Modulation of calcium current in arteriolar smooth muscle by alphav beta3 and alpha5 beta1 integrin ligands. (tamu.edu)
Vasoactive effects of soluble matrix proteins and integrin-binding peptides on arterioles are mediated by alphav beta3 and alpha5 beta1 integrins. (tamu.edu)
CD613
Integrin beta-3 (β3) or CD61 is a protein that in humans is encoded by the ITGB3 gene. (wikipedia.org)
The 2C9.G2 monoclonal antibody specifically binds to the integrin β3 chain (CD61), which associates with the integrin αv chain (CD51) to form the vitronectin receptor, as well as the αIIb chain (CD41) to form the gpIIb/IIIa complex. (bdbiosciences.com)
CD41 non-covalently associates with integrin beta3 (GPIIIa, CD61) and is expressed by megakaryocytes and platelets. (cytekbio.com)
Endothelial cell1
The compound is an antagonist of the "major endothelial cell integrin," alpha-v beta-3. (journalforclinicalstudies.com)
Subunit6
A functional polymorphism in the integrin beta3 subunit encoded by the ITGB3 gene, Leu33Pro, has been shown to modify a variety of traits of beta3-expressing cells. (nih.gov)
Defectively expressed β3 integrin subunit has been correlated with presence of endometriosis, and has been suggested as a putative marker of this condition. (wikipedia.org)
Identification of a talin-binding site in the integrin beta(3) subunit distinct from the NPLY regulatory motif of post-ligand binding functions. (wikipedia.org)
Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß2 subunit of LFA1 family (ß2 integrins). (medscape.com)
An integrin beta subunit of approximately 85-kDa in size which has been found in INTEGRIN ALPHAIIB-containing and INTEGRIN ALPHAV-containing heterodimers. (nih.gov)
Integrins are large cell-surface adhesion receptors that can be activated to a high affinity state by the formation of an intracellular complex between the integrin β-subunit tail, the membrane, and talin. (ox.ac.uk)
ITGB31
The ITGB3 protein product is the integrin beta chain beta 3. (wikipedia.org)
Peptides1
PMID 18045240 ] Immunologic and structural analysis of eight novel domain-deletion beta3 integrin peptides designed for detection of HPA-1 antibodies. (snpedia.com)
AlphaIIb2
The integrin alphaIIb beta3:Inactive SRC complex recruits PTP1B protein tyrosine phosphatase resulting in the dephosphorylation of SRC tyrosine 530. (reactome.org)
Description: The HIP8 monoclonal antibody reacts with the human CD41 molecule, the integrin alphaIIb also known as platelet GPIIb. (cytekbio.com)
Ligands3
To examine the underlying mechanisms, we measured L-type Ca2+ channel current in arteriolar smooth muscle cells in response to integrin ligands. (tamu.edu)
This would account for the vasoactive effects of integrin ligands on arterioles and provide a potential mechanism for wound recognition during tissue injury. (tamu.edu)
In addition, interaction of the αvβ3 integrin with its ligands regulates the L-type Ca2+ channel in vascular smooth muscle cells, possibly mediating vasodilatory responses to injury. (bdbiosciences.com)
Proteins3
Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. (wikipedia.org)
The integrin ανβ 3, which binds to a number of extracellular matrix proteins, is not generally expressed in normal tissues but is significantly upregulated on blood vessels undergoing angiogenesis [ 4 ]. (biomedcentral.com)
The encoded protein interacts with many other proteins, including the platelet integrin alpha-IIb-beta-3, DNA-dependent protein kinase, presenilin-2, focal adhesion kinase, p21 activated kinase, and protein kinase D. The encoded protein may be involved in cell survival and proliferation, and is associated with several disease states including cancer and Alzheimers disease. (idhinhibitor.com)
Alpha5 beta11
The data suggest that alphavbeta3 and alpha5 beta1 integrins are differentially linked through intracellular signaling pathways to the L-type Ca2+ channel and thereby alter control of Ca2+ influx in vascular smooth muscle. (tamu.edu)
