• These early uses of Intraperitoneal injections provide good examples of how the delivery method can be used, and provides a base for future studies on how to properly inject mice for research. (wikipedia.org)
  • There are few examples of the use of intraperitoneal injections in humans cited in literature because it is mainly used to study the effects of drugs in mice. (wikipedia.org)
  • Intraperitoneal injection of beta-glucan was shown to greatly delay mortality in mice exposed to whole-body X-ray radiation and tumor growth in tumor-bearing mice. (nih.gov)
  • Abetes was induced by intraperitoneal injection of streptozotocin into 8-week-old C57BL/6 male mice. (achrinhibitor.com)
  • Final results: Intracavernous injections of ESC-NVs drastically enhanced erectile function in diabetic mice, which reached up to 90 of handle values. (achrinhibitor.com)
  • Furthermore, Mamiya and Ukai ( 2001 ) reported that intracerebroventricular injection of S14G-HN (HNG) prevented scopolamine-induced amnesia in mice. (jneurosci.org)
  • Herein, chronic inflammation was induced by intraperitoneal injection of pristane into mice. (hindawi.com)
  • Previous studies from our group and other labs have demonstrated that oil granulomas represent the major pathology in response to pristane injections in C57BL/6 mice [ 2 , 3 ]. (hindawi.com)
  • 1 µm) in terms of mesothelial damage and peritoneal inflammation, after intraperitoneal (i.p.) injection in mice. (springer.com)
  • These preliminary findings, when combined with previous studies by other investigators, which reported inflammation and mesothelioma of the abdominal lining after intraperitoneal instillation (injection into the lining of the abdominal cavity) of MWCNTs in mice, provide additional justification for further research. (cdc.gov)
  • and (iv) mice received intraperitoneal injection of 1.78 µg selenium/kg body weight as sodium selenite 15 min before the exposure to waterpipe smoke. (who.int)
  • Subcutaneous injections can be used on pregnant animals or birds/reptiles carrying eggs. (abdn.ac.uk)
  • Type 1 diabetes was induced by streptozotocin intraperitoneal injection. (bl.uk)
  • Using the glowing firefly luciferase to see where the mRNA had traveled, they found that intraperitoneal injection resulted in more abundant and more specific delivery to the pancreas compared with intravenous injection. (nih.gov)
  • Overall, systematic biological data suggested that intravenous injection of nanoparticles of pharmaceutical excipients substantially affected hepatic metabolism function and induced oxidative stress and inflammation, whereas oral administration exhibited milder effects compared with intravenous injection. (frontiersin.org)
  • The few examples that do exist pertain to the treatment of pancreatic/ovarian cancers and injections of other drugs in clinical trials. (wikipedia.org)
  • With very serious pancreatic diseases, the benefits of intraperitoneal injection outweigh the risks. (nih.gov)
  • A good example of how intraperitoneal injections work is depicted through "The distribution of salicylate in mouse tissues after intraperitoneal injection" because it includes information on how a drug can travel to the blood, liver, brain, kidney, heart, spleen, diaphragm, and skeletal muscle once it has been injected intraperitoneally. (wikipedia.org)
  • These findings could be advanced by studying how the route of injection affects the organs in the peritoneal cavity. (wikipedia.org)
  • This study demonstrates how intraperitoneal injections can be used to help diagnose diseases by providing direct access to the peritoneal cavity and affecting the organs in the cavity. (wikipedia.org)
  • They investigated mRNA delivery via intraperitoneal injection, which involves injecting a drug directly into the fluid that surrounds the organs of the peritoneal cavity (including the kidneys, intestines, and pancreas). (nih.gov)
  • While intraperitoneal injection is not commonly used in humans, this type of administration is used clinically for some difficult-to-treat diseases, such as ovarian cancer," said senior study author Kathryn Whitehead, Ph.D., a professor at Carnegie Mellon University. (nih.gov)
  • Intra-peritoneal injection is commonly used. (abdn.ac.uk)
  • Intraperitoneal injections can be similar to oral administration in that hepatic metabolism could occur in both. (wikipedia.org)
  • In 1969, errors depending on a variety of techniques of administering IP injections were analyzed, and a 12% error in placement was found when using a one-man procedure versus a 1.2% error when using a two-man procedure. (wikipedia.org)
  • Depending on the genetic background of the model, pristane injection can trigger a local inflammatory response (lipogranuloma), erosive arthritis that resembles rheumatoid arthritis, and systemic lupus erythematosus, followed by autoantibody formation and many clinical manifestations [ 3 - 5 ]. (hindawi.com)
