• IGF binding proteins (IGFBPs) are proteins of 24 to 45 kDa. (wikipedia.org)
  • All six IGFBPs share 50% homology with each other and have binding affinities for IGF-I and IGF-II at the same order of magnitude as the ligands have for the IGF-IR. (wikipedia.org)
  • In humans, IGFBPs are transcribed from the following seven genes: IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 Insulin-like growth factor receptor Kalus W, Zweckstetter M, Renner C, et al. (wikipedia.org)
  • Insulin-like growth factor-binding proteins (IGFBPs) control bioavailability, activity, and distribution of insulin-like growth factor (IGF)1 and -2 through high-affinity IGFBP/IGF complexes. (rcsb.org)
  • IGF-binding sites are found on N- and C-terminal fragments of IGFBPs, the two conserved domains of IGFBPs. (rcsb.org)
  • Circulating IGF-I and -II are bound to specific insulin-like growth factor (IGF)-binding proteins (IGFBPs), of which IGFBP-3 binds the majority of the IGFs. (nih.gov)
  • The insulin-like growth factor binding proteins (IGFBPs) comprise a family of six distinct proteins which modulate insulin-like growth factor action. (eur.nl)
  • The full length protein consists of four modulesModule I shares partial identity with the N-terminal part of the Insulin-like Growth Factor Binding Proteins (IGFBPs). (neuromics.com)
  • Because IGF-1 exhibits neuroprotective and myelinogenetic effects, it possesses therapeutic potential in treating neurodegenerative demyelinating diseases such as multiple sclerosis (MS). However, IGF actions are largely dependant on high-affinity regulatory IGF binding proteins (IGFBPs), which are likely to interfere with therapeutic attempts at elevating IGF-1 levels in the CNS. (vub.be)
  • Here the possibility that this is accompanied by a corresponding episode of accelerated evolution of IGF1 receptor (IGF1R), insulin receptor (IR) and/or IGF binding proteins (IGFBPs) was investigated. (figshare.com)
  • Marked accelerated evolution on this branch was also seen for some IGFBPs, but not the mannose 6-phosphate/IGF2 receptor or epidermal growth factor receptor. (figshare.com)
  • Overall the results suggest that adaptive coevolution of IGF1, insulin and their receptors and some IGFBPs occurred during the evolution of NWM. (figshare.com)
  • Insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are key elements in fetal growth. (ox.ac.uk)
  • The predominant IGF-binding proteins (IGFBPs) produced by hFOB/ER9 and by normal trabecular osteoblasts are IGFBP-3 and IGFBP-4, of which IGFBP-4 is consistently inhibitory of IGF action. (elsevierpure.com)
  • IGFBPs modulate the biological activities of IGF proteins. (rndsystems.com)
  • Some IGFBPs may also have intrinsic bioactivity that is independent of their ability to bind IGF proteins. (rndsystems.com)
  • The insulin-like growth factor-binding protein (IGFBP) serves as a transport protein for insulin-like growth factor 1 (IGF-1). (wikipedia.org)
  • IGFBP-3, the most abundant protein, accounts for 80% of all IGF binding. (wikipedia.org)
  • IGF-1 binds to IGFBP-3 in a 1:1 molar ratio. (wikipedia.org)
  • Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions" (PDF). (wikipedia.org)
  • The structures reveal the mechanisms of IGF signaling regulation via IGFBP binding. (rcsb.org)
  • Age, sex, height, BMI, and pubertal maturation were all important factors in determining the circulating levels of IGFBP-3, whereas IGF-I levels were unaffected by BMI. (nih.gov)
  • IGF-I levels increased to relatively higher levels than IGFBP-3, leading to an increasing molar ratio between IGF-I and IGFBP-3 in puberty, when growth velocity is high. (nih.gov)
  • Using microarray expression analysis, we recently reported that expression of the insulin-like growth factor binding protein-2 (IGFBP-2) gene is elevated in advanced epithelial ovarian cancers. (rti.org)
  • We recently reported that hypoxia and/or leucine deprivation triggered hyperphosphorylation of insulin-like growth factor binding protein-1 (IGFBP-1) in decidualized human immortalized endometrial stromal cells (HIESCs), resulting in decreased insulin-like growth factor-1 (IGF-1) bioactivity. (uwo.ca)
  • Insulin-like growth factor binding protein-3 (IGFBP-3) is postulated to be a mediator of growth suppression signals. (nih.gov)