Receptors1
Integrins are heterodimeric transmembrane glycoproteins that function as key adhesion and cell signalling receptors. (nih.gov)
Talin2
Here, activation of the integrin αIIb/β3 dimer by the talin head domain was probed using multiscale molecular dynamics simulations. (ox.ac.uk)
These results, combined with various published experimental observations, suggest a model for the mechanism of inside-out activation of integrins by talin. (ox.ac.uk)
Binds1
The PAI-vitronectin complex binds to the Arg-Gly-Asp motif of αv integrins and inhibits the integrin-mediated cell migration [ 28 - 33 ]. (biomedcentral.com)
Receptor3
Moreover, mice lacking integrin αIIBβ3, the primary platelet receptor for fibrinogen, displayed a dramatic reduction in early inflammatory changes after ethanol/LPS challenge. (nih.gov)
Leukocyte-endothelial adhesion is also mediated by the binding of αvβ3 integrin or vitronectin receptor to CD31 (PECAM-1). (bdbiosciences.com)
Integrin alpha (ITGA)6 and 2 were enriched in several pathways, including focal adhesion and extracellular matrix‑receptor interaction. (spandidos-publications.com)
Antibodies1
Whole-cell, inward Ba2+ currents were inhibited after application of soluble cyclic RGD peptide, vitronectin (VN), fibronectin (FN), either of two anti-beta3 integrin antibodies, or monovalent beta3 antibody. (tamu.edu)
Adhesion4
Integrins are known to participate in cell adhesion as well as cell-surface-mediated signaling. (wikipedia.org)
CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. (exbio.cz)
Rap-1 is an essential protein involved in signaling mediated by integrins. (medscape.com)
Platelets1
Integrin beta 3 is found along with the alpha IIb chain in platelets. (wikipedia.org)
Tumor5
Expression profiling reveals genes associated with transendothelial migration of tumor cells: a functional role for alpha v beta3 integrin. (fau.de)
Start page / Publications / Expression profiling reveals genes associated with transendothelial migration of tumor cells: a functional role for alpha v beta3 integrin. (fau.de)
K. Bauer, C. Mierke, J. BehrensExpression profiling reveals genes associated with transendothelial migration of tumor cells: a functional role for alpha v beta3 integrin.In Int J Cancer, volume 121, 2007. (fau.de)
article{RN911, author = {Bauer, K. and Mierke, C. and Behrens, J.}, title = {Expression profiling reveals genes associated with transendothelial migration of tumor cells: a functional role for alpha v beta3 integrin. (fau.de)
The key role integrins play in tumor angiogenesis is illustrated by studies showing their involvement in cell migration, proliferation and survival [ 3 ]. (biomedcentral.com)
Gene1
Integrin alpha-2 and beta-3 gene polymorphisms and breast cancer risk. (cdc.gov)
Activation1
Multiscale simulations suggest a mechanism for integrin inside-out activation. (ox.ac.uk)
Migration1
Forkhead box F1 is essential for migration of mesenchymal cells and directly induces integrin-beta3 expression. (medlineplus.gov)
Mice1
Wild-type, PAI-1-/-, and integrin β3-/- mice were fed ethanol-containing Lieber-DeCarli liquid or a control diet for 6 weeks, followed by systemic LPS challenge. (nih.gov)
PMID1
PMID 22015659 ] Mean platelet volume and integrin alleles correlate with levels of integrins alpha(IIb)beta(3) and alpha(2)beta(1) in acute coronary syndrome patients and normal subjects. (snpedia.com)
Chain1
A given chain may combine with multiple partners resulting in different integrins. (wikipedia.org)
Beta1
Subunidad de la integrina beta, de aproximadamente 85 kD, que se ha encontrado en heterodímeros conteniendo GLICOPROTEINA IIB DE MEMBRANA PLAQUETARIA e INTEGRINA ALFAV. (bvsalud.org)
Human1
Description: A Rabbit Polyclonal antibody against Integrin ?4 from Human/Mouse/Rat. (cotinis.com)