Within our dataset, Interferon regulatory factor 3 (IRF3) emerged as a leading candidate mediator of leptin-induced hunger-suppression. (biorxiv.org)
Stimulation of TLRs (Toll-Like Receptors) by a pathogen induces activation of signal transduction cascades, which leads to translocation of nuclear factor-κB (NF-κB) to the nucleus [ 1 ], activation of interferon regulatory factors 3/7 (IRF3/7) and/or activator protein-1 (AP-1), which cooperate to induce transcription of various cytokines such as alpha/beta interferon (IFN-α/β) to counteract infection [ 2 - 4 ]. (biomedcentral.com)
Our study aimed to examine potentially functional genetic variants in interferon regulatory factor 3 (IRF3), IRF5, IRF7, type I and type II IFN and their receptor genes with respect to colorectal cancer (CRC) risk and clinical outcome. (cancerindex.org)
Mechanistically, ALK directly interacts with epidermal growth factor receptor (EGFR) to trigger serine-threonine protein kinase AKT phosphorylation and activate interferon regulatory factor 3 (IRF3) and nuclear factor κB (NF-κB) signaling pathways, enabling STING-dependent rigorous inflammatory responses. (medicalxpress.com)
Genes12
The cyclic GMP-AMP synthase (cGAS)-Stimulator of Interferon Genes (STING) pathway is a critical defender to sense various pathogens and trigger innate immunity of mammalian cells. (frontiersin.org)
IRF-7 undergoes PHOSPHORYLATION prior to nuclear translocation and it activates GENETIC TRANSCRIPTION of multiple interferon GENES. (umassmed.edu)
Amino acid sequence alignments were constructed for individual genes using Bioedit v. 7.2.0 or Geneious v. 11.1.3 ( 5 ) to calculate percentage identity. (cdc.gov)
Interferon regulatory factors contain a conserved N-terminal region of about 120 amino acids, which folds into a structure that binds specifically to the IRF-element (IRF-E) motifs, which is located upstream of the interferon genes. (wikipedia.org)
Inhibiting progression through mitosis or loss of pattern recognition by stimulator of interferon genes (STING)-cGAS impaired interferon signalling. (nature.com)
Our in silico findings report that there is cross-regulation between both pathways at the level of gene transcription regulation, mediated by the presence of binding sites for both factors in promoters of genes essential for these pathways. (biomedcentral.com)
Interferon tau (IFNtau) is the pregnancy recognition signal produced by the conceptus trophectoderm and acts in a paracine manner on the ovine endometrium to increase expression of IFN-stimulated genes primarily in the stroma and deep glandular epithelium, including IFN regulatory factor-1 (IRF-1). (tamu.edu)
In response to viral stimuli, cells produce and release interferons, which then act on neighboring cells to induce the transcription of hundreds of genes. (au.dk)
Single nucleotide polymorphisms within interferon signaling pathway genes are associated with colorectal cancer susceptibility and survival. (cancerindex.org)
In this new effort, the researchers took a closer look at a stimulator of interferon genes (STING), which activates prior to the onset of sepsis and which is believed to be among the agents that cause sepsis to kick off. (medicalxpress.com)
The genetic disruption of ALK expression diminishes the stimulator of interferon genes (STING)-mediated host immune response to cyclic dinucleotides in monocytes and macrophages. (medicalxpress.com)
ADARs have been shown to contribute to disease pathologies by editing of glutamate receptors, editing of serotonin receptors, mutations in ADAR genes, and by other mechanisms, including recently identified regulatory roles in microRNA processing. (biomedcentral.com)
We conclude that members of the NF-κB family may directly impact regulation of IRF family, while IRF members impact regulation of NF-κB family rather indirectly, via other transcription factors such as AP-1 and SP1. (biomedcentral.com)
In the canonical model, IFN regulation, after RNA virus infection, is conducted by IRF-3 and IRF-7. (biomedcentral.com)
Stat2, and interferon regulatory factor-9 (IRF-9) in interferon tau regulation of IRF-1. (tamu.edu)
BRD7 was also identified as a binding partner of disheveled-1 (Dvl-1) and found to play a role in Wnt signaling and the regulation of glycogen synthase kinase 3-beta activity. (novusbio.com)
Interferon regulatory factor 1 (IRF1) is functionally diverse in the regulation of immune response and is considered to be an important candidate gene for studying disease susceptibility in mammals. (geneticsmr.com)
Transcription factor5
The transcription factor interferon regulatory factor (IRF)-3 is essential for viral-induced IFN-β synthesis. (microbiologyresearch.org)
A miRNA-prognostic DEPRG-transcription factor (TF) regulatory network was created via the miRNet online tool. (hindawi.com)
The NF-κB and IRF transcription factor families are major players in inflammation and antiviral response and act as two major effectors of the innate immune response (IIR). (biomedcentral.com)
We further show that Erk inactivation or disruption of interferon signaling mediated by the transcription factor STAT1 broke the cellular blockade to myxoma virus multiplication. (elsevierpure.com)