  • Here, we examined the methylation status of IGFBP-3 to correlate to clinicopathological factors in human cancers. (nih.gov)
  • In one of two complementary studies, IARC scientists analysed data from almost 230 000 women using Mendelian randomization to examine genetic variants known to be associated with circulating concentrations of IGF-1 and insulin-like growth factor-binding protein-3 (IGFBP-3), which may modulate the availability of IGF-1. (who.int)
  • Insulin is the principal regulator of hepatic insulin-like growth factor binding protein-1 (IGFBP-1) production, mediating the rapid decrease in plasma IGFBP-1 in response to nutritional intake. (utmb.edu)
  • In this study, we defined IGFBP-1 regulation by insulin in upper and lower body obesity, conditions associated with insulin resistance and chronic hyperinsulinemia. (utmb.edu)
  • Overnight postabsorptive IGFBP-1 levels in obese and nonobese women showed an inverse, nonlinear relationship with plasma insulin concentrations. (utmb.edu)
  • Maximum suppression of IGFBP-1 was seen at 70-90 pmol/L plasma insulin. (utmb.edu)
  • Both groups of obese women had mean fasting plasma insulin concentrations above this threshold level and, consequently, markedly suppressed IGFBP-1 levels. (utmb.edu)
  • Insulin infusion rapidly decreased plasma IGFBP-1 levels in nonobese subjects (60% decrease in 2 h), but had little or no further suppressive effect in obese subjects. (utmb.edu)
  • Complete insulin withdrawal resulted in a significant rise in plasma IGFBP-1 concentrations in all subjects, but the response was blunted in obese compared to nonobese groups. (utmb.edu)
  • In conclusion, low IGFBP-1 levels in obesity are related to elevated insulin levels which are, in turn, related to body fat distribution and insulin resistance. (utmb.edu)
  • In addition, our findings imply that hepatic insulin sensitivity in terms of IGFBP-1 production is preserved despite peripheral insulin resistance in obesity. (utmb.edu)
  • CONCLUSIONS: In this population, circulating IGF-I is modestly related with the intake of protein and minerals, and with milk and cheese, while IGFBP-3 does not appear to be related with diet. (ox.ac.uk)
  • Gel mobility shift assays using 32 P-labeled -569 to -540 and -83 to -54 oligonucleotides from the IGFBP-4 gene promoter showed that Sp1 protein bound these oligonucleotides to form a retarded band, and the intensity of the band was competitively decreased after coincubation with unlabeled IGFBP-4-derived and consensus Sp1 oligonucleotides. (utmb.edu)
  • The GH study group of the Korean Endocrine Society aims to establish the Korean reference ranges of serum IGF-I and insulin-like growth factor binding protein-3 (IGFBP-3) and assess the relationship between IGF-I and IGFBP-3 and clinical parameters. (e-enm.org)
  • In blood circulation, over 75% of IGF-I is bound to the insulin-like growth factor binding protein-3 (IGFBP-3). (e-enm.org)
  • Higher levels of IGFBP-3 increase the binding capacity of IGF-I, but also decrease the circulating IGF-I bioavailability [ 2 ]. (e-enm.org)
  • Measuring serum IGF-I and IGFBP-3 is essential for diagnosis and monitoring of treatment responses in GH deficiency such as hypopituitarism, growth hormone-releasing hormone (GHRH) receptor mutation, or GH insensitivity [ 8 ] and GH excess such as acromegaly or gigantism [ 9 ]. (e-enm.org)
  • IGF-binding protein-5 (IGFBP-5) is abundant in serum and bone during normal skeletal development, but levels decrease in osteoporosis. (westminster.ac.uk)
  • IGFBP-1 is elevated in the fetal circulation of human and animal pregnancies complicated by IUGR caused by placental insufficiency and in utero hypoxia and is believed to restrict fetal growth by sequestering IGFs. (ox.ac.uk)
  • In this study, we developed a protocol to establish highly pure primary cultures of human fetal hepatocytes in vitro and investigated their expression of IGFBP-1 messenger RNA (mRNA) and protein and the effects of hypoxia on their expression of IGFBP-1 mRNA and protein. (ox.ac.uk)
  • IGFBP-1 protein in conditioned medium (CM) was measured by immunoradiometric assay and increased 3- to 4-fold under hypoxic (2% O2), compared with normoxic, conditions. (ox.ac.uk)
