• Hydroxyurea (Droxia, Siklos) is used to reduce the frequency of painful crises and reduce the need for blood transfusions in adults and children 2 years of age and older with sickle cell anemia (an inherited blood disorder in which the red blood cells are abnormally shaped [shaped like a sickle] and cannot bring enough oxygen to all parts of the body). (medlineplus.gov)
  • Hydroxyurea treats sickle cell anemia by helping to prevent formation of sickle-shaped red blood cells. (medlineplus.gov)
  • Hydroxyurea is used in less than 25% of patients with sickle cell anemia (SCA) who could benefit from it, according to results of a study published in the April 28 issue of JAMA . (medscape.com)
  • Hydroxyurea is also used for the management of sickle cell anemia. (singhealth.com.sg)
  • Hydroxyurea also increases the production of fetal hemoglobin, via an unknown mechanism of action, which increases overall hemoglobin levels and decreases sickling in patients with sickle cell anemia. (nih.gov)
  • Hydroxyurea was approved by the FDA for use in adults with sickle cell anemia in 1998. (nih.gov)
  • Hydroxyurea Capsule is a prescription medication used in the treatment of certain medical conditions, including various types of cancer and sickle cell anemia. (ambicapharmacy.com)
  • For the REACH Investigators 2016, ' Hydroxyurea Therapy for Children With Sickle Cell Anemia in Sub-Saharan Africa: Rationale and Design of the REACH Trial ', Pediatric Blood and Cancer , vol. 63, no. 1, pp. 98-104. (nebraska.edu)
  • Longitudinal analysis of cardiac abnormalities in pediatric patients with sickle cell anemia and effect of hydroxyurea therapy. (bjh.be)
  • Evaluation of the concentration of malondialdehyde and nitrite in patients with sickle cell anemia treated or not with hydroxyurea. (bvsalud.org)
  • To determine the serum levels of malondialdehyde and nitrite in patients with sickle cell anemia treated or not with hydroxyurea in outpatient 's setting. (bvsalud.org)
  • Of the 65 patients with sickle cell anemia selected for the study, 51 were not treated with hydroxyurea (Group 1), 14 made chronic use of hydroxyurea (Group 2) and 20 individuals had no hemoglobinopathies ( Control Group ). (bvsalud.org)
  • Hydrea (Hydroxyurea) is used to treat melanoma, chronic myelocytic leukemia, ovarian and primary squamous cell cancer, carcinoma of the head and neck (excluding the lip), chronic myelogenous leukemia, sickle cell anemia. (trastedtablets.com)
  • Hydroxyurea is also used in adult patients with sickle cell anemia to prevent painful episodes and reduce the need for blood transfusions. (trastedtablets.com)
  • Hydroxyurea is available in capsules of 200, 300, 400 and 500 mg generically and under brand names as Droxia (for sickle cell disease) and Hydrea (for cancer). (nih.gov)
  • Hydroxyurea (hydroxycarbamate, Hydrea) is a chemo drug that has helped some patients with CMML live longer. (cancer.org)
  • Buy Hydrea 'Hydroxyurea' Online Without Prescriptions. (trastedtablets.com)
  • Order Hydrea 'Hydroxyurea' Online Without Prescriptions. (trastedtablets.com)
  • Cheap Hydrea 'Hydroxyurea' Online No Prescription. (trastedtablets.com)
  • Hydroxyurea comes as a capsule and tablet to take by mouth. (medlineplus.gov)
  • Hydroxyurea is available in capsule form. (singhealth.com.sg)
  • With its proven effectiveness and safety profile, Hydroxyurea Capsule plays a crucial role in managing specific diseases and improving patients' quality of life. (ambicapharmacy.com)
  • Q: How does Hydroxyurea Capsule work? (ambicapharmacy.com)
  • A: Hydroxyurea Capsule works by inhibiting the growth and reproduction of certain cells in the body. (ambicapharmacy.com)
  • Q: What medical conditions are treated with Hydroxyurea Capsule? (ambicapharmacy.com)
  • A: Hydroxyurea Capsule is primarily used in the treatment of several conditions, including certain types of cancer such as chronic myelogenous leukemia, ovarian cancer, and melanoma. (ambicapharmacy.com)
  • Q: Is Hydroxyurea Capsule safe to use? (ambicapharmacy.com)
