• As a result, the development and potential utility of renal denervation (RDN) to treat hypertension, especially resistant hypertension, was welcomed as a 'spectacular' breakthrough in modern therapeutics. (medscape.com)
  • CHICAGO - Renal denervation, relative to a sham procedure, was linked with statistically significant reductions in blood pressure in the newly completed SPYRAL HTN-ON MED trial, but several factors are likely to have worked in concert to prevent the study from meeting its primary endpoint. (medscape.com)
  • Patients who entered the study were randomized to renal denervation or sham control while maintaining their baseline antihypertensive therapies. (medscape.com)
  • The prespecified definition of success for renal denervation was a 97.5% threshold for probability of superiority on the basis of this Bayesian analysis. (medscape.com)
  • Despite differences seen in BP control in favor of renal denervation, several factors were identified that likely contributed to the missed primary endpoint. (medscape.com)
  • Relative reductions in office-based systolic pressure reductions for renal denervation versus sham were 6.6 mm Hg ( P = .03) and 4.0 mm Hg (P = .03) for the pilot and expansions groups, respectively. (medscape.com)
  • On the basis of a Win ratio derived from a hierarchical analysis of ABMP and medication burden reduction, the 1.50 advantage ( P = .005) for the renal denervation arm in the newly completed SPYRAL HTN-ON MED trial was also compelling. (medscape.com)
  • At study entry, the median number of medications was 1.9 in both the renal denervation and sham arms. (medscape.com)
  • Among Black participants, for example, 14.2% of those randomized to renal denervation and 54.6% of those randomized to the sham group increased their antihypertensive therapies over the course of the study. (medscape.com)
  • The SPYRAL HTN-OFF MED Pilot trial showed that renal denervation was superior at improving blood pressure. (acc.org)
  • The goal of the trial was to evaluate renal sympathetic denervation compared with sham among patients with uncontrolled hypertension (HTN) not on blood pressure medications. (acc.org)
  • Patients with uncontrolled HTN not on blood pressure medications were randomized to renal denervation (n = 38) versus sham (n = 42). (acc.org)
  • Among patients with uncontrolled HTN not on blood pressure medications, this proof-of-concept trial revealed the efficacy of renal sympathetic denervation. (acc.org)
  • Renal Denervation Improves the Baroreflex and GABA System in Chronic Kidney Disease-induced Hypertension. (bvsalud.org)
  • For CKD with hypertension, renal denervation (RD) interrupts the afferent renal sympathetic nerves, which are connecting to the NTS. (bvsalud.org)
  • Can Renal Denervation Benefit Patients with Hypertension? (radcliffecardiology.com)
  • Sympathetic renal denervation (RDN) emerged as a therapeutic option for patients with resistant hypertension, until Symplicity HTN-3. (radcliffecardiology.com)
  • ReCor Medical has developed a unique therapeutic non-focused ultrasound system for performing renal denervation in patients with hypertension. (heart.org)
  • The PARADISE® technology (Percutaneous Renal Denervation System) includes a 6 French catheter with a transducer that emits ultrasound energy circumferentially, allowing for a more efficient renal denervation procedure. (heart.org)
  • The Paradise Renal Denervation System is designed to treat overactive nerves leading to the kidney via a minimally invasive procedure. (heart.org)
  • The Paradise Renal Denervation Catheter within the artery. (heart.org)
  • FDA-approved two renal denervation systems mark a groundbreaking step in treating uncontrolled hypertension. (medindia.net)
  • Palo Alto, Calif. and Frankfurt, Germany - 6 October, 2021 - ReCor Medical, Inc. ("ReCor"), a wholly owned subsidiary of Otsuka Medical Devices Co., Ltd., announced today that the company's Paradise™ Ultrasound Renal Denervation System (the "Paradise™ System") is now available for the treatment of uncontrolled hypertension in Germany. (recormedical.com)
  • We are pleased to be one of the first hospitals in Europe to offer renal denervation with ultrasound. (recormedical.com)
  • Paradise ultrasound renal denervation is a device-based, minimally invasive procedure for the treatment of high blood pressure. (recormedical.com)
  • In September 2021, the European Society of Hypertension published an updated position paper stating that renal denervation "is effective in reducing or interrupting the sympathetic signals to the kidneys and decreasing whole body sympathetic activity. (recormedical.com)
  • The society noted that five independent sham-controlled randomized clinical trials-including RADIANCE-HTN SOLO and TRIO-provide "conclusive evidence" that renal denervation can lower ambulatory and office blood pressure both in patients with and without concomitant antihypertensive medication. (recormedical.com)