  • This study demonstrates that human fetal hepatocytes can be cultured in defined medium, as primary cultures with high purity, and that they express IGFBP-1 mRNA and secrete IGFBP-1 protein in vitro. (ox.ac.uk)
  • In addition, the data demonstrate that hypoxia up-regulates fetal hepatocyte IGFBP-1 mRNA steady-state levels and protein, with this being the major IGFBP derived from the fetal hepatocyte. (ox.ac.uk)
  • Circulating levels of insulin-like growth factor I (IGF-I) and its main binding protein, IGF binding protein 3 (IGFBP-3), have been associated with risk of several types of cancer. (ox.ac.uk)
  • Heritable factors explain up to 60% of the variation in IGF-I and IGFBP-3 in studies of adult twins.We systematically examined common genetic variation in 18 genes in the IGF signaling pathway for associations with circulating levels of IGF-I and IGFBP-3. (ox.ac.uk)
  • However, these variants explain only a small percentage of the variation in circulating IGF-I and IGFBP-3 in Caucasian men and women.Further studies are needed to explore contributions from other genetic factors such as rare variants in these genes and variation outside of these genes. (ox.ac.uk)
  • 0.01) in a dose-dependent fashion but did not alter IGFBP-3 mRNA or protein. (elsevierpure.com)
  • ICI 182,780, a pure anti-estrogen, completely blocked E2-mediated decreases in cell proliferation and increases in levels of IGFBP-4 mRNA and protein. (elsevierpure.com)
  • The superfamily of insulin-like growth factor (IGF) binding proteins include the six high-affinity IGF binding proteins (IGFBP) and at least four additional low-affinity binding proteins referred to as IGFBP related proteins (IGFBP-rP). (rndsystems.com)
  • All IGFBP superfamily members are cysteine-rich proteins with conserved cysteine residues, which are clustered in the amino- and carboxy-terminal thirds of the molecule. (rndsystems.com)
  • Post-translational modifications of IGFBP, including glycosylation, phosphorylation and proteolysis, have been shown to modify the affinities of the binding proteins to IGF. (rndsystems.com)
  • ALS (Acid Labile Subunit) is a liver-derived protein that exists in a ternary complex with Insulin-like Growth Factor (IGF)-binding Protein-3 (IGFBP-3) or IGFBP-5, and either IGF-I or IGF-II. (rndsystems.com)
  • Cyr61, also known as IGFBP-10 and CCN1, is a 50 kDa matricellular glycoprotein that regulates the growth and adhesion of vascular endothelial cells, fibroblasts, and monocytes. (rndsystems.com)
  • Patients with idiopathic hypogonadotropic hypogonadism and severe obesity secondary to mutations of the leptin receptor gene may have decreased GH secretion, including low insulinlike growth factor I (IGF I) and insulinlike growth factor binding protein 3 (IGFBP 3) levels. (medscape.com)
  • Relationship between growth velocity and change of levels of insulin-like growth factor-1, insulin-like growth factor binding protein-3 and, IGFBP-3 promoter polymorphism during GnRH agonist treatment. (cdc.gov)
  • In IGFBP4, residues 1-38 form a rigid disulphide bond ladder-like structure, and the first five N-terminal residues bind to IGF and partially mask IGF residues responsible for the type 1 IGF receptor binding. (rcsb.org)
  • Although the C-terminal domains do not form stable binary complexes with either IGF1 or the N-terminal domain of IGFBP4, in the ternary complex, the C-terminal domain contacts both and contributes to blocking of the IGF1 receptor-binding region of IGF1. (rcsb.org)
  • Analysis of receptor sequences from a range of primates and some non-primate mammals showed that accelerated evolution did indeed occur on this branch in the case of IGF1R and IR, but not for the similar insulin receptor-related receptor (IRRR) which does not bind insulin or IGF1. (figshare.com)
  • For the most part, the residues that change on this branch could not be associated with specific functional aspects (ligand binding, receptor dimerization, glycosylation) and the physiological significance of this coevolution remains to be established. (figshare.com)
  • however, human estrogen receptor enhanced Sp1-DNA binding in a concentration-dependent manner. (utmb.edu)