  • A: Hydroxyurea Capsule is a prescription medication and should only be used under the guidance of a healthcare professional. (ambicapharmacy.com)
  • Q: How should I take Hydroxyurea Capsule? (ambicapharmacy.com)
  • A: The dosage and administration of Hydroxyurea Capsule will be determined by your healthcare provider based on your specific medical condition and individual factors. (ambicapharmacy.com)
  • The second finding is that IPF is susceptible to myelosuppressive treatment, which may additionally explain the favorable effect of hydroxyurea therapy on MPN outcome as well as the associated thrombotic risk. (maastrichtuniversity.nl)
  • Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with hydroxyurea and each time you refill your prescription. (medlineplus.gov)
  • Before you begin treatment with hydroxyurea, you and your doctor should talk about the good this medicine will do as well as the risks of using it. (trastedtablets.com)
  • The hydroxyurea 1,000-mg tablets (Siklos) are scored so that they can easily be split into halves or quarters to provide smaller doses. (medlineplus.gov)
  • Here we report that low doses of hydroxyurea, an inhibitor of ribonucleotide reductase and an important drug in the treatment of sickle cell disease and other diseases induces a high frequency of de novo CNVs in cultured human cells that resemble pathogenic and aphidicolin-induced CNVs in size and breakpoint structure. (nih.gov)
  • Serum aminotransferase and bilirubin elevations occur in a small proportion of patients on conventional doses of hydroxyurea and a greater proportion at higher doses. (nih.gov)
  • The TWiTCH study sought to determine whether giving daily doses of hydroxyurea (currently the only FDA-approved drug for sickle cell disease) lowers the TCD blood velocity in children with sickle cell disease (SCD) to a similar degree as blood transfusions. (nih.gov)
  • Tolerability and age-dependent toxicokinetics following perinatal hydroxyurea treatment in Sprague Dawley rats. (nih.gov)
  • Your doctor may need to delay your treatment or adjust your dose of hydroxyurea depending on your response to treatment and any side effects that you may experience. (medlineplus.gov)
  • The study defined treatment with hydroxyurea as filling at least one prescription during the 3, 6, or 12 months of continued enrollment after the third hospitalization or ED visit. (medscape.com)
  • The researchers hypothesize that several factors might contribute to the low use of this inexpensive and effective treatment, including clinician unfamiliarity with hydroxyurea, fear of adverse events, and absence of shared decision-making. (medscape.com)
  • Vasculitic toxicities: Discontinue hydroxyurea and initiate treatment if this occurs. (nih.gov)
  • discontinue hydroxyurea capsules, and implement treatment. (nih.gov)
  • Hydroxyurea treatment saves lives in Africa and other countries. (nih.gov)
  • Yet the study also offers promising new evidence that treatment with hydroxyurea could lead to improvement and even reversal of cardiac abnormalities in individuals with SCA. (hematology.org)
  • When we compared the group that had been on hydroxyurea treatment for less than one year to the group that had been on treatment for more than one year, we found that the people who had been treated for longer were less likely to have an enlarged heart or a thickened heart," said Dr. Dhar. (hematology.org)
  • The next phase of the study was a longitudinal analysis in which Dr. Dhar and her team assessed echocardiograms (ultrasound tests of the function of the heart's muscles and valves) performed over time on the patients receiving treatment with hydroxyurea. (hematology.org)
  • Even for asymptomatic individuals, screening should start at a young age so we can catch any abnormalities early and start treatment with hydroxyurea as soon as possible. (hematology.org)
  • An expert panel has released evidence-based guidelines for the treatment of SCD, including a strong recommendation that hydroxyurea and long-term, periodic blood transfusions should be used more often to treat patients. (medscape.com)
  • Hydroxyurea is an anticancer medication used for the treatment of leukemia. (singhealth.com.sg)
