Research suggests that integrase strand transfer inhibitors (INSTIs) are associated with greater weight gain compared to other HIV medications. (actgnetwork.org)
Certain integrase strand transfer inhibitors (INSTIs) have been associated with weight gain in the adult population, but data in the pediatric population is lacking. (iupui.edu)
Evidence suggests that integrase strand transfer inhibitors (INSTIs) are associated with greater weight gain than other antiretrovirals. (analysisgroup.com)
Long-acting injectable contraception is compatible with protease inhibitors and NNRTIs, but data are limited with integrase inhibitors. (medscape.com)
Background and Objective: Integrase strand transfer inhibitors (INSTIs) are currently the standard of practice for first-line HIV therapy for most patients. (uludag.edu.tr)
Integrase strand transfer inhibitors, often abbreviated to "integrase inhibitors", target an enzyme called Integrase, a protein essential for HIV replication. (co.sz)
Integrase strand transfer inhibitors (INSTIs) block integrase, which is an HIV enzyme that the virus uses to insert its genetic material into a cell that it has infected. (aidsmap.com)
This study aims to provide knowledge about the potential of HIV-1 integrase inhibitors for use as guiding compounds in the development of new anti-HIV drugs. (innovareacademics.in)
Methods: This study used AutoDock and AutoDock Vina for virtual screening of the Indonesian herbal database for inhibitors of HIV-1 integrase and is validated using a database of the directory of useful decoys. (innovareacademics.in)
Strand transfer6
Inhibits the strand transfer step of HIV-1 integration necessary for the HIV replication cycle by binding to the integrase active site. (medscape.com)
Nucleoside reverse transcriptase inhibitor (NRTI) transmitted drug resistance mutations (TDRMs) could increase the risk of virological failure (VF) of first-line integrase strand transfer inhibitor (InSTI)-based regimens. (nih.gov)
Integrase Strand Transfer Inhibitor (INSTI) Genotypic Resistance Analysis in Treatment-nNaive, INSTI Free Antiretroviral-Experienced and INSTI-Experienced Turkish Patients Infected with HIV-1. (uludag.edu.tr)
Integrase Strand Transfer Inhibitor (INS. (uludag.edu.tr)
Low-level viral loads and virological failure in the integrase strand transfer era. (bvsalud.org)
To analyse the occurrence of virological failure (VF) in patients starting ART with an integrase strand transfer inhibitor (INSTI)-based regimen in recent years, in relation with previous episodes of low-level viral load (LLVL). (bvsalud.org)
INSTI1
Among antiretroviral-naive people entering a RESPOND study cohort, the new AIDS cancer rate (incidence) dropped with longer time after starting an integrase inhibitor (INSTI) regimen [1]. (natap.org)
Inhibitor raltegravir1
Background: Genomic integration, an obligate step in the HIV-1 replication cycle, is blocked by the integrase inhibitor raltegravir. (nyu.edu)
Form a unique fingerprint1
Dive into the research topics of 'A structural model of the HIV-1 Rev-integrase complex: The molecular basis of integrase regulation by Rev'. Together they form a unique fingerprint. (huji.ac.il)
Recombinase1
In either strategy, the phiC31 integrase, a site-specific phage recombinase, will be used to carry out integration of the dysferlin gene into the chromosomes of target cells. (jain-foundation.org)
Large serine1
The highly directional large serine bacteriophage integrases were utilised as the basis for the synthetic circuits constructed in this study. (bl.uk)
Protein4
HIV integrase is a 32kDa viral protein consisting of three domains- N-terminus, catalytic core domain, and C-terminus, which each have distinct properties and functions contributing to the efficacy of HIV integrase. (wikipedia.org)
Integrases and their protein co-factors, the recombination directionality factor (RDF) can change the orientation of a specific DNA segment flanked by two recombination sites. (bl.uk)
A functional mini-integrase in a two-protein type V-C CRISPR system. (mendeley.com)
Moloney murine leukemia virus (M-MuLV) proviruses carrying integrase (IN) protein tagged either with a simian virus 40 (SV40) nuclear localization signal (NLS) or various antigenic epitopes were generated. (researchwithrutgers.com)
Regimens2
Data are scarce regarding the incidence of neuropsychiatric events (NPEs) in people living with human immunodeficiency virus (HIV)-1 taking integrase inhibitor (INI)- or protease inhibitor (PI)-based regimens. (psychiatrist.com)
1,5,8 Additionally, neuropsychiatric adverse events (AEs) leading to discontinuations have been seen in phase 3 studies of integrase inhibitor (INI)-based regimens. (psychiatrist.com)
PhiC311
Addgene: Efficient site-specific transgenesis and enhancer activity tests in medaka using PhiC31 integrase. (addgene.org)
