• Mice
  • We show that mice harboring a heterozygous hot spot disease mutation, D801Y (α3+/D801Y), suffer abrupt hypothermia-induced dystonia identified by electromyographic recordings. (ox.ac.uk)
  • The individual chiral isomers 7 (+) 3aR,9aR and 8 (-) 3aS,9aS of fluparoxan both had comparable levels of α2-adrenoceptors antagonist potency and α2/α1 selectivity to racemic fluparoxan 6 (±) rel 3aR,9aR in vitro and a similar potency in vivo in reversing the hypothermia induced in mice by clonidine. (wikipedia.org)
  • temperatures
  • The Pennes bioheat equation and finite element analysis are used to predict the temperatures in the spinal cord , the brain and the cerebrospinal fluid (CSF) during hypothermia . (umbc.edu)
  • Current studies have shown that the use of surgical humidification during open abdominal surgery (laparotomy) have warmer core body temperatures and reduced risk of operative hypothermia. (wikipedia.org)
  • amygdala
  • Lesions placed in the rat amygdala significantly reduce analgesic responses induced either by conditioning or exposure to a cat. (naver.com)
  • The present study expanded the situational determinants by examining whether lesions placed in the amygdala altered analgesia or hypothermia elicited by exposure to either continuous (CCWS) or intermittent (ICWS) cold-water swims. (naver.com)
  • physiological
  • These findings stand in contrast to synaptic impairments observed in adult offspring following developmental TH insufficiency, and underscore the need to control for the potential unintended consequences of hypothermia in the interpretation of hypothyroid-induced changes in physiological systems, most notably, synaptic transmission. (epa.gov)
  • Gaseous signaling molecules are gaseous molecules that are either synthesised internally (endogenously) in the organism, tissue or cell or are received by the organism, tissue or cell from outside (say, from the atmosphere or hydrosphere, as in the case of oxygen) and that are used to transmit chemical signals which induce certain physiological or biochemical changes in the organism, tissue or cell. (wikipedia.org)
  • agonist
  • A combination of drugs including a kappa opioid receptor agonist and a dopamine receptor blocker or dopamine receptor agonist provides a synergistic effect in inducing hypothermia and/or poikilothermia in humans and animals. (google.com)
  • Fluparoxan, orally prevented agonist UK-14304 induced sedation and bradycardia in a dose-related fashion in the dog. (wikipedia.org)
  • encephalopathy
  • Hypothermia therapy for neonatal encephalopathy has been proven to improve outcomes for newborn infants affected by perinatal hypoxia-ischemia, hypoxic ischemic encephalopathy or birth asphyxia. (wikipedia.org)
  • In the special case of infants suffering perinatal asphyxia it appears that apoptosis is a prominent cause of cell death and that hypothermia therapy for neonatal encephalopathy interrupts the apoptotic pathway. (wikipedia.org)
  • vivo
  • Here we report hypothyroidism induced by the synthesis inhibitor propylthiouracil (PTU, 10 ppm, 0.001%, minimum of 4 weeks), resulted in marginal alterations in excitatory postsynaptic potential (EPSP) and population spike (PS) amplitude in the dentate gyrus measured in vivo. (epa.gov)
  • Phase
  • During induction phase of hypothermia [ 10 ], decreasing serum levels of magnesium are warranted with high risk of arterial spasm due to higher intracellular levels of calcium in smooth muscle fibers. (clinmedjournals.org)
  • brain
  • Latency shifts could be reversed in hypothyroid animals by increasing the external heat source, and conversely, synaptic delays could be induced in control animals by removing the heat source with a consequent drop in body and brain temperature. (epa.gov)
  • It may also be deliberately induced by pharmaceutical agents during major neurosurgery, to preserve higher brain functions following brain trauma, or to save the patient from extreme pain during healing of injuries or diseases. (wikipedia.org)
  • decrease
  • Clinically, peritoneal injury caused by drying has been linked to post-operative pain, evaporative cooling resulting in a decrease in core temperature and increased risk of intra-operative hypothermia, as well as adhesion formation. (wikipedia.org)