  • Qin, C, Singh, P & Safe, S 1999, ' Transcriptional activation of insulin-like growth factor-binding protein-4 by 17β-estradiol in MCF-7 cells: Role of estrogen receptor-sp1 complexes ', Endocrinology , vol. 140, no. 6, pp. 2501-2508. (utmb.edu)
  • Abstract Insulin-like growth factor-I receptor (IGF-IR) overexpression may play a role in prostate cancer progression. (unical.it)
  • CREB phosphorylation involved c-Src-dependent extracellular signal-regulated kinase 1/2 activation, but not protein kinase A, protein kinase C, or calmodulin-dependent kinase II, and occurred also in cells transfected with AR or estrogen receptor mutants that do not localize into the nucleus. (unical.it)
  • We establish that IGF-II-induced HIF2A/EPAS1 expression during hypoxia is due to de novo transcription and further present the estrogen-related receptor alpha (ERRα) transcription factor as a positive regulator of HIF2A. (lu.se)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Insulin Like Growth Factor Binding Protein 2 (IGFBP2) in samples from serum, plasma, urine, tissue homogenates or other biological fluids. (novosides.eu)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Insulin Like Growth Factor Binding Protein 2 (IGFBP2) in serum, plasma, urine, tissue homogenates and other biological fluids. (novosides.eu)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Insulin Like Growth Factor Binding Protein 2 (IGFBP2) in samples from serum, plasma, urine, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (novosides.eu)
  • Given the limitations of serum creatinine as a biomarker of kidney function, different urinary and serum proteins, molecules, and, most recently, microRNAs have been rigorously investigated over the past decade as possible biomarkers for kidney disease. (medscape.com)
  • Description: A sandwich ELISA kit for detection of Insulin Like Growth Factor Binding Protein 5 from Cattle in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (orbitalbiosciences.com)
  • Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Cattle Insulin Like Growth Factor Binding Protein 4 (IGFBP4) in serum, plasma and other biological fluids. (orbitalbiosciences.com)
  • Diet, serum insulin-like growth factor-I and IGF-binding protein-3 in European women. (ox.ac.uk)
  • OBJECTIVE: The aim of this study was to examine the relationship of diet with serum insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 in women. (ox.ac.uk)
  • A severe or moderate suppression of serum insulin-like growth factor I (IGF-I) was induced in heifers, beginning at 104 days of age, by active immunization against growth hormone-releasing factor (GRFi) or by chronic feed restriction (RES), respectively. (ncsu.edu)
  • Serum LH and FSH levels cannot reliably distinguish between Kallmann syndrome or idiopathic hypogonadotropic hypogonadism patients and individuals with constitutional delay in growth and development. (medscape.com)
  • Subsamples of 193 children with goitre and 151 healthy children were assessed for urinary iodine excretion, thyroid hormone profile, insulin-like growth factor-1 (IGF-1) and serum zinc. (who.int)
  • A high-affinity IGF1-binding site is located in a globular structure between residues 39 and 82. (rcsb.org)
  • Proteolysis of the secreted full-length CCN proteins that has been reported in the case of CCN2 and CCN3 might result in the production of CCN-derived peptides with high affinity for ligands that full-length CNN proteins bind only poorly. (neuromics.com)
  • Previous work has shown that the evolution of both insulin-like growth factor 1 (IGF1) and insulin shows an episode of accelerated change on the branch leading to New World monkeys (NWM). (figshare.com)
  • ABSTRACT Adiponectin has profound insulin-sensitizing, anti-inflammatory and anti-atherogenic effects. (who.int)
  • Insulin-like growth factors (IGFs) are indispensable peptide hormones for proper development of the central nervous system (CNS). (vub.be)
  • IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. (cusabio.com)
  • The CCN genes encode secreted proteins associated with the Extracellular Matrix (ECM) and cell membrane. (neuromics.com)
  • IGF-BP also binds to IGF-1 inside the liver, allowing growth hormone to continuously act upon the liver to produce more IGF-1. (wikipedia.org)
  • Insulin-like growth factor-I (IGF-I) plays a pivotal role in the diagnosis and treatment of growth hormone (GH) excess or deficiency. (e-enm.org)
