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  • induction
  • One model for the induction of tolerance during the very early stages of pregnancy is the Eutherian Fetoembryonic Defense System (eu-FEDS) hypothesis. (wikipedia.org)
  • An exploratory, open-labeled study of patients with Pompe disease, who have previously received Myozyme (alglucosidase alfa) treatment, to evaluate the efficacy, safety and clinical benefit of 2 Immune Tolerance Induction (ITI) regimens in combination with Myozyme. (clinicaltrials.gov)
  • Specifically, the Contractor shall design and conduct clinical trials at all phases to evaluate the safety, toxicity and efficacy of promising tolerance induction strategies in these disease areas, and design and conduct studies of the underlying mechanisms involved in the induction, maintenance and loss of tolerance as an integral part of Network-sponsored clinical trials, as well as clinical trials supported by other Federal and private organizations and companies. (nih.gov)
  • The immune tolerance to OVA antigen topically applied to the conjunctiva measured by cutaneous delayed type hypersensitivity (DTH) reaction, OVA-specific T cell proliferation, Foxp3 induction, and IFN-γ production observed in WT mice was lost in the Spdef-KO mice. (jci.org)
  • Efficacy
  • Advancing immune science will lead to new approaches to investigate the biological mechanisms of disease and functional properties of foods to better determine and predict the efficacy and safety of emerging products," said Mike Luther of the DHMRI. (centerwatch.com)
  • autoimmune diseases
  • The goals of this Collaborative Network are to: (1) design a long-term research agenda to accelerate the application of tolerogenic approaches for the treatment of multiple immune system diseases, including autoimmune diseases, asthma and allergic diseases, and graft rejection on solid organ, cell and tissue transplantation. (nih.gov)
  • The ITN's approach to tolerance in autoimmune diseases attempts to address these challenges through a coordinated program of clinical studies aimed at establishing a mechanistic proof-of-principle in diseases where a self-antigen has been identified and/or where the target organ is accessible for serial sampling and mechanistic study. (immunetolerance.org)
  • cells
  • The phenomenon of immune tolerance was first described by Ray D. Owens in 1945, who noted that dizygotic twin cattle sharing a common placenta also shared a stable mixture of each other's red blood cells (though not necessarily 50/50), and retained that mixture throughout life. (wikipedia.org)
  • Still, the placental barrier is not the sole means to evade the immune system, as foreign fetal cells also persist in the maternal circulation, on the other side of the placental barrier. (wikipedia.org)
  • Myeloid cells, innate lymphoid cells, and the cytokines they secrete cooperate to maintain immune tolerance in the gut. (sciencemag.org)
  • Epigenetic analysis of immune cells is performed at Epiontis GmbH, a biotechnology company located in Berlin, Germany. (immunetolerance.org)
  • Lack of goblet cells abrogates conjunctival mucosal tolerance. (jci.org)
  • This material is then displayed to other cells of the immune system. (wikipedia.org)
  • In 1882, he studied motile (freely moving) cells in the larvae of starfishes, believing they were important to the animals' immune defenses. (wikipedia.org)
  • This prevents recognition and destruction of self host cells, making it a type of negative selection or central tolerance. (wikipedia.org)
  • The biggest weakness in Burnet's theory was that he had no explanation for how the body selected for immune cells that only identified non-self. (wikipedia.org)
  • Topical immunotherapy utilizes an immune enhancement cream (imiquimod) which produces interferon, causing the recipient's killer T cells to destroy warts, actinic keratoses, basal cell cancer, vaginal intraepithelial neoplasia, squamous cell cancer, cutaneous lymphoma, and superficial malignant melanoma. (wikipedia.org)
  • He reasoned, the immune system would be able to play a factor via a 'bystander effect' in eradicating chemotherapy-resistant cancer cells. (wikipedia.org)
  • However, extensive research is still needed on how the immune response is triggered against dying tumour cells. (wikipedia.org)
  • The suppressing and tolerance-inducing effect of Tr1 cells is mediated mainly by cytokines. (wikipedia.org)
  • organ
  • The autoimmune therapeutic area represents a broad category of human disease presentations that involve a variety of organ targets and thus presents a significant challenge with respect to the development of therapies designed to re-establish self-tolerance. (immunetolerance.org)
  • Successful approaches will allow deliberate withdrawal of immunosuppression with the possible exception of maintenance low-dose anti-inflammatory medication that sustains immune quiescence of the target organ(s). (immunetolerance.org)
  • This study is being done with the purpose of trying to understand if and why transplant recipients may develop tolerance to their transplanted organ. (clinicaltrials.gov)
