• Gestational trophoblastic tumors are sensitive to many antineoplastic agents, especially those that act in the S phase or the M phase of the cell cycle. (medscape.com)
  • Capecitabine is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. (targetmol.com)
  • Antineoplastic agents are used for induction, consolidation, and maintenance therapy and central nervous system (CNS) prophylaxis in patients with acute lymphoblastic leukemia (ALL). (medscape.com)
  • Antineoplastic agents are used for induction, consolidation, maintenance, and central nervous system (CNS) prophylaxis. (medscape.com)
  • Antineoplastic agents interfere with cell reproduction. (medscape.com)
  • Cellular apoptosis (ie, programmed cell death) is another potential mechanism of many antineoplastic agents. (medscape.com)
  • Comment: Palifermin should not be administered within 24 hrbefore, during infusion of, or within 24 hr after administration of antineoplastic agents. (medscape.com)
  • Intercalates between guanine and cytosine base pairs, inhibiting DNA and RNA synthesis and protein synthesis. (medscape.com)
  • This agent acts by inhibiting inflammatory reactions and pain via decreasing the activity of cyclooxygenase, which results in a decrease of prostaglandin synthesis. (medscape.com)
  • Recent advances in small organic molecules as DNA intercalating agents: synthesis, activity, and modeling. (uni-bielefeld.de)
  • intercalating agents manage during dna synthesis? (microleadsneuro.com)
  • Techasakul, S. Synthesis, Cytotoxicity Evaluation, and Molecular Modeling Studies of 2,N10-Substituted Acridones as DNA-Intercalating Agents. (cri.or.th)
  • Hydroxyurea, an antineoplastic agent, inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. (targetmol.com)
  • This agent inhibits dihydrofolate reductase, resulting in inhibition of DNA synthesis, repair, and cellular replication. (medscape.com)
  • The intercalating fluorescent dye PicoGreen (Thermo Fisher Scientific) was added to the sample in advance to increase sensitivity of DNA detection ( 2 ). (bioprocessintl.com)
  • Ethidium bromide is an intercalating agent commonly used as a fluorescent tag (nucleic acid stain) in molecular biology laboratories for techniques such as agarose gel electrophoresis. (medchemexpress.com)
  • I need to stain some double-stranded DNA with an intercalating fluorescent dye. (stackexchange.com)
  • We tested the toxicity of 16 new DNA-intercalating agents to cisplatin (cDDP)-sensitive human ovarian carcinoma cell lines and their resistant counterparts. (unimore.it)
  • Some agents act at specific phases of the cell cycle, whereas others (ie, alkylating agents, anthracyclines, cisplatin) are not phase specific. (medscape.com)
  • Doxorubicin, which has been the most frequently used chemotherapeutic agent in the treatment of soft tissue sarcomas, demonstrates response rates of 20-30% in disseminated disease ( 9 , 10 ). (spandidos-publications.com)
  • Doxorubicin, a brain-impermeable chemotherapeutic agent, is also readily and selectively uptaken by NSCs and reduces their proliferation, which might explain its problematic anti-neurogenic or cognitive side-effect. (elifesciences.org)
  • Dexamethasone is another corticosteroid that acts as an important chemotherapeutic agent in the treatment of ALL. (medscape.com)
  • The SyBr Green dye functions as an intercalating agent that emits detectable fluorescence when bound to double-stranded DNA. (cdc.gov)
  • In cell growth assays, BN80927 is a very potent antiproliferative agent as shown by IC 50 values consistently lower than those of SN38 in tumor cell lines as well as in their related drug-resistant lines. (aacrjournals.org)
  • Despite increasing numbers of affected patients with life-threatening infections and the concomitant increased burden on public healthcare systems, there remains only three main classes of established antifungal agents to treat systemic infections. (nature.com)
  • These concerns are exacerbated by the lack of development of novel antifungal agents in the current clinical pipeline against fungal diseases. (nature.com)
  • Candida show uniform resistance to a wide spectrum of the The devices become colonized by the microorganisms that currently available conventional antifungal agents, which form a biofilm of cells, the detachment of which can result implies that antimicrobial drugs that specifically target in septicemia (2-5,8,9,14,15). (cdc.gov)
  • Fungal biofilm-asso- ciated infections are frequently refractory to conventional iensis possesses a readily inducible fluconazole resistance therapy because of resistance to antimicrobial agents. (cdc.gov)
  • What is the best protocol of single-agent methotrexate chemotherapy in nonmetastatic or low-risk metastatic gestational trophoblastic tumors? (medscape.com)
