• with the establishment of a full donor lymphoid engraftment, we eliminate the risk of kidney rejection and the need of lifelong immunosuppression. (ca.gov)
  • Our same donor sequential αβdepleted-HSCT kidney transplantation strategy addresses the urgent unmet medical need to abrogate the need for post-kidney transplant lifelong immunosuppression, the risk of chronic rejection, and, ultimately, the need for repeated transplantation. (ca.gov)
  • Sequential same donor αβdepleted-HSCT/KT can 1) eliminate the need for lifelong immunosuppression, 2) reduce the need for a 2nd KT, and 3) cure the underlying disease, resulting in improved lives of patients, decreased societal costs and enormous socio-economic benefit to California. (ca.gov)
  • Solid organ transplant recipients (SOTRs) are on lifelong immunosuppression, which may interfere with adaptive immunity to COVID-19. (lu.se)
  • Our findings demonstrate that PKM2 promotes tumor progression and galectin-9-mediated immunosuppression via NF-κB signaling inhibition in HNSCC, which bridges metabolism and immunosuppression. (researchsquare.com)
  • This proposal will utilize knock-out and transgenic animal models to identify the molecular and cellular mechanisms that control inflammation-induced tumor immunosuppression. (grantome.com)
  • Tumor-induced immunosuppression is a common obstacle for cancer treatment. (cun.es)
  • We are pleased to share our work outlining the impact immunosuppression regimens had on outcomes following AAVHSC dosing in NHPs, as it contributes to a key area of research in the gene therapy and gene editing field," stated Albert Seymour, Ph.D., President and Chief Executive Officer of Homology Medicines. (advfn.com)
  • This study aimed to analyze adult kidney transplant recipients (KTRs) for the risk of new-onset diabetes after transplantation (NODAT) associated with viral serologies and immunosuppression regimens [tacrolimus (Tac) + mycophenolate (MPA), cyclosporine (CSA) + MPA, sirolimus (SRL) + MPA, SRL + CSA or SRL +Tac]. (ufl.edu)
  • ligands are required for balancing anti- and pro-inflammation cascades in vivo by regulating myelopoiesis, MDSC expansion and immunosuppression. (grantome.com)
  • Of therapeutic relevance, the authors showed that propranolol, a commonly prescribed β-blocker, can reduce MDSC immunosuppression and enhance the effect of other cancer therapies. (cun.es)
  • The team confirmed that the Notch pathway involvement in GVHD was conserved across species, and demonstrated in their animal models that just a single dose of the DLL4-blocking antibody given immediately before stem cell transplantation greatly increased survival and prevented signs of GVHD in the intestines, but without causing global immunosuppression. (genengnews.com)
  • New-onset diabetes after kidney transplantation: can the risk be modified by choosing immunosuppression regimen based on pretransplant viral serology? (ufl.edu)
  • Santos AH JR, Chen C, Casey MJ, Womer, KL, Wen X. New-onset diabetes after kidney transplantation: can the risk be modified by choosing immunosuppression regimen based on pretransplant viral serology? (ufl.edu)
  • Non-deliberate immunosuppression can occur in, for example, ataxia-telangiectasia, complement deficiencies, many types of cancer, and certain chronic infections such as human immunodeficiency virus (HIV). (wikipedia.org)
  • Chronic inflammation and immunosupression contribute to lung cancer formation. (grantome.com)
  • An analysis of 10-year follow-up data showed that immunosuppression may not be enough to prevent chronic kidney disease (CKD) in patients with lupus nephritis. (consultant360.com)
  • Immunosuppression is a reduction of the activation or efficacy of the immune system. (wikipedia.org)
  • Some portions of the immune system itself have immunosuppressive effects on other parts of the immune system, and immunosuppression may occur as an adverse reaction to treatment of other conditions. (wikipedia.org)
  • A person who is undergoing immunosuppression, or whose immune system is weak for some other reasons (such as chemotherapy or HIV), is said to be immunocompromised. (wikipedia.org)
  • Immunodeficiency is also a potential adverse effect of many immunosuppressant drugs, in this sense, the scope of the term immunosuppression in general includes both beneficial and potential adverse effects of decreasing the function of the immune system. (wikipedia.org)
  • The main aim of our study was to assess how energy deprivation (i.e., "semi-starvation") leading to substantial fat mass loss affects the immune system and immunosuppression in previously normal weight individuals. (jyu.fi)
