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  • 2017
  • Between early 2013 to early 2017, 916 lab-confirmed human cases of H7N9 were reported to the World Health Organization (WHO). (wikipedia.org)
  • On 9 January 2017, the National Health and Family Planning Commission of China reported to WHO 106 cases of H7N9 which occurred from late November through late December, including 35 deaths, 2 potential cases of human-to-human transmission, and 80 of these 106 persons stating that they have visited live poultry markets. (wikipedia.org)
  • After a confirmatory test done in Australia, it was confirmed that the Bird Flu strain in Pampanga in the Philippines in August 2017 was of the subtype H5N6. (wikipedia.org)
  • Seqirus 2017 H7N9 With/Without MF59 (R) in Healthy Males and Non-pregnant Females, 18-64 Years of Age. (bioportfolio.com)
  • This is a trial designed to assess the safety, reactogenicity and immunogenicity of one or two doses of monovalent inactivated split influenza 2013 and 2017 A/H7N9 virus vaccines administe. (bioportfolio.com)
  • In early 2017, Guan warned that the H7N9 influenza virus "poses the greatest threat to humanity than any other in the past 100 years. (wikipedia.org)
  • outbreaks
  • The evidence as a whole is complex and the implications of past outbreaks for predicting the future course of the current H7N9 epizootic [an epidemic among animals] are uncertain," write the authors. (redorbit.com)
  • That is not utilizing NIs for prevention or treatment "Based on these findings there appears to be no evidence for patients, clinicians or policy-makers to use these drugs to prevent serious outcomes, both in annual influenza and pandemic influenza outbreaks. (wikipedia.org)
  • Two decision analysis studies suggest that during local outbreaks of influenza, the prevalence will be over 70%, and thus patients with any of these combinations of symptoms may be treated with neuraminidase inhibitors without testing. (wikipedia.org)
  • viral
  • Ansun BioPharma is a clinical stage biopharmaceutical company focused on the development of unique host-directed anti-viral therapies for respiratory viruses. (bioportfolio.com)
  • Complications of influenza may include viral pneumonia, secondary bacterial pneumonia, sinus infections, and worsening of previous health problems such as asthma or heart failure. (wikipedia.org)
  • illness
  • Bird flu is similar to swine flu, dog flu, horse flu and human flu as an illness caused by strains of influenza viruses that have adapted to a specific host. (wikipedia.org)
  • In China during March 4-April 28, 2013, avian influenza A(H7N9) virus testing was performed on 20,739 specimens from patients with influenza-like illness in 10 provinces with confirmed human cases: 6 (0.03%) were positive, and increased numbers of unsubtypeable influenza-positive specimens were not seen. (cdc.gov)
  • To better understand the epidemiology, geographic spread, and clinical spectrum of this virus in China, we describe the Chinese National Influenza-Like Illness Surveillance Network (CNISN) and analyze data collected since March 4, 2013. (cdc.gov)
  • Surveillance for influenza-like illness (ILI) was initially conducted in 4 sentinel hospitals in Guangzhou and expanded to 19 hospitals in November 2013. (cdc.gov)
  • HPAI
  • Between 1959 and 1995, there were 15 recorded occasions of the emergence of HPAI viruses in poultry, but losses were minimal. (wikipedia.org)
  • The global HPAI situation significantly improved in the first half of 2008, but the FAO reports that imperfect disease surveillance systems mean that occurrence of the virus remains underestimated and underreported. (wikipedia.org)
  • deaths
  • By October 2, 2014, a total of 453 confirmed cases and 175 associated deaths had been reported ( http://www.who.int/influenza/human_animal_interface/influenza_h7n9/riskassessment_h7n9_2Oct14.pdf?ua=1 ). (cdc.gov)
  • transmission
  • Though influenza A is adapted to birds, it can also stably adapt and sustain person-to person transmission. (wikipedia.org)
  • The mode of subtype H7N9 virus transmission between avian species remains largely unknown, but various wild birds have been implicated as a source of transmission. (cdc.gov)
  • We demonstrate that interspecies transmission of H7N9 virus occurs readily between society finches and bobwhite quail but only sporadically between finches and chickens. (cdc.gov)
  • A third instance of rabies transmission following organ transplantation has occurred, with a patient dying 18 months after receiving a kidney from a deceased donor who was not known to be infected with the rabies virus, researchers reported. (blogspot.com)
