• paxillin
  • Paxillin is tyrosine-phosphorylated by FAK and Src upon integrin engagement or growth factor stimulation, creating binding sites for the adapter protein Crk. (wikipedia.org)
  • The current working model of costamerogenesis is that in cultured, undifferentiated myoblasts, alpha-5 integrin, vinculin and paxillin are in complex and located primarily at focal adhesions. (wikipedia.org)
  • binds
  • ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). (genecards.org)
  • Natalizumab
  • Chemotherapy combined with Natalizumab prolonged survival of NOD/SCID recipients of primary ALL, suggesting adjuvant alpha4 inhibition as a novel strategy for pre-B ALL. (nih.gov)
  • α4-integrin is required for white blood cells to move into organs, therefore, natalizumab prevents these immune cells from crossing blood vessel walls to reach affected organs thereby decreasing inflamation. (drugbank.ca)
  • induces
  • vWF binding to GP Ib-IX-V rapidly induces platelet activation, leading to cytoskeletal rearrangement, shape change, and secretion that enables alphaIIbbeta3 integrin (GP IIb-IIIa)-dependent platelet aggregation. (embl-heidelberg.de)
  • cells
  • F) Kaplan-Meier survival curve of alpha4-CreER T2 and Empty-ER T2 cells injected C57/BL6 Ly5.1+ recipient mice treated with or without nilotinib (NTB). (nih.gov)
  • This process relies on the key interaction between the integrin α4β7 and the addressin MadCAM-1 on the surfaces of the appropriate cells. (wikipedia.org)
  • It became apparent that there were significantly higher levels of the integrin α4β7 on activated T cells in comparison to naïve T cells. (wikipedia.org)
  • Additionally, this integrin was much more common on CD8+ T cells activated in the Peyer's patches (PP T-cells) compared to other T cell subsets, such as peripheral and mesenteric lymph nodes activated T cells. (wikipedia.org)
  • treatment
  • C) Deletion of alpha4 induced by tamoxifen was confirmed by flow cytometry 6 days after treatment. (nih.gov)