Induction of SRY box transcription factor 9 (SOX9) has been shown to occur in response to kidney injury in rodents, where SOX9-positive cells proliferate and regenerate the proximal tubules of injured kidneys. (lu.se)
Innate4
Rotavirus nonstructural protein 1 subverts innate immune response by inducing degradation of IFN regulatory factor 3. (microbiologyresearch.org)
Interferons (IFNs) are antiviral cytokines that play a key role in the innate immune response to viral infections. (au.dk)
Thus, the Erk-interferon-STAT1 signaling cascade elicited by myxoma virus in nonpermissive primary mouse embryo fibroblasts mediates an innate cellular barrier to poxvirus infection. (elsevierpure.com)
More importantly, the cellular factors affected by the HBV also modulate various biological processes, including innate immune response, cell cycle, proliferation, apoptosis, and invasion, and play vital roles in the development of liver diseases [ 12 ]. (biomedcentral.com)
Protein6
In this study, we found that NS1 protein inhibits IRF-3-dependent gene transcription in constitutively active IRF-3 overexpressing cells, demonstrating that NS1 directly targets IRF-3. (microbiologyresearch.org)
An interferon regulatory factor that is induced by INTERFERONS as well as LMP-1 protein from EPSTEIN-BARR VIRUS. (umassmed.edu)
Cellular nucleic acid-binding protein is essential for type I interferon-mediated immunity to RNA virus infection. (umassmed.edu)
For instance, the remaining parts of the interferon regulatory factor sequence vary depending on the precise function of the protein. (wikipedia.org)
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)
Our data also demonstrate that NS1 associates with IRF-3 and its transcriptional coactivator CBP, leading to disrupted association of IRF-3 to CBP and subsequent reduced binding of IRF-3 to the IFN-β promoter without blocking viral-induced IRF-3 phosphorylation, nuclear translocation and dimerization, thereby identifying a novel molecular mechanism by which RSV inhibits IFN-β synthesis. (microbiologyresearch.org)
The viral genome sequence was annotated by comparison with the KSHV and RFHVMn genome sequences (Geneious v. 11.1.3 ( 5 ). (cdc.gov)
RIG-I and MDA5 are two distinct sensors of viral double-stranded RNA (dsRNA) , a replication intermediate for RNA viruses [1-3]. (invivogen.com)
Since the HBV is a small DNA virus, and there is only limited genetic information in the viral genome, the virus heavily relies on cellular factors for viral replication. (biomedcentral.com)
Moreover, the HBV is capable of selectively and specifically altering the expression of intracellular factors, which are involved in the host immune response, to mediate persistent viral infection [ 11 ]. (biomedcentral.com)
Proteins1
These factors bind cooperatively to the IFN-beta enhancer and recruit coactivators and chromatin-remodeling proteins to the IFN-beta promoter. (rcsb.org)
IRF11
The results of the miRNA-prognostic DEPRG-TF regulatory network showed that GSDMC, IRF1, and PLCG1 were regulated by both specific and common miRNAs and TFs. (hindawi.com)
Directly Interacts1
Pestivirus Npro Directly Interacts with Interferon Regulatory Factor 3 Monomer and Dimer. (utmb.edu)
Cells9
Most IRF family members are expressed only in specialized cell types, but IRF-3 is widely expressed [ 10 ], stimulating synthesis of IFNβ in infected cells. (biomedcentral.com)
Research on NF-κB-deficient cells has shown that the initial kinetics of the type I interferon (IFN) response depends on concurrent NF-κB activation [ 12 ]. (biomedcentral.com)
2 , 3 , 9 Indeed, the atypical B cells of NLPHL and THRLBCL share many characteristics, including expression of pan-B-cell markers, germinal center B-cell origin and common chromosomal imbalances. (haematologica.org)
Recently, BRD7 was identified as a subunit of the polybromo-associated BRG1-associated factor (PBAF) complex and shown to be required for the modulation of transcription in embryonic stem cells. (novusbio.com)
For researchers studying these cell populations, or in cases where light scatter gating does not adequately exclude these cells from the analysis, this background may be an important factor to consider when selecting reagents for panel(s). (bdbiosciences.com)
Tumors from mice given anti-PD1 had larger numbers of memory CD8+ T cells (CD44+CD62L-KLRG1int) and T cells that expressed PD1, lymphocyte activating 3 (LAG3), and TIGIT compared with mice not given the antibody. (stanford.edu)
In Trp53KO/C-MycOE mice and mice with tumors grown from Hepa1-6 cells, injection of the combination of anti-PD1 and anti-TIGIT significantly reduced tumor growth, increased the ratio of cytotoxic to regulatory T cells in tumors, and prolonged survival.PVRL1, which is up-regulated by HCC cells, stabilizes cell surface PVR, which interacts with TIGIT, an inhibitory molecule on CD8+ effector memory T cells. (stanford.edu)
Through hypoxia-inducible factor 1 (HIF-1) which elicits various molecular events, cells are able to overcome low O2. (stanford.edu)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Interferon Regulatory Factor 4 (IRF4) in Tissue homogenates, cell lysates and other biological fluids. (operatiebrp.nl)
