bacilíferos. (bvsalud.org)
- determinar la utilidad del IGRA para diagnosticar presencia de tuberculosis latente en pacientes con factores de riesgo o exposición. (bvsalud.org)
- se revisaron 261 resultados de IGRA en muestras de sangre de pacientes de 3 a 86 años con una mediana de 49 años. (bvsalud.org)
- se confirmaron 38 (15%) LTBI en el país con el IGRA, mayoría adultos de 81 a 90 años y mujeres, 24% cuadros pulmonares, 20% contactos y autoinmunes. (bvsalud.org)
- It is currently diagnosed by in vitro detection of interferon gamma (IGRA) release Quantiferon TB Gold®In tube in blood, identifying them in rheumatological diseases, immunocompromised, solid organ transplant regimen, family contacts, health personnel with baciliferous patients. (bvsalud.org)
Value of interferon-gamma1
- A low serum value of Interferon-gamma can mean immune deficiency and increased risk of serious infection. (pickerworld.com)
Manufactures the interferon gamma1
- Gamma Elisa Laboratories manufactures the interferon gamma elisa protocol reagents distributed by Genprice. (plant-gem.org)
Protein6
- Interferon gamma receptor 1 ( IFNGR1 ) also known as CD119 ( C luster of D ifferentiation 119 ), is a protein that in humans is encoded by the IFNGR1 gene . (wikidoc.org)
- The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. (origene.com)
- Sandwich ELISA analysis of mouse IFN-γ protein using GTX02927 Interferon gamma antibody [AN18] as coating antibody and GTX02943-02 Interferon gamma antibody [R4-6A2] (Biotin) as detecting antibody. (genetex.com)
- We have previously shown that Interferon-γ inducible protein 16 (IFI16), a host nuclear innate immune DNA sensor, plays an important role in the maintenance of KSHV latency [J Virol. (technologynetworks.com)
- This leads to a decrease in the production of interferon-gamma, a protein that is involved in fighting viral infections. (pickerworld.com)
- Interferon gamma (IFN-γ) is a multifunctional protein first observed as an antiviral activity in cultures of Sindbis virus-infected human leukocytes stimulated by PHA. (eaglebio.com)
Heterodimeric receptor2
- Cellular responses to IFN-γ are activated through its interaction with a heterodimeric receptor consisting of Interferon gamma receptor 1 (IFNGR1) and Interferon gamma receptor 2 (IFNGR2). (wikipedia.org)
- A ubiquitously expressed heterodimeric receptor that is specific for both INTERFERON-ALPHA and INTERFERON-BETA . (lookformedical.com)
TYPE I INTERFERON1
- It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. (wakehealth.edu)
Receptors4
- Type II IFN is serologically different from interferon type 1, binds to different receptors, and is encoded by a separate chromosomal locus. (wikipedia.org)
- Interferons exert their pleiotropic effects through two different receptors. (lookformedical.com)
- alpha- and beta-interferon crossreact with common receptors, while gamma-interferon initiates its biological effects through its own specific receptor system. (lookformedical.com)
- Two receptors bind one interferon-gamma dimer. (lu.se)
Cytokines1
- Type II IFN expression is upregulated by the production of interleukin cytokines, such as IL-12, IL-15, IL-18, as well as type I interferons (IFN-α and IFN-β). (wikipedia.org)
Tuberculin skin1
- Tuberculin skin test or interferon gamma release assay - How to detect latent tuberculosis infection in sarcoidosis patients? (ers-education.org)
Inducers2
- Elevated kynurenine levels have been found in humans in a number of diseases and after interferon treatment, and the enzyme is induced in rodents after administration of interferon inducers, or influenza virus. (nih.gov)
- Interferon secreted by leukocytes , fibroblasts , or lymphoblasts in response to viruses or interferon inducers other than mitogens, antigens , or allo-antigens. (lookformedical.com)
Proteins2
- IRF proteins bind specific DNA sequences such as interferon-stimulated response elements, interferon regulatory elements, and the interferon consensus sequence. (lookformedical.com)
- Interferons are a family of naturally-occurring proteins that are made and secreted by cells of the immune system (for example, white blood cells, natural killer cells, fibroblasts, and epithelial cells). (medicinenet.com)
Receptor4
- The gene IFNGR1 encodes IFN-γR1, which is the ligand-binding chain (alpha) of the heterodimeric gamma interferon receptor, which is found on macrophages . (wikidoc.org)
- Interferon gamma receptor 1 has been shown to interact with Interferon-gamma . (wikidoc.org)
- The human interferon-gamma receptor. (wikidoc.org)
- The interferon alpha-beta receptor signals through the action of JANUS KINASES such as the TYK2 KINASE. (lookformedical.com)
Induces2
- Activation of the JAK-STAT pathway induces upregulation of interferon-stimulated genes (ISGs), including MHC II. (wikipedia.org)
- In particular, interferon-gamma (IFN-gamma) induces an enzyme of tryptophan catabolism, indoleamine 2,3-dioxygenase (IDO), which is responsible for conversion of tryptophan and other indole derivatives to kynurenine. (nih.gov)
