• Mice
  • Because the development of atherosclerotic lesions in Apoe −/− mice is highly dependent on sex, diet, and age, 17 we chose to study the effects of diet-induced hyperhomocysteinemia in male Apoe −/− mice fed either a control diet or a high fat (Western) diet, and we assessed atherosclerotic lesion area at two time points (12 and 24 weeks of age). (ahajournals.org)