LipoproteinsApolipoproteinHypercholesterolemiaChylomicronemiaLipoprotein lipaseDiabetesTriglyceride-richDeficiencyApoE2DrugsSecondaryPrimaryForecastPatientsExhibitReductionLevelsTreatmentAnalysisSkinDietBloodCodesHyperlipidemiaTriglyceridesCoronaryDysbetalipoproteinemiaApoEXanthomaGenotypeDiagnosisDisorderReceptorsPCSK9SerumClinicalCertain typesDisordersLipidSortMedicineOccurMedication
Lipoproteins4
- Lipoprotein disorders (also referred to as Lipid disorders, or Dyslipidemias, or Dyslipoproteinemias ) were first classified in 1967 into different phenotypes by Fredrickson according to the type of lipoproteins that are affected. (wikidoc.org)
- Hyperlipoproteinemias generally cause elevations in the affected lipids/lipoproteins and hypolipoproteinemia s generally cause reductions in the affected lipids/lipoproteins. (wikidoc.org)
- Hyperlipoproteinemia type III is one disease characterized by elevated triglycerides and beta-very low-density lipoproteins. (genebase.com)
- Type IIb hyperlipoproteinemia is caused by mutation in the receptor-binding domain of APOLIPOPROTEIN B-100 which is a major component of LOW-DENSITY LIPOPROTEINS and VERY-LOW-DENSITY LIPOPROTEINS resulting in reduced clearance of these lipoproteins. (nih.gov)
Apolipoprotein2
- Distribution of apolipoprotein(a) in the plasma from patients with lipoprotein lipase deficiency and with type III hyperlipoproteinemia. (jci.org)
- Biophysical analysis of apolipoprotein E3 variants linked with development of type III hyperlipoproteinemia. (harvard.edu)
Hypercholesterolemia2
- Hyperlipoproteinemia type II, also known as familial hypercholesterolemia (FH), is a genetic condition characterized by high cholesterol concentrations, specifically elevated levels of low-density lipoprotein (LDL), often referred to as bad cholesterol. (imarcgroup.com)
- Type IV hyperlipoproteinemia is the most typical form of hyperlipidemia, marked by hypertriglyceridemia and moderate hypercholesterolemia. (industryarc.com)
Chylomicronemia1
- AROAPOC-3 is an antisense rnai oligonucleotide commercialized by Arrowhead Pharmaceuticals , with a leading Phase III program in Familial Chylomicronemia (Type I Hyperlipoproteinemia). (pharmaceutical-technology.com)
Lipoprotein lipase2
- We have determined the phenotype, concentration, and distribution of apo(a) in plasma from patients with lipoprotein lipase (LPL) deficiency (type I hyperlipoproteinemia, n = 14), in apo E 2/2 homozygotes with type III hyperlipoproteinemia (n = 12) and in controls (n = 16). (jci.org)
- Hyperlipoproteinemia type 1 is caused due to deficiency of lipoprotein lipase. (openpr.com)
Diabetes7
- Fatty liver hepatitis and type 5 hyperlipoproteinemia in juvenile diabetes mellitus. (nih.gov)
- A 28-year-old man with poorly controlled juvenile-onset diabetes mellitus presented with jaundice and type 5 hyperlipoproteinemia . (nih.gov)
- This review will summarize the updated research progress on APOE functions and its role in Alzheimer's disease, Parkinson's disease, cardiovascular diseases, multiple sclerosis, type 2 diabetes mellitus, Type III hyperlipoproteinemia, vascular dementia, and ischemic stroke. (dovepress.com)
- 3 In this review, we discuss the biological functions of human APOE and its role in Alzheimer's disease (AD), Parkinson's disease (PD), cardiovascular diseases (CVD), multiple sclerosis (MS), type 2 diabetes mellitus (T2DM), vascular dementia (VD), and ischemic (occlusive) stroke (IS). (dovepress.com)
- Orlistat also helps in reducing blood pressure and prevents the onset of type 2 diabetes in obese people. (openpr.com)
- As apoE2 binds defectively to LDL receptors, apoE2 homozygosity can precipitate type III hyperlipoproteinemia, however, only occurs when another condition, including: diabetes, oestrogen deficiency, hypothyroidism, or obesity, leads to the overproduction of VLDL or fewer LDL receptors, overwhelming the limited ability of apoE2 to mediate the clearance of triglyceride-rich and cholesterol-rich β-VLDL. (randox.com)
- 2. Uncontrolled or newly diagnosed (=3 months since diagnosis) Type 2 diabetes mellitus as determined by the Principal Investigator. (who.int)
Triglyceride-rich1
- 300 mg/dL or those who have type 3 hyperlipoproteinemia owing to an increased secretion of triglyceride-rich particles, which can produce marked hypertriglyceridemia in some cases. (medscape.com)
Deficiency1
- Considering apo(a) type, the plasma concentration of apo(a) was normal in type III patients but significantly reduced in LPL deficiency. (jci.org)
ApoE21
- However, APOE2 carriers could develop type III hyperlipoproteinemia and exhibit increased risk of cerebrovascular diseases and neurological disorders. (j-alz.com)
Drugs2
- Who is working on investigational drugs for Hyperlipoproteinemia Type IV? (drugpatentwatch.com)