  • The insulin-like growth factor-I (IGF-I) (termed since 1978) with activity similar to insulin was initially reported in 1972 as a sulfation factor secreted by liver, mediating the stimulating effect of growth hormone (GH) [ 1 ]. (e-enm.org)
  • Recent advances in the genetic study of NVP and HG suggest a placental component to the aetiology by implicating common variants in genes encoding placental proteins (namely GDF15 and IGFBP7 ) and hormone receptors (namely GFRAL and PGR ). (nature.com)
  • Immunization against growth hormone releasing factor or chronic feed restriction initiated at 3.5 months of age reduces ovarian response to pulsatile administration of gonadotropin-releasing hormone at 6 months of age and delays onset of puberty in heifers. (ncsu.edu)
  • Obesity decreases the sex hormone-binding globulin (SHBG) level and therefore decreases the total testosterone level. (medscape.com)
  • This is thought to occur because mental stress in the child may cause increased levels of counter-regulatory hormones (eg, corticosteroids, catecholamines), which oppose the effects of growth hormone. (msdmanuals.com)
  • Our findings provide further support that the insulin-like growth factor pathway plays a significant role in epithelial ovarian cancer pathogenesis. (rti.org)
  • Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer. (ox.ac.uk)
  • From analysis of TSC and LAM related gene expression arrays, we identified many potential biomarkers including most protein coding genes and lncRNAs. (uc.edu)
  • Using a recently developed human osteoblastic cell line (hFOB/ER9) with high levels (approximately 4,000 per nucleus) of estrogen receptors and the characteristic phenotype of the mature osteoblast, we tested the hypothesis that estrogen decreases bone formation by inhibiting the action of the insulin-like growth factor (IGF) paracrine/autocrine system. (elsevierpure.com)
  • Immunoglobulins against insulin-like growth factor 1 (IGF-1) receptors activate signaling in the orbital fibroblasts. (medscape.com)
  • Aberrant promoter methylation of insulin-like growth factor binding protein-3 gene in human cancers. (nih.gov)
  • IGF-I is a major growth promoter in utero. (ox.ac.uk)
  • We also showed that CREB binds to IGF-IR promoter region and identified the relevant CREB-binding site at the 5'-untranslated region fragment of IGF-IR promoter. (unical.it)
  • Furthermore, because MGMT protein loss may be a result of promoter hypermethylation, it was reported that methylation of the MGMT promoter in gliomas is a useful predictor of the responsiveness to alkylating agents ( 7 ). (aacrjournals.org)
  • Using the novel CRISPR/Cas9-based enChIP technology in combination with SILAC-MS, we have isolated and identified potential regulatory proteins bound to the HIF2A promoter at normoxia and hypoxia. (lu.se)
  • CCN proteins are matricellular proteins which are involved in the regulation of various cellular functions including: proliferation, differentiation, survival, adhesion and migration. (neuromics.com)
  • The TNF-alpha binds and results in altered regulation of pro-inflammatory and protective proteins. (medscape.com)
  • A decrease of IGFBP6 expression can involve a decrease in the expression of N-cadherin and transcription factor Slug. (cusabio.com)
  • Collectively, these studies suggest that milkborne growth factors may provide important regulatory signals to the neonatal intestine under both normal and pathophysiological states. (ncsu.edu)
  • Circulating levels of IGF-I extensively depend on genetic factors and age [ 3 , 4 ] and are also affected by sex, anthropometric indices, physical activity, exogenous sex hormones, smoking, and nutritional status [ 5 - 7 ]. (e-enm.org)
  • Genetic line-by-dietary-protein-level interactions were generally not significant for growth, feed efficiency and body composition traits. (ncsu.edu)
  • They can be used for large-scale, massively parallel in situ analysis of genetic alterations on a DNA, RNA and protein level using in situ hybridization or immunohistochemistry on hundreds of tumor specimens at a time. (karger.com)
  • The DNA repair protein O 6 -methylguanine-DNA methyltransferase (MGMT) plays an important role in cellular resistance to alkylating agents. (aacrjournals.org)