  • The formulation contains Water for Injection, and may contain sodium hydroxide or hydrochloric acid for pH adjustment. (nih.gov)
  • 2kg), dosed by intravenous injection, the injection solutions can be made isotonic by the addition of sodium chloride. (abdn.ac.uk)
  • TROVAN is available as TROVAN Tablets (trovafloxacin mesylate) for oral administration and as TROVAN I.V. (alatrofloxacin mesylate injection), a prodrug of trovafloxacin, for intravenous administration. (nih.gov)
  • Current mRNA drug delivery routes include intramuscular injection (used in COVID-19 vaccines) and intravenous administration (used in some investigational cancer therapeutics). (nih.gov)
  • They are one of the few ways drugs can be administered through injection, and have uses in research involving animals, drug administration to treat ovarian cancers, and much more. (wikipedia.org)
  • This study examined c-Fos expression in selected brain areas consequent to intraperitoneal (IP) administration of saccharin and lithium chloride. (cardiff.ac.uk)
  • In vivo animal studies have further indicated that intracerebroventricular administration of Colivelin not only completely suppresses impairment in spatial working memory induced by repetitive intracerebroventricular injection of Aβ25-35 or Aβ1-42, but also it antagonizes neuronal loss in the CA1 region of hippocampus induced by hippocampal injection of Aβ1-42. (jneurosci.org)
  • On the other hand, oral administration of MSNs disturbed inflammatory factors and metabolites of ribose-5-phosphate, 6-phosphogluconate, GSSG, and NADP+ associated with the pentose phosphate pathway, glutathione synthesis and oxidative stress albeit to a lesser extent than intravenous injection despite the administration of a ten-fold greater dose. (frontiersin.org)
  • In 1967, the production of amnesia was studied through an injection of physostigmine. (wikipedia.org)
  • There are four alternative routes for injection: intravenous (IV), intra-muscular (IM), intra-peritoneal (IP) and sub-cutaneous (SC). (abdn.ac.uk)
  • It was found that intraperitoneal conditioning resulted in the reduction in voluntary consumption but not in the production of aversive orofacial responses to the saccharin. (cardiff.ac.uk)
  • Understanding when intraperitoneal injections can be utilized and in what applications is beneficial to advance current drug delivery methods and provide avenues for further research. (wikipedia.org)
  • One study utilized IP injections to study pain in the abdomen after a hysterectomy when administering anesthetic continuously vs patient-controlled. (wikipedia.org)
  • In addition, this study provide evidence of increased neural activity in response to intraperitoneal saccharin injections. (cardiff.ac.uk)
  • In our study the AMSCs were administered via intraperitoneal injection. (genengnews.com)
  • Patient would grease, or lick, the needle before injection. (medscape.com)
  • Detection of the transplanted cells in the retina illustrated their ability to migrate from the site of injection to the injured tissue. (genengnews.com)
  • Intra-muscular injections have been used in many studies, but these may reduce the activity of the animal post injection due to muscle damage at the injection site. (abdn.ac.uk)
  • Necrotizing fasciitis at a possible site of insulin injection in the left upper part of the thigh in a 50-year-old obese woman with diabetes. (medscape.com)
  • IP injections should be made using a steep angle of entry off the midline of the body to avoid damage to internal organs. (abdn.ac.uk)
  • Intraperitoneal injection or IP injection is the injection of a substance into the peritoneum (body cavity). (wikipedia.org)
  • citation needed] Intraperitoneal injections are a way to administer therapeutics and drugs through a peritoneal route (body cavity). (wikipedia.org)
  • In general, it is preferred when large amounts of blood replacement fluids are needed or when low blood pressure or other problems prevent the use of a suitable blood vessel for intravenous injection. (wikipedia.org)
  • A-exo was injected intravenously three instances and blood was collected immediately after final injection. (achrinhibitor.com)
  • In a case of a ruptured hepatocellular carcinoma, it was reported that the patient was treated successfully through the use of an intraperitoneal injection of OK-432, which is an immunomodulatory agent. (wikipedia.org)
  • Intravenous injection induced significant hepatic injury based on pathological inspection and increased the levels of AST/ALT and the inflammatory factors IL-6, IL-1β and TNF-a. (frontiersin.org)
  • 2015 ) reported that intravenous injection (IV) of silica nanoparticles showed significant capture of the particles in the liver and induced hepatic injury. (frontiersin.org)