  • Expert perspectives on hydroxyurea as a staple therapy in the treatment armamentarium for sickle cell disease. (consultantlive.com)
  • Hydroxyurea is our tried-and-true treatment. (consultantlive.com)
  • Hydroxyurea is the oldest federally approved treatment for patients with sickle cell disease, and since the time of the original approval for a reduction in annual rate of pain crises, it has now proven itself as a possible substitute for transfusion in young children who have strokes. (consultantlive.com)
  • Hydroxyurea is an antimetabolite that is used in the treatment of cancer and to stimulate fetal hemoglobin production in sickle cell disease. (nih.gov)
  • Hydroxyurea is used in the treatment of solid tumors and myeloproliferative diseases, the latter because of its effects in reducing excessive production of red blood cells (polycythemia vera), white blood cells (chronic myelogenous leukemia) or platelets (essential thrombocythemia). (nih.gov)
  • What is the efficacy (results from clinical studies) of hydroxyurea treatment for patients who have sickle cell disease in three groups: infants, preadolescents, and adolescents/adults? (nih.gov)
  • What is the effectiveness (in everyday practice) of hydroxyurea treatment for patients who have sickle cell disease? (nih.gov)
  • What are the short- and long-term harms of hydroxyurea treatment? (nih.gov)
  • What are the barriers to hydroxyurea treatment for patients who have sickle cell disease and what are the potential solutions? (nih.gov)
  • Along with its benefits, hydroxyurea treatment may cause severe, sometimes fatal side effects (see also Side Effects section). (healthwarehouse.com)
  • The efficacy and mechanism of hydroxyurea in the treatment of atherosclerosis have rarely been reported. (thno.org)
  • The goal of this study was to investigate the efficacy of hydroxyurea in high-fat diet-fed ApoE -/- mice against atherosclerosis and examine the possible mechanism underlying treatment outcomes. (thno.org)
  • 16S rRNA was used to detect composition changes in the intestinal bacterial community of animals after treatment with hydroxyurea. (thno.org)
  • We showed that aortic root HE staining and oil red O staining determined the therapeutic efficacy of hydroxyurea in the treatment of atherosclerosis in high-fat diet-fed ApoE -/- mice. (thno.org)
  • Further histological and ELISAs verified that the protein responsible for intestinal absorption of cholesterol in mice, NPC1L1, was significantly reduced after hydroxyurea treatment. (thno.org)
  • To address this point, in 46 essential thrombocythemia and 38 polycythemia vera consecutive patients, we measured IPF and correlated the results to JAK2V617F mutation and myelosuppressive treatment with hydroxyurea. (maastrichtuniversity.nl)
  • By developing local expertise with the use of hydroxyurea and helping to establish treatment guidelines, the REACH trial results will have the potential to transform care for children with SCA in Africa. (nebraska.edu)
  • According to a recent study published in Blood advances, timely initiation of treatment with hydroxyurea (HU) may lead to reverse cardiac remodelling and improvement in these cardiac abnormalities. (bjh.be)
  • On the other hand , no changes in oxidative parameters were detected during treatment with hydroxyurea , probably due to the short period of treatment of the patients studied. (bvsalud.org)
  • Scholars@Duke publication: Treatment patterns and economic burden of sickle-cell disease patients prescribed hydroxyurea: a retrospective claims-based study. (duke.edu)
  • BACKGROUND: This study aimed to evaluate sickle-cell disease (SCD) treatment patterns and economic burden among patients prescribed hydroxyurea (HU) in the US, through claims data. (duke.edu)
  • Hydroxyurea (HU) is one of the US-FDA approved and commonly used drug for the treatment of adult SCD patients with clinical -severity. (qxmd.com)
  • and defining the relationships between hydroxyurea treatment and fetal hemoglobin, soluble intracellular adhesion molecule-1, and nitric oxide levels, and between levels of these factors and risk of subsequent malaria. (researchprotocols.org)