  • Roberts JP, Lurain JR. Treatment of low-risk metastatic gestational trophoblastic tumors with single-agent chemotherapy. (medscape.com)
  • Relapse rate of patients with low-risk gestational trophoblastic tumor initially treated with single-agent chemotherapy. (medscape.com)
  • Is lack of response to single-agent chemotherapy in gestational trophoblastic disease associated with dose scheduling or chemotherapy resistance? (medscape.com)
  • The crystal structure of a complex containing deoxy CpG and a terpyridine platinum compound (TPH) shows a DNA double helical fragment with TPH intercalated between two Watson-Crick GC base pairs. (tmu.edu.tw)
  • Layered clays like montmorillonite and kaolinite serve as host materials while organic or inorganic nanoparticles are intercalated within their layers, often polyethylene or polystyrene matrixes are employed. (ablogwithadifference.com)
  • Mutagens are biological, physical or chemical agents that change the genetic materials (inclusive of DNA and RNA molecules) of an organism and thus increase the frequency of mutations above the natural background level. (microbiologyclass.net)
  • PCEs possessing long side chains were less effective as dispersants due to the consumption of these polymers via the ability of their PEO side chains to intercalate between the remaining layers in the calcined clay. (sintef.no)
  • Sodium montmorillonite (Na-MMT) was first added in natural rubber latex to obtain natural rubber/clay masterbatch, which was subsequently dynamically crosslinked while mixing with molten PP. The effect of Na-MMT content were examined concerning elastomeric properties of NR/PP blends dynamically vulcanized using phenolic resin as a curing agent. (degruyter.com)
  • Morphology characterization observed by X-ray diffraction (XRD), transmission electron microscopy (TEM) and 3D microfocus X-ray computerized tomography showed that the dynamic vulcanization with nanoclay addition changed the blend morphology from a co-continuous-like structure to droplet-like phase one, and the clay remained within NR phase in intercalated and aggregated forms. (degruyter.com)
  • Intercalated nanocomposites are created by inserting nanoparticles such as clay minerals or nanoscale fillers between layers of host materials using techniques such as intercalation reactions, chemical bonding, or physical processes like melt mixing. (ablogwithadifference.com)
  • Clay-based nanocomposites are the go-to choice when it comes to intercalated nanocomposites. (ablogwithadifference.com)
  • Although C. composed of a population that developed from a single albicans is the predominant etiologic agent of candidiasis, species or a community derived from multiple microbial other Candida species that tend to be less susceptible to the species (14,17). (cdc.gov)
  • For this, the in vitro activity of four non-dihydropyridine agents (amrinone, fendiline, mibefradil, and lidoflazine) was tested against different Leishmania species and their cytotoxicity to mammalian cells was evaluated. (hindawi.com)
  • An N-methylphenanthrolinium-annelated spirooxazine derivative 2(SO) whose DNA-intercalating properties are reversibly changed by a photochromic reaction was prepared. (uni-bielefeld.de)
  • They can intercalate DNA and, in an UV-initiated reaction of the furan portion, alkylate PYRIMIDINES, resulting in PHOTOSENSITIVITY DISORDERS. (curehunter.com)
  • However, the intercalating dye will detect any dsDNA (non-specific amplicons, primer dimers) produced in the reaction. (solisbiodyne.com)
  • As alkylating agent, mechanism of action of active metabolites may involve cross-linking of DNA, which may interfere with growth of normal and neoplastic cells. (medscape.com)
  • Studies involving mechanism of emodin, an herbal extract, has revealed its potential as anti-inflammatory, antioxidant and anti-cancer agent. (longdom.org)
  • Few agents such as doxorubicin, ifosfamide and dacarbazine have proven to be effective in the therapy of soft tissue sarcomas ( 2 ). (spandidos-publications.com)
  • Use as single agent or as part of multiagent regimen for treatment of malignant GTN. (medscape.com)
  • It is indicated as a component of a multi-agent chemotherapeutic regimen for the first line treatment of ALL. (medscape.com)
  • DNA footprinting utilizes a DNA damaging agent (either a chemical reagent or a nuclease) which cleaves DNA at every base pair. (lookformedical.com)
  • 1998. Documentation of the threshold limit values for chemical substances and physical agents. (cdc.gov)
  • 2000. Threshold limit values for chemical substances and physical agents and biological exposure indices. (cdc.gov)