- Drugs and a special diet may help, but the chance of a cure is uncertain because the person with Type V risks developing pancreatitis. (pharmacy-online.ca)
Secondary1
- Xanthomas commonly associated with hypercholesterinaemia and increased levels of LDL (low density lipoprotein) in type II and type III hyperlipoproteinaemia and in secondary hyperlipidaemia. (dermis.net)
Primary2
- Hyperlipoproteinemia has been thought to be a major risk factor for coronary arterial disease, which is frequently associated with patients with primary gout. (go.jp)
- If there is no contributing problem, the primary treatment for Types II, III, and IV is often dietary management - namely restricting cholesterol intake. (pharmacy-online.ca)
Forecast2
- Additionally, the emerging application of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors via subcutaneous injections to enhance treatment adherence compared to several other injectable medications is expected to drive the hyperlipoproteinemia type II market during the forecast period. (imarcgroup.com)
- 10-year Global patient forecast for Hyperlipoproteinemia Type 1. (blueprintorphan.com)
Patients3
- SLx-4090 is used to treat high blood fat level mostly observed in hyperlipoproteinemia type 1 patients. (openpr.com)
- In the previous study we demonstrated that type IIb and IV hyperlipoproteinemia coexist frequently in gouty patients. (go.jp)
- The plasma lipoprotein composition of six patients with mixed hyperlipoproteinemia (MH) was investigated in a study of influence of apoprotein content and lipase activities on mechanisms of plasma triglyceride (TG) production and removal. (utmb.edu)
Exhibit1
- The 7 major hyperlipoproteinemia type II markets are expected to exhibit a CAGR of 7.07% during 2023-2033. (imarcgroup.com)
Reduction1
- The most effective treatment for Type V hyperlipoproteinemia is often weight reduction and long-term maintenance of a low-fat diet. (pharmacy-online.ca)
Levels1
- Secondly, Fredrickson's classification of hyperlipoproteinemia s took into consideration the elevation in chylomicrons , LDL , VLDL but did not include abnormalities in HDL levels. (wikidoc.org)
Treatment2
- According to the report the United States has the largest patient pool for hyperlipoproteinemia type II and also represents the largest market for its treatment. (imarcgroup.com)
- Orlistat is used for the treatment of hyperlipoproteinemia type 1. (openpr.com)
Analysis3
- IMARC Group's new report provides an exhaustive analysis of the hyperlipoproteinemia type II market in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan. (imarcgroup.com)
- This report provides comprehensive information on the therapeutic development for Post-Operative Pain, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. (powershow.com)
- Pain, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. (powershow.com)
Skin1
- Xanthomas are one of types of skin lesions that may occur in this situation. (wikipedia.org)
Diet1
- Fasting blood samples were obtained initially and at monthly intervals following institution of a low fat, low carbohydrate, Type V diet. (utmb.edu)
Blood1
- The rising cases of genetic mutations, which can affect the body's ability to efficiently remove LDL cholesterol from the blood, thereby leading to its accumulation, are primarily driving the hyperlipoproteinemia type II market. (imarcgroup.com)
Codes1
- The contents of these tape files are presented in the Outline of Items and Codes for each record type. (cdc.gov)
Hyperlipidemia6
- One hundred forty-seven relatives of 43 patients with "classical" type III hyperlipoproteinemia (HLP) having the apolipoprotein (apo) E2/2 phenotype were studied to determine the occurrence of hyperlipidemia and the presence of further possible genes for lipoprotein disorders in these families. (nih.gov)
- Nicotinic acid is also indicated as adjunctive therapy for the treatment of adult patients with very high serum triglyceride levels (Types IV and V hyperlipidemia) † who present a risk of pancreatitis and who do not respond adequately to a determined dietary effort to control them. (rxlist.com)
- Plasma triglyceride levels greater than 150 mg/dl - includes patients with deficiency of lipoprotein lipase, hepatic lipase or apoC-II, dysbetalipoproteinemia, Type IV and Type V hyperlipidemia. (nih.gov)
- Even without a definitive diagnosis from the workup, treatment of presumed dysbetalipoproteinemia may proceed, because other lipid disorders, such as type IIb hyperlipidemia produce similar elevations in cholesterol and triglyceride levels and will respond to the same medical interventions. (medscape.com)
- Hyperlipoproteinemia kind V, also called blended hyperlipoproteinemia familial or blended hyperlipidemia, is very similar to sort I, but with high VLDL in addition to chylomicrons. (7red.com)
