IntravenousHepatic intra-arterialChemotherapy for advancedAssociated with hepaticInjectionPerfusionParenteralCatheterSystemicContinuous hepaticImplantableFloxuridineThrombolysisArteryInjectionsPeripheralMetastaticNicardipineExtravasationSuperselectiveChemo InfusionThrombolyticVenousEmbolizationPumpTherapyDiscontinueFUDRPumpsSeldingerNodulesLiverArteriesTherapeuticPatientsCancerConcentrationsSurgicalVasodilationBlood pressureTissueDrugs
Intravenous4
- CME America T-Syringe Pump - T34L PCA - Product Usage: infusion of medications or fluids requiring continuous or intermittent delivery at precisely-controlled infusion rates through clinically acceptable routes of administration, including intravenous, subcutaneous, percutaneous, intra-arterial, epidural, in close proximity to nerves, and into an intra-operative site (soft tissue/body cavity/surgical wound site). (fda.gov)
- The aim of the present study was to perform image-based absorbed dose calculation and to determine whether hepatic intra-arterial (IA) injection of 177 Lu-DOTATATE Peptide Receptor Radionuclide Therapy (PRRT) would achieve higher intratumoral concentrations, thus leading to higher absorbed dose and higher efficacy than standard intravenous administration of 177 Lu-DOTATATE. (snmjournals.org)
- Nicardipine hydrochloride injection is supplied in an ampul containing 25 mg of nicardipine hydrochloride in 10 mL (2.5 mg/mL) for intravenous infusion. (nih.gov)
- They can be attached to a catheter for intravenous, intracerebral, or intra-arterial infusion. (alzet.com)
Hepatic intra-arterial1
- Endovascular Ion Exchange Chemofiltration Device Reduces Off-Target Doxorubicin Exposure in a Hepatic Intra-arterial Chemotherapy Model " by Colin Yee, BS et al. (rsna.org)
Chemotherapy for advanced2
- 33. [Intra-arterial infusion chemotherapy for advanced or recurrent breast cancers]. (nih.gov)
- Background/aims To review the effectiveness of intra-arterial chemotherapy for advanced intra-ocular retinoblastoma with vitreous and/or subretinal seeds in naive (untreated) and previously treated eyes. (bmj.com)
Associated with hepatic1
- Common duct stricture associated with hepatic artery infusion of FUDR. (nih.gov)
Injection6
- Many types of chemo are given as an infusion or injection. (cancer.org)
- When floxuridine is given by rapid intra-arterial injection it is apparently rapidly catabolized to 5-fluorouracil. (nih.gov)
- Floxuridine for Injection, USP is effective in the palliative management of gastrointestinal adenocarcinoma metastatic to the liver, when given by continuous regional intra-arterial infusion in carefully selected patients who are considered incurable by surgery or other means. (nih.gov)
- Avoid perivascular extravasation or intra-arterial injection. (empr.com)
- Atropine (250-550 mcg) inhibits vasodilation and decreases the secretory response of the pancreas to secreting Previous intra-arterial injection of bradykinin restores the secretory response of the pancreas, thus showing that inhibitory effect of, of the atropine on the secretory response of the pancreas to secretin is partly mediated by inhibition of secretin-induced vasodilation. (erowid.org)
- To minimize the risk of peripheral venous irritation, change the site of infusion of nicardipine hydrochloride injection every 12 hours. (nih.gov)
Perfusion3
- CASE PRESENTATION: Isolated Limb Perfusion was performed as an Extended Isolated Limb Stop-Flow Infusion (EISLI) where the pelvis was included into the perfusion bed. (bvsalud.org)
- We evaluated the efficacy of regional chemotherapy (RegCTx) using arterial infusion (AI), hypoxic stop-flow abdominal perfusion (HAP), upper abdominal perfusion (UAP) and isolated-thoracic perfusion (ITP) in 36 patients with metastatic perihilar and intrahepatic CCC. (bvsalud.org)
- We evaluated the efficacy of regional chemotherapy (RegCTx) approach in diffuse metastatic EC using arterial infusion (AI), upper abdominal perfusion (UAP) and isolated-thoracic perfusion (ITP) in 14 patients (N = 8 adenocarcinoma (AC) and N = 6 squamous cell carcinoma (SQCC)) after failure to first-line palliative treatment. (bvsalud.org)