  • Graphene is a single layer of carbon atoms arranged in a two-dimensional structure that can be intercalated with various guest molecules or nanoparticles to form graphene-based nanocomposites, offering unique electronic, thermal, and mechanical properties used extensively in electronics, sensors, and advanced materials applications. (ablogwithadifference.com)
  • What are the different types of Intercalated Nanocomposites? (ablogwithadifference.com)
  • DNA intercalating agent chloroquine (ClQ) exerts cytotoxic effects in different types of cancer cells including glioma. (uni-goettingen.de)
  • The salivary secretions are then modified by a variety of cell types along a series of ducts, including the striated, intercalated, and excretory ducts, before finally being excreted through the Wharton duct into the oral cavity. (medscape.com)
  • In ALL, this agent is used because of its direct antileukemic effects. (medscape.com)
  • Intercalated nanocomposites are distinguished from similar advanced materials by this particular arrangement of their nanoparticles in its matrix host, creating what resembles an ordered or stacked arrangement within it that contains tiny gaps between nanoparticle layers known as gallery spacing. (ablogwithadifference.com)
  • Intercalated nanocomposites feature enhanced mechanical properties, including increased stiffness and strength due to reinforcing agents within their matrix, Thanks to nanoparticle layers that act as reinforcing agents intercalated nanocomposites offer excellent barrier properties, making them suitable for applications that require resistance against gases or liquids, They have superior thermal stability due to an insulating effect from nanoparticle layers. (ablogwithadifference.com)
  • in LDH nanocomposites, different anions, dyes or nanoparticles can be intercalated within these layers to create new materials with properties such as catalysis, drug delivery or flame retardancy applications. (ablogwithadifference.com)
  • Nanoparticles composed of metal sulfides like MoS2 and WS2, when intercalated into layers can create nanocomposites with various applications ranging from lubricants and electronics to energy storage devices. (ablogwithadifference.com)
  • major agents of nosocomial infections. (cdc.gov)
  • Any suspicious or confirmed publicity to a biological weapons agent must be reported instantly to the native health department, local Federal Bureau of Investigation workplace, and the Centers of Disease Control and Prevention (770�488�7100). (atpobtvs.com)
  • Cross-resistance to intercalating agents in an epipodophyllotoxin-resistant Chinese hamster ovary cell line: evidence for a common intracellular target. (mcmaster.ca)
  • Used both as single agent and in multiagent regimens for the treatment of malignant GTN. (medscape.com)
  • Pemetrexed is a parenterally administered folate antagonist and antineoplastic agent, used in the treatment of non-small cell lung cancer and malignant mesotheli. (targetmol.com)
  • Nanocomposites that are intercalated offer better properties including enhanced mechanical strength gas barrier properties and thermal stability. (ablogwithadifference.com)
  • This results in an intercalated nanocomposite with its own distinctive structure that confers several advantageous properties. (ablogwithadifference.com)
  • Although achieving full dispersion can be challenging maintaining an intercalated structure can vary based on factors like nanoparticle choice and host matrix properties. (ablogwithadifference.com)
  • The major pharmacologic action of agents in this class is noncompetitive inhibition of the enzyme carbonic anhydrase. (medscape.com)
  • Pyronin Y (Pyronine G) is a cationic dye that intercalates RNA and has been used to target cell structures including RNA, DNA and organelles. (medchemexpress.com)
  • Intercalated nanocomposites remain an effective approach to creating customized materials to address specific industrial or technological requirements. (ablogwithadifference.com)
  • Funding: the study was conducted as part of an intercalated BSc of JES and was not funded. (elsevierpure.com)
  • Graphene can also be employed as a confining agent to study undercover reactions, a trending topic in the catalysis field due to the reported higher performance of catalysts when placed in confined environments. (lu.se)
  • Natural biopolymers such as cellulose and chitosan can be intercalated with nanoparticles for use as biodegradable materials, drug delivery vehicles, and tissue engineering applications. (ablogwithadifference.com)
  • Vincristine is a vinca alkaloid agent that acts by arresting cells in metaphase. (medscape.com)
  • Like prednisone, this agent is used in induction and reinduction therapy and is also given as intermittent pulses during continuation therapy. (medscape.com)