Enzyme called1
HIV uses an enzyme called integrase to send its genetic material into the cells' DNA. (medicalnewstoday.com)
Phage1
Retroviral INs are not to be confused with phage integrases (recombinases) used in biotechnology, such as λ phage integrase, as discussed in site-specific recombination. (wikipedia.org)
Catalytic3
The catalytic core domain, like the N-terminus, contains highly conserved amino acid residues -Asp64, Asp116, Glu152- as the conserved DDE (Asp-Asp-Glu) motif contributes to the endonuclease and polynucleotide transferase functions of integrase. (wikipedia.org)
The specificity of cleavage is improved through the use of cofactors such as Mn2+ and Mg2+ which interact with the DDE motif of the catalytic core domain, acting as cofactors to integrase function. (wikipedia.org)
Raltegravir prevents integration of the proviral gene into human DNA by inhibiting the catalytic activity of integrase. (medscape.com)
Mutations1
Mutations in these regions inactivates integrase and prevents genome integration. (wikipedia.org)
Antiretroviral1
And among people who had already taken antiretroviral therapy (ART) when entering their RESPOND cohort, longer time taking an integrase inhibitor was not linked to a rising rate of new cancers. (natap.org)
Prevents1
Blocking integrase prevents HIV from replicating. (aidsmap.com)
Simian1
We investigated whether monthly injections of a long-acting formulation of the HIV integrase inhibitor GSK1265744 (GSK744 LA) prevented simian/human immunodeficiency virus (SHIV) infection by vaginal challenge in macaques. (rti.org)
Gene4
In this study, three different serine integrase-based synthetic gene circuits for cellular memory and counting were engineered and characterised. (bl.uk)
Integrase expression triggered by one input signal resulted in inversion of the invertible DNA, placing the gp3 gene in the correct orientation for transcription. (bl.uk)
In my study, I examined the presence and abundance of the Class 1 Integron-Integrase gene at bird feeders on Bard campus as a marker for antibiotic resistance. (bard.edu)
Focusing on winter resident birds, I looked at how the abundance of the Class 1 Integron-Integrase gene at the bird feeders changes over time. (bard.edu)
Functional1
Scholars@Duke publication: Transduction of human antigen-presenting cells with integrase-defective lentiviral vector enables functional expansion of primed antigen-specific CD8(+) T cells. (duke.edu)
Domain1
Crystal and NMR structures of the individual domains and 2-domain constructs of integrases from HIV-1, HIV-2, SIV, and Rous Sarcoma Virus (RSV) have been reported, with the first structures determined in 1994. (wikipedia.org)
Human immun3
Raltegravir is a human immunodeficiency virus (HIV)-integrase inhibitor that has been shown to alter the host immune response to HIV in addition to its direct antiviral effect. (microbiologyresearch.org)
In this study, a photoaffinity-labeled probe for full-length human immunodeficiency virus-1 integrase (HIV-1 IN) capture was designed and synthesized, following the structure of the FDA-approved drug Raltegravir. (unipr.it)
Integration of human immunodeficiency virus type 1 (HIV-1) into a host cell chromosome is an essential step under the control of the viral integrase (IN). (biomedcentral.com)
Activity4
Using its endonucleolytic activity, integrase cleaves a di or trinucleotide from both 3' ends of the genome in a processing known as 3'-processing. (wikipedia.org)
In November 2005, data from a phase 2 study of an investigational HIV integrase inhibitor, MK-0518, demonstrated that the compound has potent antiviral activity. (wikipedia.org)
93del is a 16-nucleotide G-quadruplex-forming aptamer which can inhibit the activity of the HIV-1 integrase enzyme at nanomolar concentration. (ntu.edu.sg)
The beta-carboline hydroxamic acid compounds and compositions containing those compounds may be used to inhibit or modulate the activity of HIV integrase enzyme and to treat HIV integrase-mediated diseases and conditions. (kisti.re.kr)
Crystal1
a 2010 crystal structure of the HFV integrase assembled on viral DNA ends has been determined. (wikipedia.org)
Target2
As metal chelation is vital in integrase efficacy, it is a target for the development of retroviral therapies. (wikipedia.org)
The emergence of mutant HIV strains has led treatment to target protease as reverse transcriptase and integrase enzyme become less effective. (innovareacademics.in)
Reverse1
Gp3 expression can then be triggered by another input signal to reverse the directionality of integrase, restoring the DNA back to its original configuration. (bl.uk)
Switch1
Placing expression of gp3 under the control of the invertible DNA, allowed a single input signal controlling only integrase expression to switch the module between OFF (0) and ON (1). (bl.uk)