Parenteral2
- An appropriate amount of reconstituted solution is then diluted with a parenteral solution for intra-arterial infusion (see DOSAGE AND ADMINISTRATION section). (nih.gov)
- Pressure infusion cuffs are designed cuff and bladder devices used to pressurize sterile parenteral fluids for rapid infusion into the body. (factmr.com)
Catheter3
- With chemo infusions, chemotherapy drugs are put into your body through a thin tube called a catheter that's placed in a vein, artery, body cavity, or body part. (cancer.org)
- 27. [Intra-arterial infusion chemotherapy for locally advanced breast cancer using implantable reservoir connected with catheter inserted in recurrent radial artery]. (nih.gov)
- Regional infusion of drugs via an arterial catheter. (nih.gov)
Systemic5
- Patients with known disease extending beyond an area capable of infusion via a single artery should, except in unusual circumstances, be considered for systemic therapy with other chemotherapeutic agents. (nih.gov)
- 35. [A comparative study of intra-arterial infusion chemotherapy and systemic chemotherapy in the treatment of locally advanced breast cancer]. (nih.gov)
- Conclusion Unlike radiation or systemic chemotherapy, intra-arterial chemotherapy can usually prevent the need for enucleation in naive eyes with advanced intraocular retinoblastoma with seeding-especially if the seeding is subretinal. (bmj.com)
- Results: With respect to prognostic factors for gastric cancer cases with liver metastasis, significant differences were observed for peritoneal metastasis, histology, lymph node metastasis, gastrectomy, systemic chemotherapy, the number of stage IV factors, the number of metastatic nodules (within 3), and intra-hepatic arterial infusion (HAI). (omicsonline.org)
- Results of several randomized prospective studies addressing the efficacy of regional versus systemic FUDR chemotherapy infusions will be available in the near future. (johnshopkins.edu)
Continuous hepatic2
- From this report, as well as those previously published, it is concluded that sclerosing cholangitis may complicate continuous hepatic artery infusion with FUDR. (nih.gov)
- In addition, fluorouracil has been used as a continuous hepatic arterial infusion in management of hepatic metastases from colorectal and other cancers. (nih.gov)
Implantable6
- 26. [Two cases of stage IV breast cancer with locally advanced lesion treated by intra-arterial infusion chemotherapy using implantable reservoir]. (nih.gov)
- Implantable infusion pumps for continuous administration of test agents to unrestrained laboratory animals. (alzet.com)
- The availability of implantable or portable drug infusion pumps has caused a renewed interest in continuous infusion therapy using these drugs for patients with colorectal metastases to the liver. (johnshopkins.edu)
- Nevertheless, there is still insufficient data to conclude that survival rates are sufficiently prolonged in patients for whom an implantable drug infusion pump has been used for regional FUDR chemotherapy. (johnshopkins.edu)
- We herein report the results of superselective intraarteial CDDP infusion therapy with an implantable reservoir system combined with radiotherapy for 10 patients with head and neck carcinomas. (gr.jp)
- We conclude that the implantable resorvoir system for both CDDP and STS administration is an easy, low-invasive method for intraarterial infusion therapy. (gr.jp)
Floxuridine6
- Extrahepatic biliary stenoses after hepatic arterial infusion (HAI) of floxuridine (FUdR) for liver metastases from colorectal cancer. (nih.gov)
- It is recommended that floxuridine be given only by or under the supervision of a qualified physician who is experienced in cancer chemotherapy and intra-arterial drug therapy and is well versed in the use of potent antimetabolites. (nih.gov)
- However, when floxuridine is given by continuous intra-arterial infusion its direct anabolism to floxuridine-monophosphate is enhanced, thus increasing the inhibition of DNA. (nih.gov)
- Pharmacokinetic data on intra-arterial infusion of floxuridine are not available. (nih.gov)