  • With its Paradise System ReCor has pioneered the minimally invasive use of ultrasound in renal denervation to treat patients with hypertension. (recormedical.com)
  • Renovascular hypertension (RVHT) denotes nonessential hypertension in which a causal relationship exists between anatomically evident arterial occlusive disease and elevated blood pressure (see the images below). (medscape.com)
  • Renovascular disease (RVD) is found in about 10% of cases of secondary childhood hypertension. (medscape.com)
  • Apart from the casual relationship of occlusive renal artery disease and hypertension , RAS is also being increasingly recognized as an important cause of chronic renal failure . (medscape.com)
  • RAS caused by atherosclerosis is generally a progressive disease with increasing luminal narrowing, which may eventually compromise renal blood flow and renal function and structure. (medscape.com)
  • it most commonly manifests as hypertension caused by RAS or as strokes caused by carotid artery disease. (medscape.com)
  • The Hantaviruses, etiologic agents of hemorrhagic fever with renal syndrome: a possible cause of hypertension and chronic renal disease in the United States. (nih.gov)
  • Distribution of hypertension and renal disease in Oregon. (cdc.gov)
  • Exercise is an effective strategy for blood pressure (BP) reduction in the general population, but its efficacy for the management of hypertension in chronic kidney disease (CKD) is not known. (karger.com)
  • In people with chronic kidney disease (CKD), hypertension is an important modifiable risk factor for both cardiovascular (CV) events and progressive renal dysfunction [1-5]. (karger.com)
  • Best medical therapy has been after the only treatment required for the majority of patients with atherosclerotic RA disease and hypertension but crucial questions remained unaswered to avoid the occurrence of terminal nephropathy and the impact on congestive heart failure and unstable angina. (academie-medecine.fr)
  • Despite substantial improvements in United States general population awareness, treatment and control of hypertension during recent decades, African Americans continue to have a disproportionately high prevalence of hypertension and risk of blood pressure (BP)-related cardiovascular and renal disease complications compared to non-Hispanic Whites. (nih.gov)
  • There is considerable heterogeneity 1 but overall non-Hispanic Blacks (in this manuscript, the term African American is used for US studies whereas the term Black is used for international studies) have an earlier onset, higher prevalence, and disproportionately high risk of complications for hypertension, including stroke, heart failure, renal disease, and mortality compared to non-Hispanic Whites and Mexican Americans2,3. (nih.gov)
  • High blood pressure caused by kidney disease is called renovascular hypertension or renal hypertension. (cincinnatikidneydocs.com)
  • Kidney disease causes hypertension and hypertension cause kidney disease. (cincinnatikidneydocs.com)
  • Renovascular hypertension (RVH) is a manifestation of atherosclerotic renovascular disease, which is associated with progressive renal dysfunction and increased cardiovascular morbidity and mortality [ 1 ]. (biomedcentral.com)
  • End-stage renal disease incidence in a cohort of US firefighters from San Francisco, Chicago, and Philadelphia. (cdc.gov)
  • The purpose of this study was to evaluate the risk of end-stage renal disease (ESRD) and types of ESRD among a cohort of US firefighters compared to the US general population, and to examine exposure-response relationships. (cdc.gov)
  • Because enalapril is primarily eliminated by the kidneys, higher doses are not recommended in patients with renal disease. (drugs.com)
  • Ambulatory blood pressure monitoring in children and adolescents: recommendations for standard assessment: a scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee of the council on cardiovascular disease in the young and the council for high blood pressure research. (monz.pl)
  • Hypertension is one of the leading contributors to disease burden worldwide, leading to increased cardiovascular morbidity and mortality, impaired quality of life, and increased cost to health systems. (recormedical.com)
  • The primary management goals in sickle cell nephropathy (SCN) are the prevention of complications and the reduction of morbidity, primarily from progression to end-stage renal disease (ESRD). (medscape.com)
  • The recommendations on treatment and monitoring link to NICE's guidelines on chronic kidney disease , type 1 diabetes and hypertension in pregnancy at points in the care pathway where treatment differs. (nice.org.uk)
  • Differential effects of low-dose sacubitril and/or valsartan on renal disease in salt-sensitive hypertension. (musc.edu)
  • These studies provide a novel treatment target and evidence of a new dichotomy in immune activation between sexes within the context of hypertensive disease where CD14 regulates immune cell activation and renal injury. (elsevierpure.com)