  • Conclusion: Treatment with hydroxyurea for 24 months did not influence GFR in young children with SCA. (elsevierpure.com)
  • Evaluation of pharmacological efficacy and safety of hydroxyurea in sickle cell disease: Study of a pediatric cohort from Chhattisgarh, India. (qxmd.com)
  • In Sub-Saharan Africa, however, the risk of malaria, hematologic toxicities, and safety of hydroxyurea in children with SCA living in malaria-endemic areas are unknown. (researchprotocols.org)
  • In conclusion, our results showed significant clinical and laboratory benefits of hydroxyurea in children with SCD. (thalassaemia.org.cy)
  • Procedure: A partnership was established between investigators in North America and sub-Saharan Africa, to develop a prospective multicenter research protocol designed to provide data on the safety, feasibility, and benefits of hydroxyurea for children with SCA. (nebraska.edu)
  • Hydroxyurea (hye drox" ee ure ee' a) is a hydroxylated analogue of urea and an antimetabolite which inhibits the enzyme ribonucleotide reductase, which is necessary for DNA synthesis and cell cycle replication. (nih.gov)
  • I would kindly like to request information regarding the use of the drug Siklos, which contains hydroxyurea, in terms of its administration to breastfeeding mothers. (infantrisk.com)
  • It contains hydroxyurea, an active ingredient that helps regulate the production of cells in the body. (ambicapharmacy.com)
  • These highlights do not include all the information needed to use HYDROXYUREA CAPSULES safely and effectively. (nih.gov)
  • See full prescribing information for HYDROXYUREA CAPSULES. (nih.gov)
  • Live Vaccinations: Avoid live vaccine use in a patient taking hydroxyurea capsules. (nih.gov)
  • Swallow hydroxyurea capsules whole. (nih.gov)
  • Do NOT open, break, or chew capsules because hydroxyurea is a cytotoxic drug. (nih.gov)
  • Monitor blood counts at least once a week during Hydroxyurea capsules therapy. (nih.gov)
  • Severe anemia must be corrected before initiating therapy with Hydroxyurea capsules. (nih.gov)
  • We used to think that hydroxyurea worked primarily by increasing the production of fetal hemoglobin, which as Dr Shah, said is naturally occurring in the Saudi Arabian population and in other populations where their disease is milder. (consultantlive.com)
  • Hydroxyurea can't quite reproduce that, but it does increase the production of the total amount of fetal hemoglobin. (consultantlive.com)
  • In 2014, the National Heart, Lung, and Blood Institute issued recommendations to treat all adults with SCA who experience at least three moderate to severe pain crises a year with hydroxyurea. (medscape.com)
  • Despite evidence that the drug reduces pain crises, hospitalizations, and blood transfusions, hydroxyurea is reportedly underused. (medscape.com)
  • The study may have underestimated the magnitude of the hydroxyurea gap in three ways: the study population was privately insured and did not include patients who could manage their pain crises at home. (medscape.com)
  • Cite this: Hydroxyurea Underused in Sickle Cell Pain Crises - Medscape - Apr 29, 2015. (medscape.com)
  • But in my mind, if they're symptomatic the way that they would be if they had hemoglobin S and have a lot of painful crises, they're going to get hydroxyurea even if they have hemoglobin SC. (consultantlive.com)
  • That means if they have a lot of crises and they're feeling poorly, and I think that it might help, I'm going to give hydroxyurea to them. (consultantlive.com)
  • In controlled clinical trials, hydroxyurea has been shown to increase hemoglobin concentrations, decrease transfusion requirements and lessen painful crises in patients with sickle cell disease. (nih.gov)
  • In the mid-1990s, researchers began investigating the potential of hydroxyurea to reduce the number and severity of pain crises in sickle cell patients. (nih.gov)
  • Hydroxyurea can cause a severe decrease in the number of blood cells in your bone marrow. (medlineplus.gov)
