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  • residues
  • The peptide binding domain spans residues 140-215 of the α subunit, and consists of a concave surface lined with multiple tyrosine residues which interact favorably with the proline-rich substrate. (wikipedia.org)
  • The active site consists of Fe2+ bound to two histidine residues and one aspartate residue, a characteristic shared by most 2-oxoglutarate-dependent dioxygenases. (wikipedia.org)

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  • EGLN1
  • EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. (proteopedia.org)
  • regulation
  • We have investigated the organ distribution of the PHDs in the rat, their regulation by hypoxia and changes in local expression after experimental myocardial infarction using RNase protection assays, in situ hybridization and immunohistochemistry. (ox.ac.uk)
  • We demonstrated in CD3-positive human T cells accumulating in inflammatory tissue expression of the hypoxia-inducible factor-1α (HIF-1α), indicating a role of hypoxia-mediated signals in regulation of T cell function. (jimmunol.org)
  • Taken together, we propose that hypoxia is a critical determinant of survival of the activated T cells via the HIF-1α-AM cascade, defining a previously unknown mode of regulation of peripheral immunity. (jimmunol.org)
  • The objective of this study was to analyze the expression and regulation of prolyl hydroxylase domain (PHD) enzymes and factor-inhibiting HIF-1α (FIH-1), which regulate cellular HIF levels, and to study the roles of these enzymes in RA fibroblast-like synoviocytes (RA FLS). (ox.ac.uk)
  • In consequence, up-regulation of HIF in tumors is not just a response of the tissue to hypoxia but represents a step in the oncogenic transformation process and it is a driving force in tumoral neovascularization, at least partially via stimulation of VEGF expression. (aacrjournals.org)
  • Hypoxia-mediated regulation of macrophage functions in pathophysiology. (semanticscholar.org)
  • responses
  • The investigators will investigate the effect of hypobaria and hypoxia on physiological responses such as: oxygen saturation, heart rate, cerebral blood flow, cerebral oxygenation, brain's. (bioportfolio.com)
  • Responses of T cells to hypoxia, therefore, may be essential not only for adaptation but also for their functional performance. (jimmunol.org)
  • OBJECTIVE: Rheumatoid arthritis (RA) is characterized by hypoxia and the expression of hypoxia-inducible transcription factors (HIFs), which coordinate cellular responses to hypoxia. (ox.ac.uk)
  • PHD-2 appears to regulate responses relevant to arthritis via HIF-α, highlighting the major importance of this enzyme in hypoxia- and angiogenesis-dependent inflammatory diseases such as RA. (ox.ac.uk)

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  • expression
  • organ distribution and changes in expression following hypoxia and coronary artery ligation. (ox.ac.uk)
  • (biomedsearch.com)
  • Their expression in tumor tissue but not in most of the normal tissues is mainly considered to reflect the relative hypoxia in a rapidly growing tissue ( 12 ). (aacrjournals.org)
  • In hypoxia-independent ways, HIF1A expression may be upregulated through a redox-sensitive mechanism. (wikipedia.org)
  • angiogenesis
  • The dysregulation and overexpression of HIF1A by either hypoxia or genetic alternations have been heavily implicated in cancer biology, as well as a number of other pathophysiologies, specifically in areas of vascularization and angiogenesis, energy metabolism, cell survival, and tumor invasion. (wikipedia.org)
  • tissue
  • Cartilage cells, the chondrocytes, have adapted to this and actually use hypoxia to drive tissue-specific functions. (ox.ac.uk)