- Intrahepatic artery infusion of fluorouracil is also associated with serum aminotransferase elevations or chemical hepatitis (in 5% to 7% of cases) and in biliary abnormalities, but it rarely causes biliary strictures or the sclerosing cholangitis-like syndrome that is common with floxuridine (FUDR) treatment. (nih.gov)
- 1% of patients treated with hepatic arterial infusions of fluorouracil as compared to 5% to 12% of those given floxuridine. (nih.gov)
Thrombolysis1
- Remember that intra-arterial thrombolysis remains investigational. (medscape.com)
Artery8
- A case of sclerosing cholangitis after a two-month treatment by hepatic artery infusion of FUDR is reported. (nih.gov)
- Purpose: To evaluate the frequency and the predictive factor of each feeding artery on intra-arterial infusion chemotherapy (IAIC) in primary tongue cancer. (elsevierpure.com)
- Hepatic artery embolization, also known as trans-arterial embolization (TAE), is one of the several therapeutic methods to treat primary liver tumors or metastases to the liver. (wikipedia.org)
- In hepatic artery chemotherapy (HAC), chemotherapy agents are given into the hepatic artery, often by steady infusion over hours or even days. (wikipedia.org)
- Hepatic artery chemoembolization (HACE), sometimes called transarterial chemoembolization (TACE), combines hepatic artery embolization with hepatic artery chemo infusion. (wikipedia.org)
- Nine of 29 naive eyes (31%) were cured with intra-arterial (super-selective ophthalmic artery infusion of chemotherapy) chemotherapy alone. (bmj.com)
- There are three historically recognized methods of intra-arterial infusion for oral cancer: Conventional intra-arterial infusion via the superfi cial temporal artery: Superselective intra-arterial infusion via the femoral artery (Seldinger method), New superselective intra-arterial infusion via the superfi cial temporal artery. (nii.ac.jp)
- Image-guided endovascular chemofiltration with ionic endovascular devices placed nonocclusively in the hepatic venous outflow tract and inferior vena cava during hepatic artery doxorubicin infusion reduced off-target blood and tissue concentrations of doxorubicin in a translational model. (rsna.org)
Injections3
- Some find out during treatment that they need a CVC because it becomes more difficult over time to find a suitable vein in their hand or arm to use for infusions or injections. (cancer.org)
- In most series both drugs have higher response rates, less myelosuppression, but greater liver toxicity when given by continuous intraarterial infusions compared to bolus injections given intravenously. (johnshopkins.edu)
- Contrast injections were performed at 2-5-mg intervals to assess effective response (a 60% increase in arterial diameter of the most severely decreased in caliber vessel compared with the very first angiographic run). (elsevierpure.com)
Peripheral3
- Give by IV infusion over 15mins into a large peripheral vein. (empr.com)
- Therapeutic recommendations include single-agent antiplatelet agents for prevention of cardiovascular events in patients wth asymptomatic and symptomatic peripheral arterial disease (PAD). (medscape.com)
- SEQURE ® microcatheters are class IIb medical devices intended for use by interventional radiologists and interventional oncologists for the infusion of contrast media into all peripheral vessels and for drug infusion in intra-arterial therapy, and infusion of embolic materials. (guerbet.com)
Metastatic1
- Infusions of fluorouracil can also result in marked shrinkage of metastatic tumors in the liver and partial atrophy of the noninvolved liver, resulting in an irregular lobular appearance suggestive of cirrhosis. (nih.gov)
Nicardipine3
- We report our initial experience with intra-arterial use of a calcium channel blocker, nicardipine. (elsevierpure.com)
- MATERIALS AND METHODS: A retrospective review of a consecutive series of patients with clinical and angiographic vasospasm treated with intra-arterial nicardipine was performed. (elsevierpure.com)