  • The Food and Drug Administration (FDA) approved hydroxyurea for severe SCD in 1998 for adults and in 2017 for children. (nih.gov)
  • By increasing hemoglobin, hydroxyurea can energy. (nih.gov)
  • Even though the book says it's for hemoglobin SS and S beta zero thalassemia, I give hydroxyurea to whoever needs it. (consultantlive.com)
  • Although there is no cure for Sickle Cell Disease yet, but there is a drug called hydroxyurea that is used to treat the crisis and maintain blood hemoglobin level. (onescdvoice.com)
  • Hydroxyurea is used alone or in conjunction with other antitumor agents or radiation therapy to treat neoplastic diseases. (nih.gov)
  • A study published today in the journal Blood Advances is the first to find that hydroxyurea therapy can improve or even reverse cardiac complications in individuals living with SCA. (hematology.org)
  • Hydroxyurea is associated with a low rate of transient serum enzyme and bilirubin elevations during therapy, and has been implicated in rare cases of clinically apparent acute liver injury with jaundice. (nih.gov)
  • Hydroxyurea was first approved for use in the United States in 1967 as an antineoplastic agent for therapy of melanoma, chronic myelogenous leukemia, ovarian carcinoma, and head and neck cancers. (nih.gov)
  • Long term hydroxyurea therapy may increase the risk of cancer. (nih.gov)
  • Hydroxyurea represents the only available disease-modifying therapy for SCA, and has proven safety and efficacy in high-resource countries. (nebraska.edu)
  • Hydroxyurea, the only disease-modifying therapy approved by the Food and Drug Administration for SCA, has proven to be a viable therapeutic option for SCA patients in resource-rich settings, given clinical improvements experienced while taking the medication and its once-daily oral dosing. (researchprotocols.org)
  • Studies have shown hydroxyurea is one potential y prevent the blockage of blood flow of several drugs that does this. (nih.gov)
  • What Other Drugs Interact with Hydroxyurea? (rxlist.com)
  • Hydroxyurea has moderate interactions with at least 115 different drugs. (rxlist.com)
  • Hydroxyurea has no known mild interactions with other drugs. (rxlist.com)
  • Hydroxyurea, one of the four drugs currently approved by the U.S. Food and Drug Administration to treat SCD, is believed to mitigate SCD symptoms by preventing the formation of sickled cells, but its precise mechanism of action is still not fully understood. (hematology.org)
  • We have 4 drugs: crizanlizumab and voxelotor are the 2 new ones, and Endari [L-glutamine] and hydroxyurea. (consultantlive.com)
  • Hydroxyurea is in a class of anti-cancer drugs and it acts to increase the overall percentage of normally structured red blood cells in the circulation. (nih.gov)
  • Hydroxyurea is an antineoplastic agent used to treat melanoma, leukemias, and other neoplasms. (infantrisk.com)
  • Hydroxyurea dermopathy is caused by chronic use of hydroxyurea for chronic myelogenous leukemia, thrombocytosis, or psoriasis, and presents with skin lesions characteristic of dermatomyositis. (wikipedia.org)
  • Hydroxyurea is an antineoplastic (anti-cancer) agent used to treat melanoma , resistant chronic myelocytic leukemia , and recurrent , metastatic, or inoperable carcinoma of the ovary and primary squamous cell (epidermoid) carcinomas of the head and neck. (rxlist.com)
  • Hydroxyurea is used to treat skin cancer (melanoma), a cancer of the white blood cells called chronic myelocytic leukemia (CML), and metastatic cancer (cancer that has spread) of the ovaries. (trastedtablets.com)
  • Hydroxyurea is an oral medicine that can help reduce sickle cel disease (SCD) complications. (nih.gov)
  • Hydroxyurea (HU) is known to decrease the frequency of vaso-occlusive complications and need for blood transfusions in severely affected individuals. (isth.org)
  • Hydroxyurea is a cytotoxic drug. (nih.gov)
  • In this research, we investigated the cytotoxic, antiproliferative and apoptosis-inducing effects of hydroxyurea on a human cervical carcinoma cell line, HeLa. (tubitak.gov.tr)
