Loading...



  • Mice
  • We show that mice harboring a heterozygous hot spot disease mutation, D801Y (α3+/D801Y), suffer abrupt hypothermia-induced dystonia identified by electromyographic recordings. (ox.ac.uk)
  • The individual chiral isomers 7 (+) 3aR,9aR and 8 (-) 3aS,9aS of fluparoxan both had comparable levels of α2-adrenoceptors antagonist potency and α2/α1 selectivity to racemic fluparoxan 6 (±) rel 3aR,9aR in vitro and a similar potency in vivo in reversing the hypothermia induced in mice by clonidine. (wikipedia.org)
  • physiological
  • These findings stand in contrast to synaptic impairments observed in adult offspring following developmental TH insufficiency, and underscore the need to control for the potential unintended consequences of hypothermia in the interpretation of hypothyroid-induced changes in physiological systems, most notably, synaptic transmission. (epa.gov)
  • Gaseous signaling molecules are gaseous molecules that are either synthesised internally (endogenously) in the organism, tissue or cell or are received by the organism, tissue or cell from outside (say, from the atmosphere or hydrosphere, as in the case of oxygen) and that are used to transmit chemical signals which induce certain physiological or biochemical changes in the organism, tissue or cell. (wikipedia.org)
  • agonist
  • A combination of drugs including a kappa opioid receptor agonist and a dopamine receptor blocker or dopamine receptor agonist provides a synergistic effect in inducing hypothermia and/or poikilothermia in humans and animals. (google.com)
  • Fluparoxan, orally prevented agonist UK-14304 induced sedation and bradycardia in a dose-related fashion in the dog. (wikipedia.org)
  • encephalopathy
  • Hypothermia therapy for neonatal encephalopathy has been proven to improve outcomes for newborn infants affected by perinatal hypoxia-ischemia, hypoxic ischemic encephalopathy or birth asphyxia. (wikipedia.org)
  • In the special case of infants suffering perinatal asphyxia it appears that apoptosis is a prominent cause of cell death and that hypothermia therapy for neonatal encephalopathy interrupts the apoptotic pathway. (wikipedia.org)
  • vivo
  • Here we report hypothyroidism induced by the synthesis inhibitor propylthiouracil (PTU, 10 ppm, 0.001%, minimum of 4 weeks), resulted in marginal alterations in excitatory postsynaptic potential (EPSP) and population spike (PS) amplitude in the dentate gyrus measured in vivo. (epa.gov)
  • temperatures
  • The Pennes bioheat equation and finite element analysis are used to predict the temperatures in the spinal cord , the brain and the cerebrospinal fluid (CSF) during hypothermia . (umbc.edu)
  • Current studies have shown that the use of surgical humidification during open abdominal surgery (laparotomy) have warmer core body temperatures and reduced risk of operative hypothermia. (wikipedia.org)
  • brain
  • Latency shifts could be reversed in hypothyroid animals by increasing the external heat source, and conversely, synaptic delays could be induced in control animals by removing the heat source with a consequent drop in body and brain temperature. (epa.gov)
  • It may also be deliberately induced by pharmaceutical agents during major neurosurgery, to preserve higher brain functions following brain trauma, or to save the patient from extreme pain during healing of injuries or diseases. (wikipedia.org)
  • decrease
  • Clinically, peritoneal injury caused by drying has been linked to post-operative pain, evaporative cooling resulting in a decrease in core temperature and increased risk of intra-operative hypothermia, as well as adhesion formation. (wikipedia.org)
  • rats
  • Electrophysiological recordings in the supraoptic nucleus (SON) slices from streptozotocin-induced DM model (STZ) rats and vehicle-treated control rats revealed that GABA functions generally as an excitatory neurotransmitter in the AVP neurons of STZ rats, whereas it evoked usually inhibitory responses in the cells of control animals. (readbyqxmd.com)
  • Rats were induced to intake kaolin by administering various emetic stimuli such as copper sulfate, apomorphine, cisplatin, and motion. (wikipedia.org)
  • suffer
  • Others have indicated concerns that the lessons might be traumatic, that the parents will have a false sense of security and not supervise young children adequately around pools, or that the infant could experience hypothermia, suffer from water intoxication after swallowing water, or develop gastrointestinal or skin infections. (wikipedia.org)
  • whereas
  • Using the oxygen-glucose deprivation (OGD) model of hippocampal neuron ischemia in vitro, we found that the overexpression of miR-134 mediated by recombinant adeno-associated virus (AAV) vector infection significantly promoted neuron death induced by OGD/reoxygenation, whereas the inhibition of miR-134 provided protective effects against OGD/reoxygenation-induced cell death. (jove.com)
  • DHCA induces hypothermia to aid preplanned surgery, whereas EPR is an emergency procedure in cases where an emergency room patient is rapidly dying from blood loss and will not otherwise survive long enough for the patient's wounds to be stitched up. (wikipedia.org)
  • death
  • Notably, the knockdown of CREB by CREB siRNA apparently abrogated the protective effect of anti-miR-134 on OGD/reoxygenation-induced cell death. (jove.com)
  • study
  • Erika's experience was mentioned as one indication of the medical relevance of a Fred Hutchinson Cancer Research Center study on "anoxia-induced suspended animation" in zebrafish. (wikipedia.org)
  • heart
  • Cold induced vasoconstriction causes the heart to work harder and the additional work can overload a weak heart, with a possible consequence of cardiac arrest. (wikipedia.org)