Indole 3 glycerol phosphate synthase. Medical search. Frequent questions

In some organisms this enzyme is part of a multifunctional protein that also includes one or more of the enzymes EC 2.4.2.18 (anthranilate phosphoribosyltransferase), EC 4.1.1.48 (indole-3-glycerol-phosphate synthase), EC 4.1.3.27 (anthranilate synthase) and EC 5.3.1.24 (phosphoribosylanthranilate isomerase). (enzyme-database.org)

Other names in common use include indoleglycerol phosphate synthetase, indoleglycerol phosphate synthase, indole-3-glycerophosphate synthase, 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate, and carboxy-lyase (cyclizing). (wikipedia.org)
It is a pyridoxal phosphate protein that also catalyzes the conversion of serine and indole into tryptophan and water and of indoleglycerol phosphate into indole and glyceraldehyde phosphate. (bvsalud.org)

Cloned Arabidopsis thaliana NAPE synthase (pNAPES). (mmpc.org)

The enzyme indole-3-glycerol-phosphate synthase (IGPS) (EC 4.1.1.48) catalyzes the chemical reaction 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate ⇌ {\displaystyle \rightleftharpoons } 1-C-(indol-3-yl)-glycerol 3-phosphate + CO2 + H2O This enzyme belongs to the family of lyases, to be specific, the carboxy-lyases, which cleave carbon-carbon bonds. (wikipedia.org)
A structure of the IGPS domain of the bifunctional enzyme from the mesophilic bacterium E. coli (eIGPS) has been compared with the monomeric indole-3-glycerol phosphate synthase from the hyperthermophilic archaeon Sulfolobus solfataricus (sIGPS). (wikipedia.org)

Probable tryptophan synthase, alpha subunit TrpA. (ntu.edu.sg)
TrpA converts indole\3\glycerol phosphate (IGP) into glyceraldehyde\3\phosphate (G3P) and indole. (ufe-eg.org)

2.0 A structure of indole-3-glycerol phosphate synthase from the hyperthermophile Sulfolobus solfataricus: possible determinants of protein stability. (expasy.org)
38678) Cobalamin-independent synthase MetE domain protein CP001857 CDS Arcpr_0044 complement(38683. (go.jp)
A pyridoxal-phosphate protein. (enzyme-database.org)
In thermophilic organisms, where the high temperature enhances diffusion and causes the loss of indole, a protein similar to the β subunit can be found ( EC 4.2.1.122 ). (enzyme-database.org)
Characterization of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (AGEPC)-induced protein phosphorylation in rabbit platelets: inhibitory effects of AGEPC analogs. (shengsci.com)

In the present study, S -phenyl-L-cysteine was synthesized from thiophenol and L-serine using a recombinant tryptophan synthase (E.C. 4.2.1.20) obtained from E. coli k-12 MG1655. (biomedcentral.com)

Strain ATSA2 T displayed PGP traits such as indole acetic acid (IAA, 62.9 μg/mL) and siderophore production, and phosphate solubilization activity. (springeropen.com)
Furthermore, genome analysis of this strain suggested the presence of gene clusters involved in iron acquisition ( fhuABD , afuABC , fbpABC , and fepCDG ) and phosphate solubilization ( pstABCHS , phoABHLU , and phnCDEP ) and other phytohormone biosynthesis genes, including indole-3-acetic acid ( trpABCDEFG ), in the genome. (springeropen.com)

In arginine biosynthesis, acetylornithine aminotransferase (AcOAT) uses pyridoxal-5'-phosphate (PLP) as a cofactor for amino group transfer. (bvsalud.org)

Previously, S -phenyl-L-cysteine was prepared using tryptophan synthase in Escherichia coli MT-10242 and Neurospora crassa ATCC 14692. (biomedcentral.com)

The systematic name of this enzyme class is 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase [cyclizing 1-C-(indol-3-yl)glycerol-3-phosphate-forming]. (wikipedia.org)