  • Reducing cardiovascular events in high-risk patients: the challenge of managing hypertension in patients with diabetic renal disease. (elsevierpure.com)
  • Dive into the research topics of 'Reducing cardiovascular events in high-risk patients: the challenge of managing hypertension in patients with diabetic renal disease. (elsevierpure.com)
  • Tubulointerstitial injury is characteristic of aging-associated renal injury and progressive renal disease. (lww.com)
  • Salt-sensitive hypertension is also associated with tubulointerstitial inflammation, especially when accompanied by microvascular disease. (lww.com)
  • With progression of tubulointerstitial disease there is also a loss of peritubular capillaries, and stimulating microvascular growth with angiogenic factors can stabilize renal function in these models. (lww.com)
  • 2. Renal disease in Type 2 Diabetic Patients with hypertension [s] 1. (ecplaza.net)
  • In Alport syndrome (AS) a spectrum of phenotypes ranging from progressive renal disease with extrarenal abnormalities to isolated hematuria with a non-progressive or very slowly progressive course is observed. (nih.gov)
  • In the absence of treatment, renal disease progresses from microscopic hematuria (microhematuria) to proteinuria, progressive renal insufficiency, and end-stage renal disease (ESRD) in all males with XLAS, and in all males and females with ARAS. (nih.gov)
  • daughters who inherit the pathogenic variant will typically have asymptomatic hematuria but may have more severe renal disease. (nih.gov)
  • To train pre-doctoral students in a multidisciplinary approach in course work and research opportunities in hypertension and cardiovascular-renal disease research. (umc.edu)
  • To provide postdoctoral students multidisciplinary training and mentoring in hypertension and cardiovascular-renal disease research. (umc.edu)
  • In evaluating hypertensive emergencies, electrolytes and creatinine levels are used to identify renal impairment. (medscape.com)
  • Dr Sharp was awarded an MD postgraduate research degree from the University of Edinburgh for his work on the hypertensive heart and his current research interests include device-based treatments for hypertension, pulmonary embolism, intracoronary imaging and coronary physiology. (radcliffecardiology.com)
  • CONCLUSIONS: Untreated high-grade hypertension and severe "benign'' nephrosclerosis represent a microvascular ischemic nephropathy (similar to critical bilateral RAS) in which a relatively minor insult can deteriorate the patient into ESRD.While being non-adherent to different anti hypertensive medications, patient did take omeprazole which triggered acute interstitial nephritis on the background of advanced ischemic nephropathy, leading to permanent loss of renal function. (bgu.ac.il)
  • The purpose of the present retrospective study was to compare the safety and efficacy of losartan (L) and valsartan (V) in the treatment of hypertensive renal transplant (Rt) recipients.Sixty four renal transplant recipients on antihypertensive therapy were included in the study because of inadequate blood pressure control, drug side effects or proteinuria. (hippokratia.gr)
  • here we test the hypothesis that CD14 contributes to the elevated pressure and renal injury observed in salt-sensitive hypertension. (elsevierpure.com)
  • Germline knockout of CD14 exacerbated salt-sensitive hypertension and renal injury in female animals but not males. (elsevierpure.com)
  • Ischemia secondary to vasoconstriction or to structural changes of the renal vasculature may have important consequences both in terms of mediating salt-sensitive hypertension and renal progression. (lww.com)
  • Hemorrhagic fever with renal syndrome in northeastern France]. (nih.gov)
  • Spontaneous ruptures of the kidney and retroperitoneal hematomas in hemorrhagic fever with renal syndrome]. (nih.gov)
  • Study group consisted of 64 untreated children aged from 6.2 to 18.0 mean 14.2±3.3 years with PH (n=31) and RH (n=33) secondary to: nephropathy due to renal scarring (n=21), glomerulopathies (n=4), cystic kidney diseases (n=4), other (n=4). (monz.pl)
  • The underlying mechanisms of renal injury or sickle cell nephropathy (SCN) relate mainly to hypoxia and ischemia. (medscape.com)
  • Elevated blood pressure contributes importantly to the development of albuminuria and progression of renal damage in diabetic nephropathy. (elsevierpure.com)
  • Recent studies suggest that chronic vasoconstriction may contribute to the renal injury associated with angiotensin II, catecholamines, nitric oxide inhibition, hypokalemia, hyperuricemia, and cyclosporine nephropathy. (lww.com)
  • The aim of this study was to test basal and after treatment erythrocyte sodium and calcium concentrations, and calcium-ATPase activity and platelet cytosolic free calcium and pH in 20 normotensive controls, 20 hemodialysis-dependent chronic renal failure patients and in 18 essential hypertensives. (nih.gov)