  • We found that hydroxyurea has cytotoxic and antiproliferative effects on HeLa cells in a dose-dependent manner. (tubitak.gov.tr)
  • We concluded that the observed antiproliferative, cytotoxic and apoptosis inducing activities of hydroxyurea might be mediated by the induction of p53 and its transcriptional target, p21. (tubitak.gov.tr)
  • REACH has an adaptive statistical design that allows for careful assessment of toxicities to accurately identify a safe hydroxyurea dose. (nebraska.edu)
  • Hydroxyurea is in a class of medications called antimetabolites. (medlineplus.gov)
  • If you are unable to swallow hydroxyurea tablets or portion(s) of tablets, you may dissolve your dose in water. (medlineplus.gov)
  • Novel use Of Hydroxyurea in an African Region with Malaria (NOHARM, NCT01976416) is a prospective, randomized, placebo-controlled, double-blinded phase III trial to compare risk of malaria with oral hydroxyurea versus placebo. (researchprotocols.org)
  • The study also did not consider, "the broadened criteria described in new guidelines for the use of hydroxyurea, such as patients who have daily pain that affects their quality of life. (medscape.com)
  • The investigators conclude that to address the gap in hydroxyurea use, "it may be necessary to enhance patient outreach and clinician training and develop health care quality measures aimed at increasing the use of hydroxyurea for all patients who would benefit. (medscape.com)
  • In patients who have demonstrated a previous hypersensitivity to hydroxyurea or any other component of its formulation. (nih.gov)
  • Sixty of the study participants were taking hydroxyurea, and the researchers noted that there was no difference in the level of LV enlargement for that group of patients as compared to the group not taking the drug. (hematology.org)
  • If patients with SCD crisis are being transported by emergency medical services (EMS), they should receive supplemental oxygen and intravenous hydration en route to the hospital. (medscape.com)
  • Drug fever occurs in up to 1% of patients treated with hydroxyurea, typically arising within 1 to 3 weeks of starting and presenting with high fevers and mild constitutional symptoms of fatigue and nausea (Case 1 below). (nih.gov)
  • Thirty-seven (37) of the patients using hydroxyurea had an increase in the mean corpuscular volume (MCV). (thalassaemia.org.cy)
  • Moreover, the frequency of blood transfusion in patients using hydroxyurea was statistically significant as p-value = 0.048. (thalassaemia.org.cy)
  • Hydroxyurea has been shown to reduce the frequency of VOC and blood transfusion in patients with SCD. (thalassaemia.org.cy)
  • An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Hydroxyurea (127-07-1). (nih.gov)
  • What Are Warnings and Precautions for Hydroxyurea? (rxlist.com)
  • Talk with your doctor about the risks of taking hydroxyurea. (medlineplus.gov)
  • Ask your healthcare provider about the potential benefits and risks, and whether hydroxyurea is right for you. (nih.gov)
  • These findings strengthen the beneficial effect of hydroxyurea in pediatric population also without any serious adverse effects and builds up ground for expanding its use under regular monitoring. (qxmd.com)
  • Until relatively recently, only one drug, hydroxyurea, was approved by the US Food and Drug Administration to ameliorate disease severity. (nih.gov)
  • This drug is prescribed when hydroxyurea and other treatments have failed. (nih.gov)
  • Since 1998, doctors have used a drug called hydroxyurea to reduce symptoms, but it can cause serious side effects and increase the risk of certain cancers. (nih.gov)
  • Because the main effect of hydroxyurea is to lower blood counts, anyone taking this drug will need to have their blood counts checked regularly. (cancer.org)
  • Hydroxyurea may increase the risk that you will develop other cancers, including skin cancer. (medlineplus.gov)
  • Hydroxyurea treats cancer by slowing or stopping the growth of cancer cells in your body. (medlineplus.gov)
  • When hydroxyurea is used to treat certain types of cancer, it may be taken once every third day. (medlineplus.gov)
