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  • IPMK
  • Functionally important motifs [inositol phosphate-binding site, ATP-binding site, catalytically important SSLL (Ser-Ser-Leu-Leu) domain] are conserved between the human IPMK and yeast ArgRIII. (biochemj.org)
  • phosphatase
  • Interestingly, the characterized PTP-like phytases from ruminal bacteria share sequence and structural homology with the mammalian PTP-like phosphoinositide/-inositol phosphatase PTEN, and significant sequence homology to the PTP domain of a type III-secreted virulence protein from Pseudomonas syringae (HopPtoD2). (wikipedia.org)
  • receptor
  • These results suggest a role for inositol 1,4,5-trisphosphate as a second messenger in hormone-induced Ca2+ mobilisation, and that a specific receptor is involved in the Ca2+-release mechanism. (biochemj.org)
  • 10 In most cell types, the pathway involves the receptor-mediated hydrolysis of membrane phospholipid PtdIns(4,5)P 2 by a specific phospholipase C (PtdIns-PLC) to generate two well-described second messengers sn -1,2-diacylglyerol (DAG) and inositol 1,4,5-trisphosphate [Ins(1,4,5)P 3 ]. (ahajournals.org)
  • lipids
  • Authoritative and cutting-edge, Inositol Phosphates and Lipids: Methods and Protocols compiles many of the techniques that underscore phosphorylated inositol cell biology in one convenient guide. (springer.com)
  • Len Stephens has contributed much to the understanding of inositol lipids functions in eukaryotic cells, and in particular in neutrophils. (wikipedia.org)
  • phytase
  • The phytase from the fungus Aspergillus niger is a HAP and is well known for its high specific activity and its commercially marketed role as an animal feed additive to increase the bioavailability of phosphate from phytic acid in the grain-based diets of poultry and swine. (wikipedia.org)
  • The Enzyme Nomenclature Committee of the International Union of Biochemistry recognizes three types of phytases based on the position of the first phosphate hydrolyzed, those are 3-phytase (EC 3.1.3.8), 4-phytase (EC 3.1.3.26), and 5-phytase (EC 3.1.3.72). (wikipedia.org)
  • phytic acid
  • E. coli and those phytases belonging to the class of PTP-like phytases Phytic acid has six phosphate groups that may be released by phytases at different rates and in different order. (wikipedia.org)
  • Phytases hydrolyze phosphates from phytic acid in a stepwise manner, yielding products that again become substrates for further hydrolysis. (wikipedia.org)
  • Most phytases are able to cleave five of the six phosphate groups from phytic acid. (wikipedia.org)
  • Phytases have been grouped based on the first phosphate position of phytic acid that is hydrolyzed. (wikipedia.org)
  • pathway
  • Chemogenetic Characterization of Inositol Phosphate Metabolic Pathway Reveals Druggable Enzymes for Targeting Kinetoplastid Parasites. (nih.gov)
  • We conditionally knocked down Trypanosoma brucei inositol phosphate (IP) pathway genes and showed that almost every pathway step is essential for parasite growth and infection. (nih.gov)
  • Biochemistry
  • Two overview chapters provide comprehensive background information on stereochemistry and nomenclature of inositol phosphates, basic biochemistry, synthetic challenges, and related pharmacology. (oup.com)
  • compounds
  • The reaction this enzyme catalyses represents the first committed step in the production of all inositol-containing compounds, including phospholipids, either directly or by salvage. (wikipedia.org)
  • Inhibitors
  • The existence of inositol in prokaryotes is not extensive, but the discovery of this enzyme first in Mycobacterium tuberculosis, nucleated activity towards finding its inhibitors. (wikipedia.org)
  • potency
  • The order of potency was inositol 1,4,5-trisphosphate greater than inositol 2,4,5-trisphosphate greater than inositol 4,5-bisphosphate. (biochemj.org)
  • All blocked L-[3H]-3-quinuclidinyl benzilate binding and exhibited a rank order of potency almost identical to that obtained in the inositol studies with Lev greater than Dex much much greater than DTG much greater than PCP MK-801. (aspetjournals.org)
  • protein
  • 05). Second, inositol 1,4,5-trisphosphate was released with postischemic reperfusion (103±18 to 207±11 pmol/mg protein), whereas release was not detected in normoxic myocardium. (ahajournals.org)
  • Gene
  • On the other hand, studies in cells have shown that ceramide-inducing agents such as tumor necrosis factor-alpha α (TNFα) and palmitate induce the ceramide-dependent removal of a phosphate group (dephosphorylation) of the retinoblastoma gene product RB and the enzymes, protein kinases B (AKT protein family) and C α (PKB and PKCα). (wikipedia.org)
  • In Saccharomyces cerevisiae (Baker's yeast), the transcriptional regulation of the INO1 gene encoding inositol-3-phosphate synthase has been studied in detail and its expression is sensitive to the availability of phospholipid precursors as well as growth phase. (wikipedia.org)
  • The regulation of the structural gene encoding 1L-myo-inositol-1-phosphate synthase has also been analyzed at the transcriptional level in the aquatic angiosperm, Spirodela polyrrhiza (Giant duckweed) and the halophyte, Mesembryanthemum crystallinum (Common ice plant). (wikipedia.org)
  • Most eukaryotes possess this gene, and it sometimes expressed to produce the rare osmolyte di-miyo-inositol 1,1' phosphate (DIP). (wikipedia.org)
  • calcium
  • In the present study, the effects of ethanol (50-500 mM) on carbachol-0stimulated PI metabolism and free intracellular calcium levels were investigated in rat primary cortical cultures, bu measuring release of inositol phosphates and utilizing the two calcium probes FLUO-3 and INDO-1 on an ACAS (Adherent Cell Analysis and Sorting) Laser Cytometer. (washington.edu)
  • It is involved in inositol signalling pathways which regulate the conductance of calcium-activated chloride channels, and therefore could be relevant in the study of cystic fibrosis. (wikipedia.org)
  • formation
  • The addition of mmanose-6-phosphate or PI-PLC-treatment on U937 cells diminishes TNF-α inducing apoptosis, indicating that the formation of nanomer, (TNF-α)_3(GPI-glycan)_3(TNFR)_3 triggers various physiological actions. (nii.ac.jp)
  • This leads to the formation of inositol 1,4,5-trisphosphate (IP3) and diacyl glycerol. (wikipedia.org)
  • Journal
  • Cite this article as: Parag Pathade , Md Imran ,Vinod Bairagi , Yogesh Ahire,Development and Validation of Stability Indicating UV Spectrophotometric Method for the Estimation of Sitagliptin Phosphate in Bulk and Tablet Dosage Form,Journal of Pharmacy Research 2011,4(3),871-873. (jprsolutions.info)
  • complex
  • Thiamine or thiamin is a water-soluble vitamin of the B complex (vitamin B1), whose phosphate derivatives are involved in many cellular processes. (essense-of-life.com)