  • The erythrocyte sodium, calcium, and magnesium concentrations were only significantly elevated in chronic renal failure, with a significant decrease in the calcium-ATPase activity in the latter population. (nih.gov)
  • Murphy, GP & Schirmer, HKA 1966, ' Renal hemodynamics and metabolism in chronic experimental renal ischemia, with and without hypertension, and their alteration by ganglionic blocking agents ', Journal of Surgical Research , vol. 6, no. 1, pp. 32-44. (johnshopkins.edu)
  • A case of idiopathic portal hypertension after renal transplantation. (nih.gov)
  • La chirurgie de l'artère rénale, apparue à l'orée du XXe siècle pour sauver le rein, s'est rapidement dirigée vers la transplantation rénale puis sur le traitement de l'HTA tout en préservant le rein pour des lésions de l'artère rénale, en prédominance, athéromateuses. (academie-medecine.fr)
  • Forty patients (28 men), 41 years old, received L3.86 years after renal transplantation at the dose of 25-100 mg/d and 21 patients (16 men), 41 years old, received V 4.21 years after renal transplantation (p:NS) at the dose of 80-160 mg/d. (hippokratia.gr)
  • renal transplantation for ESRD. (nih.gov)
  • The hypoxic, acidotic, and hyperosmolar environment of the inner medulla are known to promote sickling of red blood cells (RBCs) with resultant impairment in renal medullary blood flow, ischemia, microinfarction, and papillary necrosis. (medscape.com)
  • RVHT is the clinical consequence of renin-angiotensin-aldosterone activation as a result of renal ischemia. (medscape.com)
  • The resulting increased blood viscosity contributes to ischemia and eventual infarction that involves the renal microcirculation. (medscape.com)
  • The core curriculum covering all aspects of renal physiology, vascular system, basic immunology as well as clinical topics is given during these sessions. (cuanschutz.edu)
  • This weekly clinical conference is led by renal fellows with faculty attendance and consists of the presentation of cases with discussion initially be fellows and afterward by faculty. (cuanschutz.edu)
  • Dr Dasgupta is Clinical Research Lead Division 2 for Renal, Stroke, CVD, Diabetes and Metabolic Diseases for the West Midlands in NIHR Clinical Research Network, Honorary Secretary of the Renal Association UK, and a member of the research working party for the British and Irish Hypertension Society. (radcliffecardiology.com)
  • The Paradise System has generated a significant body of clinical evidence in the ACHIEVE, RADIOSOUND, RADIANCE-HTN SOLO and TRIO studies-executed over a number of years in centers across the U.S. and Europe-showing a significant lowering of blood pressure in patients with uncontrolled hypertension," said ReCor President and CEO Andrew M. Weiss. (recormedical.com)
  • Journal of clinical hypertension (Greenwich, Conn. (elsevierpure.com)
  • Journal of clinical hypertension (Greenwich, Conn.) , 9 (11 Suppl 4), 16-25. (elsevierpure.com)
  • The institution has made a significant commitment to basic and clinical cardiovascular and renal research and the training of students and fellows at both the pre-doctoral and postdoctoral level. (umc.edu)
  • Systemic hypertension is a common condition that substantially increases the risk of cardiovascular events. (medscape.com)
  • Kidney venous and systemic blood levels of inflammatory markers were measured and their renal release calculated. (biomedcentral.com)
  • Intra-renal MSC delivery during PTRA preserved stenotic-kidney function, reduced systemic oxidative stress and inflammation, and thereby improved cardiac function, oxygenation, and myocardial injury four weeks after revascularization, suggesting a therapeutic potential for adjunctive MSC delivery to preserve cardiac function and structure after reversal of experimental RVH. (biomedcentral.com)
  • Differences between daytime and nighttime blood pressure variability regarding systemic atherosclerotic change and renal function. (monz.pl)
  • [ 3 ] The low incidence of hypertension is attributed to reduced vascular reactivity, compensatory systemic vasodilatation associated with microvascular disturbances from sickling of RBCs and thrombotic complications, elevated levels of prostaglandins and nitric oxide, and possibly renal sodium and water wasting associated with suboptimal medullary concentrating activity. (medscape.com)
  • Percutaneous transluminal renal angioplasty (PTRA) fails to fully improve cardiac injury and dysfunction in patients with renovascular hypertension (RVH). (biomedcentral.com)
  • Fellows and faculty discuss the renal biopsies with the renal pathologist and fellows received additional training in the interpretation of renal biopsies and glomerular and tubular diseases. (cuanschutz.edu)
  • More distal tubular dysfunction may impair renal acidification and potassium secretion, leading to an incomplete form of distal renal tubular acidosis and hyperkalemia. (medscape.com)