  • Tolerance means being able to lower or take away immunosuppression (anti-rejection medications) without causing organ rejection. (clinicaltrials.gov)
  • clinical
  • The overall objective is to define molecular predictors and correlates of durable clinical remission and the development of new biomarkers of immune tolerance and regulation that will reliably guide clinical decisions to taper immunosuppressive medications. (immunetolerance.org)
  • mechanism
  • This is the same mechanism used by parasitic nematodes to avoid detection by the immune system of their host. (wikipedia.org)
  • Researchers have identified a brain mechanism that could be a drug target to help prevent tolerance and addiction to opioid pain medication, such as morphine, according to a study by Georgia State University and Emory University. (medicalxpress.com)
  • Thus, we propose that SOCS1 and PGE2, potentially interacting together, act as an alternative intestinal tolerance mechanism distinct from IL-10 and Tregs. (sigmaaldrich.com)
  • tumors
  • Cancer immunosurveillance and immunoediting are based on protection against development of tumors in animal systems and (ii) identification of targets for immune recognition of human cancer. (wikipedia.org)
  • discovery
  • The David H. Murdock Research Institute (DHMRI) has acquired the Immune Tolerance Institute (ITI) as part of the North Carolina-based Institute's mission to accelerate the discovery and development of breakthrough treatments for a range of immune-related diseases. (centerwatch.com)
  • rejection
  • Many cases of spontaneous abortion may be described in the same way as maternal transplant rejection, and a chronic insufficient tolerance may cause infertility. (wikipedia.org)
  • Since individuals almost always have different "banks" of HLAs, the immune system of the recipient recognizes the transplanted tissue as non-self and destroys the foreign tissue, leading to transplant rejection. (wikipedia.org)
  • fetus
  • It is believed that the ancestors of modern viviparous mammals evolved after an infection by this virus, enabling the fetus to better resist the immune system of the mother. (wikipedia.org)
  • The placenta does not block maternal IgG antibodies, which thereby may pass through the human placenta, providing immune protection to the fetus against infectious diseases. (wikipedia.org)
  • Tregs
  • Additionally, we find an essential role for prostaglandin E2 (PGE2) in the maintenance of tolerance within the intestine in the absence of Tregs. (sigmaaldrich.com)
  • fetal
  • This is done so that the fetal rhesus D positive erythrocytes are destroyed before the immune system of the mother can discover them and become sensitized. (wikipedia.org)
  • primary
  • Areas of research include: Primary immune defects in tolerance - Gene silencing helps demonstrate the role of STAT5A and STAT5B in human immunology and signaling. (wikipedia.org)
  • cell
  • Adaptive Biotechnologies performs immune profiling of T cell and B cell receptors using ImmunoSEQ technology. (immunetolerance.org)
  • The Rutgers University Cell & DNA Repository serves as the Immune Tolerance Network's Central Cell Isolation Facility. (immunetolerance.org)
  • CONCLUSIONS Although nasal insulin did not retard loss of residual β-cell function in adults with established T1D, evidence that it induced immune tolerance to insulin provides a rationale for its application to prevent diabetes in at-risk individuals. (diabetesjournals.org)
  • disease
  • Adults with recent-onset T1D in whom the disease process is subacute afford an opportunity to determine whether mucosal insulin induces tolerance to insulin subsequently injected for treatment. (diabetesjournals.org)
  • treatment
  • Margaret Petroff believes that decoding additional secrets to immune tolerance could lead to treatment breakthroughs for a variety of conditions. (msu.edu)
  • Margaret Petroff, an associate professor in the Department of Pathobiology and Diagnostic Investigation at Michigan State University (MSU), believes that decoding additional secrets to immune tolerance could lead to treatment breakthroughs for a variety of conditions. (msu.edu)
  • host
  • Though some pathogens can evolve to become less virulent in host-pathogen coevolution, tolerance does not refer to the change in the pathogen, but can be used to describe the changes in host physiology. (wikipedia.org)
  • study
  • Therefore, the study proposed is a laboratory investigation (using blood samples collected from the subjects) comparing immune tolerance and alloreactivity profiles in LT recipients on monotherapy IS or converted to rapamycin monotherapy, to determine tolerogenic properties of the different IS agents. (clinicaltrials.gov)
  • mother
  • That half from the father is foreign to the mother, so we want to know how her immune system copes with it. (msu.edu)
  • The mother has an intramuscular injection of anti-Rh antibodies (Rho(D) immune globulin). (wikipedia.org)