  • WEDNESDAY, June 2, 2021 (HealthDay News) - Overall, 2.8 percent of a national cohort of commercially insured U.S. adults meet criteria for drug-induced immunosuppression, of whom 67.7 percent receive oral corticosteroids, according to a research letter published online May 20 in JAMA Network Open . (physiciansweekly.com)
  • Sixty mice were divided into five groups, and the mice were injected with cyclophosphamide to establish an immunosuppression model except for those in the common group. (hindawi.com)
  • Homology Medicines, Inc. (Nasdaq: FIXX), a genetic medicines company, announced today the presentation of preclinical data that supports the targeted, prophylactic immunosuppression regimen in the ongoing pheEDIT gene editing clinical trial in adults with phenylketonuria (PKU) and juMPStart gene therapy trial in adults with Hunter syndrome (MPS II). (advfn.com)
  • Targeting PARP11 to avert immunosuppression and improve CAR T therapy in solid tumors. (bvsalud.org)
  • If the GvHD is severe and requires intense immunosuppression involving steroids and additional agents to get under control, the patient may develop severe infections [12] as a result of the immunosuppression and may die of infection. (wikipedia.org)
  • The researchers found that 2.8 percent of the participants met the criteria for drug-induced immunosuppression during the period from Jan. 1, 2018, through Dec. 31, 2019. (physiciansweekly.com)
  • Malignant neoplasms, immune-mediated conditions, and inflammatory skin conditions were the most common immunosuppression-associated diagnosis categories (73.8, 68.8, and 38.8 percent, respectively). (physiciansweekly.com)
  • In general, deliberately induced immunosuppression is performed to prevent the body from rejecting an organ transplant. (wikipedia.org)
  • People in remission from cancer who require immunosuppression are not more likely to experience a recurrence. (wikipedia.org)
  • Deliberate immunosuppression is a necessary part of the bone marrow transplant procedure to prevent graft-versus-host disease and graft rejection. (leukaemia.org.au)
  • While only 2 of 8 patients in the plasma exchange group were dialysis dependent versus 6 of 9 in the immunosuppression only group, the authors concluded that renal function and the degree of crescentic involvement on renal biopsy were better predictors of outcome than was the therapeutic intervention selected. (medscape.com)
  • In summary, this study elucidated a number of molecular pathways presumably explaining immunosuppression in individuals going through prolonged periods of intense training with low-energy availability. (jyu.fi)
  • Combined immunosuppression and radiotherapy in thyroid eye disease (CIRTED): a multicentre, 2 × 2 factorial, double-blind, randomised controlled trial. (ox.ac.uk)
  • We aimed to establish whether orbital radiotherapy or antiproliferative immunosuppression would confer any additional benefit. (ox.ac.uk)
  • Indeed, ablation of the lal gene resulted in systemic increase of MDSCs and immunosuppression of T cell proliferation/function in LAL knockout (lal-/-) mice. (grantome.com)
  • Northwestern Medicine scientists have identified how one gene connects glioblastoma stem cell self-renewal to microglia immunosuppression in glioblastoma, according to a new study published in Nature Immunology. (ground.news)
  • Immunosuppression mediated by MICCop was investigated in vivo by daily assessment of clinical signs of paralysis and in in vitro restimulation assays of peripheral immune cells. (uni-koeln.de)
  • Beth I. Wallace, M.D., from the University of Michigan Medical School in Ann Arbor, and colleagues conducted a cross-sectional study using direct pharmaceutical claims to describe the prevalence of drug-induced immunosuppression among 3,169,441 continuously enrolled patients. (physiciansweekly.com)
  • The unwanted effect in non-deliberate immunosuppression is immunodeficiency that results in increased susceptibility to pathogens, such as bacteria and viruses. (wikipedia.org)
  • We used hybridoma technology to generate monoclonal antibody to block GDF15 and evaluate its effects on HCC-associated immunosuppression. (bmj.com)
  • Conclusions Our results reveal the generation and function enhancement of Treg cells induced by GDF15 is a new mechanism for HCC-related immunosuppression. (bmj.com)
  • Neetens, A & Mortelmans, J 1975, ' Experimental brucei trypanosomiasis: immunosuppression of the blood-aqueous barrier ', Experimental Eye Research , vol. 20, pp. 109-120. (itg.be)