- A severe type of hyperlipidemia, sometimes familial, that is characterized by the elevation of both plasma CHYLOMICRONS and TRIGLYCERIDES contained in VERY-LOW-DENSITY LIPOPROTEINS. (bvsalud.org)
Triglycerides7
- The only procedure that reliably distinguishes between a mixed hyperlipoproteinemia (increased LDL cholesterol and triglycerides) and type III hyperlipoproteinemia (increased IDL) is beta quantification (lipoprotein electrophoresis). (medscape.com)
- Niacor ( niacin ), also called nicotinic acid, is a B vitamin (vitamin B3) used to treat and prevent a lack of natural niacin in the body, and to lower cholesterol and triglycerides (types of fat) in the blood. (rxlist.com)
- Some Type IV patients with triglycerides under 1000 mg/dL may, through dietary or alcoholic indiscretion, convert to a Type V pattern with massive triglyceride elevations accompanying fasting chylomicronemia, but the influence of nicotinic acid therapy on the risk of pancreatitis in such situations has not been adequately studied. (rxlist.com)
- Drug therapy is not indicated for patients with Type I hyperlipoproteinemia, who have elevations of chylomicrons and plasma triglycerides, but who have normal levels of VLDL. (rxlist.com)
- Hyperlipoproteinemia type III occurs due to the diminished metabolism of cholesterol and triglycerides in the blood. (cardiovasculardna.com)
- Apo E levels are measured for diagnosing hyperlipoproteinemia in patients with increase plasma triglycerides and cholesterol. (meridianbioscience.com)
- It works by blocking the production of certain types of cholesterol, especially the type known as triglycerides . (pocketpills.com)
Coronary3
- Both type I and II of DM are risk factors for coronary artery disease (4) but type I patients presents cardiovascular diseases in younger ages than type II (5). (ispub.com)
- Coronary artery lesions are classified regarding their complexity into three major types, according to the classification by American College of Cardiology (ACC) and American Heart Association (AHA) (8). (ispub.com)
- Atorvastatin is used to treat high cholesterol, and to lower the risk of stroke, heart attack, or other heart complications in people with type 2 diabetes, coronary heart disease, or other risk factors. (cue-state-photography.de)
Dysbetalipoproteinemia1
- Also often known as broad beta illness or dysbetalipoproteinemia, the commonest trigger for this type is the presence of ApoE E2/E2 genotype. (7red.com)
ApoE1
- Most people with hyperlipoproteinemia type III have two APOE e2 alleles. (cardiovasculardna.com)
Xanthoma1
- We report a case of eruptive xanthoma with type IV hyperlipoproteinemia and Koebner phenomenon in a 28-year-old Korean male. (elsevierpure.com)
Genotype1
- However, only a small proportion of people carrying this genotype actually develop hyperlipoproteinemia, so other genetic, environmental or hormonal factors are also thought to play a role. (cardiovasculardna.com)
Diagnosis1
- If the direct LDL cholesterol is significantly lower than the calculated LDL cholesterol, a diagnosis of type IIIhyperlipoproteinemia is likely. (medscape.com)
Disorder1
- type II is similar but is an X-linked disorder. (theodora.com)
Receptors1
- The defective binding of apolipoprotein (apo) E2 to lipoprotein receptors, an underlying cause of type III hyperlipoproteinemia, results from replacement of Arg 158 with Cys, disrupting the naturally occurring salt bridge between Asp 154 and Arg 158. (rcsb.org)
PCSK91
- Dit kan afhankelijk van type Homozygote FH bestaan uit PCSK9 remming en/of lomitapide. (horizonscangeneesmiddelen.nl)
Serum1
- It is a hyperlipoproteinemia type II A, diagnosed by: elevated serum low-density lipoprotein cholesterol (LDLc) with normal high-density lipoprotein cholesterol (HDLc), clinical aspect (xanthodermia), clear serum at direct examination. (hovawartclub.hu)
Clinical1
- Clinical features of Mexican patients with Mucopolysaccharidosis type I. (geneticsmr.com)
Certain types1
- Patients should avoid alcohol and estrogen in certain types of hyperlipoproteinemias. (medscape.com)
Disorders1
- Besides homozygosity for a receptor binding-defective isoform of apo E (apo E2), additional genes for familial lipoprotein disorders might operate in the pathogenesis of type III HLP. (nih.gov)
Lipid1
- Specialized lipid centers should be contacted if type IIb or III must be confirmed. (medscape.com)
Sort1
- Hyperlipoproteinemia sort II is further classified into sorts IIa and IIb, depending mainly on whether elevation in the triglyceride stage occurs in addition to LDL ldl cholesterol. (7red.com)
Medicine1
- Its bitter tasting leaves have been used in traditional medicine and contain labdane-type diterpene lactone andrographolide. (nih.gov)
Occur1
- Xanthomas are one of types of skin lesions that may occur in this situation. (wikipedia.org)
Medication1
- Each type of medication will also be imprinted with a unique code. (pfotenengel-ev.de)