Tumor necros1
- notably interferon- (IFN-) and tumor necrosis factor. (cdc.gov)
Immune7
- The existence of this interferon, which early in its history was known as immune interferon, was described by E. F. Wheelock as a product of human leukocytes stimulated with phytohemagglutinin, and by others as a product of antigen-stimulated lymphocytes. (wikipedia.org)
- The level of gamma interferon produced provides a measure of sensitization of the cell mediated immune system to the specific stimulus. (loinc.org)
- Interferon gamma (IFN-γ) is a member of the interferon family which plays a crucial role in the reaction of the immune system in resistance to pathogens such as M. tuberculosis . (biomedcentral.com)
- Interferons modulate the response of the immune system to viruses , bacteria, cancer , and other foreign substances that invade the body. (medicinenet.com)
- Essentially, when confronted with a virus, each cell shoots an emergency flare of interferon to tell the immune system to marshall its defenses. (medicinenet.com)
- Interferon Beta 1a, specifically, activates macrophages that engulf antigens and natural killer cells (NK cells), a type of immune T-Cell. (medicinenet.com)
- The theory is, interferon may be able to make the immune system stronger by turning on dormant parts and directing them toward the defense against SARS -nCoV-2's assault. (medicinenet.com)
Tuberculosis6
- This term was created for, but is not limited in use to, the submitter's Bovigam Mycobacterium bovis Gamma Interferon Test Kit for Cattle, a blood-based in vitro laboratory test for bovine tuberculosis. (loinc.org)
- Based on the hypothesis that genes which regulate interferon gamma may influence tuberculosis susceptibility, we investigated polymorphisms in eight candidate genes. (biomedcentral.com)
- Tuberculosis infection in cattle and other animal species is mainly detected by immunological tests, such as the skin test or the gamma interferon assay. (visavet.es)
- Ota M, Kato S. Risk of tuberculosis among air passengers estimated by interferon gamma release assay: survey of contact investigations, Japan, 2012 to 2015. (who.int)
- Tuberculosis screening using a T-cell interferon-γ release assay in Japanese medical students and non-Japanese international students. (who.int)
- Tuberculosis contact investigation using interferon-gamma release assay with chest x-ray and computed tomography. (who.int)
Antibody1
- In the present study, we demonstrate that the administration of antigamma interferon (IFN-γ) antibody (1.2 mg/kg of body weight, intravenously) accelerated tissue repair via increased fibrin deposition 12 and 24 h after CLP in rats. (researchwithrowan.com)
Detection1
- The aim of this study in Egypt was to estimate the usefulness of an interferon-gamma release assay (IFN-γ) assay for the detection of latent TB infection in contacts of active TB cases. (who.int)
Genes3
- A direct role for IDO in pteridine synthesis has not been shown, and this parallel induction may reflect coordinate regulation of genes induced by IFN-gamma. (nih.gov)
- An interferon regulatory factor that binds upstream TRANSCRIPTIONAL REGULATORY ELEMENTS in the GENES for INTERFERON-ALPHA and INTERFERON-BETA . (lookformedical.com)
- It functions as a transcriptional activator for the INTERFERON TYPE I genes. (lookformedical.com)
Antigens1
- IFNgamma(-/-) mice fail to activate Th1 cells in response to the transplanted (auto)antigens, which suggests an essential requirement for IFN-gamma-mediated Th1 activation in the induction of AA. (unboundmedicine.com)
Infection6
- André Ballesteros-Tato, Ph.D., and colleagues at the University of Alabama at Birmingham have now published a mouse-model study in the journal Immunity showing that interferon-gamma produced by T follicular helper cells, or Tfh cells, after intranasal influenza infection is required to initiate the path of B cell differentiation into lung-BRMs. (eurekalert.org)
- Obligatory role of gamma interferon for host survival in a murine model of infection with Burkholderia pseudomallei. (tropmedres.ac)
- Resistance to acute infection with B. pseudomallei was absolutely dependent upon the production of gamma interferon (IFN-gamma) in vivo. (tropmedres.ac)
- The rapid production of IFN-gamma within the first day of infection determines whether the infection proceeds to an acute lethal outcome or becomes chronic. (tropmedres.ac)
- Therefore, induction of the host tryptophan catabolizing enzyme, indoleamine-2,3-dioxgenase-1 (IDO1), by interferon gamma (IFNγ) is one of the primary protective responses against chlamydial infection. (duke.edu)
- An interferon regulatory factor that is expressed constitutively and undergoes POST-TRANSLATIONAL MODIFICATION following viral infection. (lookformedical.com)
Vitro1
- A study was conducted to ascertain the relationship between the in vitro gamma interferon (IFN-gamma) release test and cutaneous reactions to statins. (accessdermatology.com)