Induction2
2005 . IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. (invivogen.com)
Here we show that myxoma virus infection of primary mouse embryo fibroblasts elicited extracellular signal-regulated kinase (Erk) signaling, which was integrated to interferon regulatory factor 3 activation and type I interferon induction. (elsevierpure.com)
Dataset1
2.0 fluorometer (Invitrogen, USA) and a Bioanalyzer (Agilent Technologies, USA), sequencing was performed on an Illumina MiSeq using a v. 3 reagent kit (Illumina), generating a dataset of 300 nucleotide paired-end reads. (cdc.gov)
Transcriptional3
Transcriptional activation of the interferon-beta (IFN-beta) gene requires assembly of an enhanceosome containing ATF-2/c-Jun, IRF-3/IRF-7, and NFkappaB. (rcsb.org)
Identifying the relevant transcriptional regulatory pathways in these neurons has been a priority, yet such attempts have been stymied due to their low abundance and the rich cellular diversity of the ARC. (biorxiv.org)
Cis-regulatory analysis of these integrated datasets enabled the identification of 28 putative hunger-promoting and 29 putative hunger-suppressing transcriptional regulators in AgRP neurons, 16 of which were predicted to be transcriptional effectors of leptin. (biorxiv.org)
Gamma1
Decreased interferon-gamma may contribute to increased susceptibility to HSV infection in atopic skin. (medscape.com)
Inhibits2
Human respiratory syncytial virus (RSV), a leading cause of respiratory tract infections in infants, inhibits type I interferon (IFN)-dependent signalling, as well as IFN synthesis. (microbiologyresearch.org)
including vIRF1, which is a transforming oncoprotein that inhibits type 1 interferon activity. (wikipedia.org)
Type2
As the second messenger, cGAMP activates STING and induces the following cascade to produce type I interferon (IFN-I) to protect against infections. (frontiersin.org)
The most frequent type of pancreatic cancer is pancreatic ductal adenocarcinoma (PDAC), which accounts for up to 90% of pancreatic adenocarcinoma cases [ 3 ]. (hindawi.com)
Tim-3 is a Marker of Plasmacytoid Dendritic Cell Dysfunction during HIV Infection and Is Associated with the Recruitment of IRF7 and p85 into Lysosomes and with the Submembrane Displacement of TLR9. (umassmed.edu)
STAT31
Finally, we demonstrated that hepcidin is modulated at the mRNA level by alpha interferon through STAT3. (microbiologyresearch.org)
Antiviral1
Because of this extensive presence, IRF-3 function is widely targeted by viruses [ 11 ], and thus its activity has to be aided by IRF-7 which takes a major part in amplification of the antiviral response. (biomedcentral.com)
Molecular1
N. B. Stafuzza , Borges, M. M. , and Amaral-Trusty, M. E. J. , " Molecular characterization of interferon regulatory factor 1 in Bubalus bubalis " , vol. 14, pp. 10919-10928, 2015. (geneticsmr.com)
Infection1
During HBV infection, a variety of cellular factors are recruited by the virus to regulate multiple steps in the HBV replication cycle [ 10 ]. (biomedcentral.com)
STAT11
NF-κB also controls expression of the downstream IFN auto-amplification loop through STAT1, IRF-1, −5, and −7 transcription factors. (biomedcentral.com)
DsRNA1
Upon recognition of dsRNA, RIG-I and MDA5 are recruited by the MAVS adaptor to the outer membrane of the mitochondria leading to the activation of several transcription factors, including interferon regulatory factors (IRFs) and NF-κB [3]. (invivogen.com)
Epithelial1
Background: Vestigial like family member 3 (VGLL3) is associated with the prognosis of epithelial ovarian cancer and soft tissue sarcoma, but its role in gastric cancer (GC) is unclear. (researchgate.net)
Mechanisms1
The regulatory mechanisms of activation of these two pathways and their interactions during the IIR are only partially known. (biomedcentral.com)
Prognostic1
In addition, the prognostic risk model nomogram showed that VGLL3 was the most important indicator, with an area under the receiver operating characteristic (ROC) curve (AUC) of 0.613 for 3-year survival and 0.706 for 5-year survival. (researchgate.net)
Sequence1
[ 3 , 4 ] Typical and atypical clefts can both occur as an isolated anomaly, as part of a sequence of a primary defect, or as a multiple congenital anomaly (MCA). (medscape.com)
Progression1
Figure 3: Relocalization of cGAS to micronuclei following mitotic progression triggers inflammatory signalling. (nature.com)
Enhancer1
We describe here a crystal structure of the DNA-binding domains of IRF-3, IRF-7, and NFkappaB, bound to one half of the enhancer, and use a previously described structure of the remaining half to assemble a complete picture of enhanceosome architecture in the vicinity of the DNA. (rcsb.org)
Transition1
Adaptations of interferon regulatory factor 3 with transition from terrestrial to aquatic life. (cdc.gov)
Activation2
Transient overexpression of UBCv1 impaired activation of NF-κB and AP-1 transcription factors induced by several agonists of these pathways. (mdpi.com)
These findings shed light on the functional and regulatory aspects of SOX9 activation in the human kidney during injury and regeneration. (lu.se)