  • Your doctor will order certain tests on a regular basis to check your body's response to hydroxyurea and to see if your blood count has dropped. (medlineplus.gov)
  • Your doctor may need to change your dose or tell you to stop taking hydroxyurea for a period of time to allow your blood count to return to normal if it has dropped too low. (medlineplus.gov)
  • Your doctor may change the dosage of Hydroxyurea depending on blood tests results. (singhealth.com.sg)
  • The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, has ended the Transcranial Doppler (TCD) with Transfusions Changing to Hydroxyurea (TWiTCH) clinical trial early in agreement with the recommendations of the Data and Safety Monitoring Board (DSMB). (nih.gov)
  • Children with sickle cell disease who are at a higher risk for stroke are identified by measuring the velocity of blood flow to the brain by TCD ultrasound studies.Children with the highest TCD velocities have a greater risk of strokes.The early review showed that hydroxyurea reduces TCD blood velocities to a similar degree as blood transfusions. (nih.gov)
  • The results of this study show that hydroxyurea is not inferior to (that is, no worse than) regular blood transfusions in lowering TCD velocities in children with sickle cell disease who are at high risk for stroke. (nih.gov)
  • Current management strategies include prophylactic penicillin and immunizations to decrease the occurrence of pneumococcal infections, hydroxyurea (a disease-modifying agent), blood transfusions (for symptomatic acute anemia, stroke management, preoperative optimization), and bone marrow transplant. (ccjm.org)
  • Read the Patient Information Leaflet if available from your pharmacist before you start taking hydroxyurea and each time you get a refill. (healthwarehouse.com)
  • In sub-Saharan Africa, there is minimal use of hydroxyurea, due to lack of data, absence of evidence-based guidelines, and inexperience among healthcare providers. (nebraska.edu)
  • Results: The Realizing Effectiveness Across Continents with Hydroxyurea (REACH, ClinicalTrials.gov NCT01966731) trial is a prospective, phase I/II open-label dose escalation study of hydroxyurea that will treat a total of 600 children age 1-10 years with SCA: 150 at each of four different clinical sites within sub-Saharan Africa (Angola, Democratic Republic of Congo, Kenya, and Uganda). (nebraska.edu)
  • NOHARM will be the first prospective randomized, placebo-controlled clinical trial investigating the use of hydroxyurea for children with SCA in a malaria-endemic region within Africa. (researchprotocols.org)
  • SCD treatments, including hydroxyurea, may reduce symptoms and improve quality of life. (nih.gov)
  • The incidence of vaso-occlusive crisis (VOC) increased after hydroxyurea initiation from 4.555±4.08 to 6.288±9.80. (thalassaemia.org.cy)
  • How should I handle Hydroxyurea safely? (singhealth.com.sg)
  • How should I dispose of Hydroxyurea safely? (singhealth.com.sg)
  • The results of this trial have the potential to significantly advance understanding of how to safely and effectively use hydroxyurea in children with SCA in malaria-endemic areas. (researchprotocols.org)
  • In high-fat diet-fed ApoE -/- mice, hydroxyurea effectively treated atherosclerosis, lowered serum cholesterol, modulated the gut microbiota at multiple levels and affected cholesterol absorption by reducing NPC1L1 in small intestinal epithelial cells. (thno.org)
  • This study aims to determine the frequency and benefits of using hydroxyurea in treating children with SCD in King Abdulaziz University Hospital (KAUH) in Saudi Arabia. (thalassaemia.org.cy)
  • Do not use this medicine if you (or your child) is allergic to Hydroxyurea. (singhealth.com.sg)
  • The Phase III randomized double-blinded Clinical Trial of Hydroxyurea in Infants with SCA (BABY HUG) tested the hypothesis that hydroxyurea can prevent kidney dysfunction by reducing hyperfiltration. (elsevierpure.com)
  • In addition, they point to a need for further study of the genomic consequences of the therapeutic use of hydroxyurea. (nih.gov)