  • This suggests that the population at risk for avian influenza was not limited to those with direct contact to infected poultry, and that person to person transmission may have occurred on a large scale. (wikipedia.org)
  • Epidemiologic findings for a family cluster of 1 severe and 1 mild case suggested limited person-to-person transmission of this virus. (cdc.gov)
  • Although avian influenza viruses have not caused widespread human transmission in 94 years of surveillance, there have been numerous instances of avian influenza spillover and H7N9 "might arguably be more likely than other avian viruses to become human-adapted," write the authors. (redorbit.com)
  • China
  • A 5th epidemic of the H7N9 virus began in October 2016 in China. (wikipedia.org)
  • On April 3, the Chinese Center for Disease Control and Prevention (China CDC) distributed primers and probes specific for avian influenza A(H7N9) virus to all national influenza surveillance network laboratories in China. (cdc.gov)
  • Furthermore, two samples collected from environment in Nanjing and Zhejiang and one sample collected from chicken are the sources of H7N9 influenza virus that infected human in China. (hindawi.com)
  • This particular A (H7N9) virus had not previously been seen in either animals or people until 2013 in China [ 4 ]. (hindawi.com)
  • Shanghai
  • The Shanghai health ministry ordered culling of birds after pigeon samples collected at the Huhuai wholesale agricultural products market in Songjiang District of Shanghai showed H7N9. (blogspot.com)
  • all Shanghai live poultry markets closed temporarily in response to the H7N9 found in the pigeon samples. (blogspot.com)
  • China's agricultural authorities reported that the H7N9 virus had been detected from pigeon samples collected at a marketplace in Shanghai. (blogspot.com)
  • Genetic
  • Genetic factors in distinguishing between "human flu viruses" and "avian flu viruses" include: PB2: (RNA polymerase): Amino acid (or residue) position 627 in the PB2 protein encoded by the PB2 RNA gene. (wikipedia.org)
  • Despite their avian genetic background, some H7N9 viruses have HA and polymerase protein mutations that confer a replication advantage in mammals ( 1 ). (cdc.gov)
  • pigs
  • Influenza is quite common in pigs, with about half of breeding pigs having been exposed to the virus in the US. (wikipedia.org)
  • The authors point out that many H7 viruses have adapted to infect mammals, including horses and pigs, which raises the possibility that H7N9 could adapt in a similar fashion. (redorbit.com)
  • threat
  • Nevertheless, H7N9 virus persists in poultry, and human infections surged in the late 2013, demonstrating that this virus is an ongoing public health threat ( 11 ). (cdc.gov)
  • Influenza, or "flu," represents a serious threat to public health - globally, annual epidemics result in 3 to 5 million cases of severe disease, millions of hospitalizat. (bioportfolio.com)
  • symptoms
  • A 2015 systematic review and meta-analysis found oseltamivir effective at treating the symptoms of influenza, reducing the length of hospitalization, and reducing the risk of otitis media. (wikipedia.org)
  • These symptoms typically begin two days after exposure to the virus and most last less than a week. (wikipedia.org)
  • Influenza is a mixture of symptoms of common cold and pneumonia, body ache, headache, and fatigue. (wikipedia.org)
  • The symptoms most reliably seen in influenza are shown in the adjacent table. (wikipedia.org)
  • amino
  • The identification of amino acids in H9 antigenic sites revealed different distribution of antigenic areas among other subtypes. (wikipedia.org)
  • Virology
  • All the unknowns surrounding the virus make a strong case for enhancing basic and applied research into the evolution of influenza viruses and for better integration of influenza virology within human and veterinary public health efforts. (redorbit.com)
  • Prevention
  • NEW YORK (GenomeWeb News) - The US Food and Drug Administration this week issued an emergency use authorization, or EUA, for a Centers for Disease Control and Prevention assay for the detection of influenza A virus subtype H7N9. (genomeweb.com)
  • However, another meta-analysis found that oseltamivir was effective for prevention of influenza at the individual and household levels. (wikipedia.org)
  • proteins
  • Using the method, we construct the phylogenetic trees of nine proteins of H7N9 influenza virus to analyze the originated source of H7N9. (hindawi.com)
  • Antibody-dependent enhancement (ADE) occurs when non-neutralising antiviral proteins facilitate virus entry into host cells, leading to increased infectivity in the cells. (wikipedia.org)