  • A cellular DNA-repair protein, namely O 6 -methylguanine-DNA methyltransferase (MGMT) protein, reverses alkylation at the O 6 position of guanine, thereby inhibiting the lethal cross-linking and bringing about resistance to alkylating agents ( 2, 3 ). (aacrjournals.org)
  • tension,glucoseintolerance,insulin afterful explanationoftheobjectives resistance[3]andhyperlipidaemia[4]. (who.int)
  • Intrauterine growth restriction (IUGR) is often caused by placental insufficiency, which is believed to be associated with decreased delivery of oxygen and nutrients to the placental barrier. (uwo.ca)
  • Even with these similarities, some characteristics are different: chromosomal location, heparin binding domains, RGD recognition site, preference for binding IGF-I or IGF-II, and glycosylation and phosphorylation differences. (wikipedia.org)
  • The results support the theory that adiponectin might be part of a feedback mechanism improving insulin sensitivity and cardiovascular health in pre-eclamptic patients. (who.int)
  • Both low IGFBP7 protein levels and mRNA expression were associated with less aggressive tumor characteristics. (lu.se)
  • Downregulation of CCN2 expression in these cells was associated with a growth arrest at the G1/S transition while over-expression of CCN2 induced a two-fold increase of the number of cells in the G1 phase. (neuromics.com)
  • By means of oligonucleotide microarray and RNA interference, we reveal that the sensitizing effect of IFN-β was possibly due to attenuation of MGMT expression via induction of the protein p53. (aacrjournals.org)
  • In summary, we have identified, and at the molecular level characterized, signaling pathways and specific factors through which oncogenic HIF2A activity is regulated and may be targeted. (lu.se)
  • Intrinsic factors include chronically activated proliferative, invasive, and antiapoptotic signaling pathways. (springer.com)
  • Module II includes a stretch of 70amino acid residues - which shares sequence identity with the Von Willebrand Factor Type C repeat (VWC). (neuromics.com)
  • The CCN family presently consists of six members in human also known as: Cyr61 (Cystein rich 61), CTGF (Connective Tissue Growth Factor), Nov (Nephroblastoma Overexpressed gene), WISP-1, 2 and 3 (Wnt-1 Induced Secreted Proteins). (neuromics.com)
  • In addition we will address important areas of modern epidemiology such as the influence of early life factors on adult health and disease, but also the importance of the gene-diet-microbiota interaction for body function and health. (lu.se)
  • Intrauterine growth restriction (IUGR) can be a consequence of decreased uterine blood flow (uteroplacental insufficiency) and maternal and fetal hypoxia. (ox.ac.uk)
  • The former include hypoxia, high lactate levels or the abundance of growth factors within the cellular microenvironment. (springer.com)
  • We herein, report that in spite of what the current paradigm recognizes, HIF-2α is transcriptionally regulated at hypoxia by the insulin-like growth factor II (IGF-II) via the PI3K-mTORC2 axis independent of Akt-mTORC1 signaling. (lu.se)
  • We identified a novel SNP variant, Chr12:g.53494591T>C. c.T430C (p.S144P) in the insulin-like growth factor binding protein-6 (IGFBP6) gene. (cusabio.com)
  • The fibroblasts then produce hyaluronan and the cytokines interleukin (IL)-1 beta, IL-6, IL-8, IL-16, tumor necrosis factor (TNF) alpha, and CD4 ligand. (medscape.com)
  • Dilute the Capture Antibody to the working concentration in PBS without carrier protein. (rndsystems.com)
  • It is the leasts conserved one of the four domains at the level of nucleotide sequence, but it appears to be critical for several of the biological functions attributed to the CCN proteins. (neuromics.com)
  • Sequence similarities to heparin-binding motifs are also found within this domain. (neuromics.com)
  • We follow up on preliminary microarray data on IGFBP2-overexpressing GBM cells and protein sequence analysis of IGFBP2 in generating the hypothesis that IGFBP2 interacts with integnn α5 in regulating cell mobility. (tmc.edu)
  • The prognostic impact of insulin-like growth factor binding protein 7 (IGFBP7) in breast cancer is unclear. (lu.se)