  • Ang-(1-7) administration prevented sHTN and attenuated kidney injury (reduced urinary albumin/creatinine ratio, glomerular hyperfiltration, renal hypertrophy and fibrosis, and tubular apoptosis) without affecting blood glucose levels in Akita mice. (silverchair.com)
  • A notable difference of this trial compared with SYMPLICITY HTN-3 was that more ablation attempts were performed in the main renal artery and branch vessels. (acc.org)
  • Top right, Isotopic renogram (obtained with technetium mercaptoacetyltriglycine [MAG3]) after captopril shows a markedly depressed renal function in the right kidney. (medscape.com)
  • it is suggested that partial obstruction of hepatic sinusoids by perisinusoidal fibrosis could be the mechanism for increased portal venous pressure in all the patients with idiopathic portal hypertension. (nih.gov)
  • Circulating isoprostane levels and renal release of inflammatory cytokines increased in RVH and RVH + PTRA, but normalized in RVH + PTRA-MSC, as did myocardial oxidative stress, inflammation, collagen deposition, and fibrosis. (biomedcentral.com)
  • To leverage this investment of primarily public funds, the National Heart, Lung, and Blood Institute with a contribution from the National Institute of Diabetes, Digestive and Kidney Diseases, convened a 2-day working group to conduct a comprehensive assessment of the research that is needed to further improve prevention, treatment and control of hypertension among African Americans in order to prevent the devastating consequences of high blood pressure (BP). (nih.gov)
  • 1) Children with arterial hypertension secondary to renal diseases may be characterized by high diastolic blood pressure load during resting period and low nocturnal blood pressure dip. (monz.pl)
  • The National Institutes of Health (NIH), National Heart Lung and Blood Institute (NHLBI)-funded T32 training program, part of the Ruth L. Kirschstein Institutional National Research Service Award, provides pre- and postdoctoral students with multidisciplinary and balanced training in didactic course work, state-of-the-art research opportunities, and the necessary skills for a successful career in hypertension and cardiorenal diseases research (HCDR). (umc.edu)
  • To recruit, train, and retain minority pre-doctoral and postdoctoral students in hypertension and cardiovascular-renal diseases research. (umc.edu)
  • UMMC has identified hypertension and cardiovascular and renal diseases as a major area for research development in its strategic research plan. (umc.edu)
  • RD may improve CKD-induced hypertension by modulating the baroreflex response, improving GABA system dysfunction and preventing the development and reducing the severity of cardiorenal syndrome type 4 in CKD rats . (bvsalud.org)
  • Tadalafil is a phosphodiesterase 5 (PDE5) inhibitor indicated for the treatment of pulmonary arterial hypertension (PAH) (WHO Group 1) to improve exercise ability. (nih.gov)
  • abstract = "OBJECTIVE: A 43 year old male with history of hypertension, non-adherence to medications, heavy smoking (since age 8) and alcohol abuse was admitted with epigastric pain, heartburn and upper GI bleeding (hematochezia) for which he had been recently taking PPI. (bgu.ac.il)
  • abstract = "Hypertension is more prevalent and more difficult to control and is associated with a higher mortality rate in patients with diabetes than in nondiabetic patients. (elsevierpure.com)
  • However, the Cardiovascular Outcomes in Renal Atherosclerotic Lesions (CORAL) trial recently demonstrated that PTRA does not confer any additional benefit over medical therapy with respect to the prevention of hospitalization or death from myocardial infarction, congestive heart failure and other cardiovascular causes [ 4 ]. (biomedcentral.com)
  • Thought you might appreciate this item(s) I saw in Current Opinion in Nephrology and Hypertension. (lww.com)
  • In patients with SCD, supranormal renal hemodynamics-including increased renal blood flow, renal plasma flow, and glomerular filtration rate-occur as early as infancy, but decrease with age. (medscape.com)
  • Such alterations in renal hemodynamics lead to increased renal growth and glomerular enlargement. (medscape.com)
  • ReCor Medical, headquartered in Palo Alto, Calif., is a medical technology company focused on transforming the management of hypertension, the leading cardiovascular risk factor in the world. (recormedical.com)
  • Thus, in essential hypertension and in uremia, some cellular ionic abnormalities exist in platelets in baseline condition. (nih.gov)
  • Some, but not all of these abnormalities could be corrected by treatment affecting blood pressure (cellular calcium) in essential hypertension or by hemodialysis (cellular sodium, calcium, and pH). (nih.gov)
  • Haemorrhagic fever with renal syndrome (HFRS) Korean haemorrhagic fever. (nih.gov)