• receptor
  • These results suggest a role for inositol 1,4,5-trisphosphate as a second messenger in hormone-induced Ca2+ mobilisation, and that a specific receptor is involved in the Ca2+-release mechanism. (biochemj.org)
  • 10 In most cell types, the pathway involves the receptor-mediated hydrolysis of membrane phospholipid PtdIns(4,5)P 2 by a specific phospholipase C (PtdIns-PLC) to generate two well-described second messengers sn -1,2-diacylglyerol (DAG) and inositol 1,4,5-trisphosphate [Ins(1,4,5)P 3 ]. (ahajournals.org)
  • lipids
  • Authoritative and cutting-edge, Inositol Phosphates and Lipids: Methods and Protocols compiles many of the techniques that underscore phosphorylated inositol cell biology in one convenient guide. (springer.com)
  • Len Stephens has contributed much to the understanding of inositol lipids functions in eukaryotic cells, and in particular in neutrophils. (wikipedia.org)
  • triphosphate
  • Studies of the role of inositol phosphate regulatory cycle in the development of the ASS phenomenon showed that the inositol triphosphate-diacyl glycerol (ITP-DAG) step of regulation was activated at the peak of PhASS development within 15 days after the adaptation onset. (msk.ru)
  • hexaphosphate
  • Topics covered in this book include the use of inositol and its hexaphosphate (IP6) for numerous health benefits - as antioxidants, as an anti-cancer drug, for the management of atherosclerosis, diabetes, osteoporosis, Alzheimer's disease, sickle cell anemia, and even in fighting tooth decay. (benthamscience.com)
  • biochemistry
  • This reference details the biochemistry and industrial applications of inositol and its phosphate derivatives. (benthamscience.com)
  • The Enzyme Nomenclature Committee of the International Union of Biochemistry recognizes three types of phytases based on the position of the first phosphate hydrolyzed, those are 3-phytase (EC 3.1.3.8), 4-phytase (EC 3.1.3.26), and 5-phytase (EC 3.1.3.72). (wikipedia.org)
  • cells
  • Inositol, in its native or lipid derived forms, serves as a master building block which, when phosphorylated, leads to the construction of more than 30 unique isomeric forms that are employed in vital but diverse regulatory roles in cells. (springer.com)
  • EGF, isoproterenol and NECA have no effect on basal levels of inositol phosphates (InsPs) in human RPE cells, but EGF specifically elevates the carbachol-induced stimulation of InsPs. (ulster.ac.uk)
  • Mycobacterium
  • The existence of inositol in prokaryotes is not extensive, but the discovery of this enzyme first in Mycobacterium tuberculosis, nucleated activity towards finding its inhibitors. (wikipedia.org)
  • compounds
  • The reaction this enzyme catalyses represents the first committed step in the production of all inositol-containing compounds, including phospholipids, either directly or by salvage. (wikipedia.org)
  • protein
  • 05). Second, inositol 1,4,5-trisphosphate was released with postischemic reperfusion (103±18 to 207±11 pmol/mg protein), whereas release was not detected in normoxic myocardium. (ahajournals.org)
  • Bacterially expressed protein demonstrated an inositol phosphate multikinase activity similar to that of yeast ArgRIII. (biochemj.org)
  • human
  • Functionally important motifs [inositol phosphate-binding site, ATP-binding site, catalytically important SSLL (Ser-Ser-Leu-Leu) domain] are conserved between the human IPMK and yeast ArgRIII. (biochemj.org)
  • Role
  • Meerson F.Z., Kopylov Yu.N., The role of the inositol phosphate cycle in the cardioprotective effect of adaptation to repeated stressors, Voprosy meditsinskoi khimii, 1993, vol: 39(2), 6-13. (msk.ru)