The α-subunit catalyses the conversion of 1- C -(indol-3-yl)glycerol 3-phosphate to indole and D -glyceraldehyde 3-phosphate (this reaction was included formerly under EC 4.1.2.8 ). (enzyme-database.org)
The process started with the reaction of magnesium and bromobenzene, followed by a Grignard reaction, and then hydrolysis and enzymatic synthesis using tryptophan synthase. (biomedcentral.com)
Le Chatelier's principle provides an explanation as to why, in the metabolic pathway leading to the synthesis of l-tryptophan, the third reaction proceeds in the direction of formation of indole and D-glyceraldehyde 3-phosphate even though the apparent equilibrium constant greatly favors the formation of 1-(indo-3-yl)glycerol 3-phosphate. (nist.gov)
TrpB catalyzes PLP\dependent \replacement reaction in which indole displaces the hydroxyl group of MSC2530818 L\Ser to produce L\Trp. (ufe-eg.org)

1-O-Alkyl-2-acetyl-sn-glycero-3-phosphocholine (AGEPC) induced phosphorylation of two proteins having molecular masses of approximately 20- and 40-kDa in washed rabbit platelets in a concentration- and time-dependent manner. (shengsci.com)

The Catalytic Mechanism of Indole-3-Glycerol Phosphate Synthase: Crystal Structures of Complexes of the Enzyme From Sulfolobus Solfataricus with Substrate Analogue, Substrate, and Product. (atomistry.com)
Woehl, E. and Dunn, M.F. Mechanisms of monovalent cation action in enzyme catalysis: the tryptophan synthase α-, β-, and αβ-reactions. (enzyme-database.org)
The pentose phosphate pathway (PPP) can supply NADPH in cells via the 6-phosphogluconate dehydrogenase (6PGD) enzyme, which is an oxidoreductase that converts 6-phosphogluconate (6PG) to ribulose 5-phosphate (Ru5P), to produce NADPH. (bvsalud.org)
An enzyme that catalyzes the conversion of L-serine and 1-(indol-3-yl)glycerol 3-phosphate to L-tryptophan and glyceraldehyde 3-phosphate. (bvsalud.org)

Our findings indicate that the tryptophan synthase from E. coli k-12 MG1655 effectively catalyses the synthesis of L-cysteine from L-serine and sodium hydrosulfide [ 12 ]. (biomedcentral.com)

Objective Indole‐3‐carbinol (I3C), a naturally occurring compound found in cruciferous vegetables, and its metabolite 3,3′‐diindolylmethane (DIM) reduce body mass and serum glucose levels in high‐fat‐diet‐induced obese mice. (researchgate.net)
DIM, a major metabolite of indole-3-carbinol, which is naturally produced in broccoli and cabbage, enhances glucose uptake through the improvement of insulin sensitivity in 3T3-L1 cells [13] . (researchgate.net)

3,3 -diindolylmethane (DIM) is a natural compound produced from the acid-catalyzed self-condensation of indole-3-carbinol, which is abundant in cruciferous vegetables, such as broccoli and cabbage [11,12]. (researchgate.net)
3,3′-diindolylmethane (DIM)-a natural compound produced from indole-3-carbinol, found in cruciferous vegetables-enhances glucose uptake by increasing the activation of the insulin signaling pathway in 3T3-L1 adipocytes. (researchgate.net)
Glycerol (also called glycerine or glycerin) is a simple polyol (sugar alcohol) compound. (mmpc.org)

To produce amino acids, cells require nicotinamide adenine dinucleotide phosphate (NADPH), which is a biological reducing agent. (bvsalud.org)

Tryptophan synthase alpha chain [Interproscan]. (ntu.edu.sg)

A common feature of all EGF-like domains is that they are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase). (embl.de)

SH2-Domain containing inositol 5-phosphatases (SHIP1 & SHIP2) dephosphorylate the 5-position of PI(3,4,5)P3 generating PI(3,4)P2. (mmpc.org)

BC1629 is enriched for 7 functions in 3 categories. (systemsbiology.net)

We invite you to complete a survey that will take no more than 3 minutes. (bvsalud.org)