Responses3
- Scholars@Duke publication: Chlamydia trachomatis-infected cells and uninfected-bystander cells exhibit diametrically opposed responses to interferon gamma. (duke.edu)
- A signal transducer and activator of transcription that mediates cellular responses to INTERFERONS . (lookformedical.com)
- Oral administration of ovalbumin protects mice from concanavalin A-induced hepatitis through suppression of interferon-gamma responses. (bvsalud.org)
20201
- Studies around the world, including a huge WHO study, are looking at different interferons to treat COVID-19 coronavirus, but no existing COVID-19 drug trials in the U.S. included interferons as of April 7, 2020. (medicinenet.com)
Mycobacterium1
- Data on gamma interferon (IFN-γ)-secreting CD4 + T cells over time after recent Mycobacterium bovis BCG vaccination were available for 55 humans and 81 macaques. (ox.ac.uk)
Macrophage3
- Interferon-gamma inhibits macrophage apolipoprotein E production by posttranslational mechanisms. (jci.org)
- Recombinant Rabbit interferon gamma , (IFNγ), known previously as macrophage activating factor, belongs to the type II interferon family and is produced by T lymphocytes and NK cells. (bio-rad-antibodies.com)
- It is presumed that interferon gamma-1b increases macrophage cytotoxicity by enhancing the respiratory burst via generation of toxic oxygen metabolites capable of mediating the killing of intracellular micro-organisms. (rxreasoner.com)
ELISA4
- There are currently no references for Interferon gamma ELISA pair [AN18/R4-6A2] (GTX03106) . (genetex.com)
- The Interferon Gamma ELISA Assay (enzyme-linked immunoassay kit) is intended for the quantitative determination of human Interferon Gamma (IFN-γ) concentrations in cell culture supernates, serum, and plasma. (eaglebio.com)
- The Eagle Biosciences Human Interferon Gamma (IFN-γ) ELISA Assay Kit is for research use only and not to be used in diagnostic procedures. (eaglebio.com)
- The Eagle Biosciences Interferon Gamma (IFN-γ) ELISA Assay Kit employs the quantitative sandwich enzyme immunoassay technique. (eaglebio.com)
Fibroblasts1
- One of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA. (lookformedical.com)
Release1
- Agents that promote the production and release of interferons . (lookformedical.com)
Coli1
- You should not use interferon gamma-1b if you are allergic to interferon gamma-1b, or to drug products made from E. coli bacteria. (holevn.org)
Gene2
- The gene for IDO has been cloned and shown to be differentially regulated by IFN-alpha and IFN-gamma. (nih.gov)
- A family of transcription factors that share an N-terminal HELIX-TURN-HELIX MOTIF and bind INTERFERON-inducible promoters to control GENE expression . (lookformedical.com)
Lymphocytes1
- The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. (wakehealth.edu)
Drugs2
- What other drugs will affect interferon gamma-1b? (holevn.org)
- Other drugs may interact with interferon gamma-1b, including prescription and over-the-counter medicines, vitamins, and herbal products. (holevn.org)
Viral2
- Effect of combination of interferon alpha-2b and interferon-gamma or interferon alpha-2b alone for elimination of SARS-CoV-2 viral RNA. (medrxiv.org)
- This is why interferon therapies for viral infections are typically a last resort -- the potential for dire side effects. (medicinenet.com)
Biochemistry1
- The biochemistry and biological activities of the interferons have been extensively reviewed. (eaglebio.com)
Human3
- The lymphokine interferon-gamma (IFN) dramatically inhibited the accumulation of apo E in the supernatant of human monocytic THP-1 cells when present during phorbol myristate acetate-induced differentiation. (jci.org)
- A bioassay for human gamma interferon test measurement was established and validated. (pickerworld.com)
- Commercially available interferons are human interferons manufactured using recombinant DNA technology. (medicinenet.com)
Medicines1
- Do not mix interferon gamma-1b in the same syringe with other injectable medicines. (holevn.org)
Doses1
- Interferon gamma-1b doses are based on body surface area (height and weight), and any changes may affect your dose. (holevn.org)
Concentration1
- IFN-gamma concentration was interpolated from a fourpoint standard curve for IFN-gamma measured on the bioassay plate by means of an enzymeimmunoassay. (pickerworld.com)
Diagnosis1
- The content of Holevn is solely for the purpose of providing information about Thuốc Interferon gamma-1b and is not intended to be a substitute for professional medical advice, diagnosis or treatment. (holevn.org)
Injection1
- Tissue damage at the site of injection occurs with all of the interferons but more commonly with interferon beta-1b and pegylated interferon alfa-2b. (medicinenet.com)
Functional1
- To elucidate the importance of Th1 cells in the pathogenesis of AA we investigated the functional role of interferon (IFN)-gamma in the experimental induction of AA. (unboundmedicine.com)