  • Tumor-specific IGFBP7 protein levels were evaluated with immunohistochemistry using tissue microarrays in tumors from 878 patients. (lu.se)
  • Characterization of Insulin-Like Growth Factor Binding Protein 7 (Igfbp7) and Its Potential Involvement in Shell Formation and Metamorphosis of Pacific Abalone, Haliotis discus hannai . (bvsalud.org)
  • Fibroblast growth factor 21 (pg/mL) [Time Frame: Screening, days 1 and 57. (who.int)
  • Insulin-like growth factor binding protein-2 as a regulator of IGF actions in CNS: implications in multiple sclerosis. (vub.be)
  • Dive into the research topics of 'Insulin-like growth factor binding protein-2 as a regulator of IGF actions in CNS: implications in multiple sclerosis. (vub.be)
  • IGFBP6 might be an important regulator and prognostic factor for glioma. (cusabio.com)
  • The objectives of this experiment were to determine 1) whether GRFi and RES would alter follicular development and delay onset of puberty through similar mechanisms, and 2) whether GnRH would enhance follicular growth in control, GRFi, and RES heifers at 6 mo of age. (ncsu.edu)
  • In contrast, RES may delay puberty by delaying follicular development at two stages: a) decreased IGF-I in follicles ≤ 7 mm may delay predominant follicular growth, and b) decreased LH may delay maturation of the preovulatory follicle. (ncsu.edu)
  • Makorin RING finger protein 3 and central precocious puberty. (cdc.gov)
  • This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag. (cusabio.com)
  • Elevated homocysteine is also a risk factor for cardiovascular disease. (theepochtimes.com)
  • In a subset of peri-vascularly located immature neural crest-like neuroblastoma cells, aggressiveness and growth promoting charasteristics have been reported to be instigated by HIF-2α, a key element of the oxygen-sensing machinery. (lu.se)
  • Radioresistance of these tumors can be ascribed to two factors: environmental and intrinsic. (springer.com)
  • Intestinal Effects of Milkborne Growth Factors in Neonates of Agricultural Importance. (ncsu.edu)
  • Water, DNA and protein content of small intestinal mucosa were unaffected by bST administration. (ncsu.edu)
  • Intestinal fatty acid-binding protein (pg/mL) [Time Frame: Screening, Days 2, 23, 57, 58 and 79. (who.int)
  • While it is known the IGFBP2 is involved in promoting GBM tumor cell invasion, no mechanism exists for how the protein is involved in signal transduction pathways leading to enhanced cell invasion. (tmc.edu)
  • Insulin growth factor binding protein 2 mediates the progression of lymphangioleiomyomatosis. (uc.edu)
  • The prognostic impact of IGFBP7high depends on host factors and treatment. (lu.se)
  • Results suggest that insulin like growth factor binding protein 6 (IGFBP6) may be an independent prognostic biomarker for nasopharyngeal carcinoma (NPC). (cusabio.com)
  • A theoretical approach to possible biological functions of the milk-whey proteins, alpha-lactalbumin and beta-lactoglobulin. (ncsu.edu)
  • Influence of estradiol administration mode on plasma insulin-like growth factor-I (IGF-I) and its binding proteins 1 and 3 concentration in postmenopausal women treated with norethisterone acetate]. (druglib.com)
  • La concentration d'iode urinaire moyenne des enfants qui présentaient un goitre et des enfants sains était respectivement de 17,4 µg/dl et 15,3 µg/dl, suggérant un apport en iode adéquat. (who.int)
  • Aucune différence significative en termes de concentration moyenne d'iode urinaire ou de taux sérique de facteur de croissance IGF-1 ou de zinc n'a été constatée entre les élèves qui présentaient un goitre et ceux qui n'en avaient pas. (who.int)
  • Increased Insulin-like Growth Factor Binding Protein-1 Phosphorylation in Decidualized Stromal Mesenchymal Cells in Human Intrauterine Growth Restriction Placentas. (uwo.ca)
  • Insulin-like growth factor 2 mRNA-binding protein-3 as a marker for distinguishing between cutaneous squamous cell carcinoma and keratoacanthoma. (medscape.com)
  • Also, some people, especially those aged 70 and older, require extra protein to maintain adequate IGF-1 levels. (theepochtimes.com)
  • Ensuring that risk factors for diabetes and heart disease are at favorable levels is also important. (theepochtimes.com)