Substrate binding, product release, and likely chemical catalysis in the tryptophan biosynthetic enzyme indole-3-glycerol phosphate synthase (IGPS) are dependent on the structural dynamics of the β1α1 active-site loop. (nih.gov)
The study has shown that functional tryptophan synthase (TrpAB), one of the several enzymes involved in the multistep L-Trp biosynthesis, is necessary for MTB growth in vitro and in zebrafish in vivo model. (nih.gov)
A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase. (nih.gov)
Most mesophilic bacteria have a multimeric tryptophan synthase complex (EC 4.2.1.20 ) that forms L-tryptophan from L-serine and 1-C- (indol-3-yl)glycerol 3-phosphate via an indole intermediate. (expasy.org)
This enzyme, which does not combine with the alpha unit to form a complex, salvages the lost indole back to L-tryptophan. (expasy.org)
5181 tryptophan synthase beta chain trpB BBZA01000003 CDS ARMA_0032 5369. (go.jp)

The enzyme indole-3-glycerol-phosphate synthase (IGPS) (EC 4.1.1.48) catalyzes the chemical reaction 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate ⇌ {\displaystyle \rightleftharpoons } 1-C-(indol-3-yl)-glycerol 3-phosphate + CO2 + H2O This enzyme belongs to the family of lyases, to be specific, the carboxy-lyases, which cleave carbon-carbon bonds. (wikipedia.org)

It has a much lower Km for indole than the beta subunit of EC 4.2.1.20 . (expasy.org)

A pyridoxal-phosphate protein, believed to be the rate-limiting compound in the biosynthesis of polyamines. (nih.gov)

Other names in common use include indoleglycerol phosphate synthetase, indoleglycerol phosphate synthase, indole-3-glycerophosphate synthase, 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate, and carboxy-lyase (cyclizing). (wikipedia.org)

A common feature of all EGF-like domains is that they are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase). (embl-heidelberg.de)

Specific proteins such as peptidyl-prolyl cis-trans isomerase (A2WJU9), thiamine thiazole synthase (A2YM28), and alanine-tRNA ligase (B8B4H5) upregulated in IR29 and FL478 indicate key mechanisms of M. oryzae CBMB20 mediated plant growth promotion in rice. (springeropen.com)

Two PstI RFLPs in the PCCB gene on the long arm of chromosome 3. (uchicago.edu)

Glycerol (also called glycerine or glycerin) is a simple polyol (sugar alcohol) compound. (mmpc.org)

Epub 2017 Jul 3. (nih.gov)

Photocatalytic reforming of a glycerol water mixture on Pt/TiO2 catalysts. (cardiff.ac.uk)

It is composed of beta-1,3-N-acetyl glucosamine and beta-1,4-glucuronic acid repeating disaccharide units with a molecular weight (MW) up to 6 MDa. (justia.com)

Bell JK, Botos I, Hall PR, Askins J, Shiloach J, Segal DM, Davies DR. The molecular structure of the Toll-like receptor 3 ligand-binding domain. (nih.gov)
Umland, T.C., Wolff, E.C., Davies, D.R. Structure of inhibited deoxyhyposine synthase: a swinging ball and chain opens the active site. (nih.gov)

part of family of 3'-to5' exonucleases. (lbl.gov)

In thermophilic organisms the high temperature enhances diffusion and causes the loss of indole. (expasy.org)
Endothelin-3 has been found in high concentrations in the brain and may regulate important functions in neurons and astrocytes, such as proliferation and development. (lookformedical.com)

Catalysis Science & Technology 12 (3), pp.843-854. (cardiff.ac.uk)

Anatomy1

Organisms2

Chemicals and Drugs37

Phenomena and Processes2

Information Science2

Anthranilate synthase1

Indoleglycerol phosphate2

Arabidopsis1

IGPS2

TrpA2

Protein5

1.201

Acetic acid2

Biosynthesis1

Escherichia1

Lyase1

Reaction4

Acetyl1

Enzyme4

Coli1

Metabolite2

Compound3

NADPH1

Alpha chain1

Proteins1

Domain1

Functions1

Complete1

Tryptophan6

1.481

Subunit1

Pyridoxal phosphate1

Synthetase1

Prostaglandin1

Thiamine1

Gene1

Compound1

Epub1

Water1

Acid1

Structure2

Family1

High2

Science1