- CONCLUSION: In this small series, high-dose intra-arterial nicardipine infusion to treat SAH-associated vasospasm seems to be safe and effective. (elsevierpure.com)
Extravasation1
- Exercise extreme care to avoid intra-arterial administration or extravasation. (nih.gov)
Superselective2
- Here we report a recent instance of daily concurrent chemoradiotherapy using a new superselective intra-arterial infusion. (nii.ac.jp)
- Radiotherapy (total dose: 40 Gy/4weeks) and superselective intra-arterial infusion chemotherapy using docetaxel (DOC) (total dose: 60 mg/m2/4weeks, 15 mg/m2/ week) and cisplatin (CDDP) (total dose: 100 mg/m2/4weeks, 5 mg/m2/day) were concurrently performed daily, followed by surgery, after which no major complication was observed. (nii.ac.jp)
Chemo Infusion1
- The spheres not only block blood flow to the lesions but by halting the chemotherapy agents in the neighborhood of the lesions, they provide a much better targeting leverage than chemo infusion provides. (wikipedia.org)
Thrombolytic2
- 1 , 2 For patients presenting later, for whom IV-tPA is contraindicated or for whom there is no clinical improvement following IV-tPA, IAT (intra-arterial thrombolytic infusion or mechanical thrombectomy) can be performed. (ajnr.org)
- In some cases of emboli, intra-arterial thrombolytic agents may be useful. (medscape.com)
Venous2
- Biossays of sera extracted from arterial and venous chest blond on guinea pig ileum seem to indicate that vasodilation in the pancreatic vascular bed These is acompanied by release of active bradykinin into the venous effluent. (erowid.org)
- Balloon catheters were placed in the arterial and venous bifurcation in the pelvis. (bvsalud.org)
Embolization1
- Angiotherapy, either intraarterial vasopressin infusion (13 cases) or arterial embolization (two cases), was used to treat 15 patients with persistently bleeding Mallory-Weiss tears. (nih.gov)
Pump1
- Multiple reasons: 1) Due to wear and tear of pump motor block mechanism - may cause under infusion situations without the pump alarm being generated. (fda.gov)
Therapy2
- A separate and distinct syndrome associated with fluorouracil therapy is the rapid development of coma with hyperammonemia, lactic acid elevations and respiratory alkalosis that occurs most frequently with continuous infusions of high doses of fluorouracil. (nih.gov)
- While ablation is recognized as a curative therapy, all intra-arterial therapies are considered non-curative options. (qxmd.com)
Discontinue2
- Discontinue if infusion site reactions occur. (empr.com)
- If unacceptable hypotension or tachycardia occurs, discontinue the infusion. (nih.gov)
FUDR1
- The patient presented with jaundice and a marked increase in serum alkaline phosphatase activity which persisted after withdrawal of FUDR infusion. (nih.gov)
Pumps1
- These infusions can last anywhere from 1 to several days and are controlled by electronic IV pumps. (cancer.org)
Seldinger1
- After identification of the main arterial supply by the Seldinger technique and the first intraarterial infusion, we implanted an intraarterial reservoir system, using the facial, superficial temporal and superior thyroid arteries. (gr.jp)
Nodules2
- Arterial phase CT scan shows 2 nodules located in segment 8 and 2, the biggest one with a 13-mm diameter. (cancernetwork.com)
- C) In the 42 months post OLT, MRI showed (T1+Gd FatSat arterial phase) multiple hypervascular hepatic nodules (arrows) and a left adrenal metastasis (arrowhead) were documented. (cancernetwork.com)
Liver3
- 34. [Clinical experience of intra-arterial chemotherapy for liver metastases of breast cancer patients]. (nih.gov)
- Abbreviated Gadoxetic Acid-enhanced MRI with Second-Shot Arterial Phase Imaging for Liver Metastasis Evaluation " by Jeong Woo Kim, MD, et al. (rsna.org)
- Compared with a full original MRI protocol, an abbreviated gadoxetic acid-enhanced MRI protocol including second-shot arterial phase imaging showed faster image acquisition without compromising diagnostic performance, demonstrated fewer motion artifacts, and preserved visual vascularity (with assistance from the subtraction image) for liver metastasis evaluation. (rsna.org)
Arteries1
- Over twenty clinical studies since 1996 published primarily in Circulation have consistently found beneficial effects of vitamin C, administered either orally or by intra-arterial infusion, on the relaxation of arteries, or vasodilation. (mizar5.com)
Therapeutic1
- Intra-arterial administration of 177Lu-DOTATATE seems to be a powerful tool over standard i.v administration for the improvement in clinical practice, by achieving higher concentration, retention and absorbed dose in tumors in patients of hepatic metastases of GEPNETs, although, the therapeutic efficacy of the IA infusion of PRRT cannot be commented post single administration. (snmjournals.org)
Patients2
- Nevertheless, every effort should be made to improve distal arterial flow in patients with TAO, and autologous vein bypass of coexistent large-vessel atherosclerotic stenoses should be considered in patients with severe ischemia who have an acceptable distal target vessel. (medscape.com)
- Methods Retrospective study, approved by the institutional review board, of 76 eyes of 67 patients with retinoblastoma with subretinal and/or vitreous seeding treated with intra-arterial chemotherapy at Memorial Sloan-Kettering Cancer Center between May 2006 and August 2010. (bmj.com)
Cancer9
- 21. [Intra-arterial infusion chemotherapy with epirubicin for advanced breast cancer]. (nih.gov)
- 25. [Preoperative intra-arterial chemotherapy with THP-ADR for locally advanced breast cancer]. (nih.gov)
- 28. [A prospective randomized study of intra-arterial infusion chemotherapy in the treatment of advanced breast cancer]. (nih.gov)
- 29. [Histopathological evaluation of transarterial one shot infusion of adriamycin as a preoperative adjuvant chemotherapy for the breast cancer]. (nih.gov)
- 31. [The significance of neoadjuvant intra-arterial chemotherapy for locally advanced breast cancer by different methods]. (nih.gov)
- 32. First-line intra-arterial chemotherapy (IAC) with epirubicin and mitoxantrone in locally advanced breast cancer. (nih.gov)
- 36. [Intra-arterial chemotherapy to improve quality of life in cases of unresectable advanced or recurrent breast cancer]. (nih.gov)
- 37. [Intra-arterial infusion chemotherapy for breast cancer]. (nih.gov)
- 38. Neoadjuvant intra-arterial chemotherapy in locally advanced breast cancer: a prospective randomized study. (nih.gov)
Concentrations1
- Leptin in different concentrations was infused intra-arterially into rabbits fed on high salt diets and the response was compared in rabbits fed with low salt diets. (scialert.net)
Surgical1
- Surgical exploration of extensive lower-limb necrosis showed arterial thrombosis and Serratia marcescens infection. (cdc.gov)
Vasodilation1
- Conversely, even prolonged intra-arterial infusion of secretin does not release pancreatic stores of histamine: In fact, endogenous synthesis and release of histamine seem to play no role in the regulation of functional vasodilation in the pancreas. (erowid.org)
Blood pressure3
- The aim of this research is to see the effect of intra-arterial infusion of leptin on blood pressure of salt loaded rabbits in vivo . (scialert.net)
- In rabbits fed with low salt diet, leptin infused intra-arterially caused an increase in blood pressure while infusion of leptin into rabbits fed with high salt diets does not affect the blood pressure. (scialert.net)
- Increase the infusion rate by 25 mL/hr every 5 minutes (for rapid titration) to 15 minutes (for gradual titration) up to a maximum of 150 mL/hr until desired blood pressure reduction is achieved. (nih.gov)
Tissue1
- Late manifestations of compartment syndrome include the absence of a distal pulse, hypoesthesia, and extremity paresis, because the cycle of elevating tissue pressure eventually compromises arterial blood flow. (medscape.com)
Drugs1
- Intra-arterial histamine [2] (50 400 mcg), compound 48/80 (0.1-1.0 mg), serotonin (1-10 mg), isoproterenol (0.2-2.0 mcg), carbamylcholine (1100 mcg), synthetic-bradykinin DBRS Sandoz, 3-10 mcg) act as vasodilator drugs in the isolated perfused canine pancreas. (erowid.org)